ANGPTL8 protein-truncating variant associated with lower serum triglycerides and risk of coronary disease

Protein-truncating variants (PTVs) affecting dyslipidemia risk may point to therapeutic targets for cardiometabolic disease. Our objective was to identify PTVs that were associated with both lipid levels and the risk of coronary artery disease (CAD) or type 2 diabetes (T2D) and assess their possible...

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Veröffentlicht in:	PLoS genetics Jg. 17; H. 4; S. e1009501
Hauptverfasser:	Helkkula, Pyry, Kiiskinen, Tuomo, Havulinna, Aki S., Karjalainen, Juha, Koskinen, Seppo, Salomaa, Veikko, Daly, Mark J., Palotie, Aarno, Surakka, Ida, Ripatti, Samuli
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 28.04.2021 Public Library of Science (PLoS)
Schlagworte:	Analysis Biobanks Biology and Life Sciences Cardiovascular disease Cholesterol Coronary heart disease Coronary vessels Diabetes Drug delivery Drugs Dyslipidemia Genetic aspects Genomes Heart diseases Identification and classification Lipids Low density lipoprotein Medicine and Health Sciences Metabolic disorders People and Places Phenotypes Population Proteins Risk factors Side effects Statins Triglycerides Finland United Kingdom > UK
ISSN:	1553-7404, 1553-7390, 1553-7404
Online-Zugang:	Volltext
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