Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis

The global burden of disease attributable to respiratory syncytial virus (RSV) remains unknown. We aimed to estimate the global incidence of and mortality from episodes of acute lower respiratory infection (ALRI) due to RSV in children younger than 5 years in 2005. We estimated the incidence of RSV-...

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Published in:The Lancet (British edition) Vol. 375; no. 9725; pp. 1545 - 1555
Main Authors: Nair, Harish, Nokes, D James, Gessner, Bradford D, Dherani, Mukesh, Madhi, Shabir A, Singleton, Rosalyn J, O'Brien, Katherine L, Roca, Anna, Wright, Peter F, Bruce, Nigel, Chandran, Aruna, Theodoratou, Evropi, Sutanto, Agustinus, Sedyaningsih, Endang R, Ngama, Mwanajuma, Munywoki, Patrick K, Kartasasmita, Cissy, Simões, Eric AF, Rudan, Igor, Weber, Martin W, Campbell, Harry
Format: Journal Article
Language:English
Published: Kidlington Elsevier Ltd 01.05.2010
Elsevier
Elsevier Limited
Lancet Publishing Group
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ISSN:0140-6736, 1474-547X, 1474-547X
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Abstract The global burden of disease attributable to respiratory syncytial virus (RSV) remains unknown. We aimed to estimate the global incidence of and mortality from episodes of acute lower respiratory infection (ALRI) due to RSV in children younger than 5 years in 2005. We estimated the incidence of RSV-associated ALRI in children younger than 5 years, stratified by age, using data from a systematic review of studies published between January, 1995, and June, 2009, and ten unpublished population-based studies. We estimated possible boundaries for RSV-associated ALRI mortality by combining case fatality ratios with incidence estimates from hospital-based reports from published and unpublished studies and identifying studies with population-based data for RSV seasonality and monthly ALRI mortality. In 2005, an estimated 33·8 (95% CI 19·3–46·2) million new episodes of RSV-associated ALRI occurred worldwide in children younger than 5 years (22% of ALRI episodes), with at least 3·4 (2·8–4·3) million episodes representing severe RSV-associated ALRI necessitating hospital admission. We estimated that 66 000–199 000 children younger than 5 years died from RSV-associated ALRI in 2005, with 99% of these deaths occurring in developing countries. Incidence and mortality can vary substantially from year to year in any one setting. Globally, RSV is the most common cause of childhood ALRI and a major cause of admission to hospital as a result of severe ALRI. Mortality data suggest that RSV is an important cause of death in childhood from ALRI, after pneumococcal pneumonia and Haemophilus influenzae type b. The development of novel prevention and treatment strategies should be accelerated as a priority. WHO; Bill & Melinda Gates Foundation.
AbstractList The global burden of disease attributable to respiratory syncytial virus (RSV) remains unknown. We aimed to estimate the global incidence of and mortality from episodes of acute lower respiratory infection (ALRI) due to RSV in children younger than 5 years in 2005. We estimated the incidence of RSV-associated ALRI in children younger than 5 years, stratified by age, using data from a systematic review of studies published between January, 1995, and June, 2009, and ten unpublished population-based studies. We estimated possible boundaries for RSV-associated ALRI mortality by combining case fatality ratios with incidence estimates from hospital-based reports from published and unpublished studies and identifying studies with population-based data for RSV seasonality and monthly ALRI mortality. In 2005, an estimated 3.8 (95% CI 19.3-46.2) million new episodes of RSV-associated ALRI occurred worldwide in children younger than 5 years (22% of ALRI episodes), with at least 3.4 (2.8-4.3) million episodes representing severe RSV-associated ALRI necessitating hospital admission. We estimated that 66 000-199 000 children younger than 5 years died from RSV-associated ALRI in 2005, with 99% of these deaths occurring in developing countries. Incidence and mortality can vary substantially from year to year in any one setting. Globally, RSV is the most common cause of childhood ALRI and a major cause of admission to hospital as a result of severe ALRI. Mortality data suggest that RSV is an important cause of death in childhood from ALRI, after pneumococcal pneumonia and Haemophilus influenzae type b. The development of novel prevention and treatment strategies should be accelerated as a priority. WHO; Bill & Melinda Gates Foundation.
