Common, low-frequency, and rare genetic variants associated with lipoprotein subclasses and triglyceride measures in Finnish men from the METSIM study

Lipid and lipoprotein subclasses are associated with metabolic and cardiovascular diseases, yet the genetic contributions to variability in subclass traits are not fully understood. We conducted single-variant and gene-based association tests between 15.1M variants from genome-wide and exome array a...

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Bibliographic Details
Published in:	PLoS genetics Vol. 13; no. 10; p. e1007079
Main Authors:	Davis, James P., Huyghe, Jeroen R., Locke, Adam E., Jackson, Anne U., Sim, Xueling, Stringham, Heather M., Teslovich, Tanya M., Welch, Ryan P., Fuchsberger, Christian, Narisu, Narisu, Chines, Peter S., Kangas, Antti J., Soininen, Pasi, Ala-Korpela, Mika, Kuusisto, Johanna, Collins, Francis S., Laakso, Markku, Boehnke, Michael, Mohlke, Karen L.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 30.10.2017 Public Library of Science (PLoS)
Subjects:	Biology and Life Sciences Cardiovascular disease Cardiovascular diseases Cholesterol, HDL - genetics Clinical medicine Consortia Diabetes Dyslipidemia Epidemiology Etiology Exome - genetics Finland Funding Gene frequency Gene Frequency - genetics Genetic aspects Genetic diversity Genetics Genome-Wide Association Study - methods Genomes Genotype Genotypes Health care Hospitals Humans Internal medicine Kinases Laboratories Lipid Metabolism - genetics Lipids Lipids - genetics Lipoproteins Lipoproteins - genetics Male Mens health Metabolic disorders Metabolism Middle Aged NMR Nuclear magnetic resonance Pharmacy Physiological aspects Polymorphism, Single Nucleotide - genetics Preventive medicine Principal Component Analysis - methods Software Studies Supervision Triglycerides Triglycerides - genetics White People - genetics Finland Ann Arbor Michigan United States > US
ISSN:	1553-7404, 1553-7390, 1553-7404
Online Access:	Get full text
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