Vitamin B12 concentrations in milk from Norwegian women during the six first months of lactation
Human milk vitamin B12 (B12) concentrations depend on maternal status and intake; only few data are available in high-income countries. We assessed human milk B12 concentrations during the first 6 months postpartum in Norwegian women and its association with maternal dietary B12 intake and maternal...
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| Vydané v: | European journal of clinical nutrition Ročník 74; číslo 5; s. 749 - 756 |
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| Hlavní autori: | , , , , , , , , |
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| Jazyk: | English |
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Nature Publishing Group
01.05.2020
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| Abstract | Human milk vitamin B12 (B12) concentrations depend on maternal status and intake; only few data are available in high-income countries.
We assessed human milk B12 concentrations during the first 6 months postpartum in Norwegian women and its association with maternal dietary B12 intake and maternal urinary methylmalonic acid (MMA) concentration.
In this cross-sectional study, 175 mothers, exclusively (80%) or partially (20%) breastfeeding, were included. Milk B12 was measured by IMMULITE
/IMMULITE
1000 B12 competitive protein binding assay and urinary MMA relative to creatinine (MMA/Cr) by liquid chromatography-tandem-mass spectrometry. Maternal habitual B12 intake and supplement use were estimated using a food frequency questionnaire.
Mean human milk B12 concentration was 327 pmol/L (range 140-1089), with 402 pmol/L at 1 month (n = 21), 333 pmol/L at four months (n = 32), and 299 pmol/L at 6 months (n = 21). Maternal B12 intake was 5 µg/d, 89% met the Estimated Average Requirement, and supplement use did not affect milk B12 concentrations. MMA/Cr was low in all women compared with published data. In exclusively breastfeeding women, MMA/Cr (beta (95% CI) -42.5 (-82.5, -2.5) and time since birth (-4.9 (-9.6, -0.3)) were significant predictors of human milk B12 concentrations. There was no association between total B12 intake and milk B12 concentration or between total B12 intake and MMA/Cr.
Maternal B12 status and human milk B12 concentrations are likely sufficient, based on adequate maternal B12 dietary intake combined with low urinary MMA concentrations. Nevertheless, milk B12 concentration fell during 6 months postpartum while maternal B12 status did not change. |
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| AbstractList | BackgroundHuman milk vitamin B12 (B12) concentrations depend on maternal status and intake; only few data are available in high-income countries.ObjectiveWe assessed human milk B12 concentrations during the first 6 months postpartum in Norwegian women and its association with maternal dietary B12 intake and maternal urinary methylmalonic acid (MMA) concentration.MethodsIn this cross-sectional study, 175 mothers, exclusively (80%) or partially (20%) breastfeeding, were included. Milk B12 was measured by IMMULITE®/IMMULITE® 1000 B12 competitive protein binding assay and urinary MMA relative to creatinine (MMA/Cr) by liquid chromatography–tandem-mass spectrometry. Maternal habitual B12 intake and supplement use were estimated using a food frequency questionnaire.ResultsMean human milk B12 concentration was 327 pmol/L (range 140–1089), with 402 pmol/L at 1 month (n = 21), 333 pmol/L at four months (n = 32), and 299 pmol/L at 6 months (n = 21). Maternal B12 intake was 5 µg/d, 89% met the Estimated Average Requirement, and supplement use did not affect milk B12 concentrations. MMA/Cr was low in all women compared with published data. In exclusively breastfeeding women, MMA/Cr (beta (95% CI) −42.5 (−82.5, −2.5) and time since birth (−4.9 (−9.6, −0.3)) were significant predictors of human milk B12 concentrations. There was no association between total B12 intake and milk B12 concentration or between total B12 intake and MMA/Cr.ConclusionsMaternal B12 status and human milk B12 concentrations are likely sufficient, based on adequate maternal