Safety, immunogenicity, and efficacy of the ML29 reassortant vaccine for Lassa fever in small non-human primates

A single injection of ML29 reassortant vaccine for Lassa fever induces low, transient viremia, and low or moderate levels of ML29 replication in tissues of common marmosets depending on the dose of the vaccination. The vaccination elicits specific immune responses and completely protects marmosets a...

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Published in:Vaccine Vol. 26; no. 41; pp. 5246 - 5254
Main Authors: Lukashevich, Igor S., Carrion, Ricardo, Salvato, Maria S., Mansfield, Keith, Brasky, Kathleen, Zapata, Juan, Cairo, Cristiana, Goicochea, Marco, Hoosien, Gia E., Ticer, Anysha, Bryant, Joseph, Davis, Harry, Hammamieh, Rasha, Mayda, Maria, Jett, Marti, Patterson, Jean
Format: Journal Article
Language:English
Published: Oxford Elsevier Ltd 26.09.2008
Elsevier
Elsevier Limited
Subjects:
Allergy and Immunology
Animals
Applied microbiology
Arenaviruses
Biological and medical sciences
Biomedical research
Callithrix
Callithrix - immunology
CD3 Complex - immunology
Chlorocebus aethiops
Enzymes
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - immunology
Genomes
Histology
Human viral diseases
Humans
Immunity, Cellular - immunology
Immunogenicity
Infectious diseases
Kinases
Lassa fever
Lassa Fever - immunology
Lassa Fever - pathology
Lassa Fever - prevention & control
Lassa fever and arenovirus diseases
Lassa virus - genetics
Lassa virus - immunology
Lassa virus - isolation & purification
Leukocytes, Mononuclear - immunology
Lipopolysaccharide Receptors - immunology
Male
Medical sciences
Microbiology
Monkeys & apes
Protection
Proteins
Reassortant Viruses - genetics
Reassortant Viruses - immunology
RNA polymerase
Safety
Studies
Survival Analysis
T-Lymphocytes - immunology
Tropical viral diseases
Vaccine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vero Cells
Viral diseases
Viremia - immunology
Viruses
Nigeria
Guinea
Sierra Leone
Lassa fever
Vaccine
Arenaviruses
Protection
Hemorrhagic fever
Genetic reassortment
Monkey
Infection
Vertebrata
Mammalia
Immunogenicity
Efficiency
Viral disease
Arbovirus disease
Primates
ISSN:0264-410X, 1873-2518
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Abstract A single injection of ML29 reassortant vaccine for Lassa fever induces low, transient viremia, and low or moderate levels of ML29 replication in tissues of common marmosets depending on the dose of the vaccination. The vaccination elicits specific immune responses and completely protects marmosets against fatal disease by induction of sterilizing cell-mediated immunity. DNA array analysis of human peripheral blood mononuclear cells from healthy donors exposed to ML29 revealed that gene expression patterns in ML29-exposed PBMC and control, media-exposed PBMC, clustered together confirming safety profile of the ML29 in non-human primates. The ML29 reassortant is a promising vaccine candidate for Lassa fever.
AbstractList A single injection of ML29 reassortant vaccine for Lassa fever induces low, transient viremia, and low or moderate levels of ML29 replication in tissues of common marmosets depending on the dose of the vaccination. The vaccination elicits specific immune responses and completely protects marmosets against fatal disease by induction of sterilizing cell-mediated immunity. DNA array analysis of human peripheral blood mononuclear cells from healthy donors exposed to ML29 revealed that gene expression patterns in ML29-exposed PBMC and control, media-exposed PBMC, clustered together confirming safety profile of the ML29 in non-human primates. The ML29 reassortant is a promising vaccine candidate for Lassa fever.
A single injection of ML29 reassortant vaccine for Lassa fever induces low, transient viremia, and low or moderate levels of ML29 replication in tissues of common marmosets depending on the dose of the vaccination. The vaccination elicits specific immune responses and completely protects marmosets against fatal disease by induction of sterilizing cell-mediated immunity. DNA array analysis of human peripheral blood mononuclear cells from healthy donors exposed to ML29 revealed that gene expression patterns in ML29-exposed PBMC and control, media-exposed PBMC, clustered together confirming safety profile of the ML29 in non-human primates. The ML29 reassortant is a promising vaccine candidate for Lassa fever.A single injection of ML29 reassortant vaccine for Lassa fever induces low, transient viremia, and low or moderate levels of ML29 replication in tissues of common marmosets depending on the dose of the vaccination. The vaccination elicits specific immune responses and completely protects marmosets against fatal disease by induction of sterilizing cell-mediated immunity. DNA array analysis of human peripheral blood mononuclear cells from healthy donors exposed to ML29 revealed that gene expression patterns in ML29-exposed PBMC and control, media-exposed PBMC, clustered together confirming safety profile of the ML29 in non-human primates. The ML29 reassortant is a promising vaccine candidate for Lassa fever.
