Enterovirus D68–Associated Acute Flaccid Myelitis in Immunocompromised Woman, Italy

In Italy in 2016, acute flaccid myelitis developed in a woman who had received a hematopoietic stem cell transplant. Enterovirus D68 viral genome was detected in respiratory and cerebrospinal fluid samples, and the viral protein 1 sequence clustered with lineage B3. Immunocompromised adults may be a...

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Bibliographic Details
Published in:Emerging infectious diseases Vol. 23; no. 10; pp. 1690 - 1693
Main Authors: Giombini, Emanuela, Rueca, Martina, Barberi, Walter, Iori, Anna Paola, Castilletti, Concetta, Scognamiglio, Paola, Vairo, Francesco, Ippolito, Giuseppe, Capobianchi, Maria Rosaria, Valli, Maria Beatrice
Format: Journal Article
Language:English
Published: United States U.S. National Center for Infectious Diseases 01.10.2017
Centers for Disease Control and Prevention
Subjects:
Acute Disease
Care and treatment
Case studies
CNS infection
Diagnosis
Dispatch
Enterovirus D, Human - classification
Enterovirus D, Human - genetics
Enterovirus D, Human - isolation & purification
Enterovirus D, Human - pathogenicity
Enterovirus diseases
Enterovirus Infections - etiology
Enterovirus Infections - immunology
Enterovirus Infections - pathology
Enterovirus Infections - virology
Enterovirus-D68
Fatal Outcome
Female
Genotype
Hematopoietic Stem Cell Transplantation - adverse effects
human
Humans
Immunocompromised Host
immunocompromised patient
Immunosuppressive Agents - therapeutic use
Italy
Lymphoma, Large B-Cell, Diffuse - immunology
Lymphoma, Large B-Cell, Diffuse - pathology
Lymphoma, Large B-Cell, Diffuse - therapy
Lymphoma, Non-Hodgkin - immunology
Lymphoma, Non-Hodgkin - pathology
Lymphoma, Non-Hodgkin - therapy
Middle Aged
molecular epidemiology
Myelitis
Phylogeny
Transplantation, Homologous
VP1 sequencing
Italy
molecular epidemiology
Enterovirus D68
viruses
acute flaccid myelitis
immunocompromised patient
Italy
VP1 sequencing
central nervous system infection
human
ISSN:1080-6040, 1080-6059, 1080-6059
Online Access:Get full text
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Summary:In Italy in 2016, acute flaccid myelitis developed in a woman who had received a hematopoietic stem cell transplant. Enterovirus D68 viral genome was detected in respiratory and cerebrospinal fluid samples, and the viral protein 1 sequence clustered with lineage B3. Immunocompromised adults may be at risk for enterovirus D68-associated neurologic complications.
Bibliography:ObjectType-Case Study-2
SourceType-Scholarly Journals-1
ObjectType-Feature-4
content type line 23
ObjectType-Report-1
ObjectType-Article-3
ISSN:1080-6040
1080-6059
1080-6059
DOI:10.3201/eid2310.170792