Heterogeneity of cancer‐associated fibroblasts: Opportunities for precision medicine

Despite marked development in cancer therapies during recent decades, the prognosis for advanced cancer remains poor. The conventional tumor–cell‐centric view of cancer can only explain part of cancer progression, and thus a thorough understanding of the tumor microenvironment (TME) is crucial. Amon...

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Vydané v:	Cancer science Ročník 111; číslo 8; s. 2708 - 2717
Hlavní autori:	Kanzaki, Ryu, Pietras, Kristian
Médium:	Journal Article
Jazyk:	English
Vydavateľské údaje:	England John Wiley & Sons, Inc 01.08.2020 John Wiley and Sons Inc
Predmet:	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Bone marrow Brain cancer Breast cancer Cancer Cancer and Oncology Cancer och onkologi cancer progression Cancer therapies Cancer-Associated Fibroblasts - drug effects Cancer-Associated Fibroblasts - metabolism cancer‐associated fibroblast Clinical Medicine Colorectal cancer Disease Progression Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Extracellular matrix Fibroblasts Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic Heterogeneity Genomics Genotype & phenotype Growth factors heterogeneity Humans Kinases Klinisk medicin Lymphatic system Medical and Health Sciences Medicin och hälsovetenskap Metastasis Neoplasms - drug therapy Neoplasms - genetics Neoplasms - pathology Pancreatic cancer Population Precision medicine Precision Medicine - methods Proteins Review RNA-Seq Single-Cell Analysis single‐cell RNA‐sequencing Smooth muscle Stem cells Tumor microenvironment Tumor Microenvironment - drug effects Tumor Microenvironment - genetics Tumors Wound healing cancer-associated fibroblast single-cell RNA-sequencing tumor microenvironment cancer progression heterogeneity
ISSN:	1347-9032, 1349-7006, 1349-7006
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Abstract	Despite marked development in cancer therapies during recent decades, the prognosis for advanced cancer remains poor. The conventional tumor–cell‐centric view of cancer can only explain part of cancer progression, and thus a thorough understanding of the tumor microenvironment (TME) is crucial. Among cells within the TME, cancer‐associated fibroblasts (CAFs) are attracting attention as a target for cancer therapy. However, CAFs present a heterogeneous population of cells and more detailed classification of CAFs and investigation of functions of each subset is needed to develop novel CAF‐targeted therapies. In this context, application of newly developed approaches to single‐cell analysis has already made an impact on our understanding of the heterogeneity of CAFs. Here, we review the recent literature on CAF heterogeneity and function, and discuss the possibility of novel therapies targeting CAF subsets. The conventional tumor–cell‐centric view of cancer can only explain a part of cancer progression, thus understanding of the tumor microenvironment (TME) is crucial. Among cells within the TME, cancer‐associated fibroblasts (CAFs) are attracting attention as a target for cancer therapy. Here, we review the recent literature that has improved our understanding of heterogeneity in CAFs and function of each subset, and discuss the possibility of novel therapies targeting CAF subsets.
AbstractList	Despite marked development in cancer therapies during recent decades, the prognosis for advanced cancer remains poor. The conventional tumor–cell‐centric view of cancer can only explain part of cancer progression, and thus a thorough understanding of the tumor microenvironment (TME) is crucial. Among cells within the TME, cancer‐associated fibroblasts (CAFs) are attracting attention as a target for cancer therapy. However, CAFs present a heterogeneous population of cells and more detailed classification of CAFs and investigation of functions of each subset is needed to develop novel CAF‐targeted therapies. In this context, application of newly developed approaches to single‐cell analysis has already made an impact on our understanding of the heterogeneity of CAFs. Here, we review the recent literature on CAF heterogeneity and function, and discuss the possibility of novel therapies targeting CAF subsets. Despite marked development in cancer therapies during recent decades, the prognosis for advanced cancer remains poor. The conventional tumor-cell-centric view of cancer can only explain part of cancer progression, and thus a thorough understanding of the tumor microenvironment (TME) is crucial. Among cells within the TME, cancer-associated fibroblasts (CAFs) are attracting attention as a target for cancer therapy. However, CAFs present a heterogeneous population of cells and more detailed classification of CAFs and investigation of functions of each subset is needed to develop novel CAF-targeted therapies. In this context, application of newly developed approaches to single-cell analysis has already made an impact on our understanding of the heterogeneity of CAFs. Here, we review the recent literature on CAF heterogeneity and function, and discuss the possibility of novel therapies targeting CAF subsets.Despite marked development in cancer therapies during recent decades, the prognosis for advanced cancer remains poor. The conventional tumor-cell-centric view of cancer can only explain part of cancer progression, and thus a thorough understanding of the tumor microenvironment (TME) is crucial. Among cells within the TME, cancer-associated fibroblasts (CAFs) are attracting attention as a target for cancer therapy. However, CAFs present a heterogeneous population of cells and more detailed classification of CAFs and investigation of functions of each subset is needed to develop novel CAF-targeted therapies. In this context, application of newly developed approaches to single-cell analysis has already made an impact on our understanding of the heterogeneity of CAFs. Here, we review the recent literature on CAF heterogeneity and function, and discuss the possibility of novel therapies targeting CAF subsets. Despite marked development in cancer therapies during recent decades, the prognosis for advanced cancer remains poor. The conventional tumor–cell‐centric view of