AbstractA single injection of ML29 reassortant vaccine for Lassa fever induces low, transient viremia, and low or moderate levels of ML29 replication in tissues of common marmosets depending on the dose of the vaccination. The vaccination elicits specific immune responses and completely protects marmosets against fatal disease by induction of sterilizing cell-mediated immunity. DNA array analysis of human peripheral blood mononuclear cells from healthy donors exposed to ML29 revealed that gene expression patterns in ML29-exposed PBMC and control, media-exposed PBMC, clustered together confirming safety profile of the ML29 in non-human primates. The ML29 reassortant is a promising vaccine candidate for Lassa fever.
Author Patterson, Jean
Mansfield, Keith
Ticer, Anysha
Hoosien, Gia E.
Hammamieh, Rasha
Lukashevich, Igor S.
Bryant, Joseph
Salvato, Maria S.
Mayda, Maria
Davis, Harry
Cairo, Cristiana
Zapata, Juan
Goicochea, Marco
Jett, Marti
Carrion, Ricardo
Brasky, Kathleen
AuthorAffiliation a Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, United States
b Southwest Foundation for Biomedical Research, San Antonio, TX, United States
d Division of Pathology, Walter Reed Army Institute of Research, Silver Spring, MD, United States
c New England Primate Research Center, Harvard Medical School, Southborough, MA, United States
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  surname: Cairo
  fullname: Cairo, Cristiana
  organization: Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, United States
– sequence: 8
  givenname: Marco
  surname: Goicochea
  fullname: Goicochea, Marco
  organization: Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, United States
– sequence: 9
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  surname: Hoosien
  fullname: Hoosien, Gia E.
  organization: Southwest Foundation for Biomedical Research, San Antonio, TX, United States
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  surname: Ticer
  fullname: Ticer, Anysha
  organization: Southwest Foundation for Biomedical Research, San Antonio, TX, United States
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  surname: Bryant
  fullname: Bryant, Joseph
  organization: Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, United States
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  givenname: Harry
  surname: Davis
  fullname: Davis, Harry
  organization: Institute of Human Virology, University of Maryland School of Medicine, 725 West Lombard Street, Baltimore, MD 21201, United States
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  surname: Hammamieh
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– sequence: 16
  givenname: Jean
  surname: Patterson
  fullname: Patterson, Jean
  organization: Southwest Foundation for Biomedical Research, San Antonio, TX, United States
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IsDoiOpenAccess false
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Issue 41
Keywords Lassa fever
Vaccine
Arenaviruses
Protection
Hemorrhagic fever
Genetic reassortment
Monkey
Infection
Vertebrata
Mammalia
Immunogenicity
Efficiency
Viral disease
Arbovirus disease
Primates
Language English
License https://www.elsevier.com/tdm/userlicense/1.0
CC BY 4.0
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content type line 14
content type line 23
M.S.S. and J.P. contributed equally to this paper.
Corresponding author. Tel.: +1 410 706 1366; fax: +1 410 706 5198. E-mail address: ilukashevich@ihv.umaryland.edu (I.S. Lukashevich).
OpenAccessLink http://doi.org/10.1016/j.vaccine.2008.07.057
PMID 18692539
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PQPubID 105530
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Snippet A single injection of ML29 reassortant vaccine for Lassa fever induces low, transient viremia, and low or moderate levels of ML29 replication in tissues of...
AbstractA single injection of ML29 reassortant vaccine for Lassa fever induces low, transient viremia, and low or moderate levels of ML29 replication in...
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SubjectTerms Allergy and Immunology
Animals
Applied microbiology
Arenaviruses
Biological and medical sciences
Biomedical research
Callithrix
Callithrix - immunology
CD3 Complex - immunology
Chlorocebus aethiops
Enzymes
Female
Fundamental and applied biological sciences. Psychology
Gene Expression Regulation - immunology
Genomes
Histology
Human viral diseases
Humans
Immunity, Cellular - immunology
Immunogenicity
Infectious diseases
Kinases
Lassa fever
Lassa Fever - immunology
Lassa Fever - pathology
Lassa Fever - prevention & control
Lassa fever and arenovirus diseases
Lassa virus - genetics
Lassa virus - immunology
Lassa virus - isolation & purification
Leukocytes, Mononuclear - immunology
Lipopolysaccharide Receptors - immunology
Male
Medical sciences
Microbiology
Monkeys & apes
Protection
Proteins
Reassortant Viruses - genetics
Reassortant Viruses - immunology
RNA polymerase
Safety
Studies
Survival Analysis
T-Lymphocytes - immunology
Tropical viral diseases
Vaccine
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vero Cells
Viral diseases
Viremia - immunology
Viruses
Title Safety, immunogenicity, and efficacy of the ML29 reassortant vaccine for Lassa fever in small non-human primates
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Volume 26
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