Childhood Adversities Are Associated with Shorter Telomere Length at Adult Age both in Individuals with an Anxiety Disorder and Controls

Accelerated leukocyte telomere shortening has been previously associated to self-perceived stress and psychiatric disorders, including schizophrenia and mood disorders. We set out to investigate whether telomere length is affected in patients with anxiety disorders in which stress is a known risk fa...

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Vydáno v:	PloS one Ročník 5; číslo 5; s. e10826
Hlavní autoři:	Kananen, Laura, Surakka, Ida, Pirkola, Sami, Suvisaari, Jaana, Lönnqvist, Jouko, Peltonen, Leena, Ripatti, Samuli, Hovatta, Iiris
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States Public Library of Science 25.05.2010 Public Library of Science (PLoS)
Témata:	Adult Age Aging - metabolism Aging - pathology Anxiety Anxiety Disorders - complications Blood cells Case-Control Studies Child Child Abuse - psychology Childhood Children Chromosomes Diagnostic systems Disorders Genetics and Genomics/Chromosome Biology Genetics and Genomics/Complex Traits Genomics Health problems Humans Leukocytes Life Change Events Medical diagnosis Mental disorders Mental Health/Neuropsychiatric Disorders Mood Oxidative stress Patients Peripheral blood Public health Risk factors Schizophrenia Socioeconomic Factors Stress Stress, Psychological - complications Stresses Surveys Telomere - metabolism Telomeres Well being Finland
ISSN:	1932-6203, 1932-6203
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Abstract	Accelerated leukocyte telomere shortening has been previously associated to self-perceived stress and psychiatric disorders, including schizophrenia and mood disorders. We set out to investigate whether telomere length is affected in patients with anxiety disorders in which stress is a known risk factor. We also studied the effects of childhood and recent psychological distress on telomere length. We utilized samples from the nationally representative population-based Health 2000 Survey that was carried out between 2000-2001 in Finland to assess major public health problems and their determinants. We measured the relative telomere length of the peripheral blood cells by quantitative real-time PCR from 321 individuals with DSM-IV anxiety disorder or subthreshold diagnosis and 653 matched controls aged 30-87 years, who all had undergone the Composite International Diagnostic Interview. While telomere length did not differ significantly between cases and controls in the entire cohort, the older half of the anxiety disorder patients (48-87 years) exhibited significantly shorter telomeres than healthy controls of the same age (P = 0.013). Interestingly, shorter telomere length was also associated with a greater number of reported childhood adverse life events, among both the anxiety disorder cases and controls (P = 0.005). Childhood chronic or serious illness was the most significantly associated single event affecting telomere length at the adult age (P = 0.004). Self-reported current psychological distress did not affect telomere length. Our results suggest that childhood stress might lead to accelerated telomere shortening seen at the adult age. This finding has potentially important implications supporting the view that childhood adversities might have a considerable impact on well being later in life.
AbstractList	Accelerated leukocyte telomere shortening has been previously associated to self-perceived stress and psychiatric disorders, including schizophrenia and mood disorders. We set out to investigate whether telomere length is affected in patients with anxiety disorders in which stress is a known risk factor. We also studied the effects of childhood and recent psychological distress on telomere length. We utilized samples from the nationally representative population-based Health 2000 Survey that was carried out between 2000-2001 in Finland to assess major public health problems and their determinants. We measured the relative telomere length of the peripheral blood cells by quantitative real-time PCR from 321 individuals with DSM-IV anxiety disorder or subthreshold diagnosis and 653 matched controls aged 30-87 years, who all had undergone the Composite International Diagnostic Interview. While telomere length did not differ significantly between cases and controls in the entire cohort, the older half of the anxiety disorder patients (48-87 years) exhibited significantly shorter telomeres than healthy controls of the same age (P = 0.013). Interestingly, shorter telomere length was also associated with a greater number of reported childhood adverse life events, among both the anxiety disorder cases and controls (P = 0.005). Childhood chronic or serious illness was the most significantly associated single event affecting telomere length at the adult age (P = 0.004). Self-reported current psychological distress did not affect telomere length. Our results suggest that childhood stress might lead to accelerated telomere shortening seen at the adult age. This finding has potentially important implications supporting the view that childhood adversities might have a considerable impact on well being later in life.Accelerated leukocyte telomere shortening has been previously associated to self-perceived stress and psychiatric disorders, including schizophrenia and mood disorders. We set out to investigate whether telomere length is affected in patients with anxiety disorders in which stress is a known risk factor. We also studied the effects of childhood and recent psychological distress on telomere length. We utilized samples from the nationally representative population-based Health 2000 Survey that was carried out between 2000-2001 in Finland to assess major public health problems and their determinants. We measured the relative telomere length of the peripheral blood cells by quantitative real-time PCR from 321 individuals with DSM-IV anxiety disorder or subthreshold diagnosis and 653 matched controls aged 30-87 years, who all had undergone the Composite International Diagnostic Interview. While telomere length did not differ significantly between cases and controls in the entire cohort, the older half of the anxiety disorder patients (48-87 years) exhibited significantly shorter telomeres than healthy controls of the same age (P = 0.013). Interestingly, shorter telomere length was also