The Synthetic Bacterial Lipopeptide Pam3CSK4 Modulates Respiratory Syncytial Virus Infection Independent of TLR Activation

Respiratory syncytial virus (RSV) is an important cause of acute respiratory disease in infants, immunocompromised subjects and the elderly. However, it is unclear why most primary RSV infections are associated with relatively mild symptoms, whereas some result in severe lower respiratory tract infe...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 6; no. 8; p. e1001049
Main Authors:	Nguyen, D. Tien, de Witte, Lot, Ludlow, Martin, Yüksel, Selma, Wiesmüller, Karl-Heinz, Geijtenbeek, Teunis B. H., Osterhaus, Albert D. M. E., de Swart, Rik L.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.08.2010 Public Library of Science (PLoS)
Subjects:	Adjuvants Adjuvants, Immunologic - chemistry Adjuvants, Immunologic - pharmacology Bacteria Bacterial infections Bronchopneumonia Cellular signal transduction Colonization Cysteine Data processing Epithelial cells Experiments Flow cytometry Geriatrics Glycosaminoglycans HIV-1 - drug effects HIV-1 - metabolism HIV-1 - pathogenicity Human immunodeficiency virus 1 Human metapneumovirus Humans Infants Infection Infectious Diseases/Respiratory Infections Infectious Diseases/Viral Infections lipopeptides Lipopeptides - chemistry Lipopeptides - pharmacology Lymphoid cells Lysine Measles virus Measles virus - drug effects Measles virus - metabolism Measles virus - pathogenicity Metapneumovirus - drug effects Metapneumovirus - metabolism Metapneumovirus - pathogenicity Microbiology/Medical Microbiology Pathogenesis Pathogens Physiological aspects Premature birth Respiratory Medicine/Respiratory Infections Respiratory Medicine/Respiratory Pediatrics Respiratory syncytial virus Respiratory syncytial virus infection Respiratory Syncytial Virus Infections - metabolism Respiratory Syncytial Virus Infections - microbiology Respiratory Syncytial Viruses - drug effects Respiratory Syncytial Viruses - metabolism Respiratory Syncytial Viruses - pathogenicity Respiratory tract diseases Streptococcus infections Streptococcus pneumoniae Studies TLR1 protein TLR2 protein Toll-like receptors Toll-Like Receptors - metabolism Vaccines Virology/Host Invasion and Cell Entry Virology/Vaccines Virology/Virulence Factors and Mechanisms Viruses
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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