A ML29 reassortant virus protects guinea pigs against a distantly related Nigerian strain of Lassa virus and can provide sterilizing immunity

Lassa virus (LASV) is responsible for the deaths of thousands of people in West Africa annually. Genetic diversity among LASV strains is the highest among the Arenaviridae and represents a great challenge for vaccine development. Guinea pigs vaccinated with a ML29 reassortant vaccine experienced ste...

Full description

Saved in:
Bibliographic Details
Published in:Vaccine Vol. 25; no. 20; pp. 4093 - 4102
Main Authors: Carrion, Ricardo, Patterson, Jean L., Johnson, Curtis, Gonzales, Monica, Moreira, Carmen R., Ticer, Anysha, Brasky, Kathleen, Hubbard, Gene B., Moshkoff, Dmitry, Zapata, Juan, Salvato, Maria S., Lukashevich, Igor S.
Format: Journal Article
Language:English
Published: Oxford Elsevier Ltd 16.05.2007
Elsevier
Elsevier Limited
Subjects:
Allergy and Immunology
Animals
Antibody Formation - immunology
Applied microbiology
Arenaviridae
Biological and medical sciences
Biomedical research
Cloning
Cross-protection
Disease
Experiments
Fatalities
Female
Fundamental and applied biological sciences. Psychology
Genetic diversity
Genomes
Guinea Pigs
Hemorrhage
Human viral diseases
Immunity, Cellular - immunology
Infections
Infectious diseases
Laboratories
Lassa fever
Lassa Fever - immunology
Lassa Fever - pathology
Lassa Fever - prevention & control
Lassa Fever - virology
Lassa fever and arenovirus diseases
Lassa virus
Lassa virus - immunology
Lassa virus - isolation & purification
Medical sciences
Microbiology
Miscellaneous
Nigeria
Proteins
Reassortant vaccine
Reassortant Viruses - genetics
Reassortant Viruses - immunology
RNA polymerase
Sterilizing immunity
Tropical viral diseases
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral diseases
Viral Vaccines - immunology
Viral Vaccines - pharmacology
Virology
Viruses
Nigeria
Guinea
Sierra Leone
Lassa fever
Cross-protection
Reassortant vaccine
Sterilizing immunity
Hemorrhagic fever
Genetic reassortment
Cross protection
Rodentia
Vaccine
Lassa virus
Arenavirus
Strain
Infection
Virus
Vertebrata
Mammalia
Guinea pig
Viral disease
Arbovirus disease
Arenaviridae
ISSN:0264-410X, 1873-2518
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Abstract Lassa virus (LASV) is responsible for the deaths of thousands of people in West Africa annually. Genetic diversity among LASV strains is the highest among the Arenaviridae and represents a great challenge for vaccine development. Guinea pigs vaccinated with a ML29 reassortant vaccine experienced sterilizing immunity and complete protection when challenged on day 30 either with homologous virus or with the distantly related Nigerian isolate. Simultaneous vaccination–challenge or challenge on day 2 after vaccination also protected 60–100% of the animals against both strains, but without sterilizing immunity. These results indicate that simultaneous replication of ML29 and LASV attenuates the virulence of LASV infection.
AbstractList Abstract Lassa virus (LASV) is responsible for the deaths of thousands of people in West Africa annually. Genetic diversity among LASV strains is the highest among the Arenaviridae and represents a great challenge for vaccine development. Guinea pigs vaccinated with a ML29 reassortant vaccine experienced sterilizing immunity and complete protection when challenged on day 30 either with homologous virus or with the distantly related Nigerian isolate. Simultaneous vaccination–challenge or challenge on day 2 after vaccination also protected 60–100% of the animals against both strains, but without sterilizing immunity. These results indicate that simultaneous replication of ML29 and LASV attenuates the virulence of LASV infection.
Lassa virus (LASV) is responsible for the deaths of thousands of people in West Africa annually. Genetic diversity among LASV strains is the highest among the Arenaviridae and represents a great challenge for vaccine development. Guinea pigs vaccinated with a ML29 reassortant vaccine experienced sterilizing immunity and complete protection when challenged on day 30 either with homologous virus or with the distantly related Nigerian isolate. Simultaneous vaccination-challenge or challenge on day 2 after vaccination also protected 60-100% of the animals against both strains, but without sterilizing immunity. These results indicate that simultaneous replication of ML29 and LASV attenuates the virulence of LASV infection.
Lassa virus (LASV) is responsible for the deaths of thousands of people in West Africa annually. Genetic diversity among LASV strains is the highest among the Arenaviridae and represents a great challenge for vaccine development. Guinea pigs vaccinated with a ML29 reassortant vaccine experienced sterilizing immunity and complete protection when challenged on day 30 either with homologous virus or with the distantly related Nigerian isolate. Simultaneous vaccination-challenge or challenge on day 2 after vaccination also protected 60-100% of the animals against both strains, but without sterilizing immunity. These results indicate that simultaneous replication of ML29 and LASV attenuates the virulence of LASV infection.Lassa virus (LASV) is responsible for the deaths of thousands of people in West Africa annually. Genetic diversity among LASV strains is the highest among the Arenaviridae and represents a great challenge for vaccine development. Guinea pigs vaccinated with a ML29 reassortant vaccine experienced sterilizing immunity and complete protection when challenged on day 30 either with homologous virus or with the distantly related Nigerian isolate. Simultaneous vaccination-challenge or challenge on day 2 after vaccination also protected 60-100% of the animals against both strains, but without sterilizing immunity. These results indicate that simultaneous replication of ML29 and LASV attenuates the virulence of LASV infection.
Author Johnson, Curtis
Patterson, Jean L.
Ticer, Anysha
Hubbard, Gene B.
Zapata, Juan
Lukashevich, Igor S.
Gonzales, Monica
Moshkoff, Dmitry
Carrion, Ricardo
Moreira, Carmen R.
Brasky, Kathleen
Salvato, Maria S.
AuthorAffiliation b Institute of Human Virology, Baltimore, MD
a Southwest Foundation for Biomedical Research, San Antonio, TX
AuthorAffiliation_xml – name: b Institute of Human Virology, Baltimore, MD
– name: a Southwest Foundation for Biomedical Research, San Antonio, TX
Author_xml – sequence: 1
  givenname: Ricardo
  surname: Carrion
  fullname: Carrion, Ricardo
  organization: Southwest Foundation for Biomedical Research, San Antonio, TX, United States
– sequence: 2
  givenname: Jean L.
  surname: Patterson
  fullname: Patterson, Jean L.
  organization: Southwest Foundation for Biomedical Research, San Antonio, TX, United States
– sequence: 3
  givenname: Curtis
  surname: Johnson
  fullname: Johnson, Curtis
  organization: Southwest Foundation for Biomedical Research, San Antonio, TX, United States
– sequence: 4
  givenname: Monica
  surname: Gonzales
  fullname: Gonzales, Monica
  organization: Southwest Foundation for Biomedical Research, San Antonio, TX, United States
– sequence: 5
  givenname: Carmen R.
  surname: Moreira
  fullname: Moreira, Carmen R.
  organization: Southwest Foundation for Biomedical Research, San Antonio, TX, United States
– sequence: 6
  givenname: Anysha
  surname: Ticer
  fullname: Ticer, Anysha
  organization: Southwest Foundation for Biomedical Research, San Antonio, TX, United States
– sequence: 7
  givenname: Kathleen
  surname: Brasky
  fullname: Brasky, Kathleen
  organization: Southwest Foundation for Biomedical Research, San Antonio, TX, United States
– sequence: 8
  givenname: Gene B.
  surname: Hubbard
  fullname: Hubbard, Gene B.
  organization: Southwest Foundation for Biomedical Research, San Antonio, TX, United States
– sequence: 9
  givenname: Dmitry
  surname: Moshkoff
  fullname: Moshkoff, Dmitry
  organization: Institute of Human Virology, Baltimore, MD, United States
– sequence: 10
  givenname: Juan
  surname: Zapata
  fullname: Zapata, Juan
  organization: Institute of Human Virology, Baltimore, MD, United States
– sequence: 11
  givenname: Maria S.
  surname: Salvato
  fullname: Salvato, Maria S.
  organization: Institute of Human Virology, Baltimore, MD, United States
– sequence: 12
  givenname: Igor S.
  surname: Lukashevich
  fullname: Lukashevich, Igor S.
  email: lukashev@umbi.umd.edu
  organization: Institute of Human Virology, Baltimore, MD, United States
BackLink http://pascal-francis.inist.fr/vibad/index.php?action=getRecordDetail&idt=18739290$$DView record in Pascal Francis
https://www.ncbi.nlm.nih.gov/pubmed/17360080$$D View this record in MEDLINE/PubMed
BookMark eNqNk91uEzEQhVeoiKaFRwBZQnCXMPb-eYVaVFX8SQEuAIk7a9brDRM2drB3I4V34J3xKqGFSChc-WK-czz2nDlLTqyzJkkecphx4MWz5WyDWpM1MwFQzkDMIJV3kgmXZToVOZcnyQREkU0zDl9Ok7MQlgCQp7y6l5zyMi0AJEySn1fs3VxUzBsMwfkebc825IfA1t71RveBLYZ4C7I1LQLDBZINPUPWUBjhbhulHfamYe9pYTyhZaH3kWKuZfNoins_tA3TsRp9N9SYSEW6ox9kF4xWq8FSv72f3G2xC-bB_jxPPr96-en6zXT-4fXb66v5VJei6qeiqOuylTotGqnrPM_aLG0KIQtRyzYrOK_bJkcUIss1tijrFDliCyA0yDQ16XlyufNdD_XKNNrY2HKn1p5W6LfKIam_K5a-qoXbKC4rISCLBk_3Bt59H0zo1YqCNl2H1rghqDIyVVXlR0EBaVEUsojg4wNw6QZv4y8onucVyExkZaQe_dn4Tce_BxqBJ3sAg8au9Wg1hVsupqMS1cg933HauxC8aZWmHnty43upUxzUGDO1VPuYqTFmCoSKMYvq_EB9c8ER3YudzsThbsh4FTQZq01DPmZNNY6OOlweOOiOLMWnfjNbE27_TIUoUB_HFRg3AEoAHmcXDS7-bfAfDfwCR6cb0w
CODEN VACCDE
CitedBy_id crossref_primary_10_1093_infdis_jiz284
crossref_primary_10_3390_pathogens7040084
crossref_primary_10_1016_j_antiviral_2007_11_003
crossref_primary_10_1128_JVI_01948_08
crossref_primary_10_1016_j_vaccine_2008_07_057
crossref_primary_10_1016_j_coviro_2019_07_005
crossref_primary_10_1128_JVI_00019_09
crossref_primary_10_1186_s12985_024_02585_7
crossref_primary_10_1016_j_coviro_2019_07_006
crossref_primary_10_1038_s41392_024_01917_x
crossref_primary_10_1080_14760584_2016_1184575
crossref_primary_10_1038_s42003_020_01543_7
crossref_primary_10_1038_s41467_018_06741_w
crossref_primary_10_1128_JVI_02876_06
crossref_primary_10_1371_journal_pntd_0002406
