Molecular Epidemiology of Rift Valley Fever Virus

Phylogenetic relationships were examined for 198 Rift Valley fever virus isolates and 5 derived strains obtained from various sources in Saudi Arabia and 16 countries in Africa during a 67-year period (1944-2010). A maximum-likelihood tree prepared with sequence data for a 490-nt section of the Gn g...

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Bibliographic Details
Published in:Emerging infectious diseases Vol. 17; no. 12; pp. 2270 - 2276
Main Authors: Grobbelaar, Antoinette A., Weyer, Jacqueline, Leman, Patricia A., Kemp, Alan, Paweska, Janusz T., Swanepoel, Robert
Format: Journal Article
Language:English
Published: United States U.S. National Center for Infectious Diseases 01.12.2011
Centers for Disease Control and Prevention
Subjects:
Animals
Base Sequence
Communicable Diseases, Emerging - epidemiology
Communicable Diseases, Emerging - veterinary
Communicable Diseases, Emerging - virology
Disease Outbreaks - veterinary
Distribution
DNA, Viral - genetics
evolution
Genes, Viral
Genetic aspects
Genetic vectors
Humans
Molecular Epidemiology
phylogenetics
Phylogeny
Prevention
Recombination, Genetic
Rift Valley fever
Rift Valley Fever - epidemiology
Rift Valley Fever - veterinary
Rift Valley Fever - virology
Rift Valley fever virus
Rift Valley fever virus - classification
Rift Valley fever virus - genetics
Rift Valley fever virus - isolation & purification
Risk factors
Ruminants
Saudi Arabia - epidemiology
South Africa - epidemiology
Viral Proteins - genetics
Viral Vaccines - genetics
viruses
Saudi Arabia
South Africa
Zimbabwe
Egypt
ISSN:1080-6040, 1080-6059, 1080-6059
Online Access:Get full text
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Summary:Phylogenetic relationships were examined for 198 Rift Valley fever virus isolates and 5 derived strains obtained from various sources in Saudi Arabia and 16 countries in Africa during a 67-year period (1944-2010). A maximum-likelihood tree prepared with sequence data for a 490-nt section of the Gn glycoprotein gene showed that 95 unique sequences sorted into 15 lineages. A 2010 isolate from a patient in South Africa potentially exposed to co-infection with live animal vaccine and wild virus was a reassortant. The potential influence of large-scale use of live animal vaccine on evolution of Rift Valley fever virus is discussed.
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ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid1712.111035