Viral quasispecies

Viral quasispecies refers to a population structure that consists of extremely large numbers of variant genomes, termed mutant spectra, mutant swarms or mutant clouds. Fueled by high mutation rates, mutants arise continually, and they change in relative frequency as viral replication proceeds. The t...

Celý popis

Uloženo v:
Podrobná bibliografie
Vydáno v:PLoS genetics Ročník 15; číslo 10; s. e1008271
Hlavní autoři: Domingo, Esteban, Perales, Celia
Médium: Journal Article
Jazyk:angličtina
Vydáno: United States Public Library of Science 17.10.2019
Public Library of Science (PLoS)
Témata:
Analysis
Antiviral agents
Biology and Life Sciences
Biosphere
Cancer
Cloning
Drug resistance
Evolution
Evolution, Molecular
Foot & mouth disease
Genetic diversity
Genomes
Genomics
High-Throughput Nucleotide Sequencing
Mutagenesis
Mutation
Mutation Rate
Mutation rates
Origin of Life
Pathogenic microorganisms
Population
Population structure
Quasispecies
Replication
RNA
RNA viruses
RNA Viruses - genetics
RNA Viruses - immunology
RNA Viruses - physiology
Swarms
Topic Page
Viral Vaccines - immunology
Virology
Virus Replication
Viruses
United States > US
ISSN:1553-7404, 1553-7390, 1553-7404
On-line přístup:Získat plný text
Tagy: Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
Popis
Shrnutí:Viral quasispecies refers to a population structure that consists of extremely large numbers of variant genomes, termed mutant spectra, mutant swarms or mutant clouds. Fueled by high mutation rates, mutants arise continually, and they change in relative frequency as viral replication proceeds. The term quasispecies was adopted from a theory of the origin of life in which primitive replicons) consisted of mutant distributions, as found experimentally with present day RNA viruses. The theory provided a new definition of wild type, and a conceptual framework for the interpretation of the adaptive potential of RNA viruses that contrasted with classical studies based on consensus sequences. Standard clonal analyses and deep sequencing methodologies have confirmed the presence of myriads of mutant genomes in viral populations, and their participation in adaptive processes. The quasispecies concept applies to any biological entity, but its impact is more evident when the genome size is limited and the mutation rate is high. This is the case of the RNA viruses, ubiquitous in our biosphere, and that comprise many important pathogens. In virology, quasispecies are defined as complex distributions of closely related variant genomes subjected to genetic variation, competition and selection, and that may act as a unit of selection. Despite being an integral part of their replication, high mutation rates have an upper limit compatible with inheritable information. Crossing such a limit leads to RNA virus extinction, a transition that is the basis of an antiviral design termed lethal mutagenesis.
Bibliografie:ObjectType-Article-1
SourceType-Scholarly Journals-1
ObjectType-Feature-2
content type line 14
content type line 23
The authors have declared that no competing interests exist.
ISSN:1553-7404
1553-7390
1553-7404
DOI:10.1371/journal.pgen.1008271