Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region
Contemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus non-African regions, the reasons for which remain unclear. Understanding host and disease phenotypes that may vary by region is important for optimizing curative...
Uloženo v:
| Vydáno v: | PloS one Ročník 16; číslo 5; s. e0250586 |
|---|---|
| Hlavní autoři: | , , , , , , , , , , , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
| Vydáno: |
United States
Public Library of Science
05.05.2021
Public Library of Science (PLoS) |
| Témata: | |
| ISSN: | 1932-6203, 1932-6203 |
| On-line přístup: | Získat plný text |
| Tagy: |
Přidat tag
Žádné tagy, Buďte první, kdo vytvoří štítek k tomuto záznamu!
|
| Abstract | Contemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus non-African regions, the reasons for which remain unclear. Understanding host and disease phenotypes that may vary by region is important for optimizing curative treatments.
We characterized clinical features and the serum proteome of phase 2 TB clinical trial participants undergoing treatment for smear positive, culture-confirmed TB, comparing host serum protein expression in clinical trial participants enrolled in African and Non-African regions. Serum samples were collected from 289 participants enrolled in the Centers for Disease Control and Prevention TBTC Study 29 (NCT00694629) at time of enrollment and at the end of the intensive phase (after 40 doses of TB treatment).
After a peptide level proteome analysis utilizing a unique liquid chromatography IM-MS platform (LC-IM-MS) and subsequent statistical analysis, a total of 183 core proteins demonstrated significant differences at both baseline and at week 8 timepoints between participants enrolled from African and non-African regions. The majority of the differentially expressed proteins were upregulated in participants from the African region, and included acute phase proteins, mediators of inflammation, as well as coagulation and complement pathways. Downregulated proteins in the African population were primarily linked to nutritional status and lipid metabolism pathways.
We have identified differentially expressed nutrition and lipid pathway proteins by geographic region in TB patients undergoing treatment for pulmonary tuberculosis, which appear to be associated with differential treatment responses. Future TB clinical trials should collect expanded measures of nutritional status and further evaluate the relationship between nutrition and microbiologic treatment response. |
|---|---|
| AbstractList | Introduction Contemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus non-African regions, the reasons for which remain unclear. Understanding host and disease phenotypes that may vary by region is important for optimizing curative treatments. Methods We characterized clinical features and the serum proteome of phase 2 TB clinical trial participants undergoing treatment for smear positive, culture-confirmed TB, comparing host serum protein expression in clinical trial participants enrolled in African and Non-African regions. Serum samples were collected from 289 participants enrolled in the Centers for Disease Control and Prevention TBTC Study 29 (NCT00694629) at time of enrollment and at the end of the intensive phase (after 40 doses of TB treatment). Results After a peptide level proteome analysis utilizing a unique liquid chromatography IM-MS platform (LC-IM-MS) and subsequent statistical analysis, a total of 183 core proteins demonstrated significant differences at both baseline and at week 8 timepoints between participants enrolled from African and non-African regions. The majority of the differentially expressed proteins were upregulated in participants from the African region, and included acute phase proteins, mediators of inflammation, as well as coagulation and complement pathways. Downregulated proteins in the African population were primarily linked to nutritional status and lipid metabolism pathways. Conclusions We have identified differentially expressed nutrition and lipid pathway proteins by geographic region in TB patients undergoing treatment for pulmonary tuberculosis, which appear to be associated with differential treatment responses. Future TB clinical trials should collect expanded measures of nutritional status and further evaluate the relationship between nutrition and microbiologic treatment response. Contemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus non-African regions, the reasons for which remain unclear. Understanding host and disease phenotypes that may vary by region is important for optimizing curative treatments. We characterized clinical features and the serum proteome of phase 2 TB clinical trial participants undergoing treatment for smear positive, culture-confirmed TB, comparing host serum protein expression in clinical trial participants enrolled in African and Non-African regions. Serum samples were collected from 289 participants enrolled in the Centers for Disease Control and Prevention TBTC Study 29 (NCT00694629) at time of enrollment and at the end of the intensive phase (after 40 doses of TB treatment). After a peptide level proteome analysis utilizing a unique liquid chromatography IM-MS platform (LC-IM-MS) and subsequent statistical analysis, a total of 183 core proteins demonstrated significant differences at both baseline and at week 8 timepoints between participants enrolled from African and non-African regions. The majority of the differentially expressed proteins were upregulated in participants from the African region, and included acute phase proteins, mediators of inflammation, as well as coagulation and complement pathways. Downregulated proteins in the African population were primarily linked to nutritional status and lipid metabolism pathways. We have identified differentially expressed nutrition and lipid pathway proteins by geographic region in TB patients undergoing treatment for pulmonary tuberculosis, which appear to be associated with differential treatment responses. Future TB clinical trials should collect expanded measures of nutritional status and further evaluate the relationship between nutrition and microbiologic treatment response. About the Authors: Leah G. Jarsberg Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing Affiliation: Division of Pulmonary and Critical Care Medicine and UCSF Center for Tuberculosis, University of California San Francisco, San Francisco, California, United States of America ORCID logo https://orcid.org/0000-0001-6548-6337 Komal Kedia Roles Investigation, Methodology Affiliation: Department of Pharmacokinetics, Pharmacodynamics & Drug Metabolism (PPDM) Merck & Co., Inc., West Point, Pennsylvania, United States of America Jason Wendler Roles Data curation, Formal analysis Affiliation: Seattle Children’s Hospital, Seattle, Washington, United States of America ORCID logo https://orcid.org/0000-0003-4195-8138 Aaron T. Wright Roles Methodology Affiliations Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, United States of America, Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, Washington, United States of America Paul D. Piehowski Roles Investigation, Methodology Affiliation: Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, United States of America Marina A. Gritsenko Roles Formal analysis, Investigation, Methodology, Writing – original draft Affiliation: Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, United States of America Tujin Shi Roles Investigation, Methodology Affiliation: Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, United States of America David M. Lewinsohn Roles Conceptualization Affiliation: Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, Oregon, United States of America George B. Sigal Roles Conceptualization, Resources Affiliation: Meso Scale Diagnostics, Rockville, Maryland, United States of America ORCID logo https://orcid.org/0000-0001-7149-6400 Marc H. Weiner Roles Conceptualization Affiliation: University of Texas