Cooperative Genome-Wide Analysis Shows Increased Homozygosity in Early Onset Parkinson's Disease

Parkinson's disease (PD) occurs in both familial and sporadic forms, and both monogenic and complex genetic factors have been identified. Early onset PD (EOPD) is particularly associated with autosomal recessive (AR) mutations, and three genes, PARK2, PARK7 and PINK1, have been found to carry m...

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Vydané v:	PloS one Ročník 7; číslo 3; s. e28787
Hlavní autori:	Simón-Sánchez, Javier, Kilarski, Laura L., Nalls, Michael A., Martinez, Maria, Schulte, Claudia, Holmans, Peter, Gasser, Thomas, Hardy, John, Singleton, Andrew B., Wood, Nicholas W., Brice, Alexis, Heutink, Peter, Williams, Nigel, Morris, Huw R.
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	United States Public Library of Science 12.03.2012 Public Library of Science (PLoS)
Predmet:	Adult Age Aged Aged, 80 and over Alzheimer's disease Alzheimers disease Analysis Biology Bipolar disorder Brain research Cases (containers) Chromosome 19 Chromosomes, Human, Pair 19 - genetics Colorectal cancer Consortia Europe Gene sequencing Genes Genes, Recessive Genetic aspects Genetic diversity Genetic factors Genetic Predisposition to Disease - genetics Genetic variance Genetics Genome, Human - genetics Genome-Wide Association Study Genomes Genomics Genotyping Globalization Homozygosity Homozygote Humans Inbreeding Laboratories Loci Logistic Models Medical research Medicine Middle Aged Movement disorders Mutation Neurodegenerative diseases Neurology Neurosciences PARK7 protein Parkinson Disease - genetics Parkinson's disease Parkinsons disease Polymorphism, Single Nucleotide - genetics Population Predictive control PTEN-induced putative kinase Regression analysis Schizophrenia Sequence Analysis, DNA Single-nucleotide polymorphism United States United States Europe United Kingdom > UK France United States > US Maryland
ISSN:	1932-6203, 1932-6203
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