The global burden of disease attributable to respiratory syncytial virus (RSV) remains unknown. We aimed to estimate the global incidence of and mortality from episodes of acute lower respiratory infection (ALRI) due to RSV in children younger than 5 years in 2005. Methods - We estimated the incidence of RSV-associated ALRI in children younger than 5 years, stratified by age, using data from a systematic review of studies published between January, 1995, and June, 2009, and ten unpublished population-based studies. We estimated possible boundaries for RSV-associated ALRI mortality by combining case fatality ratios with incidence estimates from hospital-based reports from published and unpublished studies and identifying studies with population-based data for RSV seasonality and monthly ALRI mortality. Findings - In 2005, an estimated 33 super(.)8 (95% CI 19 super(.)3-46 super(.)2) million new episodes of RSV-associated ALRI occurred worldwide in children younger than 5 years (22% of ALRI episodes), with at least 3 super(.)4 (2 super(.)8-4 super(.)3) million episodes representing severe RSV-associated ALRI necessitating hospital admission. We estimated that 66 000-199 000 children younger than 5 years died from RSV-associated ALRI in 2005, with 99% of these deaths occurring in developing countries. Incidence and mortality can vary substantially from year to year in any one setting. Interpretation - Globally, RSV is the most common cause of childhood ALRI and a major cause of admission to hospital as a result of severe ALRI. Mortality data suggest that RSV is an important cause of death in childhood from ALRI, after pneumococcal pneumonia and Haemophilus influenzae type b. The development of novel prevention and treatment strategies should be accelerated as a priority. Funding - WHO; Bill & Melinda Gates Foundation.
The global burden of disease attributable to respiratory syncytial virus (RSV) remains unknown. We aimed to estimate the global incidence of and mortality from episodes of acute lower respiratory infection (ALRI) due to RSV in children younger than 5 years in 2005.BACKGROUNDThe global burden of disease attributable to respiratory syncytial virus (RSV) remains unknown. We aimed to estimate the global incidence of and mortality from episodes of acute lower respiratory infection (ALRI) due to RSV in children younger than 5 years in 2005.We estimated the incidence of RSV-associated ALRI in children younger than 5 years, stratified by age, using data from a systematic review of studies published between January, 1995, and June, 2009, and ten unpublished population-based studies. We estimated possible boundaries for RSV-associated ALRI mortality by combining case fatality ratios with incidence estimates from hospital-based reports from published and unpublished studies and identifying studies with population-based data for RSV seasonality and monthly ALRI mortality.METHODSWe estimated the incidence of RSV-associated ALRI in children younger than 5 years, stratified by age, using data from a systematic review of studies published between January, 1995, and June, 2009, and ten unpublished population-based studies. We estimated possible boundaries for RSV-associated ALRI mortality by combining case fatality ratios with incidence estimates from hospital-based reports from published and unpublished studies and identifying studies with population-based data for RSV seasonality and monthly ALRI mortality.In 2005, an estimated 33.8 (95% CI 19.3-46.2) million new episodes of RSV-associated ALRI occurred worldwide in children younger than 5 years (22% of ALRI episodes), with at least 3.4 (2.8-4.3) million episodes representing severe RSV-associated ALRI necessitating hospital admission. We estimated that 66 000-199 000 children younger than 5 years died from RSV-associated ALRI in 2005, with 99% of these deaths occurring in developing countries. Incidence and mortality can vary substantially from year to year in any one setting.FINDINGSIn 2005, an estimated 33.8 (95% CI 19.3-46.2) million new episodes of RSV-associated ALRI occurred worldwide in children younger than 5 years (22% of ALRI episodes), with at least 3.4 (2.8-4.3) million episodes representing severe RSV-associated ALRI necessitating hospital admission. We estimated that 66 000-199 000 children younger than 5 years died from RSV-associated ALRI in 2005, with 99% of these deaths occurring in developing countries. Incidence and mortality can vary substantially from year to year in any one setting.Globally, RSV is the most common cause of childhood ALRI and a major cause of admission to hospital as a result of severe ALRI. Mortality data suggest that RSV is an important cause of death in childhood from ALRI, after pneumococcal pneumonia and Haemophilus influenzae type b. The development of novel prevention and treatment strategies should be accelerated as a priority.INTERPRETATIONGlobally, RSV is the most common cause of childhood ALRI and a major cause of admission to hospital as a result of severe ALRI. Mortality data suggest that RSV is an important cause of death in childhood from ALRI, after pneumococcal pneumonia and Haemophilus influenzae type b. The development of novel prevention and treatment strategies should be accelerated as a priority.WHO; Bill & Melinda Gates Foundation.FUNDINGWHO; Bill & Melinda Gates Foundation.
