Measles skin rash: Infection of lymphoid and myeloid cells in the dermis precedes viral dissemination to the epidermis

Measles is characterized by fever and a maculopapular skin rash, which is accompanied by immune clearance of measles virus (MV)-infected cells. Histopathological analyses of skin biopsies from humans and non-human primates (NHPs) with measles rash have identified MV-infected keratinocytes and mononu...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 16; no. 10; p. e1008253
Main Authors:	Laksono, Brigitta M., Fortugno, Paola, Nijmeijer, Bernadien M., de Vries, Rory D., Cordisco, Sonia, Kuiken, Thijs, Geijtenbeek, Teunis B. H., Duprex, W. Paul, Brancati, Francesco, de Swart, Rik L.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 08.10.2020 Public Library of Science (PLoS)
Subjects:	Animals Biology Biology and Life Sciences Biopsy Care and treatment CD150 antigen Cell differentiation Cells, Cultured Complications and side effects Dermis Dermis - pathology Dermis - virology Development and progression Edema Environmental science Epidermis Epidermis - pathology Epidermis - virology Exanthema Fever Follicles Funding Gene expression Genetic aspects Health aspects Humans Hyperemia Immune clearance Immune response Immune system Immunology Infections Inoculation Keratinocytes Keratinocytes - pathology Keratinocytes - virology Laboratories Leukocytes Leukocytes (mononuclear) Lymphocytes Lymphocytes - pathology Lymphocytes - virology Macaca fascicularis Measles Measles - pathology Measles - virology Measles virus - isolation & purification Medicine and Health Sciences Membrane proteins Myeloid cells Myeloid Cells - pathology Myeloid Cells - virology Nectin Papillae Pathogenesis Primates Sebaceous gland Sebaceous glands Sheets Skin Skin - pathology Skin - virology Skin diseases Supervision Viruses Italy Netherlands
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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