The creation and selection of mutations resistant to a gene drive over multiple generations in the malaria mosquito

Gene drives have enormous potential for the control of insect populations of medical and agricultural relevance. By preferentially biasing their own inheritance, gene drives can rapidly introduce genetic traits even if these confer a negative fitness effect on the population. We have recently develo...

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Bibliographic Details
Published in:	PLoS genetics Vol. 13; no. 10; p. e1007039
Main Authors:	Hammond, Andrew M., Kyrou, Kyros, Bruttini, Marco, North, Ace, Galizi, Roberto, Karlsson, Xenia, Kranjc, Nace, Carpi, Francesco M., D’Aurizio, Romina, Crisanti, Andrea, Nolan, Tony
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 04.10.2017 Public Library of Science (PLoS)
Subjects:	Alleles Amino Acid Sequence Animals Anopheles - genetics Anopheles gambiae Bioinformatics Biology and life sciences Clustered Regularly Interspaced Short Palindromic Repeats - genetics Control Culicidae Female Fertility Fertility - genetics Fitness Gene Frequency Gene Library Gene mutation Genes Genes, Essential Genetic aspects Genetic Engineering Genetic research Genetics Genetics, Population Genomics Haplotypes Heredity High-Throughput Nucleotide Sequencing Homing Homology Insect Vectors - genetics Life sciences Malaria Malaria - prevention & control Male Medicine and Health Sciences Methods Models, Genetic Mosquito Control - methods Mosquitoes Mutation Nuclease Population Positive selection Reproductive fitness Research and Analysis Methods Selection, Genetic Sequence Analysis, RNA Technology assessment
ISSN:	1553-7404, 1553-7390, 1553-7404
Online Access:	Get full text
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