Health Science Center at San Antonio and the South Texas VAMC, San Antonio, Texas, United States of America Richard D. Smith Roles Resources Affiliation: Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, United States of America Joseph Keane Roles Methodology, Writing – review & editing Affiliation: Department of Clinical Medicine, Trinity Translational Medicine Institute, St. James’s Hospital, Dublin, Ireland Jon M. Jacobs Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing * E-mail: jon.jacobs@pnnl.gov Affiliation: Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, United States of America ORCID logo https://orcid.org/0000-0003-0557-7338 Payam Nahid Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing Affiliation: Division of Pulmonary and Critical Care Medicine and UCSF Center for Tuberculosis, University of California San Francisco, San Francisco, California, United States of America ORCID logo https://orcid.org/0000-0003-2811-1311 Introduction Africa is home to 11% of the world’s population but carries 29% of the global burden of tuberculosis (TB) [1]. According to the World Health Organization (WHO), 84% of TB-related deaths worldwide occur in Africa [2]. Materials and methods Ethics statement Study 29 was approved by both CDC and local institutional review boards, and written informed consent was obtained from all study participants for collection of serum for TB-related research. Study population TBTC Study 29 (ClinicalTrials.gov Identifier NCT00694629) is a prospective, multicenter, open-label Phase 2 clinical trial comparing the antimicrobial activity and safety of a standard daily regimen containing rifampin, to that of an experimental regimen with daily rifapentine (10 mg/kg/dose), both given with isoniazid, pyrazinamide and ethambutol to adults with smear positive, culture-confirmed pulmonary TB. About the Authors: Leah G. Jarsberg Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing Affiliation: Division of Pulmonary and Critical Care Medicine and UCSF Center for Tuberculosis, University of California San Francisco, San Francisco, California, United States of America ORCID logo https://orcid.org/0000-0001-6548-6337 Komal Kedia Roles Investigation, Methodology Affiliation: Department of Pharmacokinetics, Pharmacodynamics & Drug Metabolism (PPDM) Merck & Co., Inc., West Point, Pennsylvania, United States of America Jason Wendler Roles Data curation, Formal analysis Affiliation: Seattle Children’s Hospital, Seattle, Washington, United States of America ORCID logo https://orcid.org/0000-0003-4195-8138 Aaron T. Wright Roles Methodology Affiliations Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, United States of America, Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, Washington, United States of America Paul D. Piehowski Roles Investigation, Methodology Affiliation: Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, United States of America Marina A. Gritsenko Roles Formal analysis, Investigation, Methodology, Writing – original draft Affiliation: Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, United States of America Tujin Shi Roles Investigation, Methodology Affiliation: Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, United States of America David M. Lewinsohn Roles Conceptualization Affiliation: Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, Oregon, United States of America George B. Sigal Roles Conceptualization, Resources Affiliation: Meso Scale Diagnostics, Rockville, Maryland, United States of America ORCID logo https://orcid.org/0000-0001-7149-6400 Marc H. Weiner Roles Conceptualization Affiliation: University of Texas Health Science Center at San Antonio and the South Texas VAMC, San Antonio, Texas, United States of America Richard D. Smith Roles Resources Affiliation: Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, United States of America Joseph Keane Roles Methodology, Writing – review & editing Affiliation: Department of Clinical Medicine, Trinity Translational Medicine Institute, St. James’s Hospital, Dublin, Ireland Jon M. Jacobs Roles Conceptualization, Data curation, Formal analysis, Funding acquisition, Investigation, Methodology, Project administration, Resources, Supervision, Validation, Writing – original draft, Writing – review & editing * E-mail: jon.jacobs@pnnl.gov Affiliation: Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, United States of America ORCID logo https://orcid.org/0000-0003-0557-7338 Payam Nahid Roles Conceptualization, Funding acquisition, Investigation, Methodology, Resources, Writing – original draft, Writing – review & editing Affiliation: Division of Pulmonary and Critical Care Medicine and UCSF Center for Tuberculosis, University of California San Francisco, San Francisco, California, United States of America ORCID logo https://orcid.org/0000-0003-2811-1311 Introduction Africa is home to 11% of the world’s population but carries 29% of the global burden of tuberculosis (TB) [1]. According to the World Health Organization (WHO), 84% of TB-related deaths worldwide occur in Africa [2]. Materials and methods Ethics statement Study 29 was approved by both CDC and local institutional review boards, and written informed consent was obtained from all study participants for collection of serum for TB-related research. Study population TBTC Study 29 (ClinicalTrials.gov Identifier NCT00694629) is a prospective, multicenter, open-label Phase 2 clinical trial comparing the antimicrobial activity and safety of a standard daily regimen containing rifampin, to that of an experimental regimen with daily rifapentine (10 mg/kg/dose), both given with isoniazid, pyrazinamide and ethambutol to adults with smear positive, culture-confirmed pulmonary TB. Contemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus non-African regions, the reasons for which remain unclear. Understanding host and disease phenotypes that may vary by region is important for optimizing curative treatments. We characterized clinical features and the serum proteome of phase 2 TB clinical trial participants undergoing treatment for smear positive, culture-confirmed TB, comparing host serum protein expression in clinical trial participants enrolled in African and Non-African regions. Serum samples were collected from 289 participants enrolled in the Centers for Disease Control and Prevention TBTC Study 29 (NCT00694629) at time of enrollment and at the end of the intensive phase (after 40 doses of TB treatment). After a peptide level proteome analysis utilizing a unique liquid chromatography IM-MS platform (LC-IM-MS) and subsequent statistical analysis, a total of 183 core proteins demonstrated significant differences at both baseline and at week 8 timepoints between participants enrolled from African and non-African regions. The majority of the differentially expressed proteins were upregulated in participants from the African region, and included acute phase proteins, mediators of inflammation, as well as coagulation and complement pathways. Downregulated proteins in the African population were primarily linked to nutritional status and lipid metabolism pathways. We have identified differentially expressed nutrition and lipid pathway proteins by geographic region in TB patients undergoing treatment for pulmonary tuberculosis, which appear to be associated with differential treatment responses. Future TB clinical trials should collect expanded measures of nutritional status and further evaluate the relationship between nutrition and microbiologic treatment response. Contemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus non-African regions, the reasons for which remain unclear. Understanding host and disease phenotypes that may vary by region is important for optimizing curative treatments.INTRODUCTIONContemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus non-African regions, the reasons for which remain unclear. Understanding host and disease phenotypes that may vary by region is important for optimizing curative treatments.We characterized clinical