A Genome-Wide Association Scan on the Levels of Markers of Inflammation in Sardinians Reveals Associations That Underpin Its Complex Regulation

Identifying the genes that influence levels of pro-inflammatory molecules can help to elucidate the mechanisms underlying this process. We first conducted a two-stage genome-wide association scan (GWAS) for the key inflammatory biomarkers Interleukin-6 (IL-6), the general measure of inflammation ery...

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Bibliographic Details
Published in:	PLoS genetics Vol. 8; no. 1; p. e1002480
Main Authors:	Naitza, Silvia, Porcu, Eleonora, Steri, Maristella, Taub, Dennis D., Mulas, Antonella, Xiao, Xiang, Strait, James, Dei, Mariano, Lai, Sandra, Busonero, Fabio, Maschio, Andrea, Usala, Gianluca, Zoledziewska, Magdalena, Sidore, Carlo, Zara, Ilenia, Pitzalis, Maristella, Loi, Alessia, Virdis, Francesca, Piras, Roberta, Deidda, Francesca, Whalen, Michael B., Crisponi, Laura, Concas, Antonio, Podda, Carlo, Uzzau, Sergio, Scheet, Paul, Longo, Dan L., Lakatta, Edward, Abecasis, Gonçalo R., Cao, Antonio, Schlessinger, David, Uda, Manuela, Sanna, Serena, Cucca, Francesco
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 01.01.2012 Public Library of Science (PLoS)
Subjects:	Adolescent Adult Aged Aged, 80 and over Biological markers Biology Biomarkers Blood Sedimentation C-reactive protein C-Reactive Protein - genetics Chemokine CCL2 - genetics Cytokines Female Genes Genetic aspects Genetics Genome-Wide Association Study - methods Genomes Humans Inflammation Inflammation - genetics Interleukin-6 - genetics Italy Male Mathematics Middle Aged Physiological aspects Polymorphism, Single Nucleotide Population Proteins Quantitative Trait Loci - genetics Risk factors Standard deviation Italy
ISSN:	1553-7404, 1553-7390, 1553-7404
Online Access:	Get full text
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