Heterogeneity of cancer‐associated fibroblasts: Opportunities for precision medicine

Despite marked development in cancer therapies during recent decades, the prognosis for advanced cancer remains poor. The conventional tumor–cell‐centric view of cancer can only explain part of cancer progression, and thus a thorough understanding of the tumor microenvironment (TME) is crucial. Amon...

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Vydané v:	Cancer science Ročník 111; číslo 8; s. 2708 - 2717
Hlavní autori:	Kanzaki, Ryu, Pietras, Kristian
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England John Wiley & Sons, Inc 01.08.2020 John Wiley and Sons Inc
Predmet:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Bone marrow Brain cancer Breast cancer Cancer Cancer and Oncology Cancer och onkologi cancer progression Cancer therapies Cancer-Associated Fibroblasts - drug effects Cancer-Associated Fibroblasts - metabolism cancer‐associated fibroblast Clinical Medicine Colorectal cancer Disease Progression Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Extracellular matrix Fibroblasts Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic Heterogeneity Genomics Genotype & phenotype Growth factors heterogeneity Humans Kinases Klinisk medicin Lymphatic system Medical and Health Sciences Medicin och hälsovetenskap Metastasis Neoplasms - drug therapy Neoplasms - genetics Neoplasms - pathology Pancreatic cancer Population Precision medicine Precision Medicine - methods Proteins Review RNA-Seq Single-Cell Analysis single‐cell RNA‐sequencing Smooth muscle Stem cells Tumor microenvironment Tumor Microenvironment - drug effects Tumor Microenvironment - genetics Tumors Wound healing cancer-associated fibroblast single-cell RNA-sequencing tumor microenvironment cancer progression heterogeneity
ISSN:	1347-9032, 1349-7006, 1349-7006
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