features and the serum proteome of phase 2 TB clinical trial participants undergoing treatment for smear positive, culture-confirmed TB, comparing host serum protein expression in clinical trial participants enrolled in African and Non-African regions. Serum samples were collected from 289 participants enrolled in the Centers for Disease Control and Prevention TBTC Study 29 (NCT00694629) at time of enrollment and at the end of the intensive phase (after 40 doses of TB treatment).METHODSWe characterized clinical features and the serum proteome of phase 2 TB clinical trial participants undergoing treatment for smear positive, culture-confirmed TB, comparing host serum protein expression in clinical trial participants enrolled in African and Non-African regions. Serum samples were collected from 289 participants enrolled in the Centers for Disease Control and Prevention TBTC Study 29 (NCT00694629) at time of enrollment and at the end of the intensive phase (after 40 doses of TB treatment).After a peptide level proteome analysis utilizing a unique liquid chromatography IM-MS platform (LC-IM-MS) and subsequent statistical analysis, a total of 183 core proteins demonstrated significant differences at both baseline and at week 8 timepoints between participants enrolled from African and non-African regions. The majority of the differentially expressed proteins were upregulated in participants from the African region, and included acute phase proteins, mediators of inflammation, as well as coagulation and complement pathways. Downregulated proteins in the African population were primarily linked to nutritional status and lipid metabolism pathways.RESULTSAfter a peptide level proteome analysis utilizing a unique liquid chromatography IM-MS platform (LC-IM-MS) and subsequent statistical analysis, a total of 183 core proteins demonstrated significant differences at both baseline and at week 8 timepoints between participants enrolled from African and non-African regions. The majority of the differentially expressed proteins were upregulated in participants from the African region, and included acute phase proteins, mediators of inflammation, as well as coagulation and complement pathways. Downregulated proteins in the African population were primarily linked to nutritional status and lipid metabolism pathways.We have identified differentially expressed nutrition and lipid pathway proteins by geographic region in TB patients undergoing treatment for pulmonary tuberculosis, which appear to be associated with differential treatment responses. Future TB clinical trials should collect expanded measures of nutritional status and further evaluate the relationship between nutrition and microbiologic treatment response.CONCLUSIONSWe have identified differentially expressed nutrition and lipid pathway proteins by geographic region in TB patients undergoing treatment for pulmonary tuberculosis, which appear to be associated with differential treatment responses. Future TB clinical trials should collect expanded measures of nutritional status and further evaluate the relationship between nutrition and microbiologic treatment response. IntroductionContemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus non-African regions, the reasons for which remain unclear. Understanding host and disease phenotypes that may vary by region is important for optimizing curative treatments.MethodsWe characterized clinical features and the serum proteome of phase 2 TB clinical trial participants undergoing treatment for smear positive, culture-confirmed TB, comparing host serum protein expression in clinical trial participants enrolled in African and Non-African regions. Serum samples were collected from 289 participants enrolled in the Centers for Disease Control and Prevention TBTC Study 29 (NCT00694629) at time of enrollment and at the end of the intensive phase (after 40 doses of TB treatment).ResultsAfter a peptide level proteome analysis utilizing a unique liquid chromatography IM-MS platform (LC-IM-MS) and subsequent statistical analysis, a total of 183 core proteins demonstrated significant differences at both baseline and at week 8 timepoints between participants enrolled from African and non-African regions. The majority of the differentially expressed proteins were upregulated in participants from the African region, and included acute phase proteins, mediators of inflammation, as well as coagulation and complement pathways. Downregulated proteins in the African population were primarily linked to nutritional status and lipid metabolism pathways.ConclusionsWe have identified differentially expressed nutrition and lipid pathway proteins by geographic region in TB patients undergoing treatment for pulmonary tuberculosis, which appear to be associated with differential treatment responses. Future TB clinical trials should collect expanded measures of nutritional status and further evaluate the relationship between nutrition and microbiologic treatment response. |
| Audience | Academic |
| Author | Gritsenko, Marina A. Keane, Joseph Kedia, Komal Lewinsohn, David M. Jacobs, Jon M. Piehowski, Paul D. Wright, Aaron T. Nahid, Payam Jarsberg, Leah G. Weiner, Marc H. Wendler, Jason Sigal, George B. Shi, Tujin Smith, Richard D. |
| AuthorAffiliation | 7 Meso Scale Diagnostics, Rockville, Maryland, United States of America 8 University of Texas Health Science Center at San Antonio and the South Texas VAMC, San Antonio, Texas, United States of America 1 Division of Pulmonary and Critical Care Medicine and UCSF Center for Tuberculosis, University of California San Francisco, San Francisco, California, United States of America 3 Seattle Children’s Hospital, Seattle, Washington, United States of America 4 Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, United States of America 2 Department of Pharmacokinetics, Pharmacodynamics & Drug Metabolism (PPDM) Merck & Co., Inc., West Point, Pennsylvania, United States of America 5 Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, Washington, United States of America Rutgers Biomedical and Health Sciences, UNITED STATES 6 Pulmonary and Critical Care Medicine, Oregon Hea |
| AuthorAffiliation_xml | – name: 2 Department of Pharmacokinetics, Pharmacodynamics & Drug Metabolism (PPDM) Merck & Co., Inc., West Point, Pennsylvania, United States of America – name: 5 Voiland School of Chemical Engineering and Bioengineering, Washington State University, Pullman, Washington, United States of America – name: 8 University of Texas Health Science Center at San Antonio and the South Texas VAMC, San Antonio, Texas, United States of America – name: 6 Pulmonary and Critical Care Medicine, Oregon Health & Science University, Portland, Oregon, United States of America – name: 9 Department of Clinical Medicine, Trinity Translational Medicine Institute, St. James’s Hospital, Dublin, Ireland – name: 7 Meso Scale Diagnostics, Rockville, Maryland, United States of America – name: 3 Seattle Children’s Hospital, Seattle, Washington, United States of America – name: Rutgers Biomedical and Health Sciences, UNITED STATES – name: 1 Division of Pulmonary and Critical Care Medicine and UCSF Center for Tuberculosis, University of California San Francisco, San Francisco, California, United States of America – name: 4 Biological Sciences Division and Environmental Molecular Sciences Laboratory, Pacific Northwest National Laboratory, Richland, Washington, United States of America |
