Modeling the measles paradox reveals the importance of cellular immunity in regulating viral clearance

Measles virus (MV) is a highly contagious member of the Morbillivirus genus that remains a major cause of childhood mortality worldwide. Although infection induces a strong MV-specific immune response that clears viral load and confers lifelong immunity, transient immunosuppression can also occur, l...

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Bibliographic Details
Published in:	PLoS pathogens Vol. 14; no. 12; p. e1007493
Main Authors:	Morris, Sinead E., Yates, Andrew J., de Swart, Rik L., de Vries, Rory D., Mina, Michael J., Nelson, Ashley N., Lin, Wen-Hsuan W., Kouyos, Roger D., Griffin, Diane E., Grenfell, Bryan T.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 28.12.2018 Public Library of Science (PLoS)
Subjects:	Animals Biology and Life Sciences Canine distemper Cell activation Cell-mediated immunity Cellular immunity Children Colonization Computer simulation Cytotoxicity Dendritic cells Depletion Epidemiology Evolutionary biology Fitness HIV Hospitals Human immunodeficiency virus Immune clearance Immune response Immune system Immune Tolerance - immunology Immunity Immunity (cell-mediated) Immunity, Cellular - immunology Immunology Immunosuppression Infections Infectious diseases Lymphocytes Macaca mulatta Mathematical models Measles Measles - immunology Measles virus - immunology Medicine and Health Sciences Mice Models, Theoretical Morbillivirus Pathology Pediatrics Public health Virology Viruses New York Netherlands United States > US Switzerland Baltimore Maryland
ISSN:	1553-7374, 1553-7366, 1553-7374
Online Access:	Get full text
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