The global burden of disease attributable to respiratory syncytial virus (RSV) remains unknown. We aimed to estimate the global incidence of and mortality from episodes of acute lower respiratory infection (ALRI) due to RSV in children younger than 5 years in 2005. We estimated the incidence of RSV-associated ALRI in children younger than 5 years, stratified by age, using data from a systematic review of studies published between January, 1995, and June, 2009, and ten unpublished population-based studies. We estimated possible boundaries for RSV-associated ALRI mortality by combining case fatality ratios with incidence estimates from hospital-based reports from published and unpublished studies and identifying studies with population-based data for RSV seasonality and monthly ALRI mortality. In 2005, an estimated 33·8 (95% CI 19·3–46·2) million new episodes of RSV-associated ALRI occurred worldwide in children younger than 5 years (22% of ALRI episodes), with at least 3·4 (2·8–4·3) million episodes representing severe RSV-associated ALRI necessitating hospital admission. We estimated that 66 000–199 000 children younger than 5 years died from RSV-associated ALRI in 2005, with 99% of these deaths occurring in developing countries. Incidence and mortality can vary substantially from year to year in any one setting. Globally, RSV is the most common cause of childhood ALRI and a major cause of admission to hospital as a result of severe ALRI. Mortality data suggest that RSV is an important cause of death in childhood from ALRI, after pneumococcal pneumonia and Haemophilus influenzae type b. The development of novel prevention and treatment strategies should be accelerated as a priority. WHO; Bill & Melinda Gates Foundation.
Summary Background The global burden of disease attributable to respiratory syncytial virus (RSV) remains unknown. We aimed to estimate the global incidence of and mortality from episodes of acute lower respiratory infection (ALRI) due to RSV in children younger than 5 years in 2005. Methods We estimated the incidence of RSV-associated ALRI in children younger than 5 years, stratified by age, using data from a systematic review of studies published between January, 1995, and June, 2009, and ten unpublished population-based studies. We estimated possible boundaries for RSV-associated ALRI mortality by combining case fatality ratios with incidence estimates from hospital-based reports from published and unpublished studies and identifying studies with population-based data for RSV seasonality and monthly ALRI mortality. Findings In 2005, an estimated 33·8 (95% CI 19·3–46·2) million new episodes of RSV-associated ALRI occurred worldwide in children younger than 5 years (22% of ALRI episodes), with at least 3·4 (2·8–4·3) million episodes representing severe RSV-associated ALRI necessitating hospital admission. We estimated that 66 000–199 000 children younger than 5 years died from RSV-associated ALRI in 2005, with 99% of these deaths occurring in developing countries. Incidence and mortality can vary substantially from year to year in any one setting. Interpretation Globally, RSV is the most common cause of childhood ALRI and a major cause of admission to hospital as a result of severe ALRI. Mortality data suggest that RSV is an important cause of death in childhood from ALRI, after pneumococcal pneumonia and Haemophilus influenzae type b. The development of novel prevention and treatment strategies should be accelerated as a priority. Funding WHO; Bill & Melinda Gates Foundation.
The global burden of disease attributable to respiratory syncytial virus (RSV) remains unknown. We aimed to estimate the global incidence of and mortality from episodes of acute lower respiratory infection (ALRI) due to RSV in children younger than 5 years in 2005. We estimated the incidence of RSV-associated ALRI in children younger than 5 years, stratified by age, using data from a systematic review of studies published between January, 1995, and June, 2009, and ten unpublished population-based studies. We estimated possible boundaries for RSV-associated ALRI mortality by combining case fatality ratios with incidence estimates from hospital-based reports from published and unpublished studies and identifying studies with population-based data for RSV seasonality and monthly ALRI mortality. In 2005, an estimated 33.8 (95% CI 19.3-46.2) million new episodes of RSV-associated ALRI occurred worldwide in children younger than 5 years (22% of ALRI episodes), with at least 3.4 (2.8-4.3) million episodes representing severe RSV-associated ALRI necessitating hospital admission. We estimated that 66 000-199 000 children younger than 5 years died from RSV-associated ALRI in 2005, with 99% of these deaths occurring in developing countries. Incidence and mortality can vary substantially from year to year in any one setting. Globally, RSV is the most common cause of childhood ALRI and a major cause of admission to hospital as a result of severe ALRI. Mortality data suggest that RSV is an important cause of death in childhood from ALRI, after pneumococcal pneumonia and Haemophilus influenzae type b. The development of novel prevention and treatment strategies should be accelerated as a priority. WHO; Bill & Melinda Gates Foundation.