| Author_xml | – sequence: 1 givenname: Leah G. orcidid: 0000-0001-6548-6337 surname: Jarsberg fullname: Jarsberg, Leah G. – sequence: 2 givenname: Komal surname: Kedia fullname: Kedia, Komal – sequence: 3 givenname: Jason orcidid: 0000-0003-4195-8138 surname: Wendler fullname: Wendler, Jason – sequence: 4 givenname: Aaron T. surname: Wright fullname: Wright, Aaron T. – sequence: 5 givenname: Paul D. surname: Piehowski fullname: Piehowski, Paul D. – sequence: 6 givenname: Marina A. surname: Gritsenko fullname: Gritsenko, Marina A. – sequence: 7 givenname: Tujin surname: Shi fullname: Shi, Tujin – sequence: 8 givenname: David M. surname: Lewinsohn fullname: Lewinsohn, David M. – sequence: 9 givenname: George B. orcidid: 0000-0001-7149-6400 surname: Sigal fullname: Sigal, George B. – sequence: 10 givenname: Marc H. surname: Weiner fullname: Weiner, Marc H. – sequence: 11 givenname: Richard D. surname: Smith fullname: Smith, Richard D. – sequence: 12 givenname: Joseph surname: Keane fullname: Keane, Joseph – sequence: 13 givenname: Jon M. orcidid: 0000-0003-0557-7338 surname: Jacobs fullname: Jacobs, Jon M. – sequence: 14 givenname: Payam orcidid: 0000-0003-2811-1311 surname: Nahid fullname: Nahid, Payam |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33951066$$D View this record in MEDLINE/PubMed https://www.osti.gov/servlets/purl/1810101$$D View this record in Osti.gov |
| BookMark | eNqNk1trFDEUxwep2It-A9GgIPqwazKXTMYHoRQvhWLB22vI5WQ2dSYZk4y0395sdytdKSJ5mOHkd_7nnH-Sw2LPeQdF8ZjgJala8vrCz8GJYTnl8BKXDW4YvVcckK4qF7TE1d6t__3iMMYLjJuKUfqg2K-qriGY0oPi8tOcgk3WZyk0ivADQkTCaTQFn8CPgKxDk0gWXIpodhpC763rUQog0pijyPiApnkYs0S4QmmWENQ8-Ggj0tYYCEheoR58H8S0sgoF6HO5h8V9I4YIj7bfo-Lb-3dfTz4uzs4_nJ4cny1US7q0KCnVusLCdLity0rUqgUhhCyNbAQudUklE0a2tWLEaKZKRVvDsJRa1FIwUR0VTze6U26Jb02LvGzKsmIVY20mTjeE9uKCT8FmG664F5ZfB3zouQjJqgG47EjdaNZ1uJN1q2vW1BpLpbQEqSiYrPV2W22WI2iV_Qli2BHd3XF2xXv_izPcdQSXWeDZRsDHZHlUNoFaKe8cqMQJIzivDL3cVgn-5wwx8dFGBcMgHPh5MxwlTdOt0ed_oXdbsKV6kae0zvjcnFqL8mNKcctaeq21vIPKS8Noc49gbI7vJLzaSchMgsvUizlGfvrl8_-z59932Re32BWIIa2iH-b1NY674JPbx_HnHG7ufwbebAAVfIwBDM-Oi7VOHs0OnGC-fmw3pvH1Y-Pbx5aT67-Sb_T_mfYbYyAxlg |
| CitedBy_id | crossref_primary_10_1038_s41598_023_35930_x crossref_primary_10_1371_journal_pone_0294603 crossref_primary_10_1371_journal_pone_0331721 crossref_primary_10_1002_pmic_13976 crossref_primary_10_1186_s10020_024_01052_x crossref_primary_10_3390_biomedicines10040783 crossref_primary_10_3390_pathogens14080824 |
| Cites_doi | 10.1093/infdis/jis461 10.1093/jn/128.6.960 10.1111/j.1365-2125.1984.tb02377.x 10.1038/sj.ejhg.5201512 10.1378/chest.127.2.643 10.1371/journal.pone.0010753 10.1056/NEJMp0800809 10.1210/jc.2016-1104 10.1038/nature01461 10.1017/S0950268810000907 10.1074/mcp.M113.034595 10.1093/bioinformatics/btq054 10.1371/journal.pone.0077979 10.1164/rccm.200511-1834OC 10.1164/rccm.200603-360OC 10.1007/s10461-014-0730-2 10.1093/bioinformatics/btn217 10.1016/j.molonc.2014.02.004 10.1016/j.pathophys.2014.12.005 10.1079/095442200108728981 10.1016/j.tube.2018.07.005 10.1038/s41590-019-0397-y 10.1164/rccm.201410-1843OC 10.1016/S0895-4356(97)00129-7 10.1126/science.1193032 10.1136/bmj.b4248 10.1371/journal.pone.0018358 10.1210/jc.2004-2539 10.1164/rccm.200901-0078OC 10.5588/ijtld.14.0963 10.1042/cs0940321 10.1016/S0022-2275(20)41895-4 10.1093/jn/128.10.1681 10.1038/ejcn.2013.143 10.1111/j.1365-3156.2011.02761.x 10.1073/pnas.1421953112 10.1152/physrev.1991.71.4.951 10.1021/pr400178v |
| ContentType | Journal Article |
| Copyright | COPYRIGHT 2021 Public Library of Science 2021 Jarsberg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. 2021 Jarsberg et al 2021 Jarsberg et al |
| Copyright_xml | – notice: COPYRIGHT 2021 Public Library of Science – notice: 2021 Jarsberg et al. This is an open access article distributed under the terms of the Creative Commons Attribution License: http://creativecommons.org/licenses/by/4.0/ (the “License”), which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License. – notice: 2021 Jarsberg et al 2021 Jarsberg et al |
| CorporateAuthor | Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL) |
| CorporateAuthor_xml | – name: Pacific Northwest National Lab. (PNNL), Richland, WA (United States). Environmental Molecular Sciences Lab. (EMSL) |
| DBID | AAYXX CITATION CGR CUY CVF ECM EIF NPM IOV ISR 3V. 7QG 7QL 7QO 7RV 7SN 7SS 7T5 7TG 7TM 7U9 7X2 7X7 7XB 88E 8AO 8C1 8FD 8FE 8FG 8FH 8FI 8FJ 8FK ABJCF ABUWG AEUYN AFKRA ARAPS ATCPS AZQEC BBNVY BENPR BGLVJ BHPHI C1K CCPQU D1I DWQXO FR3 FYUFA GHDGH GNUQQ H94 HCIFZ K9. KB. KB0 KL. L6V LK8 M0K M0S M1P M7N M7P M7S NAPCQ P5Z P62 P64 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PKEHL PPXIY PQEST PQGLB PQQKQ PQUKI PTHSS PYCSY RC3 7X8 OIOZB OTOTI 5PM DOA |
| DOI | 10.1371/journal.pone.0250586 |
| DatabaseName | CrossRef Medline MEDLINE MEDLINE (Ovid) MEDLINE MEDLINE PubMed Gale In Context: Opposing Viewpoints Gale In Context: Science ProQuest Central (Corporate) Animal Behavior Abstracts Bacteriology Abstracts (Microbiology B) Biotechnology Research Abstracts Nursing & Allied Health Database Ecology Abstracts Entomology Abstracts (Full archive) Immunology Abstracts Meteorological & Geoastrophysical Abstracts Nucleic Acids Abstracts Virology and AIDS Abstracts Agricultural Science Collection Health & Medical Collection ProQuest Central (purchase pre-March 2016) Medical Database (Alumni Edition) ProQuest Pharma Collection Public Health Database Technology Research Database ProQuest SciTech Collection ProQuest Technology Collection ProQuest Natural Science Collection Hospital Premium Collection Hospital Premium Collection (Alumni Edition) ProQuest Central (Alumni) (purchase pre-March 2016) Materials Science & Engineering Collection ProQuest Central (Alumni) ProQuest One Sustainability ProQuest Central UK/Ireland Advanced Technologies & Computer Science Collection Agricultural & Environmental Science Collection ProQuest Central Essentials - QC Biological Science Collection ProQuest Central ProQuest Technology Collection Natural Science Collection Environmental Sciences and Pollution Management ProQuest One ProQuest Materials Science Collection ProQuest Central Engineering Research Database Health Research Premium Collection Health Research Premium Collection (Alumni) ProQuest Central Student AIDS and Cancer Research Abstracts SciTech Collection (ProQuest) ProQuest Health & Medical Complete (Alumni) Materials Science Database Nursing & Allied Health Database (Alumni Edition) Meteorological & Geoastrophysical Abstracts - Academic ProQuest Engineering Collection Biological Sciences Agricultural Science Database ProQuest Health & Medical Collection Medical Database Algology Mycology and Protozoology Abstracts (Microbiology C) Biological Science Database Engineering Database Nursing & Allied Health Premium Advanced Technologies & Aerospace Database ProQuest Advanced Technologies & Aerospace Collection Biotechnology and BioEngineering Abstracts Environmental Science Database Materials Science Collection ProQuest Central Premium ProQuest One Academic (New) ProQuest Publicly Available Content Database ProQuest Health & Medical Research Collection ProQuest One Academic Middle East (New) ProQuest One Health & Nursing ProQuest One Academic Eastern Edition (DO NOT USE) ProQuest One Applied & Life Sciences ProQuest One Academic (retired) ProQuest One Academic UKI Edition Engineering Collection Environmental Science Collection Genetics Abstracts MEDLINE - Academic OSTI.GOV - Hybrid OSTI.GOV PubMed Central (Full Participant titles) DOAJ Directory of Open Access Journals |
