HIV-1 RNA Dysregulates the Natural TLR Response to Subclinical Endotoxemia in Kenyan Female Sex-Workers

Subclinical endotoxemia has been reported in HIV-1 infected persons and may drive systemic immune activation and pathogenesis. Proinflammatory responsiveness to endotoxin (LPS) is mediated by Toll-like receptor 4 (TLR4). We therefore examined the association between plasma LPS levels, HIV RNA, and T...

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Bibliographic Details
Published in:	PloS one Vol. 4; no. 5; p. e5644
Main Authors:	Lester, Richard T., Yao, Xiao-Dan, Ball, T. Blake, McKinnon, Lyle R., Omange, Were R., Kaul, Rupert, Wachihi, Charles, Jaoko, Walter, Rosenthal, Kenneth L., Plummer, Francis A.
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 21.05.2009 Public Library of Science (PLoS)
Subjects:	Acquired immune deficiency syndrome Activation Adult AIDS Antiretroviral drugs Blood Cell culture Chronic conditions Chronic infection Cytokines Cytokines - metabolism Dementia Development and progression Drug therapy Endotoxemia Endotoxemia - blood Endotoxemia - immunology Endotoxins Female Gene expression Gene Expression Regulation HIV HIV (Viruses) HIV infection HIV Infections - blood HIV-1 - immunology Human immunodeficiency virus Human immunodeficiency virus 1 Humans Immune response Immune system Immune Tolerance - immunology Immunological tolerance Immunology Immunology/Cellular Microbiology and Pathogenesis Immunology/Immune Response Immunology/Immunity to Infections Immunology/Immunomodulation Immunology/Innate Immunity Immunology/Leukocyte Activation Infections Infectious Diseases Infectious Diseases/Bacterial Infections Infectious Diseases/HIV Infection and AIDS Infectious Diseases/Viral Infections Inflammation Kenya Laboratories Leukocytes (mononuclear) Ligands Lipopolysaccharides Lipopolysaccharides - blood Lymphocytes Lymphocytes - metabolism Middle Aged Pathogenesis Peripheral blood mononuclear cells Plasma Plasmas (physics) Polymerase chain reaction Proteins Public health Ribonucleic acid RNA RNA, Messenger - genetics RNA, Messenger - metabolism RNA, Viral - immunology Sepsis Sex Sex Work Sexually transmitted diseases Signal Transduction STD Stimulation Studies T cell receptors TLR4 protein Toll-Like Receptor 4 - genetics Toll-Like Receptor 4 - metabolism Toll-like receptors Toll-Like Receptors - immunology Trends Tumor necrosis factor-α Workers Canada Manitoba Canada
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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