associated with a greater number of reported childhood adverse life events, among both the anxiety disorder cases and controls (P = 0.005). Childhood chronic or serious illness was the most significantly associated single event affecting telomere length at the adult age (P = 0.004). Self-reported current psychological distress did not affect telomere length. Our results suggest that childhood stress might lead to accelerated telomere shortening seen at the adult age. This finding has potentially important implications supporting the view that childhood adversities might have a considerable impact on well being later in life. Accelerated leukocyte telomere shortening has been previously associated to self-perceived stress and psychiatric disorders, including schizophrenia and mood disorders. We set out to investigate whether telomere length is affected in patients with anxiety disorders in which stress is a known risk factor. We also studied the effects of childhood and recent psychological distress on telomere length. We utilized samples from the nationally representative population-based Health 2000 Survey that was carried out between 2000–2001 in Finland to assess major public health problems and their determinants. We measured the relative telomere length of the peripheral blood cells by quantitative real-time PCR from 321 individuals with DSM-IV anxiety disorder or subthreshold diagnosis and 653 matched controls aged 30–87 years, who all had undergone the Composite International Diagnostic Interview. While telomere length did not differ significantly between cases and controls in the entire cohort, the older half of the anxiety disorder patients (48–87 years) exhibited significantly shorter telomeres than healthy controls of the same age (P = 0.013). Interestingly, shorter telomere length was also associated with a greater number of reported childhood adverse life events, among both the anxiety disorder cases and controls (P = 0.005). Childhood chronic or serious illness was the most significantly associated single event affecting telomere length at the adult age (P = 0.004). Self-reported current psychological distress did not affect telomere length. Our results suggest that childhood stress might lead to accelerated telomere shortening seen at the adult age. This finding has potentially important implications supporting the view that childhood adversities might have a considerable impact on well being later in life.
Audience	Academic
Author	Hovatta, Iiris Suvisaari, Jaana Lönnqvist, Jouko Surakka, Ida Peltonen, Leena Kananen, Laura Ripatti, Samuli Pirkola, Sami
AuthorAffiliation	7 The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America 3 Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland 1 Research Program of Molecular Neurology, Faculty of Medicine, University of Helsinki, Helsinki, Finland 4 FIMM, Institute of Molecular Medicine Finland, University of Helsinki, Helsinki, Finland 5 Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland 6 Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland 8 Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom Leicester University, United Kingdom 2 Department of Medical Genetics, Faculty of Medicine, University of Helsinki, Helsinki, Finland
AuthorAffiliation_xml	– name: 7 The Broad Institute of MIT and Harvard, Cambridge, Massachusetts, United States of America – name: 8 Wellcome Trust Sanger Institute, Hinxton, Cambridge, United Kingdom – name: Leicester University, United Kingdom – name: 5 Mental Health and Substance Abuse Services, National Institute for Health and Welfare, Helsinki, Finland – name: 3 Public Health Genomics Unit, National Institute for Health and Welfare, Helsinki, Finland – name: 1 Research Program of Molecular Neurology, Faculty of Medicine, University of Helsinki, Helsinki, Finland – name: 4 FIMM, Institute of Molecular Medicine Finland, University of Helsinki, Helsinki, Finland – name: 6 Department of Psychiatry, Helsinki University Central Hospital, Helsinki, Finland – name: 2 Department of Medical Genetics, Faculty of Medicine, University of Helsinki, Helsinki, Finland
Author_xml	– sequence: 1 givenname: Laura surname: Kananen fullname: Kananen, Laura – sequence: 2 givenname: Ida surname: Surakka fullname: Surakka, Ida – sequence: 3 givenname: Sami surname: Pirkola fullname: Pirkola, Sami – sequence: 4 givenname: Jaana surname: Suvisaari fullname: Suvisaari, Jaana – sequence: 5 givenname: Jouko surname: Lönnqvist fullname: Lönnqvist, Jouko – sequence: 6 givenname: Leena surname: Peltonen fullname: Peltonen, Leena – sequence: 7 givenname: Samuli surname: Ripatti fullname: Ripatti, Samuli – sequence: 8 givenname: Iiris surname: Hovatta fullname: Hovatta, Iiris
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/20520834$$D View this record in MEDLINE/PubMed
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Copyright	COPYRIGHT 2010 Public Library of Science 2010 Kananen et al. This is an open-access article distributed under the terms of the Creative Commons Attribution License: https://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. Kananen et al. 2010
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Notes	ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 content type line 23 Conceived and designed the experiments: IH. Performed the experiments: LK IH. Analyzed the data: LK IS SP JS SR IH. Contributed reagents/materials/analysis tools: SP JS JL LP SR IH. Wrote the paper: LK SR IH.
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SubjectTerms	Adult Age Aging - metabolism Aging - pathology Anxiety Anxiety Disorders - complications Blood cells Case-Control Studies Child Child Abuse - psychology Childhood Children Chromosomes Diagnostic systems Disorders Genetics and Genomics/Chromosome Biology Genetics and Genomics/Complex Traits Genomics Health problems Humans Leukocytes Life Change Events Medical diagnosis Mental disorders Mental Health/Neuropsychiatric Disorders Mood Oxidative stress Patients Peripheral blood Public health Risk factors Schizophrenia Socioeconomic Factors Stress Stress, Psychological - complications Stresses Surveys Telomere - metabolism Telomeres Well being
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Title	Childhood Adversities Are Associated with Shorter Telomere Length at Adult Age both in Individuals with an Anxiety Disorder and Controls
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