| DatabaseTitle | CrossRef MEDLINE Medline Complete MEDLINE with Full Text PubMed MEDLINE (Ovid) Agricultural Science Database Publicly Available Content Database ProQuest Central Student ProQuest Advanced Technologies & Aerospace Collection ProQuest Central Essentials Nucleic Acids Abstracts SciTech Premium Collection Environmental Sciences and Pollution Management ProQuest One Applied & Life Sciences ProQuest One Sustainability Health Research Premium Collection Meteorological & Geoastrophysical Abstracts Natural Science Collection Health & Medical Research Collection Biological Science Collection ProQuest Central (New) ProQuest Medical Library (Alumni) Engineering Collection Advanced Technologies & Aerospace Collection Engineering Database Virology and AIDS Abstracts ProQuest Biological Science Collection ProQuest One Academic Eastern Edition Agricultural Science Collection ProQuest Hospital Collection ProQuest Technology Collection Health Research Premium Collection (Alumni) Biological Science Database Ecology Abstracts ProQuest Hospital Collection (Alumni) Biotechnology and BioEngineering Abstracts Environmental Science Collection Entomology Abstracts Nursing & Allied Health Premium ProQuest Health & Medical Complete ProQuest One Academic UKI Edition Environmental Science Database ProQuest Nursing & Allied Health Source (Alumni) Engineering Research Database ProQuest One Academic Meteorological & Geoastrophysical Abstracts - Academic ProQuest One Academic (New) Technology Collection Technology Research Database ProQuest One Academic Middle East (New) Materials Science Collection ProQuest Health & Medical Complete (Alumni) ProQuest Central (Alumni Edition) ProQuest One Community College ProQuest One Health & Nursing ProQuest Natural Science Collection ProQuest Pharma Collection ProQuest Central ProQuest Health & Medical Research Collection Genetics Abstracts ProQuest Engineering Collection Biotechnology Research Abstracts Health and Medicine Complete (Alumni Edition) ProQuest Central Korea Bacteriology Abstracts (Microbiology B) Algology Mycology and Protozoology Abstracts (Microbiology C) Agricultural & Environmental Science Collection AIDS and Cancer Research Abstracts Materials Science Database ProQuest Materials Science Collection ProQuest Public Health ProQuest Nursing & Allied Health Source ProQuest SciTech Collection Advanced Technologies & Aerospace Database ProQuest Medical Library Animal Behavior Abstracts Materials Science & Engineering Collection Immunology Abstracts ProQuest Central (Alumni) MEDLINE - Academic |
| DatabaseTitleList | Agricultural Science Database MEDLINE MEDLINE - Academic |
| Database_xml | – sequence: 1 dbid: DOA name: DOAJ Directory of Open Access Journals url: https://www.doaj.org/ sourceTypes: Open Website – sequence: 2 dbid: NPM name: PubMed url: http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?db=PubMed sourceTypes: Index Database – sequence: 3 dbid: PIMPY name: Publicly Available Content Database url: http://search.proquest.com/publiccontent sourceTypes: Aggregation Database |
| DeliveryMethod | fulltext_linktorsrc |
| Discipline | Sciences (General) Medicine |
| DocumentTitleAlternate | Nutritional markers and proteome in patients treated for pulmonary tuberculosis differ by geographic region |
| EISSN | 1932-6203 |
| ExternalDocumentID | 2522383887 oai_doaj_org_article_b9145d89909b47d4854d0bccdbebc6ef PMC8099102 1810101 A660787691 33951066 10_1371_journal_pone_0250586 |
| Genre | Multicenter Study Clinical Trial, Phase II Randomized Controlled Trial Research Support, Non-U.S. Gov't Journal Article Research Support, N.I.H., Extramural |
| GeographicLocations | South Africa Uganda North America Spain Sub-Saharan Africa Oregon San Francisco California United States--US Texas Africa California Pacific Northwest |
| GeographicLocations_xml | – name: South Africa – name: Spain – name: Uganda – name: North America – name: Sub-Saharan Africa – name: California – name: San Francisco California – name: Pacific Northwest – name: Oregon – name: Texas – name: Africa – name: United States--US |
| GrantInformation_xml | – fundername: NIGMS NIH HHS grantid: P41 GM103493 – fundername: NIAID NIH HHS grantid: R01 AI104589 – fundername: ; grantid: 1R01AI104589 – fundername: ; grantid: GM103493 |
| GroupedDBID | --- 123 29O 2WC 53G 5VS 7RV 7X2 7X7 7XC 88E 8AO 8C1 8CJ 8FE 8FG 8FH 8FI 8FJ A8Z AAFWJ AAUCC AAWOE AAYXX ABDBF ABIVO ABJCF ABUWG ACCTH ACGFO ACIHN ACIWK ACPRK ACUHS ADBBV AEAQA AENEX AEUYN AFFHD AFKRA AFPKN AFRAH AHMBA ALMA_UNASSIGNED_HOLDINGS AOIJS APEBS ARAPS ATCPS BAIFH BAWUL BBNVY BBTPI BCNDV BENPR BGLVJ BHPHI BKEYQ BPHCQ BVXVI BWKFM CCPQU CITATION CS3 D1I D1J D1K DIK DU5 E3Z EAP EAS EBD EMOBN ESX EX3 F5P FPL FYUFA GROUPED_DOAJ GX1 HCIFZ HH5 HMCUK HYE IAO IEA IGS IHR IHW INH INR IOV IPY ISE ISR ITC K6- KB. KQ8 L6V LK5 LK8 M0K M1P M48 M7P M7R M7S M~E NAPCQ O5R O5S OK1 OVT P2P P62 PATMY PDBOC PHGZM PHGZT PIMPY PJZUB PPXIY PQGLB PQQKQ PROAC PSQYO PTHSS PV9 PYCSY RNS RPM RZL SV3 TR2 UKHRP WOQ WOW ~02 ~KM ADRAZ CGR CUY CVF ECM EIF ESTFP IPNFZ NPM PUEGO RIG ALIPV BBORY 3V. 7QG 7QL 7QO 7SN 7SS 7T5 7TG 7TM 7U9 7XB 8FD 8FK AZQEC C1K DWQXO FR3 GNUQQ H94 K9. KL. M7N P64 PKEHL PQEST PQUKI RC3 7X8 AAPBV ABPTK N95 OIOZB OTOTI 5PM - 02 ADACO BBAFP KM |
| ID | FETCH-LOGICAL-c719t-266dd30af907423a4c7eaaab2fb5a02d26b8afb74c81fd8c2c67f80bbda4ba8a3 |
| IEDL.DBID | DOA |
| ISICitedReferencesCount | 9 |
| ISICitedReferencesURI | http://www.webofscience.com/api/gateway?GWVersion=2&SrcApp=Summon&SrcAuth=ProQuest&DestLinkType=CitingArticles&DestApp=WOS_CPL&KeyUT=000664610500032&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| ISSN | 1932-6203 |
| IngestDate | Fri Nov 26 17:13:29 EST 2021 Fri Oct 03 12:39:23 EDT 2025 Tue Nov 04 01:46:26 EST 2025 Thu May 18 22:37:11 EDT 2023 Sat Nov 01 15:01:59 EDT 2025 Tue Oct 07 07:53:44 EDT 2025 Sat Nov 29 13:17:15 EST 2025 Sat Nov 29 09:53:33 EST 2025 Wed Nov 26 10:29:34 EST 2025 Wed Nov 26 09:47:23 EST 2025 Thu May 22 21:20:13 EDT 2025 Sat Sep 06 06:29:43 EDT 2025 Sat Nov 29 05:10:19 EST 2025 Tue Nov 18 21:17:25 EST 2025 |
| IsDoiOpenAccess | true |
| IsOpenAccess | true |
| IsPeerReviewed | true |
| IsScholarly | true |
| Issue | 5 |
| Language | English |
| License | This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Creative Commons Attribution License |
| LinkModel | DirectLink |
| MergedId | FETCHMERGED-LOGICAL-c719t-266dd30af907423a4c7eaaab2fb5a02d26b8afb74c81fd8c2c67f80bbda4ba8a3 |
| Notes | ObjectType-Article-1 SourceType-Scholarly Journals-1 ObjectType-Feature-2 content type line 14 ObjectType-Article-2 ObjectType-Feature-1 content type line 23 ObjectType-Undefined-3 USDOE AC05-76RL01830 PNNL-SA-156554 Competing Interests: The authors declare no competing interests in regard any relevant declarations relating to employment, consultancy, patents, products in development, or marketed products, including those authors currently affiliated with Merck & Co Inc. and Meso Scale Diagnostics. |
| ORCID | 0000-0003-4195-8138 0000-0001-6548-6337 0000-0001-7149-6400 0000-0003-2811-1311 0000-0003-0557-7338 0000000328111311 0000000199929829 0000000231725253 0000000171496400 0000000151082227 0000000223812349 0000000341958138 0000000305577338 0000000165486337 |
| OpenAccessLink | https://doaj.org/article/b9145d89909b47d4854d0bccdbebc6ef |
| PMID | 33951066 |
| PQID | 2522383887 |
| PQPubID | 1436336 |
| PageCount | e0250586 |
| ParticipantIDs | plos_journals_2522383887 doaj_primary_oai_doaj_org_article_b9145d89909b47d4854d0bccdbebc6ef pubmedcentral_primary_oai_pubmedcentral_nih_gov_8099102 osti_scitechconnect_1810101 proquest_miscellaneous_2522615591 proquest_journals_2522383887 gale_infotracmisc_A660787691 gale_infotracacademiconefile_A660787691 gale_incontextgauss_ISR_A660787691 gale_incontextgauss_IOV_A660787691 gale_healthsolutions_A660787691 pubmed_primary_33951066 crossref_citationtrail_10_1371_journal_pone_0250586 crossref_primary_10_1371_journal_pone_0250586 |
| PublicationCentury | 2000 |
| PublicationDate | 2021-05-05 |
| PublicationDateYYYYMMDD | 2021-05-05 |
| PublicationDate_xml | – month: 05 year: 2021 text: 2021-05-05 day: 05 |
| PublicationDecade | 2020 |
| PublicationPlace | United States |
| PublicationPlace_xml | – name: United States – name: San Francisco – name: San Francisco, CA USA |
| PublicationTitle | PloS one |
| PublicationTitleAlternate | PLoS One |
| PublicationYear | 2021 |
| Publisher | Public Library of Science Public Library of Science (PLoS) |
| Publisher_xml | – name: Public Library of Science – name: Public Library of Science (PLoS) |