crossref_primary_10_1371_journal_pntd_0003736
crossref_primary_10_1016_j_antiviral_2011_02_012
crossref_primary_10_3390_v13020214
crossref_primary_10_1038_s41426_018_0119_9
crossref_primary_10_1016_j_coviro_2019_07_009
crossref_primary_10_1038_s41541_018_0049_5
crossref_primary_10_3389_fcimb_2018_00240
crossref_primary_10_3390_biomedicines10102433
crossref_primary_10_3390_vaccines11030635
crossref_primary_10_1155_2010_236528
crossref_primary_10_3390_futurepharmacol5020026
crossref_primary_10_3390_pathogens4020283
crossref_primary_10_3390_vaccines10101668
crossref_primary_10_1128_JVI_00307_15
crossref_primary_10_3390_v10020075
crossref_primary_10_1038_s41467_023_37050_6
crossref_primary_10_1128_JVI_03401_14
crossref_primary_10_1016_j_virol_2011_01_013
crossref_primary_10_3390_v4010083
crossref_primary_10_1016_j_virol_2011_08_022
crossref_primary_10_12688_f1000research_16989_1
crossref_primary_10_3390_v15010146
crossref_primary_10_1128_JCM_00170_17
crossref_primary_10_1126_scitranslmed_aaw3163
crossref_primary_10_1016_j_virol_2016_11_001
crossref_primary_10_1016_j_vaccine_2010_11_079
crossref_primary_10_1038_s41541_024_01012_w
crossref_primary_10_1016_j_vaccine_2017_12_046
crossref_primary_10_1038_s41541_021_00291_x
crossref_primary_10_1016_j_it_2025_05_006
crossref_primary_10_3389_fimmu_2019_00372
crossref_primary_10_2217_17460794_3_3_243
crossref_primary_10_3390_v4112514
crossref_primary_10_1080_14760584_2023_2290683
crossref_primary_10_1016_j_antiviral_2011_07_015
crossref_primary_10_1186_1743_422X_10_52
crossref_primary_10_1038_s41541_024_00930_z
crossref_primary_10_3390_v16020266
crossref_primary_10_1016_S0140_6736_23_00048_X
crossref_primary_10_2217_fvl_15_1
crossref_primary_10_1016_S2222_1808_11_60007_8
crossref_primary_10_1016_j_coviro_2012_02_007
crossref_primary_10_1093_infdis_jiac028
crossref_primary_10_1016_j_heliyon_2021_e07022
crossref_primary_10_3390_pathogens8010009
crossref_primary_10_1016_j_imlet_2019_03_008
crossref_primary_10_1126_scitranslmed_abf6348
crossref_primary_10_1038_s41467_023_41376_6
crossref_primary_10_3390_v12040386
Cites_doi 10.1016/0264-410X(90)90096-5
10.1007/BF01310811
10.1016/j.micinf.2006.02.002
10.1099/0022-1317-82-6-1365
10.1128/JVI.55.3.704-709.1985
10.1128/JVI.73.10.8196-8200.1999
10.1128/JCM.32.12.2898-2903.1994
10.1038/nature01783
10.1016/j.virol.2005.12.001
10.1002/(SICI)1096-9071(199912)59:4<552::AID-JMV21>3.0.CO;2-A
10.3201/eid1205.050052
10.1016/S0264-410X(99)00439-9
10.1128/JVI.79.22.13934-13942.2005
10.1007/BF02122419
10.1073/pnas.221447598
10.1128/JVI.74.15.6992-7004.2000
10.1128/CDLI.12.10.1223-1230.2005
10.1016/j.virol.2006.01.026
10.1006/viro.2001.1127
10.1172/JCI25608
10.1006/mpev.1997.0436
10.1016/S0042-6822(03)00233-2
10.1128/JVI.74.5.2186-2192.2000
10.1016/j.virol.2003.12.013
10.1128/JVI.69.2.1059-1070.1995
10.4049/jimmunol.176.8.4940
10.1128/IAI.37.2.771-778.1982
10.1128/JVI.74.8.3650-3658.2000
10.1007/s00705-004-0385-9
10.1128/JVI.78.19.10516-10524.2004
10.1016/j.virol.2003.08.016
10.1016/S0168-1702(97)01458-5
10.1006/viro.1997.8722
10.1099/0022-1317-78-3-547
10.1002/jmv.1890370102
10.1016/j.virol.2005.01.019
10.1128/JVI.74.15.6777-6783.2000
10.1128/JVI.63.10.4303-4310.1989
10.1006/viro.2002.1695
10.1056/NEJM198601023140104
10.2174/138920206778948673
10.4269/ajtmh.1996.55.661
10.1136/bmj.327.7426.1271
10.1016/0042-6822(86)90438-1
10.1001/jama.287.18.2391
10.1016/S0140-6736(87)90767-7
10.1099/vir.0.80121-0
10.1007/s11262-006-0050-3
10.1101/SQB.1962.027.001.046
10.4049/jimmunol.172.5.2861
10.1128/JVI.75.23.11677-11685.2001
10.1128/JVI.67.6.3497-3506.1993
10.1128/JVI.00896-06
10.1016/S0140-6736(06)68546-2
10.1084/jem.185.3.517
10.1128/JVI.78.6.3162-3169.2004
10.1002/eji.1830210513
10.1099/vir.0.81184-0
10.1128/JVI.78.16.8922-8926.2004
10.1002/jmv.1890400308
10.1128/JVI.75.11.5205-5214.2001
10.3201/eid0605.000504
10.1586/14760584.3.2.189
10.1016/0014-5793(90)81140-J
10.1002/rmv.329
10.1128/JVI.68.3.1951-1955.1994
10.1016/0042-6822(92)90514-P
10.1016/0168-1702(91)90015-N
ContentType Journal Article
Copyright 2007 Elsevier Ltd
Elsevier Ltd
2007 INIST-CNRS
Copyright Elsevier Limited May 16, 2007
Copyright_xml – notice: 2007 Elsevier Ltd
– notice: Elsevier Ltd
– notice: 2007 INIST-CNRS
– notice: Copyright Elsevier Limited May 16, 2007
DBID AAYXX
CITATION
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
3V.
7QL
7RV
7T2
7T5
7U9
7X7
7XB
88C
88E
8AO
8C1
8FE
8FH
8FI
8FJ
8FK
8G5
ABUWG
AEUYN
AFKRA
AZQEC
BBNVY
BENPR
BHPHI
C1K
CCPQU
DWQXO
FYUFA
GHDGH
GNUQQ
GUQSH
H94
HCIFZ
K9-
K9.
KB0
LK8
M0R
M0S
M0T
M1P
M2O
M7N
M7P
MBDVC
NAPCQ
PHGZM
PHGZT
PJZUB
PKEHL
PPXIY
PQEST
PQGLB
PQQKQ
PQUKI
Q9U
7X8
5PM
DOI 10.1016/j.vaccine.2007.02.038
DatabaseName CrossRef
Pascal-Francis
Medline
MEDLINE
MEDLINE (Ovid)
MEDLINE
MEDLINE
PubMed
ProQuest Central (Corporate)
Bacteriology Abstracts (Microbiology B)
Nursing & Allied Health Database
Health and Safety Science Abstracts (Full archive)
Immunology Abstracts
Virology and AIDS Abstracts
Health & Medical Collection
ProQuest Central (purchase pre-March 2016)
Healthcare Administration Database (Alumni)
Medical Database (Alumni Edition)
ProQuest Pharma Collection
Public Health Database (ProQuest)
ProQuest SciTech Collection
ProQuest Natural Science Collection
Hospital Premium Collection
Hospital Premium Collection (Alumni Edition)
ProQuest Central (Alumni) (purchase pre-March 2016)
ProQuest Research Library
ProQuest Central (Alumni)
ProQuest One Sustainability
ProQuest Central UK/Ireland
ProQuest Central Essentials
ProQuest SciTech Premium Collection Natural Science Collection Biological Science Collection
ProQuest Central
Natural Science Collection
Environmental Sciences and Pollution Management
ProQuest One
ProQuest Central Korea
Health Research Premium Collection
Health Research Premium Collection (Alumni)
ProQuest Central Student
ProQuest Research Library
AIDS and Cancer Research Abstracts
SciTech Premium Collection (via ProQuest)
Consumer Health Database
ProQuest Health & Medical Complete (Alumni)
Nursing & Allied Health Database (Alumni Edition)
Biological Sciences
Consumer Health Database (ProQuest)
ProQuest Health & Medical Collection
Health Management Database (Proquest)
Medical Database
Research Library
Algology Mycology and Protozoology Abstracts (Microbiology C)
Biological Science Database
Research Library (Corporate)
Nursing & Allied Health Premium
ProQuest Central Premium
ProQuest One Academic (New)
ProQuest Health & Medical Research Collection
ProQuest One Academic Middle East (New)
One Health & Nursing
ProQuest One Academic Eastern Edition (DO NOT USE)
One Applied & Life Sciences
ProQuest One Academic (retired)
ProQuest One Academic UKI Edition
ProQuest Central Basic
MEDLINE - Academic
PubMed Central (Full Participant titles)
DatabaseTitle CrossRef
MEDLINE
Medline Complete
MEDLINE with Full Text
PubMed
MEDLINE (Ovid)
Research Library Prep
ProQuest Central Student
ProQuest Central Essentials
SciTech Premium Collection
Environmental Sciences and Pollution Management
ProQuest One Applied & Life Sciences
ProQuest One Sustainability
Health Research Premium Collection
Natural Science Collection
Health & Medical Research Collection
Biological Science Collection
ProQuest Central (New)
ProQuest Medical Library (Alumni)
Virology and AIDS Abstracts
ProQuest Biological Science Collection
ProQuest Family Health
ProQuest One Academic Eastern Edition
ProQuest Hospital Collection
Health Research Premium Collection (Alumni)
Biological Science Database
ProQuest Hospital Collection (Alumni)
Nursing & Allied Health Premium
ProQuest Health & Medical Complete
ProQuest One Academic UKI Edition
ProQuest Health Management (Alumni Edition)
ProQuest Nursing & Allied Health Source (Alumni)
ProQuest One Academic
ProQuest One Academic (New)
ProQuest One Academic Middle East (New)
ProQuest Health & Medical Complete (Alumni)
ProQuest Central (Alumni Edition)
ProQuest One Community College
ProQuest One Health & Nursing
Research Library (Alumni Edition)
ProQuest Natural Science Collection
ProQuest Pharma Collection
ProQuest Family Health (Alumni Edition)
ProQuest Central
ProQuest Health & Medical Research Collection
Health and Medicine Complete (Alumni Edition)
ProQuest Central Korea
Bacteriology Abstracts (Microbiology B)
Algology Mycology and Protozoology Abstracts (Microbiology C)
AIDS and Cancer Research Abstracts
ProQuest Research Library
Health & Safety Science Abstracts
ProQuest Public Health
ProQuest Central Basic
ProQuest Health Management
ProQuest Nursing & Allied Health Source
ProQuest SciTech Collection
ProQuest Medical Library
Immunology Abstracts
ProQuest Central (Alumni)
MEDLINE - Academic
DatabaseTitleList
AIDS and Cancer Research Abstracts
Research Library Prep
MEDLINE



MEDLINE - Academic
Database_xml – sequence: 1
  dbid: NPM
  name: PubMed
  url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed
  sourceTypes: Index Database
– sequence: 2
  dbid: BENPR
  name: ProQuest Central
  url: https://www.proquest.com/central
  sourceTypes: Aggregation Database
DeliveryMethod fulltext_linktorsrc
Discipline Medicine
Veterinary Medicine
Biology
Pharmacy, Therapeutics, & Pharmacology
EISSN 1873-2518
EndPage 4102
ExternalDocumentID PMC1892204
3420776071
17360080
18739290
10_1016_j_vaccine_2007_02_038
S0264410X07001922
1_s2_0_S0264410X07001922
Genre Journal Article
Research Support, N.I.H., Extramural
GeographicLocations Nigeria
Guinea
Sierra Leone
GeographicLocations_xml – name: Nigeria
– name: Sierra Leone
– name: Guinea
GrantInformation_xml – fundername: NIAID NIH HHS
  grantid: R21 AI059247
– fundername: NCRR NIH HHS
  grantid: 1C06RR12087
– fundername: NIAID NIH HHS
  grantid: R21 AI053619
– fundername: NIAID NIH HHS
  grantid: U54 AI057156
– fundername: NIAID NIH HHS
  grantid: 5 U54 AI057156-03
– fundername: NIAID NIH HHS
  grantid: R01-AI52367
– fundername: NIAID NIH HHS
  grantid: R21 AI053620
– fundername: NIDCR NIH HHS
  grantid: R21 DE015061
– fundername: NIAID NIH HHS
  grantid: U54 AI057168
– fundername: NCRR NIH HHS
  grantid: C06 RR012087
GroupedDBID ---
--K
--M
.1-
.FO
.GJ
.~1
0R~
123
1B1
1P~
1RT
1~.
1~5
29Q
4.4
457
4G.
