Drug resistance testing through remote genotyping and predicted treatment options in human immunodeficiency virus type 1 infected Tanzanian subjects failing first or second line antiretroviral therapy

Antiretroviral therapy (ART) has been successfully introduced in low-middle income countries. However an increasing rate of ART failure with resistant virus is reported. We therefore described the pattern of drug resistance mutations at antiretroviral treatment (ART) failure in a real-life Tanzanian...

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Bibliographic Details
Published in:	PloS one Vol. 12; no. 6; p. e0178942
Main Authors:	Svärd, Jenny, Mugusi, Sabina, Mloka, Doreen, Neogi, Ujjwal, Meini, Genny, Mugusi, Ferdinand, Incardona, Francesca, Zazzi, Maurizio, Sönnerborg, Anders
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 05.06.2017 Public Library of Science (PLoS)
Subjects:	Abacavir Accumulation Acquired immune deficiency syndrome Adult AIDS Algorithms Amplification Analysis Anti-HIV Agents - therapeutic use Antimicrobial agents Antiretroviral agents Antiretroviral drugs Antiretroviral therapy Antiretroviral Therapy, Highly Active Atazanavir Sulfate - therapeutic use Benzoxazines - therapeutic use Bioinformatics Biology and Life Sciences Care and treatment Clinical Decision-Making Computational Biology Criteria Cross-resistance Cross-Sectional Studies Deoxyribonucleic acid Disease resistance DNA DNA polymerases DNA sequencing Dosage and administration Drug resistance Drug Resistance, Viral - genetics Drug therapy Drugs Efavirenz Emtricitabine Emtricitabine - therapeutic use Engineering and Technology Failure Female Fragmentation Gene sequencing Genotype Genotyping Guidelines Health aspects HIV HIV infections HIV Infections - drug therapy HIV Infections - virology HIV-1 - classification HIV-1 - drug effects HIV-1 - genetics HIV-1 - growth & development Human immunodeficiency virus Humans Immunology Income Inhibitors Lamivudine Lamivudine - therapeutic use Load distribution Lopinavir Lopinavir - therapeutic use Male Medicine and Health Sciences Monitoring Monitoring, Physiologic Mutation Nevirapine Nevirapine - therapeutic use Nucleoside reverse transcriptase inhibitors People and Places pol Gene Products, Human Immunodeficiency Virus - genetics Prevention Research and Analysis Methods RNA-directed DNA polymerase Salvage Sensitivity Sensitivity analysis Stavudine Stavudine - therapeutic use Switches Tanzania Tenofovir Tenofovir - therapeutic use Therapy Treatment Failure Viral Load - drug effects Viruses Sweden Tanzania
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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