| References | K Hatsuda (pone.0250586.ref026) 2015; 19 B MacLean (pone.0250586.ref013) 2010; 26 P Nahid (pone.0250586.ref008) 2010; 5 LJ Podewils (pone.0250586.ref027) 2011; 139 C Perez-Guzman (pone.0250586.ref040) 2005; 127 M Helmhold (pone.0250586.ref016) 1991; 32 J He (pone.0250586.ref014) 2014; 8 ES Baker (pone.0250586.ref010) 2014; 13 FJ Rosales (pone.0250586.ref025) 1998; 128 SE Dorman (pone.0250586.ref005) 2009; 180 M van Lettow (pone.0250586.ref034) 2005; 90 FAO I UNICEF, WFP WHO (pone.0250586.ref037) 2019 A Khan (pone.0250586.ref029) 2006; 174 N Martins (pone.0250586.ref041) 2009; 339 K Kedia (pone.0250586.ref009) 2018; 112 K Schmidt (pone.0250586.ref018) 2006; 14 G Genovese (pone.0250586.ref021) 2010; 329 FJ Rosales (pone.0250586.ref024) 1998; 128 G Jahnavi (pone.0250586.ref042) 2010; 51 R Thomson (pone.0250586.ref019) 2015; 112 WR Mac Kenzie (pone.0250586.ref007) 2011; 6 K Polasa (pone.0250586.ref033) 1984; 17 SE Dorman (pone.0250586.ref004) 2012; 206 A Bhargava (pone.0250586.ref028) 2013; 8 ML Hood (pone.0250586.ref031) 2013; 67 S de Pee (pone.0250586.ref036) 2014; 18 RE Chaisson (pone.0250586.ref001) 2008; 358 WJ Burman (pone.0250586.ref006) 2006; 174 TD Sudarsanam (pone.0250586.ref043) 2011; 16 D Chatterjee (pone.0250586.ref002) 2015; 22 C Cobbaert (pone.0250586.ref017) 1997; 50 AD Polpitiya (pone.0250586.ref015) 2008; 24 CM Nielson (pone.0250586.ref012) 2016; 101 L Vanhamme (pone.0250586.ref020) 2003; 422 pone.0250586.ref038 L Grobler (pone.0250586.ref044) 2016 SE Dorman (pone.0250586.ref003) 2015; 191 pone.0250586.ref039 H Baazim (pone.0250586.ref032) 2019; 20 T Shi (pone.0250586.ref011) 2013; 12 R Blomhoff (pone.0250586.ref023) 1991; 71 AR Aldred (pone.0250586.ref022) 1993 PC Calder (pone.0250586.ref030) 2000; 13 DC Macallan (pone.0250586.ref035) 1998; 94 40906688 - PLoS One. 2025 Sep 4;20(9):e0331721. doi: 10.1371/journal.pone.0331721. |
| References_xml | – start-page: 21 volume-title: Acute Phase Proteins Molecular Biology, Biochemistry, and Clinical Applications year: 1993 ident: pone.0250586.ref022 – ident: pone.0250586.ref039 – volume: 206 start-page: 1030 issue: 7 year: 2012 ident: pone.0250586.ref004 article-title: Substitution of rifapentine for rifampin during intensive phase treatment of pulmonary tuberculosis: study 29 of the tuberculosis trials consortium publication-title: J Infect Dis doi: 10.1093/infdis/jis461 – volume: 128 start-page: 960 issue: 6 year: 1998 ident: pone.0250586.ref024 article-title: Acute inflammation induces hyporetinemia and modifies the plasma and tissue response to vitamin A supplementation in marginally vitamin A-deficient rats publication-title: J Nutr doi: 10.1093/jn/128.6.960 – volume: 17 start-page: 481 issue: 4 year: 1984 ident: pone.0250586.ref033 article-title: Rifampicin kinetics in undernutrition publication-title: Br J Clin Pharmacol doi: 10.1111/j.1365-2125.1984.tb02377.x – volume: 14 start-page: 190 issue: 2 year: 2006 ident: pone.0250586.ref018 article-title: Genetics of the Lp(a)/apo(a) system in an autochthonous Black African population from the Gabon publication-title: Eur J Hum Genet doi: 10.1038/sj.ejhg.5201512 – volume: 127 start-page: 643 issue: 2 year: 2005 ident: pone.0250586.ref040 article-title: A cholesterol-rich diet accelerates bacteriologic sterilization in pulmonary tuberculosis publication-title: Chest doi: 10.1378/chest.127.2.643 – volume: 5 start-page: e10753 issue: 5 year: 2010 ident: pone.0250586.ref008 article-title: Influence of M. tuberculosis lineage variability within a clinical trial for pulmonary tuberculosis publication-title: PLoS One doi: 10.1371/journal.pone.0010753 – volume: 358 start-page: 1089 issue: 11 year: 2008 ident: pone.0250586.ref001 article-title: Tuberculosis in Africa—Combating an HIV-Driven Crisis publication-title: New England Journal of Medicine doi: 10.1056/NEJMp0800809 – volume: 101 start-page: 2226 issue: 5 year: 2016 ident: pone.0250586.ref012 article-title: Free 25-Hydroxyvitamin D: Impact of Vitamin D Binding Protein Assays on Racial-Genotypic Associations publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2016-1104 – volume: 422 start-page: 83 issue: 6927 year: 2003 ident: pone.0250586.ref020 article-title: Apolipoprotein L-I is the trypanosome lytic factor of human serum publication-title: Nature doi: 10.1038/nature01461 – volume: 139 start-page: 113 issue: 1 year: 2011 ident: pone.0250586.ref027 article-title: Impact of malnutrition on clinical presentation, clinical course, and mortality in MDR-TB patients publication-title: Epidemiol Infect doi: 10.1017/S0950268810000907 – volume: 13 start-page: 1119 issue: 4 year: 2014 ident: pone.0250586.ref010 article-title: Advancing the High Throughput Identification of Liver Fibrosis Protein Signatures Using Multiplexed Ion Mobility Spectrometry publication-title: Molecular & Cellular Proteomics: MCP doi: 10.1074/mcp.M113.034595 – volume: 26 start-page: 966 issue: 7 year: 2010 ident: pone.0250586.ref013 article-title: Skyline: an open source document editor for creating and analyzing targeted proteomics experiments publication-title: Bioinformatics doi: 10.1093/bioinformatics/btq054 – volume: 8 start-page: e77979 issue: 10 year: 2013 ident: pone.0250586.ref028 article-title: Nutritional status of adult patients with pulmonary tuberculosis in rural central India and its association with mortality publication-title: PLoS One doi: 10.1371/journal.pone.0077979 – volume-title: The State of Food Security and Nutrition in the World year: 2019 ident: pone.0250586.ref037 – volume: 174 start-page: 344 issue: 3 year: 2006 ident: pone.0250586.ref029 article-title: Lack of weight gain and relapse risk in a large tuberculosis treatment trial publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200511-1834OC – volume: 174 start-page: 331 issue: 3 year: 2006 ident: pone.0250586.ref006 article-title: Moxifloxacin versus ethambutol in the first 2 months of treatment for pulmonary tuberculosis publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200603-360OC – volume: 18 start-page: S531 issue: Suppl 5 year: 2014 ident: pone.0250586.ref036 article-title: The enabling effect of food assistance in improving adherence and/or treatment completion for antiretroviral therapy and tuberculosis treatment: a literature review publication-title: AIDS Behav doi: 10.1007/s10461-014-0730-2 – start-page: CD006086 issue: 6 year: 2016 ident: pone.0250586.ref044 article-title: Nutritional supplements for people being treated for active tuberculosis publication-title: Cochrane Database Syst Rev – volume: 24 start-page: 1556 issue: 13 year: 2008 ident: pone.0250586.ref015 article-title: DAnTE: a statistical tool for quantitative analysis of -omics data publication-title: Bioinformatics doi: 10.1093/bioinformatics/btn217 – ident: pone.0250586.ref038 – volume: 8 start-page: 1169 issue: 7 year: 2014 ident: pone.0250586.ref014 article-title: Antibody‐independent targeted quantification of TMPRSS2-ERG fusion protein products in prostate cancer publication-title: Molecular Oncology doi: 10.1016/j.molonc.2014.02.004 – volume: 22 start-page: 73 issue: 1 year: 2015 ident: pone.0250586.ref002 article-title: Tuberculosis in the African continent: A comprehensive review publication-title: Pathophysiology doi: 10.1016/j.pathophys.2014.12.005 – volume: 13 start-page: 3 issue: 1 year: 2000 ident: pone.0250586.ref030 article-title: Undernutrition, infection and immune function publication-title: Nutr Res Rev doi: 10.1079/095442200108728981 – volume: 112 start-page: 52 year: 2018 ident: pone.0250586.ref009 article-title: Application of multiplexed ion mobility spectrometry towards the identification of host protein signatures of treatment effect in pulmonary tuberculosis publication-title: Tuberculosis doi: 10.1016/j.tube.2018.07.005 – volume: 20 start-page: 701 issue: 6 year: 2019 ident: pone.0250586.ref032 article-title: CD8(+) T cells induce cachexia during chronic viral infection publication-title: Nat Immunol doi: 10.1038/s41590-019-0397-y – volume: 191 start-page: 333 issue: 3 year: 2015 ident: pone.0250586.ref003 article-title: Daily rifapentine for treatment of pulmonary tuberculosis. A randomized, dose-ranging trial publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.201410-1843OC – volume: 50 start-page: 1045 issue: 9 year: 1997 ident: pone.0250586.ref017 article-title: Serum LP(a) levels in African aboriginal Pygmies and Bantus, compared with Caucasian and Asian population samples publication-title: J Clin Epidemiol doi: 10.1016/S0895-4356(97)00129-7 – volume: 329 start-page: 841 issue: 5993 year: 2010 ident: pone.0250586.ref021 article-title: Association of trypanolytic