Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region

Contemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus non-African regions, the reasons for which remain unclear. Understanding host and disease phenotypes that may vary by region is important for optimizing curative...

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Bibliographic Details
Published in:	PloS one Vol. 16; no. 5; p. e0250586
Main Authors:	Jarsberg, Leah G., Kedia, Komal, Wendler, Jason, Wright, Aaron T., Piehowski, Paul D., Gritsenko, Marina A., Shi, Tujin, Lewinsohn, David M., Sigal, George B., Weiner, Marc H., Smith, Richard D., Keane, Joseph, Jacobs, Jon M., Nahid, Payam
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 05.05.2021 Public Library of Science (PLoS)
Subjects:	Adult Analysis Antiinfectives and antibacterials Antimicrobial activity BASIC BIOLOGICAL SCIENCES Bioengineering Biology and Life Sciences Biomarkers Biomarkers - metabolism Blood proteins Care and treatment Chemical engineering Clinical medicine Clinical trials Critical care Data analysis Dosage Drug metabolism Editing Ethambutol Female Funding Humans Informed consent Isoniazid Laboratories Lipid Metabolism Male Medicine Medicine and Health Sciences Metabolism Methodology Middle Aged Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - isolation & purification Mycobacterium tuberculosis - metabolism North America Nutrition Nutritional Physiological Phenomena People and Places Pharmacodynamics Pharmacokinetics Pharmacology Physical sciences Population studies Product/Service Evaluations Proteome - metabolism Proteomes Proteomics - methods Pulmonary tuberculosis Pyrazinamide Review boards Rifampin South Africa Spain Treatment Outcome Tuberculosis Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - metabolism Tuberculosis, Pulmonary - microbiology Uganda Young Adult South Africa Uganda North America Spain Sub-Saharan Africa Oregon San Francisco California United States > US Texas Africa California Pacific Northwest
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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