Vascular occlusion by neutrophil extracellular traps in COVID-19
Coronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that trigger organ damage in COVID-19 are incompletely understood. Samples were donated from hospitalized patients. Sera, plasma, and autopsy-deri...
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| Vydané v: | EBioMedicine Ročník 58; s. 102925 |
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| Hlavní autori: | , , , , , , , , , , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | English |
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Netherlands
Elsevier B.V
01.08.2020
Elsevier |
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| ISSN: | 2352-3964, 2352-3964 |
| On-line prístup: | Získať plný text |
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| Abstract | Coronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that trigger organ damage in COVID-19 are incompletely understood.
Samples were donated from hospitalized patients. Sera, plasma, and autopsy-derived tissue sections were examined employing flow cytometry, enzyme-linked immunosorbent assays, and immunohistochemistry.
Here, we show that severe COVID-19 is characterized by a highly pronounced formation of neutrophil extracellular traps (NETs) inside the micro-vessels. Intravascular aggregation of NETs leads to rapid occlusion of the affected vessels, disturbed microcirculation, and organ damage. In severe COVID-19, neutrophil granulocytes are strongly activated and adopt a so-called low-density phenotype, prone to spontaneously form NETs. In accordance, markers indicating NET turnover are consistently increased in COVID-19 and linked to disease severity. Histopathology of the lungs and other organs from COVID-19 patients showed congestions of numerous micro-vessels by aggregated NETs associated with endothelial damage.
These data suggest that organ dysfunction in severe COVID-19 is associated with excessive NET formation and vascular damage.
Deutsche Forschungsgemeinschaft (DFG), EU, Volkswagen-Stiftung |
|---|---|
| AbstractList | Coronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that trigger organ damage in COVID-19 are incompletely understood.
Samples were donated from hospitalized patients. Sera, plasma, and autopsy-derived tissue sections were examined employing flow cytometry, enzyme-linked immunosorbent assays, and immunohistochemistry.
Here, we show that severe COVID-19 is characterized by a highly pronounced formation of neutrophil extracellular traps (NETs) inside the micro-vessels. Intravascular aggregation of NETs leads to rapid occlusion of the affected vessels, disturbed microcirculation, and organ damage. In severe COVID-19, neutrophil granulocytes are strongly activated and adopt a so-called low-density phenotype, prone to spontaneously form NETs. In accordance, markers indicating NET turnover are consistently increased in COVID-19 and linked to disease severity. Histopathology of the lungs and other organs from COVID-19 patients showed congestions of numerous micro-vessels by aggregated NETs associated with endothelial damage.
These data suggest that organ dysfunction in severe COVID-19 is associated with excessive NET formation and vascular damage.
Deutsche Forschungsgemeinschaft (DFG), EU, Volkswagen-Stiftung AbstractBackgroundCoronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that trigger organ damage in COVID-19 are incompletely understood. MethodsSamples were donated from hospitalized patients. Sera, plasma, and autopsy-derived tissue sections were examined employing flow cytometry, enzyme-linked immunosorbent assays, and immunohistochemistry. Patient findingsHere, we show that severe COVID-19 is characterized by a highly pronounced formation of neutrophil extracellular traps (NETs) inside the micro-vessels. Intravascular aggregation of NETs leads to rapid occlusion of the affected vessels, disturbed microcirculation, and organ damage. In severe COVID-19, neutrophil granulocytes are strongly activated and adopt a so-called low-density phenotype, prone to spontaneously form NETs. In accordance, markers indicating NET turnover are consistently increased in COVID-19 and linked to disease severity. Histopathology of the lungs and other organs from COVID-19 patients showed congestions of numerous micro-vessels by aggregated NETs associated with endothelial damage. InterpretationThese data suggest that organ dysfunction in severe COVID-19 is associated with excessive NET formation and vascular damage. FundingDeutsche Forschungsgemeinschaft (DFG), EU, Volkswagen-Stiftung Background: Coronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that trigger organ damage in COVID-19 are incompletely understood. Methods: Samples were donated from hospitalized patients. Sera, plasma, and autopsy-derived tissue sections were examined employing flow cytometry, enzyme-linked immunosorbent assays, and immunohistochemistry. Patient findings: Here, we show that severe COVID-19 is characterized by a highly pronounced formation of neutrophil extracellular traps (NETs) inside the micro-vessels. Intravascular aggregation of NETs leads to rapid occlusion of the affected vessels, disturbed microcirculation, and organ damage. In severe COVID-19, neutrophil granulocytes are strongly activated and adopt a so-called low-density phenotype, prone to spontaneously form NETs. In accordance, markers indicating NET turnover are consistently increased in COVID-19 and linked to