53G
5RE
5VS
7-5
71M
7RV
7X7
88E
8AO
8C1
8FE
8FH
8FI
8FJ
8G5
8P~
9JM
AAAJQ
AABNK
AAEDT
AAEDW
AAHBH
AAIKJ
AAKOC
AALRI
AAOAW
AAQFI
AAQXK
AARKO
AATTM
AAXKI
AAXUO
AAYWO
ABBQC
ABFNM
ABFRF
ABJNI
ABKYH
ABMAC
ABMZM
ABRWV
ABUWG
ABWVN
ABXDB
ACDAQ
ACGFO
ACGFS
ACIEU
ACIUM
ACLOT
ACMHX
ACPRK
ACRLP
ACRPL
ACVFH
ADBBV
ADCNI
ADEZE
ADFRT
ADMUD
ADNMO
ADSLC
ADVLN
AEBSH
AEFWE
AEIPS
AEKER
AENEX
AEUPX
AEUYN
AEVXI
AEXOQ
AFJKZ
AFKRA
AFPUW
AFRAH
AFRHN
AFTJW
AFXIZ
AGEKW
AGGSO
AGHFR
AGQPQ
AGUBO
AGWPP
AGYEJ
AHHHB
AHMBA
AIEXJ
AIGII
AIIUN
AIKHN
AITUG
AJRQY
AJUYK
AKBMS
AKRWK
AKYEP
ALMA_UNASSIGNED_HOLDINGS
AMRAJ
ANKPU
ANZVX
APXCP
AQUVI
ASPBG
AVWKF
AXJTR
AZFZN
AZQEC
BBNVY
BENPR
BHPHI
BKEYQ
BKNYI
BKOJK
BLXMC
BNPGV
BPHCQ
BVXVI
CCPQU
CJTIS
CNWQP
CS3
DWQXO
EBS
EFJIC
EFKBS
EFLBG
EJD
EO8
EO9
EP2
EP3
F5P
FDB
FEDTE
FGOYB
FIRID
FNPLU
FYGXN
FYUFA
G-2
G-Q
GBLVA
GNUQQ
GUQSH
HCIFZ
HEJ
HLV
HMCUK
HMG
HMK
HMO
HVGLF
HX~
HZ~
IHE
J1W
K9-
KOM
L7B
LK8
LUGTX
LW9
M0R
M0T
M1P
M29
M2O
M41
M7P
MO0
N9A
NAPCQ
O-L
O9-
O9~
OAUVE
OK0
OZT
P-8
P-9
P2P
PC.
PHGZM
PHGZT
PJZUB
PPXIY
PQGLB
PQQKQ
PROAC
PSQYO
Q38
R2-
ROL
RPZ
SAB
SAE
SCC
SDF
SDG
SDP
SES
SEW
SIN
SNL
SPCBC
SSH
SSI
SSZ
SVS
T5K
UKHRP
UV1
WH7
WOW
WUQ
XPP
Z5R
ZGI
ZXP
~G-
~HD
3V.
AACTN
AFCTW
AFKWA
AJOXV
ALIPV
AMFUW
RIG
AAIAV
ABLVK
ABYKQ
AESVU
AJBFU
LCYCR
QYZTP
9DU
AAYXX
AFFHD
CITATION
AGCQF
AGRNS
IQODW
CGR
CUY
CVF
ECM
EIF
NPM
PMFND
7QL
7T2
7T5
7U9
7XB
8FK
C1K
H94
K9.
M7N
MBDVC
PKEHL
PQEST
PQUKI
Q9U
PUEGO
7X8
5PM
ID FETCH-LOGICAL-c729t-26bb7f8c36d8cb554f43d62862b8f4611bfd5aa2245cafa8b3a1aaf002c0833e3
IEDL.DBID 7RV
ISICitedReferencesCount 74
ISICitedReferencesURI http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000246835900020&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
ISSN 0264-410X
IngestDate Tue Nov 04 02:00:00 EST 2025
Thu Oct 02 16:48:19 EDT 2025
Sun Sep 28 00:51:12 EDT 2025
Sat Nov 29 14:50:22 EST 2025
Fri May 30 10:49:37 EDT 2025
Mon Jul 21 09:14:49 EDT 2025
Tue Nov 18 21:07:22 EST 2025
Sat Nov 29 05:53:46 EST 2025
Fri Feb 23 02:32:28 EST 2024
Sun Feb 23 10:19:53 EST 2025
Tue Oct 14 19:34:39 EDT 2025
IsDoiOpenAccess false
IsOpenAccess true
IsPeerReviewed true
IsScholarly true
Issue 20
Keywords Lassa fever
Cross-protection
Reassortant vaccine
Sterilizing immunity
Hemorrhagic fever
Genetic reassortment
Cross protection
Rodentia
Vaccine
Lassa virus
Arenavirus
Strain
Infection
Virus
Vertebrata
Mammalia
Guinea pig
Viral disease
Arbovirus disease
Arenaviridae
Language English
License https://www.elsevier.com/tdm/userlicense/1.0
CC BY 4.0
LinkModel DirectLink
MergedId FETCHMERGED-LOGICAL-c729t-26bb7f8c36d8cb554f43d62862b8f4611bfd5aa2245cafa8b3a1aaf002c0833e3
Notes ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
Corresponding author: Igor S. Lukashevich Institute of Human Virology University of Maryland Biotechnology Institute 725 West Lombard Street, Baltimore, MD 21201 TELE: 410-706-1366; FAX 410-706-5198; email: lukashev@umbi.umd.edu
OpenAccessLink http://doi.org/10.1016/j.vaccine.2007.02.038
PMID 17360080
PQID 1559084247
PQPubID 105530
PageCount 10
ParticipantIDs pubmedcentral_primary_oai_pubmedcentral_nih_gov_1892204
proquest_miscellaneous_70439995
proquest_miscellaneous_20366686
proquest_journals_1559084247
pubmed_primary_17360080
pascalfrancis_primary_18739290
crossref_citationtrail_10_1016_j_vaccine_2007_02_038
crossref_primary_10_1016_j_vaccine_2007_02_038
elsevier_sciencedirect_doi_10_1016_j_vaccine_2007_02_038
elsevier_clinicalkeyesjournals_1_s2_0_S0264410X07001922
elsevier_clinicalkey_doi_10_1016_j_vaccine_2007_02_038
PublicationCentury 2000
PublicationDate 2007-05-16
PublicationDateYYYYMMDD 2007-05-16
PublicationDate_xml – month: 05
  year: 2007
  text: 2007-05-16
  day: 16
PublicationDecade 2000
PublicationPlace Oxford
PublicationPlace_xml – name: Oxford
– name: Netherlands
– name: Kidlington
PublicationTitle Vaccine
PublicationTitleAlternate Vaccine
PublicationYear 2007
Publisher Elsevier Ltd
Elsevier
Elsevier Limited
Publisher_xml – name: Elsevier Ltd
– name: Elsevier
– name: Elsevier Limited
References Zarozinkski, McNally, Lohman, Daniels, Welsh (bib73) 2000; 74
Djavani, Yin, Lukashevich, Rodas, Rai, Salvato (bib50) 2001; 4
Bowen, Rollin, Ksiazek, Hustad, Bausch, Demby (bib28) 2000; 74
Lukashevich, Salvato (bib14) 2006; 7
Lukashevich, Stelmakh, Golubev, Stchesljenok, Lemeshko (bib13) 1984; 79
McCormick, Fisher-Hoch (bib43) 2002; 262
Peters, Jahrling, Liu, Kenyon, McKee, OroF J.G.B. (bib32) 1987; 134
Maiztegui, Sabattini, Barrera Oro (bib62) 1972; 32
Schulz, Aichele, Schneider, Hansen, Zinkernagel, Hengartner (bib48) 1991; 21
Hewson, Gmyl, Gmyl, Smirnova, Karganova, Jamil (bib27) 2004; 85
Jahrling, Smith, Hesse, Rhoderick (bib39) 1982; 37
Djavani, Yin, Xia, Lukashevich, Pauza, Salvato (bib49) 2000; 18
Saluzzo, Smith (bib30) 1990; 8
Pushko, Geisbert, Parker, Jahrling, Smith (bib33) 2001; 75
Liu, Feuer, Hassett, Whitton (bib60) 2006; 116
Archer, Rico-Hesse (bib23) 2002; 304
Bray (bib75) 2001; 82
Demby, Chamberlain, Brown, Clegg (bib34) 1994; 32
Glushakova, Lukashevich, Baratova (bib53) 1990; 269
Moskophidis, Battegay, Bruendler, Laine, Gresser, Zinkernagel (bib71) 1994; 68
Macher, Wolfe (bib3) 2006; 12
Lukashevich, Patterson, Carrion, Moshkoff, Ticer, Zapata (bib11) 2005; 79
Clegg (bib46) 2002; 262
Lukashevich (bib10) 1992; 188
Le Nouën, Rivallan, Toquin, Darlu, Morin, Beven (bib31) 2006; 87
Bredenbeek, Molenkamp, Spaan, Deubel, Marianneau, Salvato (bib38) 2006; 345
Mahanty, Gupta, Paragas, Bray, Ahmed, Rollin (bib74) 2003; 312
Fisher-Hoch, McCormick (bib7) 2001; 11
Clegg, Wilson, Oram (bib18) 1991; 18
Charrel, Lemasson, Garbutt, Khelifa, De Micco, Feldmann (bib22) 2003; 317
Lozano, Posik, Albarino, Schujman, Ghiringhelli, Calderon (bib44) 1997; 49
Anonymous (bib2) 2005; 80
Borio, Inglesby, Peters, Schmaljohn, Hughes, Jahrling (bib4) 2002; 287
Meulen, Badusche, Satoguina, Strecker, Lenz, Loeliger (bib54) 2004; 321
Hotchin (bib68) 1962; 27
Pannetier, Faure, Georges-Courbot, Deubel, Baize (bib67) 2004; 78
Baize, Kaplon, Faure, Pannetier, Georges-Courbot, Deubel (bib65) 2004; 172
Lukashevich, Trofimov, Golubev, Maryankova (bib41) 1985; 29
Djavani, Lukashevich, Sanchez, Nichol, Salvato (bib16) 1997; 235
Lukashevich, Djavani, Shapiro, Sanchez, Ravkov, Nichol (bib15) 1997; 78
Ter Meulen, Lukashevich, Sidibe, Inapogui, Marx, Dorlemann (bib61) 1996; 55
Gunther, Emmerich, Laue, Kuhle, Asper, Jung (bib29) 2000; 6
Jasenosky, Neumann, Lukashevich, Kawaoka (bib37) 2001; 75
Pedras-Vasconcelos, Goucher, Tonelli, Wang, Ito, Verthelyi (bib76) 2006; 176
McCormick, Mitchell, Kiley, Ruo, Fisher-Hoch (bib5) 1992; 31
Asper, Sternsdorf, Hass, Drosten, Rhode, Schmitz (bib42) 2004; 78
Sall, Zanotto, Sene, Zeller, Digoutte, Thiongane (bib26) 1999; 73
Emonet, Lemasson, Gonzalez, Lamballerie, Charrel (bib21) 2006; 350
Clegg, Lloyd (bib55) 1987; 2
Monath (bib9) 2004
Baize, Pannetier, Faure, Marianneau, Marendat, Georges-Courbot (bib64) 2006; 8
Binder, Fehr, Hengartner, Zinkernagel (bib69) 1997; 185
Lukashevich, Clegg, Sidibe (bib36) 1993; 40
La Posta, Auperin, Kamin-Lewis, Cole (bib52) 1993; 67
Lukashevich, Lemeshko, Stelmakh, Golubev, Stcheslyenok (bib40) 1986; 175
Zhang, Marriott, Harnis, Aronson (bib24) 2001; 290
Diebold, Montoya, Unger, Alexopoulou, Roy, Haswell (bib70) 2003; 424
ter Meulen, Badusche, Kuhnt, Doetze, Satoguina, Marti (bib57) 2000; 74
Daddario-DiCaprio, Geisbert, Stroher, Geisbert, Grolla, Fritz (bib63) 2006; 367
Richmond, Baglole (bib1) 2003; 327
McCormick, King, Webb, Scribner, Craven, Johnson (bib6) 1986; 314
Auperin, Sasso, McCormick (bib17) 1986; 154
Bowen, Peters, Nichol (bib45) 1997; 8
Whitton, Tishon, Lewicki, Gebhard, Cook, Salvato (bib47) 1989; 63
Gerrard, Li, Barrett, Nichol (bib25) 2004; 78
Botten, Alexander, Pasquetto, Sidney, Barrowman, Ting (bib59) 2006; 80
Fisher-Hoch, Hutwagner, Brown, McCormick (bib56) 2000; 74
Borrow, Evans, Oldstone (bib72) 1995; 69
Fisher-Hoch, McCormick (bib8) 2004; 3
Riviere, Ahmed, Southern, Buchmeier, Oldstone (bib20) 1985; 55
Moshkoff, Salvato, Lukashevich (bib12) 2007; 34
Rodriguez-Carreno, Nelson, Botten, Smith-Nixon, Buchmeier, Whitton (bib51) 2005; 335
Boesen, Sundar, Coico (bib58) 2005; 12
Lukashevich, Rodas, Tikhonov, Zapata, Yang, Djavani (bib35) 2004; 149
Lenz, ter Meulen, Klenk, Seidah, Garten (bib19) 2001; 98
Lukashevich, Maryankova, Vladyko, Nashkevich, Koleda, Djavani (bib66) 1999; 59
Gunther (10.1016/j.vaccine.2007.02.038_bib29) 2000; 6
La Posta (10.1016/j.vaccine.2007.02.038_bib52) 1993; 67
Asper (10.1016/j.vaccine.2007.02.038_bib42) 2004; 78
Glushakova (10.1016/j.vaccine.2007.02.038_bib53) 1990; 269
Pedras-Vasconcelos (10.1016/j.vaccine.2007.02.038_bib76) 2006; 176
Fisher-Hoch (10.1016/j.vaccine.2007.02.038_bib7) 2001; 11
Moshkoff (10.1016/j.vaccine.2007.02.038_bib12) 2007; 34
Djavani (10.1016/j.vaccine.2007.02.038_bib50) 2001; 4
Peters (10.1016/j.vaccine.2007.02.038_bib32) 1987; 134
Borio (10.1016/j.vaccine.2007.02.038_bib4) 2002; 287
Pushko (10.1016/j.vaccine.2007.02.038_bib33) 2001; 75
Zarozinkski (10.1016/j.vaccine.2007.02.038_bib73) 2000; 74
Bray (10.1016/j.vaccine.2007.02.038_bib75) 2001; 82
Macher (10.1016/j.vaccine.2007.02.038_bib3) 2006; 12
Jasenosky (10.1016/j.vaccine.2007.02.038_bib37) 2001; 75
McCormick (10.1016/j.vaccine.2007.02.038_bib6) 1986; 314
Gerrard (10.1016/j.vaccine.2007.02.038_bib25) 2004; 78
Lukashevich (10.1016/j.vaccine.2007.02.038_bib35) 2004; 149
Fisher-Hoch (10.1016/j.vaccine.2007.02.038_bib56) 2000; 74
Boesen (10.1016/j.vaccine.2007.02.038_bib58) 2005; 12
Bowen (10.1016/j.vaccine.2007.02.038_bib28) 2000; 74
Baize (10.1016/j.vaccine.2007.02.038_bib65) 2004; 172
Richmond (10.1016/j.vaccine.2007.02.038_bib1) 2003; 327
Clegg (10.1016/j.vaccine.2007.02.038_bib18) 1991; 18
Lukashevich (10.1016/j.vaccine.2007.02.038_bib36) 1993; 40
Ter Meulen (10.1016/j.vaccine.2007.02.038_bib61) 1996; 55
Moskophidis (10.1016/j.vaccine.2007.02.038_bib71) 1994; 68
Whitton (10.1016/j.vaccine.2007.02.038_bib47) 1989; 63
Maiztegui (10.1016/j.vaccine.2007.02.038_bib62) 1972; 32
Demby (10.1016/j.vaccine.2007.02.038_bib34) 1994; 32
Lukashevich (10.1016/j.vaccine.2007.02.038_bib13) 1984; 79
Zhang (10.1016/j.vaccine.2007.02.038_bib24) 2001; 290