Author Rudan, Igor
Sedyaningsih, Endang R
Campbell, Harry
Madhi, Shabir A
Chandran, Aruna
Singleton, Rosalyn J
Simões, Eric AF
O'Brien, Katherine L
Dherani, Mukesh
Gessner, Bradford D
Ngama, Mwanajuma
Weber, Martin W
Nair, Harish
Kartasasmita, Cissy
Bruce, Nigel
Roca, Anna
Munywoki, Patrick K
Theodoratou, Evropi
Sutanto, Agustinus
Nokes, D James
Wright, Peter F
AuthorAffiliation a Centre for Population Health Sciences, Global Health Academy, The University of Edinburgh, Edinburgh, UK
i Arctic Investigations Program, National Center for Preparedness, Detection and Control of Infectious Disease, CDC, Anchorage, AK, USA
f Division of Public Health, University of Liverpool, Liverpool, UK
s WHO, Indonesia Country Office, Jakarta, Indonesia
d Department of Biological Sciences, University of Warwick, Coventry, UK
r Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia
h Alaska Native Tribal Health Consortium, Anchorage, AK, USA
p Medical Faculty, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Indonesia
k Barcelona Centre for International Health Research (CRESIB), Hospital Clínic/IDIBAPS, Universitat de Barcelona, Barcelona, Spain
b Public Health Foundation of India, New Delhi, India
o Indonesian Ministry of Health, Jakarta, Indonesia
c Kenya Medical Research Institute (KEMRI), Centre for Geographic Medicine Research-Coast
AuthorAffiliation_xml – name: b Public Health Foundation of India, New Delhi, India
– name: l Centro de Investigação em Saúde da Manhiça (CISM), Ministerio de Saúde, Maputo, Mozambique
– name: m Division of Infectious Disease and International Health, Dartmouth Medical School, Lebanon, NH, USA
– name: f Division of Public Health, University of Liverpool, Liverpool, UK
– name: g Medical Research Council Respiratory and Meningeal Pathogens Research Unit and Department of Science and Technology/National Research Foundation in Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa
– name: i Arctic Investigations Program, National Center for Preparedness, Detection and Control of Infectious Disease, CDC, Anchorage, AK, USA
– name: q University of Colorado Denver and The Children's Hospital, Denver, CO, USA
– name: a Centre for Population Health Sciences, Global Health Academy, The University of Edinburgh, Edinburgh, UK
– name: h Alaska Native Tribal Health Consortium, Anchorage, AK, USA
– name: k Barcelona Centre for International Health Research (CRESIB), Hospital Clínic/IDIBAPS, Universitat de Barcelona, Barcelona, Spain
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– name: e Agence de Médecine Préventive, Paris, France
– name: r Croatian Centre for Global Health, Faculty of Medicine, University of Split, Split, Croatia
– name: n West Nusa Tenggara Provincial Government, Lombok, Indonesia
– name: o Indonesian Ministry of Health, Jakarta, Indonesia
– name: p Medical Faculty, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Indonesia
– name: j Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
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  surname: Nair
  fullname: Nair, Harish
  organization: Centre for Population Health Sciences, Global Health Academy, The University of Edinburgh, Edinburgh, UK
– sequence: 2
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  surname: Nokes
  fullname: Nokes, D James
  organization: Kenya Medical Research Institute (KEMRI), Centre for Geographic Medicine Research-Coast, Kilifi, Kenya
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  givenname: Bradford D
  surname: Gessner
  fullname: Gessner, Bradford D
  organization: Agence de Médecine Préventive, Paris, France
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  organization: Division of Public Health, University of Liverpool, Liverpool, UK
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  surname: Madhi
  fullname: Madhi, Shabir A
  organization: Medical Research Council Respiratory and Meningeal Pathogens Research Unit and Department of Science and Technology/National Research Foundation in Vaccine Preventable Diseases, University of the Witwatersrand, Johannesburg, South Africa
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  surname: Singleton
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  organization: Alaska Native Tribal Health Consortium, Anchorage, AK, USA
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  surname: O'Brien
  fullname: O'Brien, Katherine L
  organization: Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
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  givenname: Anna
  surname: Roca
  fullname: Roca, Anna
  organization: Barcelona Centre for International Health Research (CRESIB), Hospital Clínic/IDIBAPS, Universitat de Barcelona, Barcelona, Spain
