The Antipsychotic Thioridazine Shows Promising Therapeutic Activity in a Mouse Model of Multidrug-Resistant Tuberculosis
Multidrug- and extensively drug-resistant tuberculosis have emerged as grave threats to public health worldwide. Very few active drugs are available or likely to become available soon. To address these problems we revisited a classical observation, the applicability of phenothiazines as antimicrobia...
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| Vydáno v: | PloS one Ročník 5; číslo 9; s. e12640 |
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| Hlavní autoři: | , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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United States
Public Library of Science
09.09.2010
Public Library of Science (PLoS) |
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| ISSN: | 1932-6203, 1932-6203 |
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| Abstract | Multidrug- and extensively drug-resistant tuberculosis have emerged as grave threats to public health worldwide. Very few active drugs are available or likely to become available soon. To address these problems we revisited a classical observation, the applicability of phenothiazines as antimicrobial drugs. Within this pharmacological class we selected thioridazine, which is most efficacious and least toxic, when used as an antipsychotic drug. We tested thioridazine monotherapy in the Balb/c mouse model for its activity to treat both susceptible and multidrug-resistant tuberculosis by a two months daily oral administration of 32 and 70 mg/kg. In addition, we tested its additive value when combined with a standard first-line regimen for susceptible tuberculosis. Thioridazine treatment resulted in a significant reduction of colony-forming-units of the susceptible (-4.4 log CFU, p<0.05) and multidrug-resistant tuberculosis bacilli (-2.4 log CFU, p<0.009) in the lung both at one and two months after infection, compared to controls. Moreover, when thioridazine was added to a regimen containing rifampicin, isoniazid and pyrazinamide for susceptible tuberculosis, a significant synergistic effect was achieved (-6.2 vs -5.9 log CFU, p<0.01). Thioridazine may represent an effective compound for treatment of susceptible and multidrug-resistant tuberculosis. The phenothiazines and their targets represent interesting novel opportunities in the search for antituberculosis drugs. |
|---|---|
| AbstractList | Multidrug- and extensively drug-resistant tuberculosis have emerged as grave threats to public health worldwide. Very few active drugs are available or likely to become available soon. To address these problems we revisited a classical observation, the applicability of phenothiazines as antimicrobial drugs. Within this pharmacological class we selected thioridazine, which is most efficacious and least toxic, when used as an antipsychotic drug. We tested thioridazine monotherapy in the Balb/c mouse model for its activity to treat both susceptible and multidrug-resistant tuberculosis by a two months daily oral administration of 32 and 70 mg/kg. In addition, we tested its additive value when combined with a standard first-line regimen for susceptible tuberculosis. Thioridazine treatment resulted in a significant reduction of colony-forming-units of the susceptible (−4.4 log CFU, p<0.05) and multidrug-resistant tuberculosis bacilli (−2.4 log CFU, p<0.009) in the lung both at one and two months after infection, compared to controls. Moreover, when thioridazine was added to a regimen containing rifampicin, isoniazid and pyrazinamide for susceptible tuberculosis, a significant synergistic effect was achieved (−6.2 vs −5.9 log CFU, p<0.01). Thioridazine may represent an effective compound for treatment of susceptible and multidrug-resistant tuberculosis. The phenothiazines and their targets represent interesting novel opportunities in the search for antituberculosis drugs. Multidrug- and extensively drug-resistant tuberculosis have emerged as grave threats to public health worldwide. Very few active drugs are available or likely to become available soon. To address these problems we revisited a classical observation, the applicability of phenothiazines as antimicrobial drugs. Within this pharmacological class we selected thioridazine, which is most efficacious and least toxic, when used as an antipsychotic drug. We tested thioridazine monotherapy in the Balb/c mouse model for its activity to treat both susceptible and multidrug-resistant tuberculosis by a two months daily oral administration of 32 and 70 mg/kg. In addition, we tested its additive value when combined with a standard first-line regimen for susceptible tuberculosis. Thioridazine treatment resulted in a significant