disease severity. Histopathology of the lungs and other organs from COVID-19 patients showed congestions of numerous micro-vessels by aggregated NETs associated with endothelial damage. Interpretation: These data suggest that organ dysfunction in severe COVID-19 is associated with excessive NET formation and vascular damage. Funding: Deutsche Forschungsgemeinschaft (DFG), EU, Volkswagen-Stiftung Coronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that trigger organ damage in COVID-19 are incompletely understood.BACKGROUNDCoronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that trigger organ damage in COVID-19 are incompletely understood.Samples were donated from hospitalized patients. Sera, plasma, and autopsy-derived tissue sections were examined employing flow cytometry, enzyme-linked immunosorbent assays, and immunohistochemistry.METHODSSamples were donated from hospitalized patients. Sera, plasma, and autopsy-derived tissue sections were examined employing flow cytometry, enzyme-linked immunosorbent assays, and immunohistochemistry.Here, we show that severe COVID-19 is characterized by a highly pronounced formation of neutrophil extracellular traps (NETs) inside the micro-vessels. Intravascular aggregation of NETs leads to rapid occlusion of the affected vessels, disturbed microcirculation, and organ damage. In severe COVID-19, neutrophil granulocytes are strongly activated and adopt a so-called low-density phenotype, prone to spontaneously form NETs. In accordance, markers indicating NET turnover are consistently increased in COVID-19 and linked to disease severity. Histopathology of the lungs and other organs from COVID-19 patients showed congestions of numerous micro-vessels by aggregated NETs associated with endothelial damage.PATIENT FINDINGSHere, we show that severe COVID-19 is characterized by a highly pronounced formation of neutrophil extracellular traps (NETs) inside the micro-vessels. Intravascular aggregation of NETs leads to rapid occlusion of the affected vessels, disturbed microcirculation, and organ damage. In severe COVID-19, neutrophil granulocytes are strongly activated and adopt a so-called low-density phenotype, prone to spontaneously form NETs. In accordance, markers indicating NET turnover are consistently increased in COVID-19 and linked to disease severity. Histopathology of the lungs and other organs from COVID-19 patients showed congestions of numerous micro-vessels by aggregated NETs associated with endothelial damage.These data suggest that organ dysfunction in severe COVID-19 is associated with excessive NET formation and vascular damage.INTERPRETATIONThese data suggest that organ dysfunction in severe COVID-19 is associated with excessive NET formation and vascular damage.Deutsche Forschungsgemeinschaft (DFG), EU, Volkswagen-Stiftung.FUNDINGDeutsche Forschungsgemeinschaft (DFG), EU, Volkswagen-Stiftung. Coronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that trigger organ damage in COVID-19 are incompletely understood. Samples were donated from hospitalized patients. Sera, plasma, and autopsy-derived tissue sections were examined employing flow cytometry, enzyme-linked immunosorbent assays, and immunohistochemistry. Here, we show that severe COVID-19 is characterized by a highly pronounced formation of neutrophil extracellular traps (NETs) inside the micro-vessels. Intravascular aggregation of NETs leads to rapid occlusion of the affected vessels, disturbed microcirculation, and organ damage. In severe COVID-19, neutrophil granulocytes are strongly activated and adopt a so-called low-density phenotype, prone to spontaneously form NETs. In accordance, markers indicating NET turnover are consistently increased in COVID-19 and linked to disease severity. Histopathology of the lungs and other organs from COVID-19 patients showed congestions of numerous micro-vessels by aggregated NETs associated with endothelial damage. These data suggest that organ dysfunction in severe COVID-19 is associated with excessive NET formation and vascular damage. Deutsche Forschungsgemeinschaft (DFG), EU, Volkswagen-Stiftung. |
| ArticleNumber | 102925 |
| Author | Stürzl, Michael Hartmann, Arndt Herrmann, Martin Völkl, Simon Schett, Georg Evert, Katja Herrmann, Irmgard Lindemann, Aylin Kremer, Anita N. Muñoz, Luis E. Mahajan, Aparna Wehrfritz, Andreas Rieker, Ralf J. Naschberger, Elisabeth Singh, Jeeshan Knopf, Jasmin Neurath, Markus F. Staats, Léonie Amann, Kerstin Leppkes, Moritz Kremer, Andreas E. Schauer, Christine Falkeis, Christina |
| Author_xml | – sequence: 1 givenname: Moritz orcidid: 0000-0003-2311-090X surname: Leppkes fullname: Leppkes, Moritz email: moritz.leppkes@uk-erlangen.de organization: Department of Internal Medicine 1, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany – sequence: 2 givenname: Jasmin surname: Knopf fullname: Knopf, Jasmin organization: Department of Internal Medicine 3, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany – sequence: 3 givenname: Elisabeth surname: Naschberger fullname: Naschberger, Elisabeth organization: Division of Molecular and Experimental Surgery, Translational Research Center, Department of Surgery, University Medical Center Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany – sequence: 4 givenname: Aylin surname: Lindemann fullname: Lindemann, Aylin organization: Department of Internal Medicine 1, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany – sequence: 5 givenname: Jeeshan