Relationship between neurotoxic kynurenine metabolites and reductions in right medial prefrontal cortical thickness in major depressive disorder

•Thickness of right BA24 and right BA32 was reduced in major depressive disorder.•Serum KynA/3HK and KynA/QA was reduced in MDD.•CRP was inversely associated with BA32 thickness.•KynA/3HK partially mediated the relationship between CRP and thickness of BA32. Reductions in gray matter volume of the m...

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Bibliographic Details
Published in:	Brain, behavior, and immunity Vol. 53; pp. 39 - 48
Main Authors:	Meier, Timothy B., Drevets, Wayne C., Wurfel, Brent E., Ford, Bart N., Morris, Harvey M., Victor, Teresa A., Bodurka, Jerzy, Teague, T. Kent, Dantzer, Robert, Savitz, Jonathan
Format:	Journal Article
Language:	English
Published:	Netherlands Elsevier Inc 01.03.2016
Subjects:	Adult Allergy and Immunology Brain - metabolism Brain - pathology C-Reactive Protein - metabolism Case-Control Studies Cerebral Cortex - metabolism Cerebral Cortex - pathology Depressive Disorder, Major - blood Depressive Disorder, Major - diagnostic imaging Depressive Disorder, Major - metabolism Depressive Disorder, Major - pathology Female Gray Matter - metabolism Gray Matter - pathology Humans Inflammation Kynurenic Acid - blood Kynurenic Acid - metabolism Kynurenine Kynurenine - analogs & derivatives Kynurenine - blood Kynurenine - metabolism Magnetic Resonance Imaging Major depressive disorder Male Medial prefrontal cortex Neurotoxicity Syndromes - blood Neurotoxicity Syndromes - metabolism Neurotoxicity Syndromes - pathology Prefrontal Cortex - diagnostic imaging Prefrontal Cortex - metabolism Prefrontal Cortex - pathology Psychiatry Quinolinic acid Quinolinic Acid - blood Quinolinic Acid - metabolism Tryptophan - blood Kynurenine Medial prefrontal cortex Inflammation Quinolinic acid Magnetic resonance imaging Major depressive disorder
ISSN:	0889-1591, 1090-2139
Online Access:	Get full text
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