ApoL1 variants with kidney disease in African Americans publication-title: Science doi: 10.1126/science.1193032 – volume: 339 start-page: b4248 year: 2009 ident: pone.0250586.ref041 article-title: Food incentives to improve completion of tuberculosis treatment: randomised controlled trial in Dili, Timor-Leste publication-title: BMJ doi: 10.1136/bmj.b4248 – volume: 6 start-page: e18358 issue: 4 year: 2011 ident: pone.0250586.ref007 article-title: Geographic differences in time to culture conversion in liquid media: Tuberculosis Trials Consortium study 28. Culture conversion is delayed in Africa publication-title: PLoS One doi: 10.1371/journal.pone.0018358 – volume: 90 start-page: 4771 issue: 8 year: 2005 ident: pone.0250586.ref034 article-title: Interleukin-6 and human immunodeficiency virus load, but not plasma leptin concentration, predict anorexia and wasting in adults with pulmonary tuberculosis in Malawi publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2004-2539 – volume: 51 start-page: 957 issue: 12 year: 2010 ident: pone.0250586.ref042 article-title: Randomised controlled trial of food supplements in patients with newly diagnosed tuberculosis and wasting publication-title: Singapore Med J – volume: 180 start-page: 273 issue: 3 year: 2009 ident: pone.0250586.ref005 article-title: Substitution of moxifloxacin for isoniazid during intensive phase treatment of pulmonary tuberculosis publication-title: Am J Respir Crit Care Med doi: 10.1164/rccm.200901-0078OC – volume: 19 start-page: 1369 issue: 11 year: 2015 ident: pone.0250586.ref026 article-title: The impact of nutritional state on the duration of sputum positivity of Mycobacterium tuberculosis publication-title: Int J Tuberc Lung Dis doi: 10.5588/ijtld.14.0963 – volume: 94 start-page: 321 issue: 3 year: 1998 ident: pone.0250586.ref035 article-title: Whole body protein metabolism in human pulmonary tuberculosis and undernutrition: evidence for anabolic block in tuberculosis publication-title: Clin Sci (Lond) doi: 10.1042/cs0940321 – volume: 32 start-page: 1919 issue: 12 year: 1991 ident: pone.0250586.ref016 article-title: Contribution of the apo[a] phenotype to plasma Lp[a] concentrations shows considerable ethnic variation publication-title: J Lipid Res doi: 10.1016/S0022-2275(20)41895-4 – volume: 128 start-page: 1681 issue: 10 year: 1998 ident: pone.0250586.ref025 article-title: A low molar ratio of retinol binding protein to transthyretin indicates vitamin A deficiency during inflammation: studies in rats and a posterior analysis of vitamin A-supplemented children with measles publication-title: J Nutr doi: 10.1093/jn/128.10.1681 – volume: 67 start-page: 1122 issue: 11 year: 2013 ident: pone.0250586.ref031 article-title: A narrative review of recent progress in understanding the relationship between tuberculosis and protein energy malnutrition publication-title: Eur J Clin Nutr doi: 10.1038/ejcn.2013.143 – volume: 16 start-page: 699 issue: 6 year: 2011 ident: pone.0250586.ref043 article-title: Pilot randomized trial of nutritional supplementation in patients with tuberculosis and HIV-tuberculosis coinfection receiving directly observed short-course chemotherapy for tuberculosis publication-title: Trop Med Int Health doi: 10.1111/j.1365-3156.2011.02761.x – volume: 112 start-page: 2894 issue: 9 year: 2015 ident: pone.0250586.ref019 article-title: Human trypanolytic factor APOL1 forms pH-gated cation-selective channels in planar lipid bilayers: relevance to trypanosome lysis publication-title: Proc Natl Acad Sci U S A doi: 10.1073/pnas.1421953112 – volume: 71 start-page: 951 issue: 4 year: 1991 ident: pone.0250586.ref023 article-title: Vitamin A metabolism: new perspectives on absorption, transport, and storage publication-title: Physiol Rev doi: 10.1152/physrev.1991.71.4.951 – volume: 12 start-page: 3353 issue: 7 year: 2013 ident: pone.0250586.ref011 article-title: Targeted quantification of low ng/mL level proteins in human serum without immunoaffinity depletion publication-title: Journal of proteome research doi: 10.1021/pr400178v – reference: 40906688 - PLoS One. 2025 Sep 4;20(9):e0331721. doi: 10.1371/journal.pone.0331721. |
| SSID | ssj0053866 |
| Score | 2.408315 |
| Snippet | Contemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus non-African regions,... Introduction Contemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus... About the Authors: Leah G. Jarsberg Roles Data curation, Formal analysis, Writing – original draft, Writing – review & editing Affiliation: Division of... IntroductionContemporary phase 2 TB disease treatment clinical trials have found that microbiologic treatment responses differ between African versus... |
| SourceID | plos doaj pubmedcentral osti proquest gale pubmed crossref |
| SourceType | Open Website Open Access Repository Aggregation Database Index Database Enrichment Source |
| StartPage | e0250586 |
| SubjectTerms | Adult Analysis Antiinfectives and antibacterials Antimicrobial activity BASIC BIOLOGICAL SCIENCES Bioengineering Biology and Life Sciences Biomarkers Biomarkers - metabolism Blood proteins Care and treatment Chemical engineering Clinical medicine Clinical trials Critical care Data analysis Dosage Drug metabolism Editing Ethambutol Female Funding Humans Informed consent Isoniazid Laboratories Lipid Metabolism Male Medicine Medicine and Health Sciences Metabolism Methodology Middle Aged Mycobacterium tuberculosis - drug effects Mycobacterium tuberculosis - isolation & purification Mycobacterium tuberculosis - metabolism North America Nutrition Nutritional Physiological Phenomena People and Places Pharmacodynamics Pharmacokinetics Pharmacology Physical sciences Population studies Product/Service Evaluations Proteome - metabolism Proteomes Proteomics - methods Pulmonary tuberculosis Pyrazinamide Review boards Rifampin South Africa Spain Treatment Outcome Tuberculosis Tuberculosis, Pulmonary - drug therapy Tuberculosis, Pulmonary - metabolism Tuberculosis, Pulmonary - microbiology Uganda Young Adult |
| SummonAdditionalLinks | – databaseName: Nursing & Allied Health Database dbid: 7RV link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwpV1Lb9QwELZgQYgL0PLo0gIGIQGHtHmt7ZxQQVQgwYIKVL1ZfmW70jZZkg2i_56ZxBsaVAES18wkcTwPz8Tjbwh5muQusrnIAhsJG6RMsEAJywMXZbkSmivWgj0fvefTqTg-zj75H261L6tc-8TWUdvS4D_yvRgCBcimwCZeLr8F2DUKd1d9C43L5EqEsTHoMz88WntisGXG_HG5hEd7Xjq7y7Jwu-3ajyeozy1HLWp_75tHJRgZYp4uyvqi-PP3Mspz69LBzf_9olvkho9I6X6nQhvkkis2ybUPfs99k2x486_pc49R_eI2-TFdo_jDradY4lPVVBWWtrgP5amj84J6zNaa4kG1albCKkn7wnYK0TJdNgsYharO6KrRrjINTMK8pl3XFqrP6Kzr0X4yNxRbSJTFHfL14M2X128D38QhMDzKVgEEANYmocrbLDxRqeFOKaXjXE9UGNuYaaFyzVMjotwKExvGcxFqbVWqlVDJXTIqQGBbhGoWuxwyMAfreupYqi14JBfq1IYiS0U-JslaltJ4hHNstLGQ7bYdh0ynm1KJGiC9BoxJ0N-17BA-_sL_CtWk50V87vZCWc2kN3epsyidWMhlw0yn3KZiAoPUxljttGEOhvoIlUx2h117LyP3GYOYjbMsGpMnLQdidBRYBDRTTV3Ldx-P_oHp8-GA6ZlnykuYDqP8wQv4JsT-GnDuDDjB05gBeRtNQkJshgDDBiuxzEpGiBEXAnULLWU9Z7X8pd_w3LUFXEx-3JPxlVj2V7iy6XjajXN4-r3O2Pp5TxJMDhjIgw_McCCYIaWYn7QA6gLSIgis7_95WNvkeowFTFjdOtkho1XVuAfkqvm-mtfVw9bT_ASEY423 priority: 102 providerName: ProQuest – databaseName: Public Library of Science (PLoS) Journals Open Access dbid: FPL link: http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwlV1Zb9QwELZgQYgXoOXo0gIGIUEfUnKt7TwWRAVSWSqOqm-Wr2xX2iarZIPov2cm8QZStQJed8ZZe-y55PE3hLxMchfZXGSBjYQNUiZYoITlgYuyXAnNFWvBno8P-XQqTk6yo9-J4oUb_IRHb7xM95Zl4fZajy3YdXIjThjDZOvg6HBteUF3GfPP464aOXA_LUp_b4tHJSgVYpwuyvqyePNi2eQffujg7v-u4B654yNOut8dkQ1yzRWb5NYnf6e-STa8etf0tceg3r1Pfk7XKP0w9AxLeKqaqsLSFtehPHN0XlCPyVpTfIhWzUrwgrQvXKcQDdNls4Bjrqpzumq0q0wDi57XtOvKQvU5nXU92E_nhmKLiLJ4QL4fvP_27kPgmzQEhkfZKgAHb20SqrzNshOVGu6UUjrO9USFsY2ZFirXPDUiyq0wsWE8F6HWVqVaCZU8JKMCBLNFqGaxyyHDcuC3U8dSbcHiuFCnNhRZKvIxSdZ7J41HMMdGGgvZXstxyGQ6kUqUtPSSHpOgH7XsEDz-wv8Wj0XPi_jb7Q-wpdKrs9RZlE4s5KphplNuUzGBSWpjrHbaMAdTfYaHSnaPWXsrIvcZg5iMsywakxctB2JwFFjkM1NNXcuPn4__genrlwHTK8-UlyAOo_zDClgTYnsNOHcGnGBJzIC8jSogIfZCAGGDlVZmJSPEgAuBuoWasZZZLWMI3RORgJeC76615XLy856Mf4llfYUrm46nvRiHrz_qlKuXe5Jg8M9gP_hA7QYbM6QU89MWIF1A2gOB8-OrZ7xNbsdYnISVq5MdMlpVjXtCbpofq3ldPW2tyi-XVHve priority: 102 providerName: Public Library of Science |