surname: Singh fullname: Singh, Jeeshan organization: Department of Internal Medicine 3, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany – sequence: 6 givenname: Irmgard surname: Herrmann fullname: Herrmann, Irmgard organization: Department of Internal Medicine 3, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany – sequence: 7 givenname: Michael surname: Stürzl fullname: Stürzl, Michael organization: Division of Molecular and Experimental Surgery, Translational Research Center, Department of Surgery, University Medical Center Erlangen, Friedrich-Alexander University Erlangen-Nürnberg, Erlangen, Germany – sequence: 8 givenname: Léonie surname: Staats fullname: Staats, Léonie organization: Department of Internal Medicine 1, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany – sequence: 9 givenname: Aparna surname: Mahajan fullname: Mahajan, Aparna organization: Department of Internal Medicine 3, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany – sequence: 10 givenname: Christine surname: Schauer fullname: Schauer, Christine organization: Department of Internal Medicine 3, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany – sequence: 11 givenname: Anita N. surname: Kremer fullname: Kremer, Anita N. organization: Department of Internal Medicine 5, Hematology and Oncology, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany – sequence: 12 givenname: Simon surname: Völkl fullname: Völkl, Simon organization: Department of Internal Medicine 5, Hematology and Oncology, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany – sequence: 13 givenname: Kerstin surname: Amann fullname: Amann, Kerstin organization: Department of Nephropathology, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany – sequence: 14 givenname: Katja surname: Evert fullname: Evert, Katja organization: Institute of Pathology, University Medical Center Regensburg, Germany – sequence: 15 givenname: Christina surname: Falkeis fullname: Falkeis, Christina organization: Institut of Pathology, Klinikum Bayreuth, Germany – sequence: 16 givenname: Andreas surname: Wehrfritz fullname: Wehrfritz, Andreas organization: Department of Anaesthesiology, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany – sequence: 17 givenname: Ralf J. surname: Rieker fullname: Rieker, Ralf J. organization: Institute of Pathology, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany – sequence: 18 givenname: Arndt surname: Hartmann fullname: Hartmann, Arndt organization: Institute of Pathology, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany – sequence: 19 givenname: Andreas E. surname: Kremer fullname: Kremer, Andreas E. organization: Department of Internal Medicine 1, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany – sequence: 20 givenname: Markus F. surname: Neurath fullname: Neurath, Markus F. organization: Department of Internal Medicine 1, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany – sequence: 21 givenname: Luis E. surname: Muñoz fullname: Muñoz, Luis E. organization: Department of Internal Medicine 3, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany – sequence: 22 givenname: Georg surname: Schett fullname: Schett, Georg organization: Department of Internal Medicine 3, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany – sequence: 23 givenname: Martin surname: Herrmann fullname: Herrmann, Martin organization: Department of Internal Medicine 3, University Medical Center Erlangen, Friedrich-Alexander-University Erlangen-Nürnberg, Erlangen, Germany |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/32745993$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1038/s41586-020-2012-7 10.1007/s00441-018-2802-5 10.1146/annurev-pathol-011811-132453 10.1097/ALN.0000000000002619 10.1056/NEJMoa2015432 10.1186/s12931-017-0651-5 10.1038/ncomms10973 10.1016/j.phrs.2016.08.008 10.1038/s41590-019-0571-2 10.1016/S0049-3848(98)00121-2 10.1002/jmv.25819 10.5858/134.5.719 10.1172/JCI61303 10.1073/pnas.1005743107 10.21037/atm.2019.11.86 10.1126/science.1092385 10.1016/j.cell.2020.02.052 10.1002/path.1570 10.1182/blood-2013-07-514984 10.1016/j.chom.2012.06.011 10.1073/pnas.1301059110 10.3389/fimmu.2016.00366 10.1016/j.immuni.2019.07.002 10.1038/nchembio.1735 10.3389/fimmu.2019.02481 10.1056/NEJMoa2001017 10.1136/annrheumdis-2013-204837 10.1016/S0140-6736(20)30183-5 10.1182/blood.2020006000 10.1016/S0140-6736(20)30211-7 10.1084/jem.20112322 10.1160/th15-03-0214 10.1038/s41418-018-0261-x 10.1038/nm.3547 10.1021/bi981536o 10.1111/jth.14768 10.1111/jth.13493 10.1016/S0140-6736(20)30937-5 10.1111/eci.13319 10.1038/nm.2184 10.1007/BF00914089 10.1111/j.1742-4658.2008.06849.x 10.1126/science.aam8897 |
