Investigation of correlates of protection against pharyngeal carriage of Neisseria meningitidis genogroups W and Y in the African meningitis belt

Serum bactericidal antibody titres that correlate with protection against invasive meningococcal disease have been characterised. However, titres that are associated with protection against acquisition of pharyngeal carriage of Neisseria meningitidis are not known. Sera were obtained from the member...

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Vydáno v:	PloS one Ročník 12; číslo 8; s. e0182575
Hlavní autoři:	Cooper, Laura V., Boukary, Rahamatou Moustapha, Aseffa, Abraham, Mihret, Wude, Collard, Jean-Marc, Daugla, Doumagoum, Hodgson, Abraham, Sokhna, Cheikh, Omotara, Babatunji, Sow, Samba, Quaye, Stephen Laryea, Diallo, Kanny, Manigart, Olivier, Maiden, Martin C. J., Findlow, Helen, Borrow, Ray, Stuart, James M., Greenwood, Brian M., Trotter, Caroline L.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 10.08.2017 Public Library of Science (PLoS)
Témata:	Antibodies, Bacterial Antibodies, Bacterial - blood Bacteria Bacterial meningitis Bacteriology Biology and Life Sciences Carrier State Carriers Causes of Consortia Cross-Sectional Studies Development and progression Endemic Diseases Epidemics Female Health surveillance Households Human health and pathology Humans Hygiene Infections Infectious diseases Invasive meningococcal disease Life Sciences Male Medical research Medicine and Health Sciences Meningitis Meningitis, Meningococcal Meningitis, Meningococcal - epidemiology Meningitis, Meningococcal - immunology Meningitis, Meningococcal - microbiology Meningitis, Meningococcal - prevention & control Meningococcal disease Microbiology and Parasitology Neisseria Neisseria meningitidis Neisseria meningitidis, Serogroup W-135 Neisseria meningitidis, Serogroup W-135 - immunology Neisseria meningitidis, Serogroup Y Neisseria meningitidis, Serogroup Y - immunology Pharynx Pharynx - microbiology Physiological aspects Protective Factors Public health Risk Factors Santé publique et épidémiologie Studies Vaccination Vaccines Veterinary medicine Young Adult United Kingdom Nigeria Ethiopia Addis Ababa Ethiopia
ISSN:	1932-6203, 1932-6203
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Shrnutí:	Serum bactericidal antibody titres that correlate with protection against invasive meningococcal disease have been characterised. However, titres that are associated with protection against acquisition of pharyngeal carriage of Neisseria meningitidis are not known. Sera were obtained from the members of a household in seven countries of the African meningitis belt in which a pharyngeal carrier of N. meningitidis had been identified during a cross-sectional survey. Serum bactericidal antibody titres at baseline were compared between individuals in the household of the carrier who became a carrier of a meningococcus of the same genogroup during six months of subsequent follow-up and household members who did not become a carrier of a meningococcus of this genogroup during this period. Serum bacterial antibody titres were significantly higher in carriers of a serogroup W or Y meningococcus at the time of recruitment than in those who were not a carrier of N. meningitidis of the same genogroup. Serum bactericidal antibody titres to a strain of N. meningitis of the same genogroup as the index cases were no different in individuals who acquired carriage with a meningococcus of the same genogroup as the index case than in those who did not become a carrier during six months of follow-up. Serum bacterial antibody titres to N. meningitidis of genogroup W or Y in the range of those acquired by natural exposure to meningococci of these genogroups, or with cross-reactive bacteria, are not associated with protection against acquisition of carriage with meningococci of either of these genogroups.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 PMCID: PMC5552120 Competing Interests: RB and HF report performing contract research on behalf of Public Health England for Pfizer, Sanofi Pasteur, Serum Institute of India, and GSK. CLT and OM report receiving a consulting payment from GSK. All other authors report no potential conflicts. This does not alter our adherence to PLOS ONE policies on sharing data and materials. These authors are joint first authors on this work.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0182575