A large-scale RNAi screen in human cells identifies new components of the p53 pathway

RNA interference (RNAi) is a powerful new tool with which to perform loss-of-function genetic screens in lower organisms and can greatly facilitate the identification of components of cellular signalling pathways 1 , 2 , 3 . In mammalian cells, such screens have been hampered by a lack of suitable t...

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Veröffentlicht in:	Nature Jg. 428; H. 6981; S. 431 - 437
Hauptverfasser:	Berns, Katrien, Hijmans, E. Marielle, Mullenders, Jasper, Brummelkamp, Thijn R., Velds, Arno, Heimerikx, Mike, Kerkhoven, Ron M., Madiredjo, Mandy, Nijkamp, Wouter, Weigelt, Britta, Agami, Reuven, Ge, Wei, Cavet, Guy, Linsley, Peter S., Beijersbergen, Roderick L., Bernards, René
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 25.03.2004 Nature Publishing Nature Publishing Group
Schlagworte:	Biological and medical sciences Cell cycle Cell Division Cell Line, Tumor Cloning, Molecular Cyclin-Dependent Kinase Inhibitor p16 Cyclin-Dependent Kinase Inhibitor p21 Cyclins - genetics Cyclins - metabolism Down-Regulation Fibroblasts Fundamental and applied biological sciences. Psychology Gene expression Gene Library Genes. Genome Genetic Vectors - genetics Genetics Humanities and Social Sciences Humans letter Mammals Medical screening Molecular and cellular biology Molecular genetics multidisciplinary Reproducibility of Results Retroviridae - genetics Ribonucleic acid RNA RNA Interference RNA, Small Interfering - genetics RNA, Small Interfering - metabolism Science Science (multidisciplinary) shRNA Tumor Suppressor Protein p14ARF - metabolism Tumor Suppressor Protein p53 - genetics Tumor Suppressor Protein p53 - metabolism
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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