Borrow (10.1016/j.vaccine.2007.02.038_bib72) 1995; 69
Lukashevich (10.1016/j.vaccine.2007.02.038_bib11) 2005; 79
McCormick (10.1016/j.vaccine.2007.02.038_bib43) 2002; 262
Binder (10.1016/j.vaccine.2007.02.038_bib69) 1997; 185
Monath (10.1016/j.vaccine.2007.02.038_bib9) 2004
Lukashevich (10.1016/j.vaccine.2007.02.038_bib40) 1986; 175
Diebold (10.1016/j.vaccine.2007.02.038_bib70) 2003; 424
Pannetier (10.1016/j.vaccine.2007.02.038_bib67) 2004; 78
Bredenbeek (10.1016/j.vaccine.2007.02.038_bib38) 2006; 345
Daddario-DiCaprio (10.1016/j.vaccine.2007.02.038_bib63) 2006; 367
Charrel (10.1016/j.vaccine.2007.02.038_bib22) 2003; 317
ter Meulen (10.1016/j.vaccine.2007.02.038_bib57) 2000; 74
Lozano (10.1016/j.vaccine.2007.02.038_bib44) 1997; 49
Liu (10.1016/j.vaccine.2007.02.038_bib60) 2006; 116
Lukashevich (10.1016/j.vaccine.2007.02.038_bib66) 1999; 59
Auperin (10.1016/j.vaccine.2007.02.038_bib17) 1986; 154
Botten (10.1016/j.vaccine.2007.02.038_bib59) 2006; 80
Lukashevich (10.1016/j.vaccine.2007.02.038_bib10) 1992; 188
Lukashevich (10.1016/j.vaccine.2007.02.038_bib14) 2006; 7
Hewson (10.1016/j.vaccine.2007.02.038_bib27) 2004; 85
Riviere (10.1016/j.vaccine.2007.02.038_bib20) 1985; 55
Djavani (10.1016/j.vaccine.2007.02.038_bib16) 1997; 235
Rodriguez-Carreno (10.1016/j.vaccine.2007.02.038_bib51) 2005; 335
Bowen (10.1016/j.vaccine.2007.02.038_bib45) 1997; 8
Schulz (10.1016/j.vaccine.2007.02.038_bib48) 1991; 21
Mahanty (10.1016/j.vaccine.2007.02.038_bib74) 2003; 312
Clegg (10.1016/j.vaccine.2007.02.038_bib55) 1987; 2
Baize (10.1016/j.vaccine.2007.02.038_bib64) 2006; 8
Meulen (10.1016/j.vaccine.2007.02.038_bib54) 2004; 321
Le Nouën (10.1016/j.vaccine.2007.02.038_bib31) 2006; 87
Lenz (10.1016/j.vaccine.2007.02.038_bib19) 2001; 98
Lukashevich (10.1016/j.vaccine.2007.02.038_bib15) 1997; 78
McCormick (10.1016/j.vaccine.2007.02.038_bib5) 1992; 31
Jahrling (10.1016/j.vaccine.2007.02.038_bib39) 1982; 37
Djavani (10.1016/j.vaccine.2007.02.038_bib49) 2000; 18
Sall (10.1016/j.vaccine.2007.02.038_bib26) 1999; 73
Fisher-Hoch (10.1016/j.vaccine.2007.02.038_bib8) 2004; 3
Lukashevich (10.1016/j.vaccine.2007.02.038_bib41) 1985; 29
Clegg (10.1016/j.vaccine.2007.02.038_bib46) 2002; 262
Saluzzo (10.1016/j.vaccine.2007.02.038_bib30) 1990; 8
Emonet (10.1016/j.vaccine.2007.02.038_bib21) 2006; 350
Archer (10.1016/j.vaccine.2007.02.038_bib23) 2002; 304
Anonymous (10.1016/j.vaccine.2007.02.038_bib2) 2005; 80
Hotchin (10.1016/j.vaccine.2007.02.038_bib68) 1962; 27
References_xml – volume: 4
  start-page: 103
  year: 2001
  end-page: 108
  ident: bib50
  article-title: Mucosal immunization with
  publication-title: J Hum Virol
– volume: 154
  start-page: 155
  year: 1986
  end-page: 167
  ident: bib17
  article-title: Nucleotide sequence of the glycoprotein gene and intergenic region of the Lassa virus S genome RNA
  publication-title: Virology
– volume: 12
  start-page: 1223
  year: 2005
  end-page: 1230
  ident: bib58
  article-title: Lassa fever virus peptides predicted by computational analysis induce epitope-specific cytotoxic-T-lymphocyte responses in HLA-A2.1 transgenic mice
  publication-title: Clin Diagn Lab Immunol
– volume: 269
  start-page: 145
  year: 1990
  end-page: 147
  ident: bib53
  article-title: Prediction of arenavirus fusion peptides on the basis of computer analysis of envelope protein sequences
  publication-title: FEBS Lett
– volume: 12
  start-page: 835
  year: 2006
  end-page: 837
  ident: bib3
  article-title: Historical Lassa fevers reports and 30-year clinical update
  publication-title: Emerg Infect Dis
– volume: 287
  start-page: 2391
  year: 2002
  end-page: 2405
  ident: bib4
  article-title: Hemorrhagic fever viruses as biological weapons: medical and public health management
  publication-title: JAMA
– volume: 75
  start-page: 5205
  year: 2001
  end-page: 5214
  ident: bib37
  article-title: Ebola virus VP40-induced particle formation and association with lipid bilayer
  publication-title: J Virol
– volume: 321
  start-page: 134
  year: 2004
  end-page: 143
  ident: bib54
  article-title: Old and New World arenaviruses share a highly conserved epitope in the fusion domain of the glycoprotein 2, which is recognized by Lassa virus-specific human CD4+ T cell clones
  publication-title: Virology
– volume: 55
  start-page: 661
  year: 1996
  end-page: 666
  ident: bib61
  article-title: Hunting of peridomestic rodents and consumption of their meat as possible risk factors for rodent-to-human transmission of Lassa virus in the Republic of Guinea
  publication-title: Am J Trop Med Hyg
– volume: 27
  start-page: 479
  year: 1962
  end-page: 499
  ident: bib68
  article-title: The biology of lymphocytic choriomeningitis virus: virus induced immune disease
  publication-title: Coldspring Harbor Symp Quant Biol
– volume: 87
  start-page: 209
  year: 2006
  end-page: 216
  ident: bib31
  article-title: Very virulent infectious bursal disease virus: reduced pathogenicity in a rare natural segment-B-reassorted isolate
  publication-title: J Gen Virol
– volume: 55
  start-page: 704
  year: 1985
  end-page: 709
  ident: bib20
  article-title: Genetic mapping of lymphocytic choriomeningitis virus pathogenicity: virulence in guinea pigs is associated with the L RNA segment
  publication-title: J Virol
– volume: 262
  start-page: 75
  year: 2002
  end-page: 109
  ident: bib43
  article-title: Lassa fever
  publication-title: Curr Top Microbiol Immunol
– volume: 18
  start-page: 1543
  year: 2000
  end-page: 1554
  ident: bib49
  article-title: Murine immune responses to mucosally delivered
  publication-title: Vaccine
– volume: 21
  start-page: 1181
  year: 1991
  end-page: 1185
  ident: bib48
  article-title: Major histocompatibility complex binding and T cell recognition of a viral nonapeptide containing a minimal tetrapeptide
  publication-title: Eur J Immunol
– volume: 29
  start-page: 455
  year: 1985
  end-page: 460
  ident: bib41
  article-title: Sedimentation analysis of the RNAs isolated from interfering particles of Lassa and Machupo viruses
  publication-title: Acta Virol
– volume: 3
  start-page: 103
  year: 2004
  end-page: 111
  ident: bib8
  article-title: Lassa fever vaccine
  publication-title: Expert Rev Vaccines
– volume: 80
  start-page: 8351
  year: 2006
  end-page: 8361
  ident: bib59
  article-title: Identification of protective Lassa virus epitopes that are restricted by HLA-A2
  publication-title: J Virol
– volume: 235
  start-page: 414
  year: 1997
  end-page: 418
  ident: bib16
  article-title: Completion of the Lassa fever virus sequence and identification of a RING finger open reading frame at the L RNA 5′ end
  publication-title: Virology
– volume: 49
  start-page: 79
  year: 1997
  end-page: 89
  ident: bib44
  article-title: Characterization of arenaviruses using a family-specific primer set for RT-PCR amplification and RFLP analysis. Its potential use for detection of uncharacterized arenaviruses
  publication-title: Virus Res
– volume: 188
  start-page: 600
  year: 1992
  end-page: 605
  ident: bib10
  article-title: Generation of reassortants between African arenaviruses
  publication-title: Virology
– volume: 82
  start-page: 1365
  year: 2001
  end-page: 1373
  ident: bib75
  article-title: The role of the type I interferon response in the resistance of mice to filovirus infection
  publication-title: J Gen Virol
– volume: 327
  start-page: 1271
  year: 2003
  end-page: 1275
  ident: bib1
  article-title: Lassa fever: epidemiology, clinical features, and social consequences
  publication-title: BMJ
– volume: 78
  start-page: 8922
  year: 2004
  end-page: 8926
  ident: bib25
  article-title: Ngari virus is a bunyamwera virus reassortant that can be associated with large outbreaks of hemorrhagic fever in Africa
  publication-title: J Virol
– volume: 80
  start-page: 86
  year: 2005
  end-page: 88
  ident: bib2
  article-title: Update on Lassa fever in West Africa
  publication-title: Weekly Epidemiol Rec
– volume: 74
  start-page: 3650
  year: 2000
  end-page: 3658
  ident: bib73
  article-title: Bystander sensitization to activation-induced cell death as a mechanism of virus-induced immune suppression
  publication-title: J Virol
– volume: 31
  start-page: 1
  year: 1992
  end-page: 7
  ident: bib5
  article-title: Inactivated Lassa virus elicits a non protective immune response in rhesus monkeys
  publication-title: J Med Virol
– volume: 32
  start-page: 131
  year: 1972
  end-page: 137
  ident: bib62
  article-title: Activity of lymphocytic choriomeningitis virus (LCM) in the endemic area of Argentine hemorrhagic fever (AHF). Part I. Serological studies in rodents captured in the City of Pergamino
  publication-title: Medicina (B Aires)
– volume: 37
  start-page: 771
  year: 1982
  end-page: 778
  ident: bib39
  article-title: Pathogenesis of Lassa virus infection in guinea pigs
  publication-title: Infect Immun
– volume: 69
  start-page: 1059
  year: 1995
  end-page: 1070
  ident: bib72
  article-title: Destruction of virus-infected dendritic cells results in generalized immune suppression
  publication-title: J Virol
– volume: 18
  start-page: 151
  year: 1991
  end-page: 164
  ident: bib18
  article-title: Nucleotide sequence of the S RNA of Lassa virus (Nigerian strain) and comparative analysis of arenavirus gene products
  publication-title: Virus Res
– volume: 345
  start-page: 299
  year: 2006
  end-page: 304
  ident: bib38
  article-title: A recombinant Yellow Fever 17D vaccine expressing Lassa virus glycoproteins
  publication-title: Virology
– volume: 172
  start-page: 2861
  year: 2004
  end-page: 2869
  ident: bib65
  article-title: Lassa virus infection of human dendritic cells and macrophages is productive but fails to activate cells
  publication-title: J Immunol
– volume: 2
  start-page: 186
  year: 1987
  end-page: 188
  ident: bib55
  article-title: Vaccinia recombinant expressing Lassa-virus internal nucleocapsid protein protects guinea pigs against Lassa fever
  publication-title: Lancet
– volume: 85
  start-page: 3059
  year: 2004
  end-page: 3070
  ident: bib27
  article-title: Evidence of segment reassortment in Crimean-Congo haemorrhagic fever virus