| Title | Nutritional markers and proteome in patients undergoing treatment for pulmonary tuberculosis differ by geographic region |
| URI | https://www.ncbi.nlm.nih.gov/pubmed/33951066 https://www.proquest.com/docview/2522383887 https://www.proquest.com/docview/2522615591 https://www.osti.gov/servlets/purl/1810101 https://pubmed.ncbi.nlm.nih.gov/PMC8099102 https://doaj.org/article/b9145d89909b47d4854d0bccdbebc6ef http://dx.doi.org/10.1371/journal.pone.0250586 |
| Volume | 16 |
| WOSCitedRecordID | wos000664610500032&url=https%3A%2F%2Fcvtisr.summon.serialssolutions.com%2F%23%21%2Fsearch%3Fho%3Df%26include.ft.matches%3Dt%26l%3Dnull%26q%3D |
| hasFullText | 1 |
| inHoldings | 1 |
| isFullTextHit | |
| isPrint | |
| journalDatabaseRights | – providerCode: PRVAON databaseName: DOAJ Directory of Open Access Journals customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: DOA dateStart: 20060101 isFulltext: true titleUrlDefault: https://www.doaj.org/ providerName: Directory of Open Access Journals – providerCode: PRVHPJ databaseName: ROAD: Directory of Open Access Scholarly Resources customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M~E dateStart: 20060101 isFulltext: true titleUrlDefault: https://road.issn.org providerName: ISSN International Centre – providerCode: PRVPQU databaseName: Advanced Technologies & Aerospace Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: P5Z dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/hightechjournals providerName: ProQuest – providerCode: PRVPQU databaseName: Agricultural Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M0K dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/agriculturejournals providerName: ProQuest – providerCode: PRVPQU databaseName: Biological Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7P dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/biologicalscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Engineering Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: M7S dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com providerName: ProQuest – providerCode: PRVPQU databaseName: Environmental Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PATMY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/environmentalscience providerName: ProQuest – providerCode: PRVPQU databaseName: Health Medical collection customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7X7 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/healthcomplete providerName: ProQuest – providerCode: PRVPQU databaseName: Materials Science Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: KB. dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/materialsscijournals providerName: ProQuest – providerCode: PRVPQU databaseName: Nursing & Allied Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 7RV dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/nahs providerName: ProQuest – providerCode: PRVPQU databaseName: ProQuest Central customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: BENPR dateStart: 20061201 isFulltext: true titleUrlDefault: https://www.proquest.com/central providerName: ProQuest – providerCode: PRVPQU databaseName: Public Health Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: 8C1 dateStart: 20061201 isFulltext: true titleUrlDefault: https://search.proquest.com/publichealth providerName: ProQuest – providerCode: PRVPQU databaseName: Publicly Available Content Database customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: PIMPY dateStart: 20061201 isFulltext: true titleUrlDefault: http://search.proquest.com/publiccontent providerName: ProQuest – providerCode: PRVATS databaseName: Public Library of Science (PLoS) Journals Open Access customDbUrl: eissn: 1932-6203 dateEnd: 99991231 omitProxy: false ssIdentifier: ssj0053866 issn: 1932-6203 databaseCode: FPL dateStart: 20060101 isFulltext: true titleUrlDefault: http://www.plos.org/publications/ providerName: Public Library of Science |
| link | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMwrV1Lb9NAEF5B4MAFUV4NLWVBSMDBqV_ZXR_bqhFV22C1EJVerH25jZTaVZwg-u-ZWTtWjSqVA5c5ZMeOPTM7D3n2G0I-RrkNTC4SzwTCeDETzJPCcM8GSS6F4pI5sOfJER-PxdlZkt4a9YU9YTU8cC24bZUE8dBAVeAnKuYmFsPY-Epro6zSzObofX2erIqp2gfDLmasOSgX8WC70cvguizswEV9PDt9KxA5vP7WK_dK2F6Idjorq7syz78bKG9FpNEz8rRJJelO_Qpr5IEtnpO1ZrNW9HODKP3lBfk9XmHuA_8VNuTMKyoLQx1KQ3ll6bSgDcJqRfFY2fyihJhG2zZ0CrktvV7OwGjl_IYulsrO9RIefFrResYKVTf0op6ofjnVFAc-lMVL8mO0_33vq9eMXPA0D5KFB-HamMiXuauZIxlrbqWUKszVUPqhCZkSMlc81iLIjdChZjwXvlJGxkoKGb0ivQKEvE6oYqHNoV6yEIVjy2JlwH9YX4H6RBKLvE-ilfwz3eCR41iMWeY-snGoS2o5Zqi1rNFan3jtVdc1Hsc9_Luo2pYX0bTdD2BjWWNj2X021ifv0DCy-mhq6xOyHcYgw-IsCfrkg-NARI0CW3Yu5LKqsoNvk39gOj3pMH1qmPISxKFlc0wC3gmRujqcmx1O8Au6s7yBZpxBJoVwwBr7pvQiCxDRzYfVdbTulcyqLIREPBIRxBy478ri715-3y7jX2KTXmHLZc3jPnPD3V_XG6SVexRhKs9AH7yzdTqK6a4U00sHdy6giIE0-M3_0OQGeRJiUxJ2rA43SW8xX9q35LH-tZhW8y3ykJ9MkJ5xRwVQsRdskUe7--P0ZMv5GKCj9Ajo4e4A6LF_iJSnjp4CTYfncEV6cJz-_AOV-4oq |
| linkProvider | Directory of Open Access Journals |
| linkToHtml | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3dT9RAEN_gadQXFfwAQVmNRn0o9Ou22wdj8INAgJMgEuJL3a8el0B7tncq_5R_ozPttlJD1BcefO1Ot9vZmdmZduY3hDwJUuPplMeO9rh2QsaZI7iOHOPFqeAyEqwCez7YjgYDfngY786QH00tDKZVNjaxMtQ6V_iNfNUHRwGiKdCJV-MvDnaNwr-rTQuNWiy2zOk3CNnKl5tvYX-f-v76u_03G47tKuCoyIsnDpxIWgeuSKuwMBChiowQQvqp7AvX1z6TXKQyChX3Us2Vr1iUcldKLUIpuAhg3kvkchj6LmrRbv9TY_nBdjBmy_OCyFu10rAyzjOzUvkaWLF95virugS0Z0EvB6VGjNXjvDzP3_09bfPMObh-83_j4C1yw3rcdK1WkVkyY7I5cnXH5hTMkVlr3kr63GJwv7hNvg-aLgVw6wmmMBUlFZmmFa5FfmLoKKMWk7akWIhXDHPwAmibuE8hGqDj6TG8tShO6WQqTaGmwPRRSeuuNFSe0mHdg_5opCi2yMizO-TjhTDjLullICDzhErmmxQiTAN-S2hYKDVYXOPKULs8Dnm6QIJGdhJlEdyxkchxUv2WjCCSq1maoMQlVuIWiNPeNa4RTP5C_xrFsqVF_PHqQl4ME2vOEhl7YV9DrO7GMox0yPuwSKmUlkYqZmCpyyjUSV3M21rRZI0x8EkjFnsL5HFFgRgkGSY5DcW0LJPN9wf_QPRhr0P0zBKlObBDCVtYAu-E2GYdyqUOJVhS1RleRBVMwPdEAGWFmWZqkniIgefC6DxqZsOzMvmlTzBvo3HnDz9qh_GRmNaYmXxa01SJATD7vVq5W74HAQY_DPYj6qh9Z2O6I9noqAKI5xD2QeBw_8_LWibXNvZ3tpPtzcHWIrnuY7IWZvL2l0hvUkzNA3JFfZ2MyuJhZeUo-XzRRuEnWIHuhQ |
| linkToPdf | http://cvtisr.summon.serialssolutions.com/2.0.0/link/0/eLvHCXMw1V3dT9RAEN8gGuKLCn6AoKxGoz4U-nXb7YMxKF4k4ElECfGl7lePS472bO9U_jX_OmfabaWGqC88-Ho73Wt3Z2Zn2t_8hpBHQWo8nfLY0R7XTsg4cwTXkWO8OBVcRoJVZM-He9FgwI-O4v058qOphUFYZeMTK0etc4XvyDd9CBQgmwKb2EwtLGJ_u_9i8sXBDlL4pbVpp1GryK45_QbpW_l8Zxv2-rHv919_ePXGsR0GHBV58dSB00nrwBVplSIGIlSREUJIP5U94fraZ5KLVEah4l6qufIVi1LuSqlFKAUXAcx7iVyOIMdEOOF-71NzCoAfYcyW6gWRt2k1Y2OSZ2ajijuwevvMUVh1DGjPhfkcDBz5Vsd5eV7s-zuE88yZ2L_-P6_mDXLNRuJ0qzadRTJnsiWy8NZiDZbIonV7JX1qubmf3STfB033Arj0BKFNRUlFpmnFd5GfGDrKqOWqLSkW6BXDHKID2gL6KWQJdDIbw1OL4pROZ9IUagYbMCpp3a2GylM6rHvTH48UxdYZeXaLfLyQxbhN5jNQlmVCJfNNCpmngXgmNCyUGjyxcWWoXR6HPF0hQaNHibLM7thgZJxUnysjyPDqJU1Q-xKrfSvEaa-a1Mwmf5F_iSrayiIvefVDXgwT6-YSGXthT0MO78YyjHTIe3CTUiktjVTMwK2uo4IndZFv612TLcYgVo1Y7K2Qh5UEcpNkqJdDMSvLZOfd4T8IHbzvCD2xQmkOy6GELTiBZ0LOs47kWkcSPKzqDK-iOSYQkyKxskIEmpomHnLjuTC6jFbarFmZ_LItmLexvvOHH7TD-JcId8xMPqtlKsAAzH6nNvR23YMAkyIG-xF1XEBnY7oj2ei4Io7nkA5CQnH3z7e1ThbAFyR7O4PdVXLVRwwXAnx7a2R-WszMPXJFfZ2OyuJ-5fAo-XzRPuEnh8T3Tw |
| openUrl | ctx_ver=Z39.88-2004&ctx_enc=info%3Aofi%2Fenc%3AUTF-8&rfr_id=info%3Asid%2Fsummon.serialssolutions.com&rft_val_fmt=info%3Aofi%2Ffmt%3Akev%3Amtx%3Ajournal&rft.genre=article&rft.atitle=Nutritional+markers+and+proteome+in+patients+undergoing+treatment+for+pulmonary+tuberculosis+differ+by+geographic+region&rft.jtitle=PloS+one&rft.au=Leah+G+Jarsberg&rft.au=Komal+Kedia&rft.au=Jason+Wendler&rft.au=Aaron+T+Wright&rft.date=2021-05-05&rft.pub=Public+Library+of+Science+%28PLoS%29&rft.eissn=1932-6203&rft.volume=16&rft.issue=5&rft.spage=e0250586&rft_id=info:doi/10.1371%2Fjournal.pone.0250586&rft.externalDBID=DOA&rft.externalDocID=oai_doaj_org_article_b9145d89909b47d4854d0bccdbebc6ef |
| thumbnail_l | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/lc.gif&issn=1932-6203&client=summon |
| thumbnail_m | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/mc.gif&issn=1932-6203&client=summon |
| thumbnail_s | http://covers-cdn.summon.serialssolutions.com/index.aspx?isbn=/sc.gif&issn=1932-6203&client=summon |