BRCA1-mutated and basal-like breast cancers have similar aCGH profiles and a high incidence of protein truncating TP53 mutations

Background Basal-like breast cancers (BLBC) are aggressive breast cancers for which, so far, no targeted therapy is available because they typically lack expression of hormone receptors and HER2. Phenotypic features of BLBCs, such as clinical presentation and early age of onset, resemble those of br...

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Bibliographic Details
Published in:	BMC cancer Vol. 10; no. 1; p. 654
Main Authors:	Holstege, Henne, Horlings, Hugo M, Velds, Arno, Langerød, Anita, Børresen-Dale, Anne-Lise, van de Vijver, Marc J, Nederlof, Petra M, Jonkers, Jos
Format:	Journal Article
Language:	English
Published:	London BioMed Central 30.11.2010 BioMed Central Ltd Springer Nature B.V BMC
Subjects:	Adult Analysis Biomedical and Life Sciences Biomedicine BRCA1 Protein - genetics Breast cancer Breast Neoplasms - drug therapy Breast Neoplasms - genetics Breast Neoplasms - pathology Cancer Cancer Research Care and treatment Chemotherapy Cluster Analysis Comparative Genomic Hybridization Databases, Genetic DNA Mutational Analysis Female Gene Expression Profiling Gene Expression Regulation, Neoplastic Gene mutations Genetic aspects Genetics Genomic Instability genomics and epigenetics Genotype Health aspects Health Promotion and Disease Prevention Humans Medical research Medicine/Public Health Middle Aged Mutation Netherlands Oncology Phenotype Physiological aspects Proteins Research Article Surgical Oncology Tumor Suppressor Protein p53 - genetics Tumors Netherlands Luminal Tumor PARP Inhibitor TP53 Mutation Breast Tumor Tumor Group
ISSN:	1471-2407, 1471-2407
Online Access:	Get full text
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