  publication-title: J Gen Virol
– volume: 74
  start-page: 6777
  year: 2000
  end-page: 6783
  ident: bib56
  article-title: Effective vaccine for Lassa fever
  publication-title: J Virol
– volume: 367
  start-page: 1399
  year: 2006
  end-page: 13404
  ident: bib63
  article-title: Postexposure protection against Marburg haemorrhagic fever with recombinant vesicular stomatitis virus vectors in non-human primates: an efficacy assessment
  publication-title: Lancet
– volume: 11
  start-page: 331
  year: 2001
  end-page: 341
  ident: bib7
  article-title: Towards a human Lassa fever vaccine
  publication-title: Rev Med Virol
– volume: 290
  start-page: 30
  year: 2001
  end-page: 38
  ident: bib24
  article-title: Reassortant analysis of guinea pig virulence of Pichinde virus variants
  publication-title: Virology
– volume: 78
  start-page: 3162
  year: 2004
  end-page: 3169
  ident: bib42
  article-title: Inhibition of different Lassa virus strains by alpha and gamma interferons and comparison with a less pathogenic arenavirus
  publication-title: J Virol
– volume: 6
  start-page: 466
  year: 2000
  end-page: 476
  ident: bib29
  article-title: Imported Lassa fever in Germany: molecular characterization of a new Lassa virus strain
  publication-title: Emerg Infect Dis
– volume: 134
  start-page: 5
  year: 1987
  end-page: 68
  ident: bib32
  article-title: Experimental studies of arenaviral hemorrhagic fevers
  publication-title: Curr Top Microbiol Immunol
– volume: 312
  start-page: 415
  year: 2003
  end-page: 424
  ident: bib74
  article-title: Protection from lethal infection is determined by innate immune responses in a mouse model of Ebola virus infection
  publication-title: Virology
– volume: 175
  start-page: 73
  year: 1986
  end-page: 77
  ident: bib40
  article-title: Some biochemical properties of Lassa virus RNA and polypeptides
  publication-title: Med Microbiol Immunol (Berl)
– volume: 79
  start-page: 13934
  year: 2005
  end-page: 13942
  ident: bib11
  article-title: A live-attenuated vaccine for Lassa fever made by reassortment of Lassa and Mopeia viruses
  publication-title: J Virol
– volume: 8
  start-page: 1194
  year: 2006
  end-page: 1202
  ident: bib64
  article-title: Role of interferons in the control of Lassa virus replication in human dendritic cells and macrophages
  publication-title: Microbes Infect
– volume: 149
  start-page: 2319
  year: 2004
  end-page: 2336
  ident: bib35
  article-title: LCMV-mediated hepatitis in rhesus macaques: WE but not ARM strain activates hepatocytes and induces liver regeneration
  publication-title: Arch Virol
– volume: 67
  start-page: 3497
  year: 1993
  end-page: 3506
  ident: bib52
  article-title: Cross-protection against lymphocytic choriomeningitis virus mediated by a CD4+ T cell clone specific for an envelope glycoprotein epitope of Lassa virus
  publication-title: J Virol
– start-page: 1095
  year: 2004
  end-page: 1176
  ident: bib9
  article-title: Yellow fever vaccine
  publication-title: Vaccines
– volume: 78
  start-page: 10516
  year: 2004
  end-page: 10524
  ident: bib67
  article-title: Human macrophages, but not dendritic cells, are activated and produce alpha/beta interferons in response to Mopeia virus infection
  publication-title: J Virol
– volume: 74
  start-page: 2186
  year: 2000
  end-page: 2192
  ident: bib57
  article-title: Characterization of human CD4+ T cell clones recognizing conserved and variable epitopes of the Lassa virus nucleoprotein
  publication-title: J Virol
– volume: 79
  start-page: 189
  year: 1984
  end-page: 203
  ident: bib13
  article-title: Ribonucleic acids of Machupo and Lassa viruses
  publication-title: Arch Virol
– volume: 314
  start-page: 20
  year: 1986
  end-page: 26
  ident: bib6
  article-title: Lassa fever. Effective therapy with ribavirin
  publication-title: N Engl J Med
– volume: 34
  start-page: 169
  year: 2007
  end-page: 176
  ident: bib12
  article-title: Molecular characterization of a reassortant virus derived from Lassa and Mopeia viruses
  publication-title: Virus Genes
– volume: 63
  start-page: 4303
  year: 1989
  end-page: 4310
  ident: bib47
  article-title: Molecular analyses of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: an immunodominant region which induces nonreciprocal CTL cross-reactivity
  publication-title: J Virol
– volume: 335
  start-page: 87
  year: 2005
  end-page: 98
  ident: bib51
  article-title: Evaluating the immunogenicity and protective efficacy of a DNA vaccine encoding Lassa virus nucleoprotein
  publication-title: Virology
– volume: 68
  start-page: 1951
  year: 1994
  end-page: 1955
  ident: bib71
  article-title: Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon
  publication-title: J Virol
– volume: 78
  start-page: 547
  year: 1997
  end-page: 551
  ident: bib15
  article-title: The Lassa fever virus L gene: nucleotide sequence, comparison, and precipitation of a predicted 250
  publication-title: J Gen Virol
– volume: 32
  start-page: 2898
  year: 1994
  end-page: 2903
  ident: bib34
  article-title: Early diagnosis of Lassa fever by reverse transcription-PCR
  publication-title: J Clin Microbiol
– volume: 8
  start-page: 369
  year: 1990
  end-page: 375
  ident: bib30
  article-title: Use of reassortant viruses to map attenuating and temperature-sensitive mutations of the Rift Valley fever virus MP-12 vaccine
  publication-title: Vaccine
– volume: 59
  start-page: 552
  year: 1999
  end-page: 560
  ident: bib66
  article-title: Lassa and Mopeia virus replication in human monocytes/macrophages and in endothelial cells: different effects on IL-8 and TNF-a gene expression
  publication-title: J Med Virol
– volume: 304
  start-page: 274
  year: 2002
  end-page: 281
  ident: bib23
  article-title: High genetic divergence and recombination in Arenaviruses from the Americas
  publication-title: Virology
– volume: 116
  start-page: 465
  year: 2006
  end-page: 475
  ident: bib60
  article-title: Peptide vaccination of mice immune to LCMV or vaccinia virus causes serious CD8+ T cell-mediated TNF-dependent immunopathology
  publication-title: J Clin Invest
– volume: 40
  start-page: 210
  year: 1993
  end-page: 217
  ident: bib36
  article-title: Lassa virus activity in Guinea: distribution of human antiviral antibody defined using enzyme-linked immunosorbent assay with recombinant antigen
  publication-title: J Med Virol
– volume: 350
  start-page: 251
  year: 2006
  end-page: 257
  ident: bib21
  article-title: Phylogeny and evolution of old world arenaviruses
  publication-title: Virology
– volume: 176
  start-page: 4940
  year: 2006
  end-page: 4949
  ident: bib76
  article-title: CpG ODN protect newborn mice from a lethal challenge with the neurotropic Tacaribe Arenavirus
  publication-title: J Immunol
– volume: 98
  start-page: 12701
  year: 2001
  end-page: 12705
  ident: bib19
  article-title: The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P
  publication-title: PNAS
– volume: 424
  start-page: 324
  year: 2003
  end-page: 328
  ident: bib70
  article-title: Viral infection switches non-plasmacytoid dendritic cells into high interferon producers
  publication-title: Nature
– volume: 8
  start-page: 301
  year: 1997
  end-page: 316
  ident: bib45
  article-title: Phylogenetic analysis of the Arenaviridae: patterns of virus evolution and evidence for cospeciation between arenaviruses and their rodent hosts
  publication-title: Mol Phylogenet Evol
– volume: 75
  start-page: 11677
  year: 2001
  end-page: 11685
  ident: bib33
  article-title: Individual and bivalent vaccines based on alphavirus replicons protect guinea pigs against infection with Lassa and Ebola viruses
  publication-title: J Virol
– volume: 7
  start-page: 351
  year: 2006
  end-page: 379
  ident: bib14
  article-title: Lassa virus genome
  publication-title: Curr Genomics
– volume: 73
  start-page: 8196
  year: 1999
  end-page: 8200
  ident: bib26
  article-title: Genetic reassortment of Rift Valley fever virus in nature
  publication-title: J Virol
– volume: 74
  start-page: 6992
  year: 2000
  end-page: 7004
  ident: bib28
  article-title: Genetic diversity among Lassa virus strains
  publication-title: J Virol
– volume: 185
  start-page: 517
  year: 1997
  end-page: 530
  ident: bib69
  article-title: Virus-induced transient bone marrow aplasia: Major role of interferon-alpha/beta during acute infection with the noncytopathic lymphocytic choriomeningitis virus
  publication-title: J Exp Med
– volume: 317
  start-page: 191
  year: 2003
  end-page: 196
  ident: bib22
  article-title: New insights into the evolutionary relationships between arenaviruses provided by comparative analysis of small and large segment sequences
  publication-title: Virology
– volume: 262
  start-page: 1
  year: 2002
  end-page: 24
  ident: bib46
  article-title: Molecular phylogeny of the Arenaviridae
  publication-title: Curr Top Microbiol Immunol
– volume: 8
  start-page: 369
  issue: 4
  year: 1990
  ident: 10.1016/j.vaccine.2007.02.038_bib30
  article-title: Use of reassortant viruses to map attenuating and temperature-sensitive mutations of the Rift Valley fever virus MP-12 vaccine
  publication-title: Vaccine
  doi: 10.1016/0264-410X(90)90096-5
– volume: 79
  start-page: 189
  issue: 3–4
  year: 1984
  ident: 10.1016/j.vaccine.2007.02.038_bib13
  article-title: Ribonucleic acids of Machupo and Lassa viruses
  publication-title: Arch Virol
  doi: 10.1007/BF01310811
– volume: 4
  start-page: 103
  issue: 2
  year: 2001
  ident: 10.1016/j.vaccine.2007.02.038_bib50
  article-title: Mucosal immunization with Salmonella typhimurium expressing Lassa virus nucleocapsid protein cross-protects mice from lethal challenge with lymphocytic choriomeningitis virus
  publication-title: J Hum Virol
– volume: 8
  start-page: 1194
  issue: 5
  year: 2006
  ident: 10.1016/j.vaccine.2007.02.038_bib64
  article-title: Role of interferons in the control of Lassa virus replication in human dendritic cells and macrophages
  publication-title: Microbes Infect
  doi: 10.1016/j.micinf.2006.02.002