reduction of colony-forming-units of the susceptible (-4.4 log CFU, p<0.05) and multidrug-resistant tuberculosis bacilli (-2.4 log CFU, p<0.009) in the lung both at one and two months after infection, compared to controls. Moreover, when thioridazine was added to a regimen containing rifampicin, isoniazid and pyrazinamide for susceptible tuberculosis, a significant synergistic effect was achieved (-6.2 vs -5.9 log CFU, p<0.01). Thioridazine may represent an effective compound for treatment of susceptible and multidrug-resistant tuberculosis. The phenothiazines and their targets represent interesting novel opportunities in the search for antituberculosis drugs. Multidrug- and extensively drug-resistant tuberculosis have emerged as grave threats to public health worldwide. Very few active drugs are available or likely to become available soon. To address these problems we revisited a classical observation, the applicability of phenothiazines as antimicrobial drugs. Within this pharmacological class we selected thioridazine, which is most efficacious and least toxic, when used as an antipsychotic drug. We tested thioridazine monotherapy in the Balb/c mouse model for its activity to treat both susceptible and multidrug-resistant tuberculosis by a two months daily oral administration of 32 and 70 mg/kg. In addition, we tested its additive value when combined with a standard first-line regimen for susceptible tuberculosis. Thioridazine treatment resulted in a significant reduction of colony-forming-units of the susceptible (-4.4 log CFU, p<0.05) and multidrug-resistant tuberculosis bacilli (-2.4 log CFU, p<0.009) in the lung both at one and two months after infection, compared to controls. Moreover, when thioridazine was added to a regimen containing rifampicin, isoniazid and pyrazinamide for susceptible tuberculosis, a significant synergistic effect was achieved (-6.2 vs -5.9 log CFU, p<0.01). Thioridazine may represent an effective compound for treatment of susceptible and multidrug-resistant tuberculosis. The phenothiazines and their targets represent interesting novel opportunities in the search for antituberculosis drugs.Multidrug- and extensively drug-resistant tuberculosis have emerged as grave threats to public health worldwide. Very few active drugs are available or likely to become available soon. To address these problems we revisited a classical observation, the applicability of phenothiazines as antimicrobial drugs. Within this pharmacological class we selected thioridazine, which is most efficacious and least toxic, when used as an antipsychotic drug. We tested thioridazine monotherapy in the Balb/c mouse model for its activity to treat both susceptible and multidrug-resistant tuberculosis by a two months daily oral administration of 32 and 70 mg/kg. In addition, we tested its additive value when combined with a standard first-line regimen for susceptible tuberculosis. Thioridazine treatment resulted in a significant reduction of colony-forming-units of the susceptible (-4.4 log CFU, p<0.05) and multidrug-resistant tuberculosis bacilli (-2.4 log CFU, p<0.009) in the lung both at one and two months after infection, compared to controls. Moreover, when thioridazine was added to a regimen containing rifampicin, isoniazid and pyrazinamide for susceptible tuberculosis, a significant synergistic effect was achieved (-6.2 vs -5.9 log CFU, p<0.01). Thioridazine may represent an effective compound for treatment of susceptible and multidrug-resistant tuberculosis. The phenothiazines and their targets represent interesting novel opportunities in the search for antituberculosis drugs. |
| Audience | Academic |
| Author | van Ingen, Jakko Magis-Escurra, Cecile Boeree, Martin J. Orozco, Hector Aguilar, Diana Amaral, Leonard van Soolingen, Dick Hernandez-Pando, Rogelio |
| AuthorAffiliation | 4 University Centre for Chronic Diseases Dekkerswald, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands University of Cape Town, South Africa 5 Mycobacteriology Unit, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Lisbon, Portugal 1 National Mycobacteria Reference Laboratory, Laboratories for Infectious Diseases and Perinatal Screening, National Institute for Public Health and the Environment, Bilthoven, The Netherlands 2 Departments of Clinical Microbiology and Respiratory Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands 3 Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition Salvador Zubiràn, Mexico City, Mexico |
