Long Non-Coding RNA-ROR Mediates the Reprogramming in Cardiac Hypertrophy

Cardiac hypertrophy associated with various cardiovascular diseases results in heart failure and sudden death. A clear understanding of the mechanisms of hypertrophy will benefit the development of novel therapies. Long non-coding RNAs (lncRNAs) have been shown to play essential roles in many biolog...

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Vydáno v:	PloS one Ročník 11; číslo 4; s. e0152767
Hlavní autoři:	Jiang, Feng, Zhou, Xiangyu, Huang, Jing
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 15.04.2016 Public Library of Science (PLoS)
Témata:	Animals Biological activity Biology and Life Sciences Cardiology Cardiomegaly - genetics Cardiomegaly - pathology Cardiomyocytes Cardiovascular diseases Coronary artery disease Coronary vessels Deoxyribonucleic acid DNA DNA damage Gene expression Gene Expression Regulation - drug effects Gene Knockdown Techniques Genetic aspects Heart diseases Heart failure Heart hypertrophy Hospitals Hypertrophy Kinases Laboratory animals Male Medicine and Health Sciences Mice Mice, Inbred C57BL MicroRNA MicroRNAs MicroRNAs - genetics Myocytes, Cardiac - drug effects Myocytes, Cardiac - pathology Non-coding RNA Pathogenesis Phenylephrine Phenylephrine - pharmacology Physiological aspects Plasmids Research and Analysis Methods Ribonucleic acid Risk factors RNA RNA, Long Noncoding - genetics RNA, Long Noncoding - metabolism Stem cells Ventilators China
ISSN:	1932-6203, 1932-6203
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Popis
Shrnutí:	Cardiac hypertrophy associated with various cardiovascular diseases results in heart failure and sudden death. A clear understanding of the mechanisms of hypertrophy will benefit the development of novel therapies. Long non-coding RNAs (lncRNAs) have been shown to play essential roles in many biological process, however, whether lncRNA-ROR plays functional roles in the reprogramming of cardiomyocyte remains unclear. Here we show that lncRNA-ROR plays important roles in the pathogenesis of cardiac hypertrophy. In hypertrophic heart and cardiomyocytes, the expression of lncRNA-ROR is dramatically increased, downregulation of which attenuates the hypertrophic responses. Furthermore, the expression of lncRNA-ROR negatively correlates with miR-133, whose expression is increased when lncRNA-ROR is knocked down. In line with this, overexpression of miR-133 prevents the elevation of lncRNA-ROR and re-expression of ANP and BNP in cardiomyocytes subject to phenylephrine treatment. Taken together, our study demonstrates that lncRNA-ROR promotes cardiac hypertrophy via interacting with miR-133, indicating that lncRNA-ROR could be targeted for developing novel antihypertrophic therapeutics.
Bibliografie:	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Competing Interests: The authors have declared that no competing interests exist. Conceived and designed the experiments: XZ JH. Performed the experiments: FJ XZ. Analyzed the data: FJ XZ. Contributed reagents/materials/analysis tools: FJ XZ. Wrote the paper: FJ JH.
ISSN:	1932-6203 1932-6203
DOI:	10.1371/journal.pone.0152767