– volume: 82
  start-page: 1365
  issue: 6
  year: 2001
  ident: 10.1016/j.vaccine.2007.02.038_bib75
  article-title: The role of the type I interferon response in the resistance of mice to filovirus infection
  publication-title: J Gen Virol
  doi: 10.1099/0022-1317-82-6-1365
– volume: 55
  start-page: 704
  issue: 3
  year: 1985
  ident: 10.1016/j.vaccine.2007.02.038_bib20
  article-title: Genetic mapping of lymphocytic choriomeningitis virus pathogenicity: virulence in guinea pigs is associated with the L RNA segment
  publication-title: J Virol
  doi: 10.1128/JVI.55.3.704-709.1985
– volume: 73
  start-page: 8196
  issue: 10
  year: 1999
  ident: 10.1016/j.vaccine.2007.02.038_bib26
  article-title: Genetic reassortment of Rift Valley fever virus in nature
  publication-title: J Virol
  doi: 10.1128/JVI.73.10.8196-8200.1999
– volume: 32
  start-page: 2898
  year: 1994
  ident: 10.1016/j.vaccine.2007.02.038_bib34
  article-title: Early diagnosis of Lassa fever by reverse transcription-PCR
  publication-title: J Clin Microbiol
  doi: 10.1128/JCM.32.12.2898-2903.1994
– volume: 424
  start-page: 324
  year: 2003
  ident: 10.1016/j.vaccine.2007.02.038_bib70
  article-title: Viral infection switches non-plasmacytoid dendritic cells into high interferon producers
  publication-title: Nature
  doi: 10.1038/nature01783
– volume: 345
  start-page: 299
  issue: 2
  year: 2006
  ident: 10.1016/j.vaccine.2007.02.038_bib38
  article-title: A recombinant Yellow Fever 17D vaccine expressing Lassa virus glycoproteins
  publication-title: Virology
  doi: 10.1016/j.virol.2005.12.001
– volume: 59
  start-page: 552
  year: 1999
  ident: 10.1016/j.vaccine.2007.02.038_bib66
  article-title: Lassa and Mopeia virus replication in human monocytes/macrophages and in endothelial cells: different effects on IL-8 and TNF-a gene expression
  publication-title: J Med Virol
  doi: 10.1002/(SICI)1096-9071(199912)59:4<552::AID-JMV21>3.0.CO;2-A
– volume: 12
  start-page: 835
  issue: 5
  year: 2006
  ident: 10.1016/j.vaccine.2007.02.038_bib3
  article-title: Historical Lassa fevers reports and 30-year clinical update
  publication-title: Emerg Infect Dis
  doi: 10.3201/eid1205.050052
– volume: 18
  start-page: 1543
  issue: 15
  year: 2000
  ident: 10.1016/j.vaccine.2007.02.038_bib49
  article-title: Murine immune responses to mucosally delivered Salmonella expressing Lassa fever virus nucleoprotein
  publication-title: Vaccine
  doi: 10.1016/S0264-410X(99)00439-9
– volume: 79
  start-page: 13934
  issue: 22
  year: 2005
  ident: 10.1016/j.vaccine.2007.02.038_bib11
  article-title: A live-attenuated vaccine for Lassa fever made by reassortment of Lassa and Mopeia viruses
  publication-title: J Virol
  doi: 10.1128/JVI.79.22.13934-13942.2005
– volume: 175
  start-page: 73
  issue: 2–3
  year: 1986
  ident: 10.1016/j.vaccine.2007.02.038_bib40
  article-title: Some biochemical properties of Lassa virus RNA and polypeptides
  publication-title: Med Microbiol Immunol (Berl)
  doi: 10.1007/BF02122419
– volume: 98
  start-page: 12701
  issue: 22
  year: 2001
  ident: 10.1016/j.vaccine.2007.02.038_bib19
  article-title: The Lassa virus glycoprotein precursor GP-C is proteolytically processed by subtilase SKI-1/S1P
  publication-title: PNAS
  doi: 10.1073/pnas.221447598
– volume: 74
  start-page: 6992
  issue: 15
  year: 2000
  ident: 10.1016/j.vaccine.2007.02.038_bib28
  article-title: Genetic diversity among Lassa virus strains
  publication-title: J Virol
  doi: 10.1128/JVI.74.15.6992-7004.2000
– volume: 12
  start-page: 1223
  issue: 10
  year: 2005
  ident: 10.1016/j.vaccine.2007.02.038_bib58
  article-title: Lassa fever virus peptides predicted by computational analysis induce epitope-specific cytotoxic-T-lymphocyte responses in HLA-A2.1 transgenic mice
  publication-title: Clin Diagn Lab Immunol
  doi: 10.1128/CDLI.12.10.1223-1230.2005
– volume: 350
  start-page: 251
  issue: 2
  year: 2006
  ident: 10.1016/j.vaccine.2007.02.038_bib21
  article-title: Phylogeny and evolution of old world arenaviruses
  publication-title: Virology
  doi: 10.1016/j.virol.2006.01.026
– volume: 290
  start-page: 30
  issue: 1
  year: 2001
  ident: 10.1016/j.vaccine.2007.02.038_bib24
  article-title: Reassortant analysis of guinea pig virulence of Pichinde virus variants
  publication-title: Virology
  doi: 10.1006/viro.2001.1127
– volume: 134
  start-page: 5
  year: 1987
  ident: 10.1016/j.vaccine.2007.02.038_bib32
  article-title: Experimental studies of arenaviral hemorrhagic fevers
  publication-title: Curr Top Microbiol Immunol
– volume: 116
  start-page: 465
  issue: 2
  year: 2006
  ident: 10.1016/j.vaccine.2007.02.038_bib60
  article-title: Peptide vaccination of mice immune to LCMV or vaccinia virus causes serious CD8+ T cell-mediated TNF-dependent immunopathology
  publication-title: J Clin Invest
  doi: 10.1172/JCI25608
– volume: 8
  start-page: 301
  issue: 3
  year: 1997
  ident: 10.1016/j.vaccine.2007.02.038_bib45
  article-title: Phylogenetic analysis of the Arenaviridae: patterns of virus evolution and evidence for cospeciation between arenaviruses and their rodent hosts
  publication-title: Mol Phylogenet Evol
  doi: 10.1006/mpev.1997.0436
– volume: 312
  start-page: 415
  year: 2003
  ident: 10.1016/j.vaccine.2007.02.038_bib74
  article-title: Protection from lethal infection is determined by innate immune responses in a mouse model of Ebola virus infection
  publication-title: Virology
  doi: 10.1016/S0042-6822(03)00233-2
– volume: 74
  start-page: 2186
  issue: 5
  year: 2000
  ident: 10.1016/j.vaccine.2007.02.038_bib57
  article-title: Characterization of human CD4+ T cell clones recognizing conserved and variable epitopes of the Lassa virus nucleoprotein
  publication-title: J Virol
  doi: 10.1128/JVI.74.5.2186-2192.2000
– volume: 32
  start-page: 131
  issue: 2
  year: 1972
  ident: 10.1016/j.vaccine.2007.02.038_bib62
  article-title: Activity of lymphocytic choriomeningitis virus (LCM) in the endemic area of Argentine hemorrhagic fever (AHF). Part I. Serological studies in rodents captured in the City of Pergamino
  publication-title: Medicina (B Aires)
– volume: 321
  start-page: 134
  issue: 1
  year: 2004
  ident: 10.1016/j.vaccine.2007.02.038_bib54
  article-title: Old and New World arenaviruses share a highly conserved epitope in the fusion domain of the glycoprotein 2, which is recognized by Lassa virus-specific human CD4+ T cell clones
  publication-title: Virology
  doi: 10.1016/j.virol.2003.12.013
– volume: 69
  start-page: 1059
  year: 1995
  ident: 10.1016/j.vaccine.2007.02.038_bib72
  article-title: Destruction of virus-infected dendritic cells results in generalized immune suppression
  publication-title: J Virol
  doi: 10.1128/JVI.69.2.1059-1070.1995
– volume: 176
  start-page: 4940
  year: 2006
  ident: 10.1016/j.vaccine.2007.02.038_bib76
  article-title: CpG ODN protect newborn mice from a lethal challenge with the neurotropic Tacaribe Arenavirus
  publication-title: J Immunol
  doi: 10.4049/jimmunol.176.8.4940
– volume: 37
  start-page: 771
  issue: 2
  year: 1982
  ident: 10.1016/j.vaccine.2007.02.038_bib39
  article-title: Pathogenesis of Lassa virus infection in guinea pigs
  publication-title: Infect Immun
  doi: 10.1128/IAI.37.2.771-778.1982
– volume: 74
  start-page: 3650
  year: 2000
  ident: 10.1016/j.vaccine.2007.02.038_bib73
  article-title: Bystander sensitization to activation-induced cell death as a mechanism of virus-induced immune suppression
  publication-title: J Virol
  doi: 10.1128/JVI.74.8.3650-3658.2000
– volume: 149
  start-page: 2319
  issue: 12
  year: 2004
  ident: 10.1016/j.vaccine.2007.02.038_bib35
  article-title: LCMV-mediated hepatitis in rhesus macaques: WE but not ARM strain activates hepatocytes and induces liver regeneration
  publication-title: Arch Virol
  doi: 10.1007/s00705-004-0385-9
– volume: 78
  start-page: 10516
  issue: 19
  year: 2004
  ident: 10.1016/j.vaccine.2007.02.038_bib67
  article-title: Human macrophages, but not dendritic cells, are activated and produce alpha/beta interferons in response to Mopeia virus infection
  publication-title: J Virol
  doi: 10.1128/JVI.78.19.10516-10524.2004
– volume: 262
  start-page: 75
  year: 2002
  ident: 10.1016/j.vaccine.2007.02.038_bib43
  article-title: Lassa fever
  publication-title: Curr Top Microbiol Immunol
– volume: 262
  start-page: 1
  year: 2002
  ident: 10.1016/j.vaccine.2007.02.038_bib46
  article-title: Molecular phylogeny of the Arenaviridae
  publication-title: Curr Top Microbiol Immunol
– volume: 317
  start-page: 191
  issue: 2
  year: 2003
  ident: 10.1016/j.vaccine.2007.02.038_bib22
  article-title: New insights into the evolutionary relationships between arenaviruses provided by comparative analysis of small and large segment sequences
  publication-title: Virology
  doi: 10.1016/j.virol.2003.08.016
– volume: 49
  start-page: 79
  issue: 1
  year: 1997
  ident: 10.1016/j.vaccine.2007.02.038_bib44
  article-title: Characterization of arenaviruses using a family-specific primer set for RT-PCR amplification and RFLP analysis. Its potential use for detection of uncharacterized arenaviruses
  publication-title: Virus Res
  doi: 10.1016/S0168-1702(97)01458-5
– volume: 235
  start-page: 414
  issue: 2
  year: 1997
  ident: 10.1016/j.vaccine.2007.02.038_bib16
  article-title: Completion of the Lassa fever virus sequence and identification of a RING finger open reading frame at the L RNA 5′ end
  publication-title: Virology
  doi: 10.1006/viro.1997.8722
– volume: 78
  start-page: 547
  issue: 3
  year: 1997
  ident: 10.1016/j.vaccine.2007.02.038_bib15
  article-title: The Lassa fever virus L gene: nucleotide sequence, comparison, and precipitation of a predicted 250kDa protein with monospecific antiserum
  publication-title: J Gen Virol
  doi: 10.1099/0022-1317-78-3-547
– volume: 31
  start-page: 1
  issue: 1
  year: 1992
  ident: 10.1016/j.vaccine.2007.02.038_bib5
  article-title: Inactivated Lassa virus elicits a non protective immune response in rhesus monkeys
  publication-title: J Med Virol
  doi: 10.1002/jmv.1890370102