| AuthorAffiliation_xml | – name: 1 National Mycobacteria Reference Laboratory, Laboratories for Infectious Diseases and Perinatal Screening, National Institute for Public Health and the Environment, Bilthoven, The Netherlands – name: 3 Experimental Pathology Section, Department of Pathology, National Institute of Medical Sciences and Nutrition Salvador Zubiràn, Mexico City, Mexico – name: 4 University Centre for Chronic Diseases Dekkerswald, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands – name: 5 Mycobacteriology Unit, Institute of Hygiene and Tropical Medicine, Universidade Nova de Lisboa, Lisbon, Portugal – name: University of Cape Town, South Africa – name: 2 Departments of Clinical Microbiology and Respiratory Diseases, Radboud University Nijmegen Medical Centre, Nijmegen, The Netherlands |
| Author_xml | – sequence: 1 givenname: Dick surname: van Soolingen fullname: van Soolingen, Dick – sequence: 2 givenname: Rogelio surname: Hernandez-Pando fullname: Hernandez-Pando, Rogelio – sequence: 3 givenname: Hector surname: Orozco fullname: Orozco, Hector – sequence: 4 givenname: Diana surname: Aguilar fullname: Aguilar, Diana – sequence: 5 givenname: Cecile surname: Magis-Escurra fullname: Magis-Escurra, Cecile – sequence: 6 givenname: Leonard surname: Amaral fullname: Amaral, Leonard – sequence: 7 givenname: Jakko surname: van Ingen fullname: van Ingen, Jakko – sequence: 8 givenname: Martin J. surname: Boeree fullname: Boeree, Martin J. |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/20844587$$D View this record in MEDLINE/PubMed |
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| Cites_doi | 10.1016/0028-3908(93)90096-L 10.1177/039463200902200318 10.2165/11531850-000000000-00000 10.1176/appi.ajp.158.11.1774 10.1371/journal.pone.0010069 10.1517/14740338.1.2.121 10.1016/S0140-6736(05)70196-3 10.1056/NEJMoa0808427 10.1086/426453 10.1016/S0924-8579(00)00343-5 10.1016/j.ijantimicag.2009.12.019 10.1086/422532 10.1023/A:1022061513581 10.1016/j.ijantimicag.2009.02.015 10.1016/S0924-8579(00)00199-0 10.1128/JB.01857-07 10.3109/10520298009067249 10.1086/518663 10.1111/j.1365-2249.2004.02454.x 10.1128/AAC.47.3.917-922.2003 10.1093/jac/47.5.505 |
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| Copyright | COPYRIGHT 2010 Public Library of Science 2010 van Soolingen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. van Soolingen et al. 2010 |
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| References | V Leimane (ref17) 2005; 365 RA Fabre (ref12) 2004; 136 NK Dutta (ref21) 2010; 5 MK Spigelman (ref4) 2007; 196 E Poluzzi (ref26) 2010; 33 V Hadjimitova (ref22) 2003; 19 PB Iannini (ref27) 2002; 1 (ref3) 2008 D Ordway (ref8) 2004; 190 D Ordway (ref6) 2003; 47 J van Ingen (ref7) 2009; 34 AH Glassman (ref25) 2001; 158 L Amaral (ref2) 2001; 47 JE de Steenwinkel (ref16) 2009; 22 R Hernández-Pando (ref13) 2005; 191 (ref14); 144 GS Dhaunsi (ref11) 1993; 32 L Amaral (ref18) 2010; 35 AH Diacon (ref5) 2009; 360 CD Sohaskey (ref19) 2008; 190 R Hernandez-Pando (ref9) 1996; 89 M Martins (ref15) 2007; 21 FM Forrest (ref24) 1963; 4 M Viveiros (ref20) 2001; 17 MV Bettencourt (ref23) 2000; 16 JE Kristiansen (ref1) 1979; 87 JL Jarnagin (ref10) 1980; 55 |
| References_xml | – volume: 32 start-page: 439 year: 1993 ident: ref11 article-title: Thioridazine induces lipid peroxidation in myelin of rat brain. publication-title: Neuropharmacology doi: 10.1016/0028-3908(93)90096-L – volume: 22 start-page: 723 year: 2009 ident: ref16 article-title: Immunological parameters to define infection progression and therapy response in a well-defined tuberculosis model in mice. publication-title: Int J Immunopathol Pharmacol doi: 10.1177/039463200902200318 – volume: 33 start-page: 303 year: 2010 ident: ref26 article-title: Antimicrobials and the risk of torsades de pointes: the contribution from data mining of the US FDA Adverse Event Reporting System. publication-title: Drug Saf doi: 10.2165/11531850-000000000-00000 – volume: 158 start-page: 1774 year: 2001 ident: ref25 article-title: Antipsychotic drugs: prolonged QTc interval, torsade de pointes, and sudden death. publication-title: Am J Psychiatry doi: 10.1176/appi.ajp.158.11.1774 – volume: 5 start-page: e10069 issue: 4 year: 2010 ident: ref21 article-title: A Mycobacterium tuberculosis sigma factor network responds to cell-envelope damage by the promising anti-mycobacterial thioridazine. publication-title: PLoS One doi: 10.1371/journal.pone.0010069 – volume: 1 start-page: 121 year: 2002 ident: ref27 article-title: Cardiotoxicity of macrolides, ketolides and fluoroquinolones that prolong the QTc interval. publication-title: Expert Opin Drug Saf doi: 10.1517/14740338.1.2.121 – volume: 21 start-page: 771 year: 2007 ident: ref15 article-title: The curative activity of thioridazine on mice infected with Mycobacterium tuberculosis. publication-title: In Vivo – volume: 4 start-page: 259 year: 1963 ident: ref24 article-title: Clinical, biochemical and post mortem studies on a patient treated with chlorpromazine. publication-title: Revue