Bidirectional communication between oocytes and follicle cells: ensuring oocyte developmental competence

Female fertility is determined to a large extent by the quality (developmental competence) of the oocyte as reflected in its ability to undergo meiosis, be fertilized, and give rise to a healthy embryo. Growth of the mammalian oocyte is coordinated with that of the follicle that encloses it by the a...

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Bibliographic Details
Published in:Canadian journal of physiology and pharmacology Vol. 88; no. 4; p. 399
Main Authors: Kidder, Gerald M, Vanderhyden, Barbara C
Format: Journal Article
Language:English
Published: Canada 01.04.2010
Subjects:
Animals
Cell Communication - physiology
Cell Proliferation
Female
Fertility - physiology
Gap Junctions - physiology
Granulosa Cells - physiology
Humans
Male
Oocytes - physiology
Oogenesis - physiology
Ovarian Follicle - physiology
Paracrine Communication
Signal Transduction
ISSN:1205-7541, 1205-7541
Online Access:Get more information
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Summary:Female fertility is determined to a large extent by the quality (developmental competence) of the oocyte as reflected in its ability to undergo meiosis, be fertilized, and give rise to a healthy embryo. Growth of the mammalian oocyte is coordinated with that of the follicle that encloses it by the actions of signals that pass in both directions between the germline and somatic components. This review summarizes what is known about the roles played by 2 different modes of intrafollicular signalling in oogenesis: paracrine factors activating receptors on the opposite cell type, and direct sharing of small molecules throughout the follicle via gap junction channels. Recent evidence indicates that these 2 modes of signalling interact to regulate oocyte growth and granulosa cell proliferation and that defects in either can contribute to female infertility.
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ISSN:1205-7541
1205-7541
DOI:10.1139/y10-009