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| References | Connors, Levy (bib0038) 2020; 135 Varga, Flammer, Steiger (bib0035) 2020; 395 Martinod, Demers, Fuchs (bib0029) 2013; 110 Ackermann, Verleden, Kuehnel (bib0036) 2020 Craddock, Hammerschmidt, Moldow, Yamada, Jacob (bib0042) 1979; 16 Huang, Wang, Li (bib0003) 2020; 395 Lewis, Liddle, Coote (bib0044) 2015; 11 WHO. Coronavirus disease 2019 (COVID-19) Situation Report –142. 10.06.2020 2020. Belorgey, Bieth (bib0024) 1998; 37 Abe, Okajima, Okabe, Takatsuki, Binder (bib0031) 1994; 123 Bach-Gansmo, Godal, Skjonsberg (bib0023) 1998; 92 Jenne, Liao, Singh (bib0008) 2018; 371 McDonald, Urrutia, Yipp, Jenne, Kubes (bib0016) 2012; 12 Jimenez-Alcazar, Rangaswamy, Panda (bib0020) 2017; 358 Longstaff, Hogwood, Gray (bib0049) 2016; 115 Lv, Wen, Song (bib0017) 2017; 18 Michels, Albanez, Mewburn (bib0025) 2016; 14 Carmona-Rivera, Zhao, Yalavarthi, Kaplan (bib0010) 2015; 74 Hamming, Timens, Bulthuis, Lely, Navis, van Goor (bib0034) 2004; 203 Wichmann, Sperhake, Lutgehetmann (bib0037) 2020 Zhu, Zhang, Wang (bib0001) 2020; 382 von Bruhl, Stark, Steinhart (bib0028) 2012; 209 Brinkmann, Reichard, Goosmann (bib0011) 2004; 303 Boeltz, Amini, Anders (bib0013) 2019; 26 McGonagle, O'Donnell, Sharif, Emery, Bridgewood (bib0050) 2020 Massberg, Grahl, von Bruehl (bib0027) 2010; 16 Giacobbe, Battaglini, Ball (bib0045) 2020 Adrover, Aroca-Crevillen, Crainiciuc (bib0009) 2020; 21 Manfredi, Rovere-Querini, D'Angelo, Maugeri (bib0047) 2017; 123 Zhou, Yang, Wang (bib0032) 2020; 579 Bendib, de Chaisemartin, Granger (bib0015) 2019; 130 Napirei, Ludwig, Mezrhab, Klockl, Mannherz (bib0046) 2009; 276 Munoz, Boeltz, Bilyy (bib0022) 2019; 51 Jennette, Falk, Hu, Xiao (bib0041) 2013; 8 Beasley (bib0039) 2010; 134 Zwahlen, Roth, Wyder-Walther (bib0043) 1990; 14 Wildhagen, Garcia de Frutos, Reutelingsperger (bib0048) 2014; 123 Liu, Yan, Wan (bib0004) 2020 Gosswein, Lindemann, Mahajan (bib0030) 2019; 10 Chen, Zhou, Dong (bib0006) 2020; 395 Leppkes, Maueroder, Hirth (bib0021) 2016; 7 Schonrich, Raftery (bib0012) 2016; 7 Lagunas-Rangel (bib0007) 2020 Bery, Hachem (bib0040) 2020; 8 Fuchs, Brill, Duerschmied (bib0026) 2010; 107 Schauer, Janko, Munoz (bib0019) 2014; 20 Tang, Li, Wang, Sun (bib0005) 2020; 18 Caudrillier, Kessenbrock, Gilliss (bib0014) 2012; 122 Zuo, Yalavarthi, Shi (bib0018) 2020; 5 Hoffmann, Kleine-Weber, Schroeder (bib0033) 2020; 181 Accessed 11.06.2020 2020). Jenne (10.1016/j.ebiom.2020.102925_bib0008) 2018; 371 von Bruhl (10.1016/j.ebiom.2020.102925_bib0028) 2012; 209 Schonrich (10.1016/j.ebiom.2020.102925_bib0012) 2016; 7 Tang (10.1016/j.ebiom.2020.102925_bib0005) 2020; 18 Zhou (10.1016/j.ebiom.2020.102925_bib0032) 2020; 579 Zhu (10.1016/j.ebiom.2020.102925_bib0001) 2020; 382 Chen (10.1016/j.ebiom.2020.102925_bib0006) 2020; 395 Jennette (10.1016/j.ebiom.2020.102925_bib0041) 2013; 8 Boeltz (10.1016/j.ebiom.2020.102925_bib0013) 2019; 26 Lagunas-Rangel (10.1016/j.ebiom.2020.102925_bib0007) 2020 Napirei (10.1016/j.ebiom.2020.102925_bib0046) 2009; 276 Zwahlen (10.1016/j.ebiom.2020.102925_bib0043) 1990; 14 Schauer (10.1016/j.ebiom.2020.102925_bib0019) 2014; 20 Bery (10.1016/j.ebiom.2020.102925_bib0040) 2020; 8 Brinkmann (10.1016/j.ebiom.2020.102925_bib0011) 2004; 303 Gosswein (10.1016/j.ebiom.2020.102925_bib0030) 2019; 10 Lewis (10.1016/j.ebiom.2020.102925_bib0044) 2015; 11 Leppkes (10.1016/j.ebiom.2020.102925_bib0021) 2016; 7 Belorgey (10.1016/j.ebiom.2020.102925_bib0024) 1998; 37 Abe (10.1016/j.ebiom.2020.102925_bib0031) 1994; 123 Connors (10.1016/j.ebiom.2020.102925_bib0038) 2020; 135 Giacobbe (10.1016/j.ebiom.2020.102925_bib0045) 2020 McDonald (10.1016/j.ebiom.2020.102925_bib0016) 2012; 12 Michels (10.1016/j.ebiom.2020.102925_bib0025) 2016; 14 Bendib (10.1016/j.ebiom.2020.102925_bib0015) 2019; 130 Munoz (10.1016/j.ebiom.2020.102925_bib0022) 2019; 51 Liu (10.1016/j.ebiom.2020.102925_bib0004) 2020 Bach-Gansmo (10.1016/j.ebiom.2020.102925_bib0023) 1998; 92 Carmona-Rivera (10.1016/j.ebiom.2020.102925_bib0010) 2015; 74 Zuo (10.1016/j.ebiom.2020.102925_bib0018) 2020; 5 Hamming (10.1016/j.ebiom.2020.102925_bib0034) 2004; 203 Adrover (10.1016/j.ebiom.2020.102925_bib0009) 2020; 21 Varga (10.1016/j.ebiom.2020.102925_bib0035) 2020; 395 10.1016/j.ebiom.2020.102925_bib0002 Jimenez-Alcazar (10.1016/j.ebiom.2020.102925_bib0020) 2017; 358 Wichmann (10.1016/j.ebiom.2020.102925_bib0037) 2020 Ackermann (10.1016/j.ebiom.2020.102925_bib0036) 2020 Fuchs (10.1016/j.ebiom.2020.102925_bib0026) 2010; 107 Longstaff (10.1016/j.ebiom.2020.102925_bib0049) 2016; 115 Wildhagen (10.1016/j.ebiom.2020.102925_bib0048) 2014; 123 Beasley (10.1016/j.ebiom.2020.102925_bib0039) 2010; 134 Huang (10.1016/j.ebiom.2020.102925_bib0003) 2020; 395 Craddock (10.1016/j.ebiom.2020.102925_bib0042) 1979; 16 Massberg (10.1016/j.ebiom.2020.102925_bib0027) 2010; 16 Caudrillier (10.1016/j.ebiom.2020.102925_bib0014) 2012; 122 Martinod (10.1016/j.ebiom.2020.102925_bib0029) 2013; 110 Lv (10.1016/j.ebiom.2020.102925_bib0017) 2017; 18 Hoffmann (10.1016/j.ebiom.2020.102925_bib0033) 2020; 181 McGonagle (10.1016/j.ebiom.2020.102925_bib0050) 2020 Manfredi (10.1016/j.ebiom.2020.102925_bib0047) 2017; 123 32810824 - EBioMedicine. 2020 Sep;59:102942. doi: 10.1016/j.ebiom.2020.102942 |
| References_xml | – volume: 14 start-page: 2274 year: 2016 end-page: 2286 ident: bib0025 article-title: Histones link inflammation and thrombosis through the induction of Weibel-Palade body exocytosis publication-title: J Thromb Haemost – volume: 382 start-page: 727 year: 2020 end-page: 733 ident: bib0001 article-title: A Novel Coronavirus from Patients with Pneumonia in China, 2019 publication-title: N Engl J Med – volume: 16 start-page: 887 year: 2010 end-page: 896 ident: bib0027 article-title: Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases publication-title: Nat Med – start-page: e13319 year: 2020 ident: bib0045 article-title: Bloodstream infections in critically ill patients with COVID-19 publication-title: Eur J Clin Invest – volume: 203 start-page: 631 year: 2004 end-page: 637 ident: bib0034 article-title: Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis publication-title: J Pathol – volume: 92 start-page: 125 year: 1998 end-page: 134 ident: bib0023 article-title: Degradation of fibrinogen and cross-linked fibrin by