Agressologie – volume: 365 start-page: 318 year: 2005 ident: ref17 article-title: Clinical outcome of individualised treatment of multidrug-resistant tuberculosis in Latvia: a retrospective cohort study. publication-title: Lancet doi: 10.1016/S0140-6736(05)70196-3 – volume: 87 start-page: 317 year: 1979 ident: ref1 article-title: Experiments to illustrate the effect of chlorpromazine on the permeability of the bacterial cell wall. publication-title: Acta Pathol Microbiol Scand (B) – volume: 360 start-page: 2397 year: 2009 ident: ref5 article-title: The diarylquinoline TMC207 for multidrug-resistant tuberculosis. publication-title: N Engl J Med doi: 10.1056/NEJMoa0808427 – volume: 89 start-page: 26 year: 1996 ident: ref9 article-title: Correlation between the kinetics of Th1/Th2 cells and pathology in a murine model of experimental pulmonary tuberculosis. publication-title: Immunology – volume: 191 start-page: 299 year: 2005 ident: ref13 article-title: 16alpha-Bromoepiandrosterone restores T helper cell type 1 activity and accelerates chemotherapy-induced bacterial clearance in a model of progressive pulmonary tuberculosis. publication-title: J Infect Dis doi: 10.1086/426453 – volume: 17 start-page: 225 year: 2001 ident: ref20 article-title: Enhancement of antibiotic activity against poly-drug resistant Mycobacterium tuberculosis by phenothiazines. publication-title: Int J Antimicrob Agents doi: 10.1016/S0924-8579(00)00343-5 – volume: 35 start-page: 524 year: 2010 ident: ref18 article-title: Thioridazine cures extensively drug-resistant tuberculosis (XDR-TB) and the need for global trials is now! publication-title: Int J Antimicrob Agents doi: 10.1016/j.ijantimicag.2009.12.019 – volume: 190 start-page: 756 year: 2004 ident: ref8 article-title: Increased IL-4 production by CD8 and gammadelta T cells in health care workers is associated with the subsequent development of active tuberculosis. publication-title: J Infect Dis doi: 10.1086/422532 – volume: 19 start-page: 3 year: 2003 ident: ref22 article-title: Effect of phenothiazines on protein kinase C- and calcium-dependent activation of peritoneal macrophages. publication-title: Cell Biol Toxicol doi: 10.1023/A:1022061513581 – volume: 34 start-page: 190 year: 2009 ident: ref7 article-title: In vitro activity of thioridazine against mycobacteria. publication-title: Int J Antimicrob Agents doi: 10.1016/j.ijantimicag.2009.02.015 – volume: 16 start-page: 69 year: 2000 ident: ref23 article-title: Comparative in vitro activity of phenothiazines against multidrug-resistant Mycobacterium tuberculosis. publication-title: Int J Antimicrob Agents doi: 10.1016/S0924-8579(00)00199-0 – volume: 190 start-page: 2981 year: 2008 ident: ref19 article-title: Nitrate enhances the survival of Mycobacterium tuberculosis during inhibition of respiration. publication-title: J Bacteriol doi: 10.1128/JB.01857-07 – volume: 55 start-page: 253 year: 1980 ident: ref10 article-title: The use of fluorescein diacetate and ethidium bromide as a stain for evaluating viability of mycobacteria. publication-title: Stain Technol doi: 10.3109/10520298009067249 – volume: 196 start-page: S28 year: 2007 ident: ref4 article-title: New tuberculosis therapeutics: a growing pipeline. publication-title: J Infect Dis doi: 10.1086/518663 – year: 2008 ident: ref3 article-title: Anti-tuberculosis drug resistance in the World. – volume: 136 start-page: 215 year: 2004 ident: ref12 article-title: Transfer factors as immunotherapy and supplement of chemotherapy in experimental pulmonary tuberculosis. publication-title: Clin Exp Immunol doi: 10.1111/j.1365-2249.2004.02454.x – volume: 47 start-page: 917 year: 2003 ident: ref6 article-title: Clinical concentrations of thioridazine kill intracellular multidrug-resistant Mycobacterium tuberculosis. publication-title: Antimicrob Agents Chemother doi: 10.1128/AAC.47.3.917-922.2003 – volume: 47 start-page: 505 year: 2001 ident: ref2 article-title: Activity of phenothiazines against antibiotic-resistant Mycobacterium tuberculosis: a review supporting further studies that may elucidate the potential use of thioridazine as antituberculosis therapy. publication-title: J Antimicrob Chemother doi: 10.1093/jac/47.5.505 – volume: 144 start-page: 264 ident: ref14 article-title: Hernandez Pando R, Orozco-Esteves H, Maldonado HA, et al. A combination of a transforming growth factor-beta antagonist and an inhibitor of cyclooxygenase is an effective treatment for murine pulmonary tuberculosis. publication-title: Clin Exp Immunol 2006; |
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| Title | The Antipsychotic Thioridazine Shows Promising Therapeutic Activity in a Mouse Model of Multidrug-Resistant Tuberculosis |
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