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  surname: Wright
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  organization: Division of Infectious Disease and International Health, Dartmouth Medical School, Lebanon, NH, USA
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  surname: Bruce
  fullname: Bruce, Nigel
  organization: Division of Public Health, University of Liverpool, Liverpool, UK
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  givenname: Aruna
  surname: Chandran
  fullname: Chandran, Aruna
  organization: Center for American Indian Health, Johns Hopkins Bloomberg School of Public Health, Baltimore, MD, USA
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  surname: Theodoratou
  fullname: Theodoratou, Evropi
  organization: Centre for Population Health Sciences, Global Health Academy, The University of Edinburgh, Edinburgh, UK
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  givenname: Agustinus
  surname: Sutanto
  fullname: Sutanto, Agustinus
  organization: West Nusa Tenggara Provincial Government, Lombok, Indonesia
– sequence: 14
  givenname: Endang R
  surname: Sedyaningsih
  fullname: Sedyaningsih, Endang R
  organization: Indonesian Ministry of Health, Jakarta, Indonesia
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  givenname: Mwanajuma
  surname: Ngama
  fullname: Ngama, Mwanajuma
  organization: Kenya Medical Research Institute (KEMRI), Centre for Geographic Medicine Research-Coast, Kilifi, Kenya
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  givenname: Patrick K
  surname: Munywoki
  fullname: Munywoki, Patrick K
  organization: Kenya Medical Research Institute (KEMRI), Centre for Geographic Medicine Research-Coast, Kilifi, Kenya
– sequence: 17
  givenname: Cissy
  surname: Kartasasmita
  fullname: Kartasasmita, Cissy
  organization: Medical Faculty, Padjadjaran University, Hasan Sadikin General Hospital, Bandung, Indonesia
– sequence: 18
  givenname: Eric AF
  surname: Simões
  fullname: Simões, Eric AF
  organization: University of Colorado Denver and The Children's Hospital, Denver, CO, USA
– sequence: 19
  givenname: Igor
  surname: Rudan
  fullname: Rudan, Igor
  organization: Centre for Population Health Sciences, Global Health Academy, The University of Edinburgh, Edinburgh, UK
– sequence: 20
  givenname: Martin W
  surname: Weber
  fullname: Weber, Martin W
  organization: WHO, Indonesia Country Office, Jakarta, Indonesia
– sequence: 21
  givenname: Harry
  surname: Campbell
  fullname: Campbell, Harry
  email: Harry.Campbell@ed.ac.uk
  organization: Centre for Population Health Sciences, Global Health Academy, The University of Edinburgh, Edinburgh, UK
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=22730114$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/20399493$$D View this record in MEDLINE/PubMed
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Issue 9725
Keywords Human
Preschool age
Human respiratory syncytial virus
Pneumovirinae
Acute
Systematic review
Respiratory system
Paramyxoviridae
Metaanalysis
Virus
Infection
Medicine
Respiratory tract
Mononegavirales
Pneumovirus
Child
Language English
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Snippet The global burden of disease attributable to respiratory syncytial virus (RSV) remains unknown. We aimed to estimate the global incidence of and mortality from...
Summary Background The global burden of disease attributable to respiratory syncytial virus (RSV) remains unknown. We aimed to estimate the global incidence of...
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proquest
pubmed
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StartPage 1545
SubjectTerms Age
Age Distribution
Ambulatory Care Facilities
Biological and medical sciences
Child, Preschool
Data collection
Developed Countries
Developing Countries
Estimates
Fatalities
General aspects
Global Health
Haemophilus influenzae
Hospitalization
Hospitals
Human viral diseases
Humans
Incidence
Infant
Infant, Newborn
Infectious diseases
Internal Medicine
LDCs
Medical research
Medical sciences
Mortality
Pneumonia
Population studies
Report writing
Respiratory Syncytial Virus Infections - epidemiology
Seasonal variations
Severity of Illness Index
Studies
Systematic review
Viral diseases
Viral diseases of the respiratory system and ent viral diseases
Title Global burden of acute lower respiratory infections due to respiratory syncytial virus in young children: a systematic review and meta-analysis
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Volume 375
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