Heterogeneity of cancer‐associated fibroblasts: Opportunities for precision medicine

Despite marked development in cancer therapies during recent decades, the prognosis for advanced cancer remains poor. The conventional tumor–cell‐centric view of cancer can only explain part of cancer progression, and thus a thorough understanding of the tumor microenvironment (TME) is crucial. Amon...

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Vydané v:Cancer science Ročník 111; číslo 8; s. 2708 - 2717
Hlavní autori: Kanzaki, Ryu, Pietras, Kristian
Médium: Journal Article
Jazyk:English
Vydavateľské údaje: England John Wiley & Sons, Inc 01.08.2020
John Wiley and Sons Inc
Predmet:
Antineoplastic Agents - pharmacology
Antineoplastic Agents - therapeutic use
Bone marrow
Brain cancer
Breast cancer
Cancer
Cancer and Oncology
Cancer och onkologi
cancer progression
Cancer therapies
Cancer-Associated Fibroblasts - drug effects
Cancer-Associated Fibroblasts - metabolism
cancer‐associated fibroblast
Clinical Medicine
Colorectal cancer
Disease Progression
Drug Resistance, Neoplasm - drug effects
Drug Resistance, Neoplasm - genetics
Extracellular matrix
Fibroblasts
Gene expression
Gene Expression Regulation, Neoplastic - drug effects
Genetic Heterogeneity
Genomics
Genotype & phenotype
Growth factors
heterogeneity
Humans
Kinases
Klinisk medicin
Lymphatic system
Medical and Health Sciences
Medicin och hälsovetenskap
Metastasis
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - pathology
Pancreatic cancer
Population
Precision medicine
Precision Medicine - methods
Proteins
Review
RNA-Seq
Single-Cell Analysis
single‐cell RNA‐sequencing
Smooth muscle
Stem cells
Tumor microenvironment
Tumor Microenvironment - drug effects
Tumor Microenvironment - genetics
Tumors
Wound healing
cancer-associated fibroblast
single-cell RNA-sequencing
tumor microenvironment
cancer progression
heterogeneity
ISSN:1347-9032, 1349-7006, 1349-7006
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Popis
Shrnutí:Despite marked development in cancer therapies during recent decades, the prognosis for advanced cancer remains poor. The conventional tumor–cell‐centric view of cancer can only explain part of cancer progression, and thus a thorough understanding of the tumor microenvironment (TME) is crucial. Among cells within the TME, cancer‐associated fibroblasts (CAFs) are attracting attention as a target for cancer therapy. However, CAFs present a heterogeneous population of cells and more detailed classification of CAFs and investigation of functions of each subset is needed to develop novel CAF‐targeted therapies. In this context, application of newly developed approaches to single‐cell analysis has already made an impact on our understanding of the heterogeneity of CAFs. Here, we review the recent literature on CAF heterogeneity and function, and discuss the possibility of novel therapies targeting CAF subsets. The conventional tumor–cell‐centric view of cancer can only explain a part of cancer progression, thus understanding of the tumor microenvironment (TME) is crucial. Among cells within the TME, cancer‐associated fibroblasts (CAFs) are attracting attention as a target for cancer therapy. Here, we review the recent literature that has improved our understanding of heterogeneity in CAFs and function of each subset, and discuss the possibility of novel therapies targeting CAF subsets.
Bibliografia:ObjectType-Article-1
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ISSN:1347-9032
1349-7006
1349-7006
DOI:10.1111/cas.14537