A Large Scale shRNA Barcode Screen Identifies the Circadian Clock Component ARNTL as Putative Regulator of the p53 Tumor Suppressor Pathway

The p53 tumor suppressor gene is mutated in about half of human cancers, but the p53 pathway is thought to be functionally inactivated in the vast majority of cancer. Understanding how tumor cells can become insensitive to p53 activation is therefore of major importance. Using an RNAi-based genetic...

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Vydané v:	PloS one Ročník 4; číslo 3; s. e4798
Hlavní autori:	Mullenders, Jasper, Fabius, Armida W. M., Madiredjo, Mandy, Bernards, René, Beijersbergen, Roderick L.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 11.03.2009 Public Library of Science (PLoS)
Predmet:	Activation Antigens ARNTL Transcription Factors Bar codes Basic Helix-Loop-Helix Transcription Factors - genetics Basic Helix-Loop-Helix Transcription Factors - physiology BMAL1 protein Cancer Cell Biology/Cell Signaling Cell Biology/Cellular Death and Stress Responses Cell Biology/Gene Expression Cell cycle Cell Division Cell Line Circadian rhythm Circadian Rhythm - genetics Circadian rhythms Cyclin-dependent kinase inhibitor p21 Cyclin-Dependent Kinase Inhibitor p21 - biosynthesis Cyclin-Dependent Kinase Inhibitor p21 - genetics Cytokines Deoxyribonucleic acid DNA DNA damage DNA methylation DNA-Binding Proteins - genetics DNA-Binding Proteins - physiology Gene Library Genes Genes, p53 Genetic screening Genetic testing Genetic Vectors - genetics Genetics Genomics Humans Inverted Repeat Sequences Medical screening Modulators Molecular Biology Oligonucleotide Probes Oncology p53 Protein Population Proteins Regulators RNA Interference RNA, Small Interfering - genetics RNA, Small Interfering - isolation & purification RNA-mediated interference Transcription Factors - genetics Transcription Factors - physiology Tumor cells Tumor necrosis factor-TNF Tumor proteins Tumor suppressor genes Tumor Suppressor Protein p53 - physiology Ubiquitin-Protein Ligases
ISSN:	1932-6203, 1932-6203
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