human neutrophil elastase generates D-like fragments detected by ELISA but not latex D-dimer test publication-title: Thromb Res – volume: 18 start-page: 165 year: 2017 ident: bib0017 article-title: Extracellular histones are clinically relevant mediators in the pathogenesis of acute respiratory distress syndrome publication-title: Respir Res – volume: 14 start-page: 375 year: 1990 end-page: 387 ident: bib0043 article-title: In vitro aggregation of bovine neonatal neutrophils. A comparative study with adult cattle publication-title: Inflammation – volume: 21 start-page: 135 year: 2020 end-page: 144 ident: bib0009 article-title: Programmed 'disarming' of the neutrophil proteome reduces the magnitude of inflammation publication-title: Nat Immunol – volume: 37 start-page: 16416 year: 1998 end-page: 16422 ident: bib0024 article-title: Effect of polynucleotides on the inhibition of neutrophil elastase by mucus proteinase inhibitor and alpha 1-proteinase inhibitor publication-title: Biochemistry – volume: 130 start-page: 581 year: 2019 end-page: 591 ident: bib0015 article-title: Neutrophil Extracellular Traps Are Elevated in Patients with Pneumonia-related Acute Respiratory Distress Syndrome publication-title: Anesthesiology – volume: 181 start-page: 271 year: 2020 end-page: 280 ident: bib0033 article-title: SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor publication-title: Cell – volume: 579 start-page: 270 year: 2020 end-page: 273 ident: bib0032 article-title: A pneumonia outbreak associated with a new coronavirus of probable bat origin publication-title: Nature – volume: 123 start-page: 146 year: 2017 end-page: 156 ident: bib0047 article-title: Low molecular weight heparins prevent the induction of autophagy of activated neutrophils and the formation of neutrophil extracellular traps publication-title: Pharmacol Res – volume: 123 start-page: 1098 year: 2014 end-page: 1101 ident: bib0048 article-title: Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis publication-title: Blood – volume: 358 start-page: 1202 year: 2017 end-page: 1206 ident: bib0020 article-title: Host DNases prevent vascular occlusion by neutrophil extracellular traps publication-title: Science – volume: 8 start-page: 139 year: 2013 end-page: 160 ident: bib0041 article-title: Pathogenesis of antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitis publication-title: Annu Rev Pathol – volume: 115 start-page: 591 year: 2016 end-page: 599 ident: bib0049 article-title: Neutralisation of the anti-coagulant effects of heparin by histones in blood plasma and purified systems publication-title: Thromb Haemost – volume: 51 start-page: 443 year: 2019 end-page: 450 ident: bib0022 article-title: Neutrophil Extracellular Traps Initiate Gallstone Formation publication-title: Immunity – volume: 7 start-page: 10973 year: 2016 ident: bib0021 article-title: Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis publication-title: Nat Commun – volume: 8 start-page: 411 year: 2020 ident: bib0040 article-title: Antibody-mediated rejection after lung transplantation publication-title: Ann Transl Med – volume: 10 start-page: 2481 year: 2019 ident: bib0030 article-title: Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation publication-title: Front Immunol – reference: . Accessed 11.06.2020 2020). – volume: 123 start-page: 874 year: 1994 end-page: 881 ident: bib0031 article-title: Granulocyte proteases and hydrogen peroxide synergistically inactivate thrombomodulin of endothelial cells in vitro publication-title: J Lab Clin Med – volume: 5 year: 2020 ident: bib0018 article-title: Neutrophil extracellular traps in COVID-19 publication-title: JCI Insight – volume: 209 start-page: 819 year: 2012 end-page: 835 ident: bib0028 article-title: Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo publication-title: J Exp Med – year: 2020 ident: bib0007 article-title: Neutrophil-to-lymphocyte ratio and lymphocyte-to-C-reactive protein ratio in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis publication-title: J Med Virol – volume: 12 start-page: 324 year: 2012 end-page: 333 ident: bib0016 article-title: Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis publication-title: Cell Host Microbe – volume: 395 start-page: 497 year: 2020 end-page: 506 ident: bib0003 article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China publication-title: Lancet – year: 2020 ident: bib0036 article-title: Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 publication-title: N Engl J Med – volume: 18 start-page: 844 year: 2020 end-page: 847 ident: bib0005 article-title: Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia publication-title: J Thromb Haemost – volume: 110 start-page: 8674 year: 2013 end-page: 8679 ident: bib0029 article-title: Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice publication-title: Proc Natl Acad Sci U S A – volume: 26 start-page: 395 year: 2019 end-page: 408 ident: bib0013 article-title: To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps publication-title: Cell Death Differ – volume: 395 start-page: 1417 year: 2020 end-page: 1418 ident: bib0035 article-title: Endothelial cell infection and endotheliitis in COVID-19 publication-title: Lancet – volume: 135 start-page: 2033 year: 2020 end-page: 2040 ident: bib0038 article-title: COVID-19 and its implications for thrombosis and anticoagulation publication-title: Blood – reference: WHO. Coronavirus disease 2019 (COVID-19) Situation Report –142. 