– volume: 335
  start-page: 87
  issue: 1
  year: 2005
  ident: 10.1016/j.vaccine.2007.02.038_bib51
  article-title: Evaluating the immunogenicity and protective efficacy of a DNA vaccine encoding Lassa virus nucleoprotein
  publication-title: Virology
  doi: 10.1016/j.virol.2005.01.019
– volume: 74
  start-page: 6777
  issue: 15
  year: 2000
  ident: 10.1016/j.vaccine.2007.02.038_bib56
  article-title: Effective vaccine for Lassa fever
  publication-title: J Virol
  doi: 10.1128/JVI.74.15.6777-6783.2000
– volume: 63
  start-page: 4303
  issue: 10
  year: 1989
  ident: 10.1016/j.vaccine.2007.02.038_bib47
  article-title: Molecular analyses of a five-amino-acid cytotoxic T-lymphocyte (CTL) epitope: an immunodominant region which induces nonreciprocal CTL cross-reactivity
  publication-title: J Virol
  doi: 10.1128/JVI.63.10.4303-4310.1989
– volume: 304
  start-page: 274
  issue: 2
  year: 2002
  ident: 10.1016/j.vaccine.2007.02.038_bib23
  article-title: High genetic divergence and recombination in Arenaviruses from the Americas
  publication-title: Virology
  doi: 10.1006/viro.2002.1695
– volume: 314
  start-page: 20
  issue: 1
  year: 1986
  ident: 10.1016/j.vaccine.2007.02.038_bib6
  article-title: Lassa fever. Effective therapy with ribavirin
  publication-title: N Engl J Med
  doi: 10.1056/NEJM198601023140104
– volume: 7
  start-page: 351
  issue: 6
  year: 2006
  ident: 10.1016/j.vaccine.2007.02.038_bib14
  article-title: Lassa virus genome
  publication-title: Curr Genomics
  doi: 10.2174/138920206778948673
– volume: 55
  start-page: 661
  issue: 6
  year: 1996
  ident: 10.1016/j.vaccine.2007.02.038_bib61
  article-title: Hunting of peridomestic rodents and consumption of their meat as possible risk factors for rodent-to-human transmission of Lassa virus in the Republic of Guinea
  publication-title: Am J Trop Med Hyg
  doi: 10.4269/ajtmh.1996.55.661
– volume: 327
  start-page: 1271
  issue: 7426
  year: 2003
  ident: 10.1016/j.vaccine.2007.02.038_bib1
  article-title: Lassa fever: epidemiology, clinical features, and social consequences
  publication-title: BMJ
  doi: 10.1136/bmj.327.7426.1271
– volume: 154
  start-page: 155
  issue: 1
  year: 1986
  ident: 10.1016/j.vaccine.2007.02.038_bib17
  article-title: Nucleotide sequence of the glycoprotein gene and intergenic region of the Lassa virus S genome RNA
  publication-title: Virology
  doi: 10.1016/0042-6822(86)90438-1
– volume: 287
  start-page: 2391
  issue: 18
  year: 2002
  ident: 10.1016/j.vaccine.2007.02.038_bib4
  article-title: Hemorrhagic fever viruses as biological weapons: medical and public health management
  publication-title: JAMA
  doi: 10.1001/jama.287.18.2391
– volume: 2
  start-page: 186
  issue: 8552
  year: 1987
  ident: 10.1016/j.vaccine.2007.02.038_bib55
  article-title: Vaccinia recombinant expressing Lassa-virus internal nucleocapsid protein protects guinea pigs against Lassa fever
  publication-title: Lancet
  doi: 10.1016/S0140-6736(87)90767-7
– volume: 85
  start-page: 3059
  year: 2004
  ident: 10.1016/j.vaccine.2007.02.038_bib27
  article-title: Evidence of segment reassortment in Crimean-Congo haemorrhagic fever virus
  publication-title: J Gen Virol
  doi: 10.1099/vir.0.80121-0
– volume: 34
  start-page: 169
  year: 2007
  ident: 10.1016/j.vaccine.2007.02.038_bib12
  article-title: Molecular characterization of a reassortant virus derived from Lassa and Mopeia viruses
  publication-title: Virus Genes
  doi: 10.1007/s11262-006-0050-3
– volume: 27
  start-page: 479
  year: 1962
  ident: 10.1016/j.vaccine.2007.02.038_bib68
  article-title: The biology of lymphocytic choriomeningitis virus: virus induced immune disease
  publication-title: Coldspring Harbor Symp Quant Biol
  doi: 10.1101/SQB.1962.027.001.046
– volume: 172
  start-page: 2861
  issue: 5
  year: 2004
  ident: 10.1016/j.vaccine.2007.02.038_bib65
  article-title: Lassa virus infection of human dendritic cells and macrophages is productive but fails to activate cells
  publication-title: J Immunol
  doi: 10.4049/jimmunol.172.5.2861
– volume: 75
  start-page: 11677
  issue: 23
  year: 2001
  ident: 10.1016/j.vaccine.2007.02.038_bib33
  article-title: Individual and bivalent vaccines based on alphavirus replicons protect guinea pigs against infection with Lassa and Ebola viruses
  publication-title: J Virol
  doi: 10.1128/JVI.75.23.11677-11685.2001
– volume: 67
  start-page: 3497
  issue: 6
  year: 1993
  ident: 10.1016/j.vaccine.2007.02.038_bib52
  article-title: Cross-protection against lymphocytic choriomeningitis virus mediated by a CD4+ T cell clone specific for an envelope glycoprotein epitope of Lassa virus
  publication-title: J Virol
  doi: 10.1128/JVI.67.6.3497-3506.1993
– volume: 80
  start-page: 8351
  issue: 17
  year: 2006
  ident: 10.1016/j.vaccine.2007.02.038_bib59
  article-title: Identification of protective Lassa virus epitopes that are restricted by HLA-A2
  publication-title: J Virol
  doi: 10.1128/JVI.00896-06
– volume: 367
  start-page: 1399
  issue: 9520
  year: 2006
  ident: 10.1016/j.vaccine.2007.02.038_bib63
  article-title: Postexposure protection against Marburg haemorrhagic fever with recombinant vesicular stomatitis virus vectors in non-human primates: an efficacy assessment
  publication-title: Lancet
  doi: 10.1016/S0140-6736(06)68546-2
– volume: 185
  start-page: 517
  year: 1997
  ident: 10.1016/j.vaccine.2007.02.038_bib69
  article-title: Virus-induced transient bone marrow aplasia: Major role of interferon-alpha/beta during acute infection with the noncytopathic lymphocytic choriomeningitis virus
  publication-title: J Exp Med
  doi: 10.1084/jem.185.3.517
– volume: 78
  start-page: 3162
  issue: 6
  year: 2004
  ident: 10.1016/j.vaccine.2007.02.038_bib42
  article-title: Inhibition of different Lassa virus strains by alpha and gamma interferons and comparison with a less pathogenic arenavirus
  publication-title: J Virol
  doi: 10.1128/JVI.78.6.3162-3169.2004
– volume: 21
  start-page: 1181
  issue: 5
  year: 1991
  ident: 10.1016/j.vaccine.2007.02.038_bib48
  article-title: Major histocompatibility complex binding and T cell recognition of a viral nonapeptide containing a minimal tetrapeptide
  publication-title: Eur J Immunol
  doi: 10.1002/eji.1830210513
– volume: 87
  start-page: 209
  year: 2006
  ident: 10.1016/j.vaccine.2007.02.038_bib31
  article-title: Very virulent infectious bursal disease virus: reduced pathogenicity in a rare natural segment-B-reassorted isolate
  publication-title: J Gen Virol
  doi: 10.1099/vir.0.81184-0
– volume: 78
  start-page: 8922
  issue: 16
  year: 2004
  ident: 10.1016/j.vaccine.2007.02.038_bib25
  article-title: Ngari virus is a bunyamwera virus reassortant that can be associated with large outbreaks of hemorrhagic fever in Africa
  publication-title: J Virol
  doi: 10.1128/JVI.78.16.8922-8926.2004
– start-page: 1095
  year: 2004
  ident: 10.1016/j.vaccine.2007.02.038_bib9
  article-title: Yellow fever vaccine
– volume: 40
  start-page: 210
  issue: 3
  year: 1993
  ident: 10.1016/j.vaccine.2007.02.038_bib36
  article-title: Lassa virus activity in Guinea: distribution of human antiviral antibody defined using enzyme-linked immunosorbent assay with recombinant antigen
  publication-title: J Med Virol
  doi: 10.1002/jmv.1890400308
– volume: 75
  start-page: 5205
  year: 2001
  ident: 10.1016/j.vaccine.2007.02.038_bib37
  article-title: Ebola virus VP40-induced particle formation and association with lipid bilayer
  publication-title: J Virol
  doi: 10.1128/JVI.75.11.5205-5214.2001
– volume: 6
  start-page: 466
  issue: 5
  year: 2000
  ident: 10.1016/j.vaccine.2007.02.038_bib29
  article-title: Imported Lassa fever in Germany: molecular characterization of a new Lassa virus strain
  publication-title: Emerg Infect Dis
  doi: 10.3201/eid0605.000504
– volume: 80
  start-page: 86
  issue: 10
  year: 2005
  ident: 10.1016/j.vaccine.2007.02.038_bib2
  article-title: Update on Lassa fever in West Africa
  publication-title: Weekly Epidemiol Rec
– volume: 29
  start-page: 455
  issue: 6
  year: 1985
  ident: 10.1016/j.vaccine.2007.02.038_bib41
  article-title: Sedimentation analysis of the RNAs isolated from interfering particles of Lassa and Machupo viruses
  publication-title: Acta Virol
– volume: 3
  start-page: 103
  issue: 2
  year: 2004
  ident: 10.1016/j.vaccine.2007.02.038_bib8
  article-title: Lassa fever vaccine
  publication-title: Expert Rev Vaccines
  doi: 10.1586/14760584.3.2.189
– volume: 269
  start-page: 145
  year: 1990
  ident: 10.1016/j.vaccine.2007.02.038_bib53
  article-title: Prediction of arenavirus fusion peptides on the basis of computer analysis of envelope protein sequences
  publication-title: FEBS Lett
  doi: 10.1016/0014-5793(90)81140-J
– volume: 11
  start-page: 331
  year: 2001
  ident: 10.1016/j.vaccine.2007.02.038_bib7
  article-title: Towards a human Lassa fever vaccine
  publication-title: Rev Med Virol
  doi: 10.1002/rmv.329
– volume: 68
  start-page: 1951
  year: 1994
  ident: 10.1016/j.vaccine.2007.02.038_bib71
  article-title: Resistance of lymphocytic choriomeningitis virus to alpha/beta interferon and to gamma interferon
  publication-title: J Virol
  doi: 10.1128/JVI.68.3.1951-1955.1994
– volume: 188
  start-page: 600
  issue: 2
  year: 1992
  ident: 10.1016/j.vaccine.2007.02.038_bib10
  article-title: Generation of reassortants between African arenaviruses
  publication-title: Virology
  doi: 10.1016/0042-6822(92)90514-P
– volume: 18
  start-page: 151
  issue: 2–3
  year: 1991
  ident: 10.1016/j.vaccine.2007.02.038_bib18
  article-title: Nucleotide sequence of the S RNA of Lassa virus (Nigerian strain) and comparative analysis of arenavirus gene products
  publication-title: Virus Res
  doi: 10.1016/0168-1702(91)90015-N
SSID ssj0005319
Score 2.1622205
Snippet Lassa virus (LASV) is responsible for the deaths of thousands of people in West Africa annually. Genetic diversity among LASV strains is the highest among the...
Abstract Lassa virus (LASV) is responsible for the deaths of thousands of people in West Africa annually. Genetic diversity among LASV strains is the highest...
