Alternative Splicing and Nonsense-Mediated RNA Decay Contribute to the Regulation of SHOX Expression

The human SHOX gene is composed of seven exons and encodes a paired-related homeodomain transcription factor. SHOX mutations or deletions have been associated with different short stature syndromes implying a role in growth and bone formation. During development, SHOX is expressed in a highly specif...

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Vydáno v:	PloS one Ročník 6; číslo 3; s. e18115
Hlavní autoři:	Durand, Claudia, Roeth, Ralph, Dweep, Harsh, Vlatkovic, Irena, Decker, Eva, Schneider, Katja Ute, Rappold, Gudrun
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 23.03.2011 Public Library of Science (PLoS)
Témata:	3' Untranslated regions Alternative splicing Alternative Splicing - genetics Binding Sites Biology Biosynthesis Bone growth Brain Codon, Nonsense - genetics Decay Deoxyribonucleic acid DNA Embryos Exons Exons - genetics Experiments Fetuses Fibroblasts Functional analysis Gene expression Genes Genetic disorders Genomics Homeobox Homeodomain Proteins - genetics Homeodomain Proteins - metabolism Human tissues Humans Isoforms MicroRNAs MicroRNAs - genetics MicroRNAs - metabolism miRNA Mutation Osteogenesis Polymerase chain reaction Protein Isoforms - genetics Protein Isoforms - metabolism Regulatory mechanisms (biology) Ribonucleic acid RNA RNA sequencing RNA Stability - genetics RNA, Messenger - genetics RNA, Messenger - metabolism Short Stature Homeobox Protein Tissues Transcription (Genetics) Transcription factors Germany
ISSN:	1932-6203, 1932-6203
On-line přístup:	Získat plný text
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