10.06.2020 2020. – year: 2020 ident: bib0004 article-title: Viral dynamics in mild and severe cases of COVID-19 publication-title: Lancet Infect Dis – volume: 371 start-page: 395 year: 2018 end-page: 397 ident: bib0008 article-title: Neutrophils: multitasking first responders of immunity and tissue homeostasis publication-title: Cell Tissue Res – volume: 276 start-page: 1059 year: 2009 end-page: 1073 ident: bib0046 article-title: Murine serum nucleases–contrasting effects of plasmin and heparin on the activities of DNase1 and DNase1-like 3 (DNase1l3) publication-title: FEBS J – volume: 122 start-page: 2661 year: 2012 end-page: 2671 ident: bib0014 article-title: Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury publication-title: J Clin Invest – volume: 134 start-page: 719 year: 2010 end-page: 727 ident: bib0039 article-title: The pathologist's approach to acute lung injury publication-title: Arch Pathol Lab Med – volume: 16 start-page: 140 year: 1979 end-page: 147 ident: bib0042 article-title: Granulocyte aggregation as a manifestation of membrane interactions with complement: possible role in leukocyte margination, microvascular occlusion, and endothelial damage publication-title: Semin Hematol – year: 2020 ident: bib0050 article-title: Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia publication-title: Lancet Rheumatol – volume: 303 start-page: 1532 year: 2004 end-page: 1535 ident: bib0011 article-title: Neutrophil extracellular traps kill bacteria publication-title: Science – volume: 7 start-page: 366 year: 2016 ident: bib0012 article-title: Neutrophil Extracellular Traps Go Viral publication-title: Front Immunol – volume: 107 start-page: 15880 year: 2010 end-page: 15885 ident: bib0026 article-title: Extracellular DNA traps promote thrombosis publication-title: Proc Natl Acad Sci U S A – year: 2020 ident: bib0037 article-title: Autopsy Findings and Venous Thromboembolism in Patients With COVID-19 publication-title: Ann Intern Med – volume: 11 start-page: 189 year: 2015 end-page: 191 ident: bib0044 article-title: Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation publication-title: Nat Chem Biol – volume: 395 start-page: 507 year: 2020 end-page: 513 ident: bib0006 article-title: Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study publication-title: Lancet – volume: 20 start-page: 511 year: 2014 end-page: 517 ident: bib0019 article-title: Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines publication-title: Nat Med – volume: 74 start-page: 1417 year: 2015 end-page: 1424 ident: bib0010 article-title: Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2 publication-title: Ann Rheum Dis – volume: 579 start-page: 270 issue: 7798 year: 2020 ident: 10.1016/j.ebiom.2020.102925_bib0032 article-title: A pneumonia outbreak associated with a new coronavirus of probable bat origin publication-title: Nature doi: 10.1038/s41586-020-2012-7 – volume: 371 start-page: 395 issue: 3 year: 2018 ident: 10.1016/j.ebiom.2020.102925_bib0008 article-title: Neutrophils: multitasking first responders of immunity and tissue homeostasis publication-title: Cell Tissue Res doi: 10.1007/s00441-018-2802-5 – year: 2020 ident: 10.1016/j.ebiom.2020.102925_bib0037 article-title: Autopsy Findings and Venous Thromboembolism in Patients With COVID-19 publication-title: Ann Intern Med – volume: 16 start-page: 140 issue: 2 year: 1979 ident: 10.1016/j.ebiom.2020.102925_bib0042 article-title: Granulocyte aggregation as a manifestation of membrane interactions with complement: possible role in leukocyte margination, microvascular occlusion, and endothelial damage publication-title: Semin Hematol – volume: 8 start-page: 139 year: 2013 ident: 10.1016/j.ebiom.2020.102925_bib0041 article-title: Pathogenesis of antineutrophil cytoplasmic autoantibody-associated small-vessel vasculitis publication-title: Annu Rev Pathol doi: 10.1146/annurev-pathol-011811-132453 – volume: 130 start-page: 581 issue: 4 year: 2019 ident: 10.1016/j.ebiom.2020.102925_bib0015 article-title: Neutrophil Extracellular Traps Are Elevated in Patients with Pneumonia-related Acute Respiratory Distress Syndrome publication-title: Anesthesiology doi: 10.1097/ALN.0000000000002619 – year: 2020 ident: 10.1016/j.ebiom.2020.102925_bib0036 article-title: Pulmonary Vascular Endothelialitis, Thrombosis, and Angiogenesis in Covid-19 publication-title: N Engl J Med doi: 10.1056/NEJMoa2015432 – ident: 10.1016/j.ebiom.2020.102925_bib0002 – volume: 18 start-page: 165 issue: 1 year: 2017 ident: 10.1016/j.ebiom.2020.102925_bib0017 article-title: Extracellular histones are clinically relevant mediators in the pathogenesis of acute respiratory distress syndrome publication-title: Respir Res doi: 10.1186/s12931-017-0651-5 – volume: 7 start-page: 10973 year: 2016 ident: 10.1016/j.ebiom.2020.102925_bib0021 article-title: Externalized decondensed neutrophil chromatin occludes pancreatic ducts and drives pancreatitis publication-title: Nat Commun doi: 10.1038/ncomms10973 – volume: 123 start-page: 146 year: 2017 ident: 10.1016/j.ebiom.2020.102925_bib0047 article-title: Low molecular weight heparins prevent the induction of autophagy of activated neutrophils and the formation of neutrophil extracellular traps publication-title: Pharmacol Res doi: 10.1016/j.phrs.2016.08.008 – volume: 21 start-page: 135 issue: 2 year: 2020 ident: 10.1016/j.ebiom.2020.102925_bib0009 article-title: Programmed 'disarming' of the neutrophil proteome reduces the magnitude of inflammation publication-title: Nat Immunol doi: 10.1038/s41590-019-0571-2 – volume: 92 start-page: 125 issue: 3 year: 1998 ident: 10.1016/j.ebiom.2020.102925_bib0023 article-title: Degradation of fibrinogen and cross-linked fibrin by human neutrophil elastase generates D-like fragments detected by ELISA but not latex D-dimer test publication-title: Thromb Res doi: 10.1016/S0049-3848(98)00121-2 – year: 2020 ident: 10.1016/j.ebiom.2020.102925_bib0007 article-title: Neutrophil-to-lymphocyte ratio and lymphocyte-to-C-reactive protein ratio in patients with severe coronavirus disease 2019 (COVID-19): A meta-analysis publication-title: J Med Virol doi: 10.1002/jmv.25819 – year: 2020 ident: 10.1016/j.ebiom.2020.102925_bib0004 article-title: Viral dynamics in mild and severe cases of COVID-19 publication-title: Lancet Infect Dis – volume: 134 start-page: 719 issue: 5 year: 2010 ident: 10.1016/j.ebiom.2020.102925_bib0039 article-title: The pathologist's approach to acute lung injury publication-title: Arch Pathol Lab Med doi: 10.5858/134.5.719 – volume: 122 start-page: 2661 issue: 7 year: 2012 ident: 10.1016/j.ebiom.2020.102925_bib0014 article-title: Platelets induce neutrophil extracellular traps in transfusion-related acute lung injury publication-title: J Clin Invest doi: 10.1172/JCI61303 – volume: 107 start-page: 15880 issue: 36 year: 2010 ident: 10.1016/j.ebiom.2020.102925_bib0026 article-title: Extracellular DNA traps promote thrombosis publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1005743107 – volume: 8 start-page: 411 issue: 6 year: 2020 ident: 10.1016/j.ebiom.2020.102925_bib0040 article-title: Antibody-mediated rejection after lung transplantation publication-title: Ann Transl Med doi: 10.21037/atm.2019.11.86 – volume: 303 start-page: 1532 issue: 5663 year: 2004 ident: 10.1016/j.ebiom.2020.102925_bib0011 article-title: Neutrophil extracellular traps kill bacteria publication-title: Science doi: 10.1126/science.1092385 – volume: 181 start-page: 271 issue: 2 year: 2020 ident: 10.1016/j.ebiom.2020.102925_bib0033 article-title: SARS-CoV-2 Cell Entry Depends on ACE2 and TMPRSS2 and Is Blocked by a Clinically Proven Protease Inhibitor publication-title: Cell doi: 10.1016/j.cell.2020.02.052 – volume: 203 start-page: 631 issue: 2 year: 2004 ident: 10.1016/j.ebiom.2020.102925_bib0034 article-title: Tissue distribution of ACE2 protein, the functional receptor for SARS coronavirus. A first step in understanding SARS pathogenesis publication-title: J Pathol doi: 10.1002/path.1570 – volume: 123 start-page: 1098 issue: 7 year: 2014 ident: 10.1016/j.ebiom.2020.102925_bib0048 article-title: Nonanticoagulant heparin prevents histone-mediated cytotoxicity in vitro and improves survival in sepsis publication-title: Blood doi: 10.1182/blood-2013-07-514984 – volume: 12 start-page: 324 issue: 3 year: 2012 ident: 10.1016/j.ebiom.2020.102925_bib0016 article-title: Intravascular neutrophil extracellular traps capture bacteria from the bloodstream during sepsis publication-title: Cell Host Microbe doi: 10.1016/j.chom.2012.06.011 – volume: 110 start-page: 8674 issue: 21 year: 2013 ident: 10.1016/j.ebiom.2020.102925_bib0029 article-title: Neutrophil histone modification by peptidylarginine deiminase 4 is critical for deep vein thrombosis in mice publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1301059110 – volume: 7 start-page: 366 year: 2016 ident: 10.1016/j.ebiom.2020.102925_bib0012 article-title: Neutrophil Extracellular Traps Go Viral publication-title: Front Immunol doi: 10.3389/fimmu.2016.00366 – volume: 51 start-page: 443 issue: 3 year: 2019 ident: 10.1016/j.ebiom.2020.102925_bib0022 article-title: Neutrophil Extracellular Traps Initiate Gallstone Formation publication-title: Immunity doi: 10.1016/j.immuni.2019.07.002 – volume: 11 start-page: 189 issue: 3 year: 2015 ident: 10.1016/j.ebiom.2020.102925_bib0044 article-title: Inhibition of PAD4 activity is sufficient to disrupt mouse and human NET formation publication-title: Nat Chem Biol doi: 10.1038/nchembio.1735 – volume: 5 issue: 11 year: 2020 ident: 10.1016/j.ebiom.2020.102925_bib0018 article-title: Neutrophil extracellular traps in COVID-19 publication-title: JCI Insight – volume: 10 start-page: 2481 year: 2019 ident: 10.1016/j.ebiom.2020.102925_bib0030 article-title: Citrullination Licenses Calpain to Decondense Nuclei in Neutrophil Extracellular Trap Formation publication-title: Front Immunol doi: 10.3389/fimmu.2019.02481 – volume: 382 start-page: 727 issue: 8 year: 2020 ident: 10.1016/j.ebiom.2020.102925_bib0001 article-title: A Novel Coronavirus from Patients with Pneumonia in China, 2019 publication-title: N Engl J Med doi: 10.1056/NEJMoa2001017 – volume: 74 start-page: 1417 issue: 7 year: 2015 ident: 10.1016/j.ebiom.2020.102925_bib0010 article-title: Neutrophil extracellular traps induce endothelial dysfunction in systemic lupus erythematosus through the activation of matrix metalloproteinase-2 publication-title: Ann Rheum Dis doi: 10.1136/annrheumdis-2013-204837 – volume: 395 start-page: 497 issue: 10223 year: 2020 ident: 10.1016/j.ebiom.2020.102925_bib0003 article-title: Clinical features of patients infected with 2019 novel coronavirus in Wuhan, China publication-title: Lancet doi: 10.1016/S0140-6736(20)30183-5 – volume: 135 start-page: 2033 issue: 23 year: 2020 ident: 10.1016/j.ebiom.2020.102925_bib0038 article-title: COVID-19 and its implications for thrombosis and anticoagulation publication-title: Blood doi: 10.1182/blood.2020006000 – volume: 395 