SourceID pubmedcentral
proquest
pubmed
pascalfrancis
crossref
elsevier
SourceType Open Access Repository
Aggregation Database
Index Database
Enrichment Source
Publisher
StartPage 4093
SubjectTerms Allergy and Immunology
Animals
Antibody Formation - immunology
Applied microbiology
Arenaviridae
Biological and medical sciences
Biomedical research
Cloning
Cross-protection
Disease
Experiments
Fatalities
Female
Fundamental and applied biological sciences. Psychology
Genetic diversity
Genomes
Guinea Pigs
Hemorrhage
Human viral diseases
Immunity, Cellular - immunology
Infections
Infectious diseases
Laboratories
Lassa fever
Lassa Fever - immunology
Lassa Fever - pathology
Lassa Fever - prevention & control
Lassa Fever - virology
Lassa fever and arenovirus diseases
Lassa virus
Lassa virus - immunology
Lassa virus - isolation & purification
Medical sciences
Microbiology
Miscellaneous
Nigeria
Proteins
Reassortant vaccine
Reassortant Viruses - genetics
Reassortant Viruses - immunology
RNA polymerase
Sterilizing immunity
Tropical viral diseases
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Viral diseases
Viral Vaccines - immunology
Viral Vaccines - pharmacology
Virology
Viruses
Title A ML29 reassortant virus protects guinea pigs against a distantly related Nigerian strain of Lassa virus and can provide sterilizing immunity
URI https://www.clinicalkey.com/#!/content/1-s2.0-S0264410X07001922
https://www.clinicalkey.es/playcontent/1-s2.0-S0264410X07001922
https://dx.doi.org/10.1016/j.vaccine.2007.02.038
https://www.ncbi.nlm.nih.gov/pubmed/17360080
https://www.proquest.com/docview/1559084247
https://www.proquest.com/docview/20366686
https://www.proquest.com/docview/70439995
https://pubmed.ncbi.nlm.nih.gov/PMC1892204
Volume 25
WOSCitedRecordID wos000246835900020&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D
hasFullText 1
inHoldings 1
isFullTextHit
isPrint
journalDatabaseRights – providerCode: PRVESC
  databaseName: ScienceDirect
  customDbUrl:
  eissn: 1873-2518
  dateEnd: 20091019
  omitProxy: false
  ssIdentifier: ssj0005319
  issn: 0264-410X
  databaseCode: AIEXJ
  dateStart: 19950101
  isFulltext: true
  titleUrlDefault: https://www.sciencedirect.com
  providerName: Elsevier
– providerCode: PRVPQU
  databaseName: Biological Science Database
  customDbUrl:
  eissn: 1873-2518
  dateEnd: 20251006
  omitProxy: false
  ssIdentifier: ssj0005319
  issn: 0264-410X
  databaseCode: M7P
  dateStart: 20020101
  isFulltext: true
  titleUrlDefault: http://search.proquest.com/biologicalscijournals
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Consumer Health Database
  customDbUrl:
  eissn: 1873-2518
  dateEnd: 20251006
  omitProxy: false
  ssIdentifier: ssj0005319
  issn: 0264-410X
  databaseCode: M0R
  dateStart: 20020101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/familyhealth
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Health & Medical Collection
  customDbUrl:
  eissn: 1873-2518
  dateEnd: 20251006
  omitProxy: false
  ssIdentifier: ssj0005319
  issn: 0264-410X
  databaseCode: 7X7
  dateStart: 20020101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthcomplete
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Healthcare Administration Database (ProQuest)
  customDbUrl:
  eissn: 1873-2518
  dateEnd: 20251006
  omitProxy: false
  ssIdentifier: ssj0005319
  issn: 0264-410X
  databaseCode: M0T
  dateStart: 20020101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/healthmanagement
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Nursing & Allied Health Database
  customDbUrl:
  eissn: 1873-2518
  dateEnd: 20251006
  omitProxy: false
  ssIdentifier: ssj0005319
  issn: 0264-410X
  databaseCode: 7RV
  dateStart: 20020101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/nahs
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Central
  customDbUrl:
  eissn: 1873-2518
  dateEnd: 20251006
  omitProxy: false
  ssIdentifier: ssj0005319
  issn: 0264-410X
  databaseCode: BENPR
  dateStart: 20020101
  isFulltext: true
  titleUrlDefault: https://www.proquest.com/central
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: ProQuest Research library
  customDbUrl:
  eissn: 1873-2518
  dateEnd: 20251006
  omitProxy: false
  ssIdentifier: ssj0005319
  issn: 0264-410X
  databaseCode: M2O
  dateStart: 20020101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/pqrl
  providerName: ProQuest
– providerCode: PRVPQU
  databaseName: Public Health Database
  customDbUrl:
  eissn: 1873-2518
  dateEnd: 20251006
  omitProxy: false
  ssIdentifier: ssj0005319
  issn: 0264-410X
  databaseCode: 8C1
  dateStart: 20020101
  isFulltext: true
  titleUrlDefault: https://search.proquest.com/publichealth
  providerName: ProQuest
link http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV3db9MwELdgA4SE-ChfgVH8gPa0dImTxs4TGtMmHtpSjTH1LbKdpGSq0tK0lcr_wP_MXeI0FBWGxMtJUXyJbZ3PP_u-CHkXK9jmlA5tphSz_Rj1YCo8W2pXpqETqFCV2fV7fDAQo1E4NBduhXGrrHViqajjqcY78mM0nznCZz5_P_tmY9UotK6aEhq3yb6LezfIM7-4alw8vLKwBxwzfNt3nVETwXN83VlJjaZrk8WQdRwMUdm9Nz2YyQJmLK1KXezCor-7VP6yR50_-t_RPSYPDTqlJ5U4PSG3krxF7lb1Ktctcq9vLPEtcjiscl6vj-hlE8JVHNFDOmyyYQNP6wodbsqoX1qzPyU_Tmi_x0KKLvEFngDyBV1l82VBTeKIgo6X0FLSGXSSyrHMAMdSSWPEu_lisqZlFE4S00E2xlWU06Isd0GnKe3BR6X5nsxjCuJDTcghxcQQ2ST7Dls2zcrgmMX6GflyfnZ5-tE2lSFsDYeBhc0CpXgqtBfEQitARKnvxRhky5RI_cB1VRp3pQR40tUylUJ50pUyBe2vAXJ6ifec7OXTPHlJaKhBhSVxmAiY_5gxIcPE51InHqgyyUKL-LVMRNqkTcfhTKLaP-46MqKEJT155LAIRMkinQ3brMobchNDUAtcVAfFghqPYGe7iZHvYkwKo4yKyI0KaBl9dkrw64wcXgJ7ZhGx4TR4q8JR__LT9taaaMYoOCJuxyIHtaBHTUc2Um6Rt5vXoM_QSCXzZLosIjSMB4EI_tyCYzR3GHYt8qJac83PuRfgEQimZGs1bhpgLvXtN3n2tcyp7gqYEMd_9fduvyb3q7v9ru0GB2RvMV8mb8gdvVpkxbxdKh-kI15SAVScum2y_-FsMLyAp75T0Uuk7BNSPvwJFQSasg
linkProvider ProQuest
linkToHtml http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF6V8pQQj_AylHYO0FOd2mvHuz4gVAFVqyZRJALKbVmv7eAqckKcBIX_wF_hNzLrR0xQoFx64OydXXt355sZz4uQF2GAYi5QvkmDgJpuqHEw5o4plS1j3_ICP8ir67dZt8sHA7-3RX5UuTA6rLLCxByow7HS_8gPtfvM4i512evJF1N3jdLe1aqFRnEtzqLlVzTZslenb_F8X1J6_K7_5sQsuwqYChXJmUm9IGAxV44XchWgNI1dJ9QJmjTgsevZdhCHLSlRtLWUjCUPHGlLGSNyKFRXnMjBea-Qq4jjTIeQsQGrQ0qcvJEImjWu6drWoM4YOjxvLqTSrvKyaiJtWjolZrMsvD2RGZ5QXLTW2KT7_h7C-YtMPL77v-3mPXKn1L7hqGCX-2QrShvketGPc9kgNzplpEGD7PeKmt7LA-jXKWrZAexDr672jTSNjzqgKM9qhor8Afl-BJ029UGH_GfawklnsEim8wzKwhgZDOc4UsIENwXkUCaop4OEUOvz6Wy0hDzLKAqhmww1SqSQ5e08YBxDGyeV5XwyDQHZA8qUStCFL5JR8g1VEkjy5J_Z8iH5cCm7-ohsp-M0ekLAVwjRUehHHM87pJRLP3KZVJGDUC2pbxC3uoNClWXh9eeMRBX_dy7Kq6tbljJhUYFX1yDNFdmkqItyEYFXXXBRJf2imBIouS8iZJsIo6wE20zYIsOR4r2VK_fWwGK54UINwleUpT5Z6In_sujuGg_W38iZtigsg-xUjCXqF1lxlUH2Vo8Rr7UTTqbReJ4J7fj3PO79eQTT2eq-3zLI44LH68WZ42kTD7dkjftXA3St-PUnafI5rxlvc9wQy33699feIzdP-p22aJ92z56RW4Ufo2Xa3g7Znk3n0XNyTS1mSTbdzYEPyKfLxoafUOPwoQ
linkToPdf http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V1Lb9NAEF6VAhUS4hFehtLOAXqqE3vt2OsDQhUlomoSRSKg3Jb12g6uIifETlD4D_whfh2zfsQEBcqlB87eWdvrnW9mvPPNEPIi8NHM-dLTqe9T3Q4UDkbM0oU0ReQZju_5eXX9rtvvs9HIG-yQHxUXRqVVVpiYA3UwleofeUsdnxnMprbbisq0iMFp5_Xsi646SKmT1qqdRrFFzsPVVwzf0ldnp_itX1LaeTt8804vOwzoEp3KTKeO77sRk5YTMOmjZY1sK1BkTeqzyHZM04-CthBo5tpSRIL5ljCFiBBFJLouVmjhvNfIddduU5VO1jOGdXqJlTcVwRDH1m3TGNXsodZFcymkOjYvKyjSpqHoMdvt4u2ZSPFrRUWbjW1-8O_pnL_Yx87d_3ll75E7pVcOJ4Ua3Sc7YdIgN4s-nasG2euVGQgNcjQoan2vjmFYU9fSYziCQV0FHGUaH1WiUc52hkr8Afl-Ar0u9UBRAVIV-SQZLOP5IoWyYEYK4wWOFDDDRQExFjH67yAgUH5-kk1WkLOPwgD68VihRwJp3uYDphF0cVJRzieSAFBtoKRagiqIEU_ib-iqQJyTgrLVQ_LhSlb1EdlNpkn4hIAnEbrDwAsZfvuAUia80HaFDC2EcEE9jdjVfuSyLBevXmfCq7zAC15uY9XK1OUG5biNNdJci82KeimXCTjVZucVGRjNF0eLfpmgu00wTEsQTrnJUxzJ3xu502-MDDcPaKhG2Fqy9DML__FfbnqwoY_1OzJXRRqGRvYrJeP1g6w1TCOH68uI4-pwTiThdJFylRDgOMz58whXsdg9r62Rx4W-1zd3LUeFfrgkG0iwHqBqyG9eSeLPeS15k-GCGPbTvz_2IdlDSODds_75M3KrON5o66azT3az-SJ8Tm7IZRan84McA4F8umpo-An4gflx
openUrl ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=A+ML29+reassortant+virus+protects+guinea+pigs+against+a+distantly+related+Nigerian+strain+of+Lassa+virus+and+can+provide+sterilizing+immunity&rft.jtitle=Vaccine&rft.au=Carrion%2C+Ricardo&rft.au=Patterson%2C+Jean+L&rft.au=Johnson%2C+Curtis&rft.au=Gonzales%2C+Monica&rft.date=2007-05-16&rft.pub=Elsevier+Limited&rft.issn=0264-410X&rft.eissn=1873-2518&rft.volume=25&rft.issue=20&rft.spage=4093&rft_id=info:doi/10.1016%2Fj.vaccine.2007.02.038&rft.externalDBID=HAS_PDF_LINK&rft.externalDocID=3420776071
thumbnail_m http://cvtisr.summon.serialssolutions.com/2.0.0/image/custom?url=https%3A%2F%2Fcdn.clinicalkey.com%2Fck-thumbnails%2F0264410X%2FS0264410X07X0416X%2Fcov150h.gif