The Pathogenesis and Long-Term Consequences of COVID-19 Cardiac Injury

•COVID-19 myocardial injury results from immune and hypercoagulability responses.•Long-term cardiac consequences of COVID-19 include structural and functional changes.•Myocarditis after COVID-19 vaccination is uncommon (highest risk in teenage males).•Larger population-based studies are necessary to...

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Vydáno v:	JACC. Basic to translational science Ročník 7; číslo 3; s. 294 - 308
Hlavní autoři:	Siripanthong, Bhurint, Asatryan, Babken, Hanff, Thomas C., Chatha, Salman R., Khanji, Mohammed Y., Ricci, Fabrizio, Muser, Daniele, Ferrari, Victor A., Nazarian, Saman, Santangeli, Pasquale, Deo, Rajat, Cooper, Leslie T., Mohiddin, Saidi A., Chahal, C. Anwar A.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Elsevier Inc 01.03.2022 Elsevier
Témata:	athlete Cardiology and Cardiovascular Disease Cardiovascular cardiovascular magnetic resonance imaging Clinical Medicine COVID-19 inflammation Kardiologi och kardiovaskulära sjukdomar Klinisk medicin Medical and Health Sciences Medicin och hälsovetenskap myocardial injury myocarditis State-of-the-Art Review sudden cardiac death troponin athlete myocarditis CMR sudden cardiac death LGE COVID-19 cardiovascular magnetic resonance imaging CT SARS-CoV-2 myocardial injury troponin inflammation MI coronavirus disease-2019 severe acute respiratory syndrome coronavirus-2 myocardial infarction cardiovascular magnetic resonance Computerized Tomography late gadolinium enhancement SARS-CoV-2, severe acute respiratory syndrome coronavirus-2 MI, myocardial infarction CT, Computerized Tomography LGE, late gadolinium enhancement CMR, cardiovascular magnetic resonance COVID-19, coronavirus disease-2019
ISSN:	2452-302X, 2452-302X
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Shrnutí:	•COVID-19 myocardial injury results from immune and hypercoagulability responses.•Long-term cardiac consequences of COVID-19 include structural and functional changes.•Myocarditis after COVID-19 vaccination is uncommon (highest risk in teenage males).•Larger population-based studies are necessary to validate these early results. The mechanisms of coronavirus disease-2019 (COVID-19)–related myocardial injury comprise both direct viral invasion and indirect (hypercoagulability and immune-mediated) cellular injuries. Some patients with COVID-19 cardiac involvement have poor clinical outcomes, with preliminary data suggesting long-term structural and functional changes. These include persistent myocardial fibrosis, edema, and intraventricular thrombi with embolic events, while functionally, the left ventricle is enlarged, with a reduced ejection fraction and new-onset arrhythmias reported in a number of patients. Myocarditis post-COVID-19 vaccination is rare but more common among young male patients. Larger studies, including prospective data from biobanks, will be useful in expanding these early findings and determining their validity. [Display omitted]
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 ObjectType-Review-3 content type line 23 Mr Siripanthong and Dr Asatryan contributed equally to this work and are joint first authors.
ISSN:	2452-302X 2452-302X
DOI:	10.1016/j.jacbts.2021.10.011