start-page: 507 issue: 10223 year: 2020 ident: 10.1016/j.ebiom.2020.102925_bib0006 article-title: Epidemiological and clinical characteristics of 99 cases of 2019 novel coronavirus pneumonia in Wuhan, China: a descriptive study publication-title: Lancet doi: 10.1016/S0140-6736(20)30211-7 – volume: 209 start-page: 819 issue: 4 year: 2012 ident: 10.1016/j.ebiom.2020.102925_bib0028 article-title: Monocytes, neutrophils, and platelets cooperate to initiate and propagate venous thrombosis in mice in vivo publication-title: J Exp Med doi: 10.1084/jem.20112322 – year: 2020 ident: 10.1016/j.ebiom.2020.102925_bib0050 article-title: Immune mechanisms of pulmonary intravascular coagulopathy in COVID-19 pneumonia publication-title: Lancet Rheumatol – volume: 115 start-page: 591 issue: 3 year: 2016 ident: 10.1016/j.ebiom.2020.102925_bib0049 article-title: Neutralisation of the anti-coagulant effects of heparin by histones in blood plasma and purified systems publication-title: Thromb Haemost doi: 10.1160/th15-03-0214 – volume: 26 start-page: 395 issue: 3 year: 2019 ident: 10.1016/j.ebiom.2020.102925_bib0013 article-title: To NET or not to NET:current opinions and state of the science regarding the formation of neutrophil extracellular traps publication-title: Cell Death Differ doi: 10.1038/s41418-018-0261-x – volume: 20 start-page: 511 issue: 5 year: 2014 ident: 10.1016/j.ebiom.2020.102925_bib0019 article-title: Aggregated neutrophil extracellular traps limit inflammation by degrading cytokines and chemokines publication-title: Nat Med doi: 10.1038/nm.3547 – volume: 37 start-page: 16416 issue: 46 year: 1998 ident: 10.1016/j.ebiom.2020.102925_bib0024 article-title: Effect of polynucleotides on the inhibition of neutrophil elastase by mucus proteinase inhibitor and alpha 1-proteinase inhibitor publication-title: Biochemistry doi: 10.1021/bi981536o – volume: 18 start-page: 844 issue: 4 year: 2020 ident: 10.1016/j.ebiom.2020.102925_bib0005 article-title: Abnormal coagulation parameters are associated with poor prognosis in patients with novel coronavirus pneumonia publication-title: J Thromb Haemost doi: 10.1111/jth.14768 – volume: 123 start-page: 874 issue: 6 year: 1994 ident: 10.1016/j.ebiom.2020.102925_bib0031 article-title: Granulocyte proteases and hydrogen peroxide synergistically inactivate thrombomodulin of endothelial cells in vitro publication-title: J Lab Clin Med – volume: 14 start-page: 2274 issue: 11 year: 2016 ident: 10.1016/j.ebiom.2020.102925_bib0025 article-title: Histones link inflammation and thrombosis through the induction of Weibel-Palade body exocytosis publication-title: J Thromb Haemost doi: 10.1111/jth.13493 – volume: 395 start-page: 1417 issue: 10234 year: 2020 ident: 10.1016/j.ebiom.2020.102925_bib0035 article-title: Endothelial cell infection and endotheliitis in COVID-19 publication-title: Lancet doi: 10.1016/S0140-6736(20)30937-5 – start-page: e13319 year: 2020 ident: 10.1016/j.ebiom.2020.102925_bib0045 article-title: Bloodstream infections in critically ill patients with COVID-19 publication-title: Eur J Clin Invest doi: 10.1111/eci.13319 – volume: 16 start-page: 887 issue: 8 year: 2010 ident: 10.1016/j.ebiom.2020.102925_bib0027 article-title: Reciprocal coupling of coagulation and innate immunity via neutrophil serine proteases publication-title: Nat Med doi: 10.1038/nm.2184 – volume: 14 start-page: 375 issue: 4 year: 1990 ident: 10.1016/j.ebiom.2020.102925_bib0043 article-title: In vitro aggregation of bovine neonatal neutrophils. A comparative study with adult cattle publication-title: Inflammation doi: 10.1007/BF00914089 – volume: 276 start-page: 1059 issue: 4 year: 2009 ident: 10.1016/j.ebiom.2020.102925_bib0046 article-title: Murine serum nucleases–contrasting effects of plasmin and heparin on the activities of DNase1 and DNase1-like 3 (DNase1l3) publication-title: FEBS J doi: 10.1111/j.1742-4658.2008.06849.x – volume: 358 start-page: 1202 issue: 6367 year: 2017 ident: 10.1016/j.ebiom.2020.102925_bib0020 article-title: Host DNases prevent vascular occlusion by neutrophil extracellular traps publication-title: Science doi: 10.1126/science.aam8897 – reference: 32810824 - EBioMedicine. 2020 Sep;59:102942. doi: 10.1016/j.ebiom.2020.102942 |
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| Snippet | Coronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The processes that... AbstractBackgroundCoronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs.... Background: Coronavirus induced disease 2019 (COVID-19) can be complicated by severe organ damage leading to dysfunction of the lungs and other organs. The... |
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| SubjectTerms | Advanced Basic Science Aggregated neutrophil extracellular traps Cells, Cultured Coagulopathy Coronavirus Infections - complications Coronavirus Infections - metabolism Coronavirus Infections - pathology COVID-19 Endothelialitis Endothelium, Vascular - metabolism Endothelium, Vascular - pathology Extracellular Traps - metabolism Humans Immunothrombosis Internal Medicine Microvessels - metabolism Microvessels - pathology Neutrophils - metabolism Neutrophils - pathology Pandemics Pneumonia, Viral - complications Pneumonia, Viral - metabolism Pneumonia, Viral - pathology Research paper SARS-CoV-2 Thrombosis - etiology Thrombosis - metabolism Thrombosis - pathology |
| Title | Vascular occlusion by neutrophil extracellular traps in COVID-19 |
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