B12 dietary intake combined with low urinary MMA concentrations. Nevertheless, milk B12 concentration fell during 6 months postpartum while maternal B12 status did not change. Human milk vitamin B12 (B12) concentrations depend on maternal status and intake; only few data are available in high-income countries.BACKGROUNDHuman milk vitamin B12 (B12) concentrations depend on maternal status and intake; only few data are available in high-income countries.We assessed human milk B12 concentrations during the first 6 months postpartum in Norwegian women and its association with maternal dietary B12 intake and maternal urinary methylmalonic acid (MMA) concentration.OBJECTIVEWe assessed human milk B12 concentrations during the first 6 months postpartum in Norwegian women and its association with maternal dietary B12 intake and maternal urinary methylmalonic acid (MMA) concentration.In this cross-sectional study, 175 mothers, exclusively (80%) or partially (20%) breastfeeding, were included. Milk B12 was measured by IMMULITE®/IMMULITE® 1000 B12 competitive protein binding assay and urinary MMA relative to creatinine (MMA/Cr) by liquid chromatography-tandem-mass spectrometry. Maternal habitual B12 intake and supplement use were estimated using a food frequency questionnaire.METHODSIn this cross-sectional study, 175 mothers, exclusively (80%) or partially (20%) breastfeeding, were included. Milk B12 was measured by IMMULITE®/IMMULITE® 1000 B12 competitive protein binding assay and urinary MMA relative to creatinine (MMA/Cr) by liquid chromatography-tandem-mass spectrometry. Maternal habitual B12 intake and supplement use were estimated using a food frequency questionnaire.Mean human milk B12 concentration was 327 pmol/L (range 140-1089), with 402 pmol/L at 1 month (n = 21), 333 pmol/L at four months (n = 32), and 299 pmol/L at 6 months (n = 21). Maternal B12 intake was 5 µg/d, 89% met the Estimated Average Requirement, and supplement use did not affect milk B12 concentrations. MMA/Cr was low in all women compared with published data. In exclusively breastfeeding women, MMA/Cr (beta (95% CI) -42.5 (-82.5, -2.5) and time since birth (-4.9 (-9.6, -0.3)) were significant predictors of human milk B12 concentrations. There was no association between total B12 intake and milk B12 concentration or between total B12 intake and MMA/Cr.RESULTSMean human milk B12 concentration was 327 pmol/L (range 140-1089), with 402 pmol/L at 1 month (n = 21), 333 pmol/L at four months (n = 32), and 299 pmol/L at 6 months (n = 21). Maternal B12 intake was 5 µg/d, 89% met the Estimated Average Requirement, and supplement use did not affect milk B12 concentrations. MMA/Cr was low in all women compared with published data. In exclusively breastfeeding women, MMA/Cr (beta (95% CI) -42.5 (-82.5, -2.5) and time since birth (-4.9 (-9.6, -0.3)) were significant predictors of human milk B12 concentrations. There was no association between total B12 intake and milk B12 concentration or between total B12 intake and MMA/Cr.Maternal B12 status and human milk B12 concentrations are likely sufficient, based on adequate maternal B12 dietary intake combined with low urinary MMA concentrations. Nevertheless, milk B12 concentration fell during 6 months postpartum while maternal B12 status did not change.CONCLUSIONSMaternal B12 status and human milk B12 concentrations are likely sufficient, based on adequate maternal B12 dietary intake combined with low urinary MMA concentrations. Nevertheless, milk B12 concentration fell during 6 months postpartum while maternal B12 status did not change. Human milk vitamin B12 (B12) concentrations depend on maternal status and intake; only few data are available in high-income countries. We assessed human milk B12 concentrations during the first 6 months postpartum in Norwegian women and its association with maternal dietary B12 intake and maternal urinary methylmalonic acid (MMA) concentration. In this cross-sectional study, 175 mothers, exclusively (80%) or partially (20%) breastfeeding, were included. Milk B12 was measured by IMMULITE /IMMULITE 1000 B12 competitive protein binding assay and urinary MMA relative to creatinine (MMA/Cr) by liquid chromatography-tandem-mass spectrometry. Maternal habitual B12 intake and supplement use were estimated using a food frequency questionnaire. Mean human milk B12 concentration was 327 pmol/L (range 140-1089), with 402 pmol/L at 1 month (n = 21), 333 pmol/L at four months (n = 32), and 299 pmol/L at 6 months (n = 21). Maternal B12 intake was 5 µg/d, 89% met the Estimated Average Requirement, and supplement use did not affect milk B12 concentrations. MMA/Cr was low in all women compared with published data. In exclusively breastfeeding women, MMA/Cr (beta (95% CI) -42.5 (-82.5, -2.5) and time since birth (-4.9 (-9.6, -0.3)) were significant predictors of human milk B12 concentrations. There was no association between total B12 intake and milk B12 concentration or between total B12 intake and MMA/Cr. Maternal B12 status and human milk B12 concentrations are likely sufficient, based on adequate maternal B12 dietary intake combined with low urinary MMA concentrations. Nevertheless, milk B12 concentration fell during 6 months postpartum while maternal B12 status did not change. |
| Author | Hampel, Daniela Brantsæter, Anne Lise Refsum, Helga Shahab-Ferdows, Setareh Bastani, Nasser E Henjum, Sigrun Strand, Tor A Allen, Lindsay H Manger, Mari |
| Author_xml | – sequence: 1 givenname: Sigrun orcidid: 0000-0002-0671-2688 surname: Henjum fullname: Henjum, Sigrun email: shenjum@oslomet.no organization: Department of Nursing and Health Promotion, Faculty of Health Sciences, Oslo Metropolitan University, 0130, Oslo, Norway. shenjum@oslomet.no – sequence: 2 givenname: Mari surname: Manger fullname: Manger, Mari organization: Children's Hospital Oakland Research Institute, Oakland, CA, 94609, USA – sequence: 3 givenname: Daniela surname: Hampel fullname: Hampel, Daniela organization: Department of Nutrition, University of California, Davis, CA, 95616, USA – sequence: 4 givenname: Anne Lise orcidid: 0000-0001-6315-7134 surname: Brantsæter fullname: Brantsæter, Anne Lise organization: Division of Infection Control, Environment and Health, Norwegian Institute of Public Health, 0213, Oslo, Norway – sequence: 5 givenname: Setareh orcidid: 0000-0002-5058-4935 surname: Shahab-Ferdows fullname: Shahab-Ferdows, Setareh organization: USDA/ARS Western Human Nutrition Research Center, Davis, CA, 95616, USA – sequence: 6 givenname: Nasser E surname: Bastani fullname: Bastani, Nasser E organization: Department of Nutrition, Institute of Medical Biosciences, University of Oslo, 0317, Oslo, Norway – sequence: 7 givenname: Tor A surname: Strand fullname: Strand, Tor A organization: Centre for International Health, University of Bergen, 5020, Bergen, Norway – sequence: 8 givenname: Helga surname: Refsum fullname: Refsum, Helga organization: Department of Nutrition, Institute of Medical Biosciences, University of Oslo, 0317, Oslo, Norway – sequence: 9 givenname: Lindsay H surname: Allen fullname: Allen, Lindsay H organization: Department of Nutrition, University of California, Davis, CA, 95616, USA |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32001810$$D View this record in MEDLINE/PubMed |
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| Snippet | Human milk vitamin B12 (B12) concentrations depend on maternal status and intake; only few data are available in high-income countries.
We assessed human milk... BackgroundHuman milk vitamin B12 (B12) concentrations depend on maternal status and intake; only few data are available in high-income countries.ObjectiveWe... Human milk vitamin B12 (B12) concentrations depend on maternal status and intake; only few data are available in high-income countries.BACKGROUNDHuman milk... |
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| SubjectTerms | Baby foods Breast feeding Breast milk Breastfeeding & lactation Creatinine Cyanocobalamin Diet Dietary intake Dietary supplements Food intake Lactation Liquid chromatography Mass spectrometry Mass spectroscopy Milk Nutrition Postpartum Vitamin B Vitamin B12 |
| Title | Vitamin B12 concentrations in milk from Norwegian women during the six first months of lactation |
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