Paired Immunoglobulin-like Type 2 Receptor Alpha G78R variant alters ligand binding and confers protection to Alzheimer's disease

Paired Immunoglobulin-like Type 2 Receptor Alpha (PILRA) is a cell surface inhibitory receptor that recognizes specific O-glycosylated proteins and is expressed on various innate immune cell types including microglia. We show here that a common missense variant (G78R, rs1859788) of PILRA is the like...

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Vydáno v:	PLoS genetics Ročník 14; číslo 11; s. e1007427
Hlavní autoři:	Rathore, Nisha, Ramani, Sree Ranjani, Pantua, Homer, Payandeh, Jian, Bhangale, Tushar, Wuster, Arthur, Kapoor, Manav, Sun, Yonglian, Kapadia, Sharookh B., Gonzalez, Lino, Zarrin, Ali A., Goate, Alison, Hansen, David V., Behrens, Timothy W., Graham, Robert R.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 02.11.2018 Public Library of Science (PLoS)
Témata:	Alzheimer's disease Amino acids Bioinformatics Biology Biology and Life Sciences Cell receptors Cell surface Chromosome 7 Gene expression Genetic aspects Genetics Genomes Glycoprotein B Health aspects Herpes simplex Herpes simplex virus Herpes viruses Herpesvirus infections Immunoglobulins Immunology Infections Infectious diseases Ligand binding (Biochemistry) Ligands Macrophages Medicine and Health Sciences Microglia Neurodegenerative diseases Neurosciences Novels Organic acids Physiological aspects Prevention Proteins Proteomics Recurrence (Disease) Research and Analysis Methods Supervision New York South San Francisco California California United States > US
ISSN:	1553-7404, 1553-7390, 1553-7404
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