Association between Birth Characteristics and Cardiovascular Autonomic Function at Mid-Life

Low birth weight is associated with an increased risk of cardiovascular diseases in adulthood. As abnormal cardiac autonomic function is a common feature in cardiovascular diseases, we tested the hypothesis that low birth weight may also be associated with poorer cardiac autonomic function in middle...

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Vydáno v:	PloS one Ročník 11; číslo 8; s. e0161604
Hlavní autoři:	Perkiömäki, Nelli, Auvinen, Juha, Tulppo, Mikko P., Hautala, Arto J., Perkiömäki, Juha, Karhunen, Ville, Keinänen-Kiukaanniemi, Sirkka, Puukka, Katri, Ruokonen, Aimo, Järvelin, Marjo-Riitta, Huikuri, Heikki V., Kiviniemi, Antti M.
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 23.08.2016 Public Library of Science (PLoS)
Témata:	Age Analysis of Variance Anthropometry Autonomic nervous system Autonomic Nervous System - physiopathology Baroreceptors Baroreflex Biology and Life Sciences Biomarkers Birth Weight Births Blood Pressure Body mass index Cardiovascular diseases Cardiovascular Diseases - epidemiology Cardiovascular Diseases - etiology Cardiovascular System - innervation Cardiovascular System - physiopathology Childbirth & labor Diabetes Diabetes mellitus Diseases Economic factors Female Health aspects Health risks Heart diseases Heart Rate Hospitals Humans Internal medicine Life Style Lifestyles Low birth weight Male Males Medical research Medicine Medicine and Health Sciences Men Middle Aged Mothers Observations Parameter sensitivity People and Places Physiological regulation Pregnancy Prenatal Exposure Delayed Effects Primary care Reflexes Risk Factors Smoking Social factors Socioeconomic factors Young adults
ISSN:	1932-6203, 1932-6203
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Shrnutí:	Low birth weight is associated with an increased risk of cardiovascular diseases in adulthood. As abnormal cardiac autonomic function is a common feature in cardiovascular diseases, we tested the hypothesis that low birth weight may also be associated with poorer cardiac autonomic function in middle-aged subjects. At the age of 46, the subjects of the Northern Finland Birth Cohort 1966 were invited to examinations including questionnaires about health status and life style and measurement of vagally-mediated heart rate variability (rMSSD) from R-R intervals (RRi) and spontaneous baroreflex sensitivity (BRS) in both seated and standing positions. Maternal parameters had been collected in 1965-1966 since the 16th gestational week and birth variables immediately after delivery. For rMSSD, 1,799 men and 2,279 women without cardiorespiratory diseases and diabetes were included and 902 men and 1,020 women for BRS. The analyses were adjusted for maternal (age, anthropometry, socioeconomics, parity, gestational smoking) and adult variables (life style, anthropometry, blood pressure, glycemic and lipid status) potentially confounding the relationship between birth weight and autonomic function. In men, birth weight correlated negatively with seated (r = -0.058, p = 0.014) and standing rMSSD (r = -0.090, p<0.001), as well as with standing BRS (r = -0.092, p = 0.006). These observations were verified using relevant birth weight categories (<2,500 g; 2,500-3,999 g; ≥4,000 g). In women, birth weight was positively correlated with seated BRS (r = 0.081, p = 0.010), but none of the other measures of cardiovascular autonomic function. These correlations remained significant after adjustment for potential confounders (p<0.05 for all). In men, higher birth weight was independently associated with poorer cardiac autonomic function at mid-life. Same association was not observed in women. Our findings suggest that higher, not lower, birth weight in males may contribute to less favourable cardiovascular autonomic regulation and potentially to an elevated cardiovascular risk in later life.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: NP JA MPT AJH JP SKK KP AR MRJ HVH AMK.Analyzed the data: NP AMK SKK JA MRJ KP AR VK.Contributed reagents/materials/analysis tools: MRJ HVH SKK KP AR.Wrote the paper: NP JA MPT AJH JP SKK KP AR MRJ HVH AMK VK. Competing Interests: The authors have declared that no competing interests exist.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0161604