cancer can only explain part of cancer progression, and thus a thorough understanding of the tumor microenvironment (TME) is crucial. Among cells within the TME, cancer‐associated fibroblasts (CAFs) are attracting attention as a target for cancer therapy. However, CAFs present a heterogeneous population of cells and more detailed classification of CAFs and investigation of functions of each subset is needed to develop novel CAF‐targeted therapies. In this context, application of newly developed approaches to single‐cell analysis has already made an impact on our understanding of the heterogeneity of CAFs. Here, we review the recent literature on CAF heterogeneity and function, and discuss the possibility of novel therapies targeting CAF subsets. The conventional tumor–cell‐centric view of cancer can only explain a part of cancer progression, thus understanding of the tumor microenvironment (TME) is crucial. Among cells within the TME, cancer‐associated fibroblasts (CAFs) are attracting attention as a target for cancer therapy. Here, we review the recent literature that has improved our understanding of heterogeneity in CAFs and function of each subset, and discuss the possibility of novel therapies targeting CAF subsets. Despite marked development in cancer therapies during recent decades, the prognosis for advanced cancer remains poor. The conventional tumor–cell‐centric view of cancer can only explain part of cancer progression, and thus a thorough understanding of the tumor microenvironment (TME) is crucial. Among cells within the TME, cancer‐associated fibroblasts (CAFs) are attracting attention as a target for cancer therapy. However, CAFs present a heterogeneous population of cells and more detailed classification of CAFs and investigation of functions of each subset is needed to develop novel CAF‐targeted therapies. In this context, application of newly developed approaches to single‐cell analysis has already made an impact on our understanding of the heterogeneity of CAFs. Here, we review the recent literature on CAF heterogeneity and function, and discuss the possibility of novel therapies targeting CAF subsets. The conventional tumor–cell‐centric view of cancer can only explain a part of cancer progression, thus understanding of the tumor microenvironment (TME) is crucial. Among cells within the TME, cancer‐associated fibroblasts (CAFs) are attracting attention as a target for cancer therapy. Here, we review the recent literature that has improved our understanding of heterogeneity in CAFs and function of each subset, and discuss the possibility of novel therapies targeting CAF subsets.
Author	Pietras, Kristian Kanzaki, Ryu
AuthorAffiliation	1 Division of Translational Cancer Research Department of Laboratory Medicine Lund University Cancer Centre Lund University Lund Sweden
AuthorAffiliation_xml	– name: 1 Division of Translational Cancer Research Department of Laboratory Medicine Lund University Cancer Centre Lund University Lund Sweden
Author_xml	– sequence: 1 givenname: Ryu surname: Kanzaki fullname: Kanzaki, Ryu organization: Lund University – sequence: 2 givenname: Kristian orcidid: 0000-0001-6738-4705 surname: Pietras fullname: Pietras, Kristian email: kristian.pietras@med.lu.se organization: Lund University
BackLink	https://www.ncbi.nlm.nih.gov/pubmed/32573845$$D View this record in MEDLINE/PubMed
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Copyright	2020 The Authors. published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. 2020 The Authors. Cancer Science published by John Wiley & Sons Australia, Ltd on behalf of Japanese Cancer Association. 2020. This work is published under http://creativecommons.org/licenses/by-nc/4.0/ (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.
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CorporateAuthor	LUCC: Lunds universitets cancercentrum Avdelningen för translationell cancerforskning Övriga starka forskningsmiljöer Division of Translational Cancer Research Profile areas and other strong research environments Lunds universitet Department of Laboratory Medicine Lund University Institutionen för laboratoriemedicin Experimentell onkologi Other Strong Research Environments Faculty of Medicine Experimental oncology LUCC: Lund University Cancer Centre Medicinska fakulteten Profilområden och andra starka forskningsmiljöer
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Snippet	Despite marked development in cancer therapies during recent decades, the prognosis for advanced cancer remains poor. The conventional tumor–cell‐centric view... Despite marked development in cancer therapies during recent decades, the prognosis for advanced cancer remains poor. The conventional tumor-cell-centric view... Despite marked development in cancer therapies during recent decades, the prognosis for advanced cancer remains poor. The conventional tumor–cell-centric view...
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SubjectTerms	Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Bone marrow Brain cancer Breast cancer Cancer Cancer and Oncology Cancer och onkologi cancer progression Cancer therapies Cancer-Associated Fibroblasts - drug effects Cancer-Associated Fibroblasts - metabolism cancer‐associated fibroblast Clinical Medicine Colorectal cancer Disease Progression Drug Resistance, Neoplasm - drug effects Drug Resistance, Neoplasm - genetics Extracellular matrix Fibroblasts Gene expression Gene Expression Regulation, Neoplastic - drug effects Genetic Heterogeneity Genomics Genotype & phenotype Growth factors heterogeneity Humans Kinases Klinisk medicin Lymphatic system Medical and Health Sciences Medicin och hälsovetenskap Metastasis Neoplasms - drug therapy Neoplasms - genetics Neoplasms - pathology Pancreatic cancer Population Precision medicine Precision Medicine - methods Proteins Review RNA-Seq Single-Cell Analysis single‐cell RNA‐sequencing Smooth muscle Stem cells Tumor microenvironment Tumor Microenvironment - drug effects Tumor Microenvironment - genetics Tumors Wound healing
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Title	Heterogeneity of cancer‐associated fibroblasts: Opportunities for precision medicine
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