The phylodynamics of the rabies virus in the Russian Federation

Near complete rabies virus N gene sequences (1,110 nt) were determined for 82 isolates obtained from different regions of Russia between 2008 and 2016. These sequences were analyzed together with 108 representative GenBank sequences from 1977-2016 using the Bayesian coalescent approach. The timing o...

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Veröffentlicht in:PloS one Jg. 12; H. 2; S. e0171855
Hauptverfasser: Deviatkin, Andrei A., Lukashev, Alexander N., Poleshchuk, Elena M., Dedkov, Vladimir G., Tkachev, Sergey E., Sidorov, Gennadiy N., Karganova, Galina G., Galkina, Irina V., Shchelkanov, Mikhail Yu, Shipulin, German A.
Format: Journal Article
Sprache:Englisch
Veröffentlicht: United States Public Library of Science 22.02.2017
Public Library of Science (PLoS)
Schlagworte:
Analysis
Animals
Anthropogenic factors
Bats
Bayesian analysis
Biology and life sciences
Budgets
Epidemiology
Federated searching
Gene sequencing
Genes
Genetic aspects
Genetic diversity
Genome, Viral
Genomes
Immunization
Infections
Lyssavirus
Medicine and Health Sciences
N gene
Occupational health
People and Places
Phylogenetics
Phylogeny
Poliomyelitis
Rabies
Rabies - virology
Rabies virus
Rabies virus - genetics
Rabies virus - isolation & purification
Research and Analysis Methods
Russia
Science
Soil sciences
Steppes
Studies
Ursus arctos
Viruses
Russia
ISSN:1932-6203, 1932-6203
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Zusammenfassung:Near complete rabies virus N gene sequences (1,110 nt) were determined for 82 isolates obtained from different regions of Russia between 2008 and 2016. These sequences were analyzed together with 108 representative GenBank sequences from 1977-2016 using the Bayesian coalescent approach. The timing of the major evolutionary events was estimated. Most of the isolates represented the steppe rabies virus group C, which was found over a vast geographic region from Central Russia to Mongolia and split into three groups (C0-C2) with discrete geographic prevalence. A single strain of the steppe rabies virus lineage was isolated in the far eastern part of Russia (Primorsky Krai), likely as a result of a recent anthropogenic introduction. For the first time the polar rabies virus group A2, previously reported in Alaska, was described in the northern part of European Russia and at the Franz Josef Land. Phylogenetic analysis suggested that all currently circulating rabies virus groups in the Russian Federation were introduced within the few last centuries, with most of the groups spreading in the 20th century. The dating of evolutionary events was highly concordant with the historical epidemiological data.
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Conceptualization: AAD ANL EMP VGD GAS.Formal analysis: AAD ANL EMP GGK.Investigation: AAD ANL EMP SET GNS VGD.Resources: EMP GNS GGK SET IVG MYS GAS.Writing – original draft: AAD ANL.Writing – review & editing: AAD ANL EMP GGK.
Competing Interests: The authors have declared that no competing interests exist.
ISSN:1932-6203
1932-6203
DOI:10.1371/journal.pone.0171855