White blood cell count and mortality in the Baltimore Longitudinal Study of Aging

We investigated the secular trend in white blood cell (WBC) count and the relationship between WBC count and mortality between 1958 and 2002. The WBC count is a clinical marker of inflammation and a strong predictor of mortality. Limited data exist on the WBC count secular trend and the relationship...

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Vydáno v:	Journal of the American College of Cardiology Ročník 49; číslo 18; s. 1841
Hlavní autoři:	Ruggiero, Carmelinda, Metter, E Jeffrey, Cherubini, Antonio, Maggio, Marcello, Sen, Ranjan, Najjar, Samer S, Windham, Gwen B, Ble, Alessandro, Senin, Umberto, Ferrucci, Luigi
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	United States 08.05.2007
Témata:	Baltimore - epidemiology Body Mass Index Cardiovascular Diseases - blood Cardiovascular Diseases - mortality Cause of Death Female Humans Leukocyte Count Longitudinal Studies Male Mortality Proportional Hazards Models Survival Analysis Baltimore
ISSN:	1558-3597, 1558-3597
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Abstract	We investigated the secular trend in white blood cell (WBC) count and the relationship between WBC count and mortality between 1958 and 2002. The WBC count is a clinical marker of inflammation and a strong predictor of mortality. Limited data exist on the WBC count secular trend and the relationship between WBC and mortality. One thousand eighty-three women and 1,720 men were evaluated longitudinally in the Baltimore Longitudinal Study of Aging. Blood samples and medical information were collected at the study entry and every 2 years during follow-up visits. The WBC count and all-cause, cardiovascular, and cancer mortality were assessed. A downward trend in WBC count was observed from 1958 to 2002. The secular downward trend was independent of age, gender, race, smoking, body mass index, and physical activity. The WBC count was nonlinearly associated with all-cause mortality and almost linearly associated with cardiovascular mortality. Participants with baseline WBC <3,500 cells/mm3 and WBC >6,000 cells/mm3 had higher mortality than those with 3,500 to 6,000 WBC/mm3. Within each WBC group, age-adjusted mortality rates declined in successive cohorts from the 1960s to the 1990s. Participants who died had higher WBC than those who survived, and the difference was statistically significant within 5 years before death. Our study provides evidence for a secular downward trend in WBC count over the period from 1958 to 2002. Higher WBC counts are associated with higher mortality in successive cohorts. We found no evidence that the decline of age-specific mortality rates that occurred from 1960 to 2000 was attributable to a secular downward trend in WBC.
AbstractList	We investigated the secular trend in white blood cell (WBC) count and the relationship between WBC count and mortality between 1958 and 2002.OBJECTIVESWe investigated the secular trend in white blood cell (WBC) count and the relationship between WBC count and mortality between 1958 and 2002.The WBC count is a clinical marker of inflammation and a strong predictor of mortality. Limited data exist on the WBC count secular trend and the relationship between WBC and mortality.BACKGROUNDThe WBC count is a clinical marker of inflammation and a strong predictor of mortality. Limited data exist on the WBC count secular trend and the relationship between WBC and mortality.One thousand eighty-three women and 1,720 men were evaluated longitudinally in the Baltimore Longitudinal Study of Aging. Blood samples and medical information were collected at the study entry and every 2 years during follow-up visits. The WBC count and all-cause, cardiovascular, and cancer mortality were assessed.METHODSOne thousand eighty-three women and 1,720 men were evaluated longitudinally in the Baltimore Longitudinal Study of Aging. Blood samples and medical information were collected at the study entry and every 2 years during follow-up visits. The WBC count and all-cause, cardiovascular, and cancer mortality were assessed.A downward trend in WBC count was observed from 1958 to 2002. The secular downward trend was independent of age, gender, race, smoking, body mass index, and physical activity. The WBC count was nonlinearly associated with all-cause mortality and almost linearly associated with cardiovascular mortality. Participants with baseline WBC <3,500 cells/mm3 and WBC >6,000 cells/mm3 had higher mortality than those with 3,500 to 6,000 WBC/mm3. Within each WBC group, age-adjusted mortality rates declined in successive cohorts from the 1960s to the 1990s. Participants who died had higher WBC than those who survived, and the difference was statistically significant within 5 years before death.RESULTSA downward trend in WBC count was observed from 1958 to 2002. The secular downward trend was independent of age, gender, race, smoking, body mass index, and physical activity. The WBC count was nonlinearly associated with all-cause mortality and almost linearly associated with cardiovascular mortality. Participants with baseline WBC <3,500 cells/mm3 and WBC >6,000 cells/mm3 had higher mortality than those with 3,500 to 6,000 WBC/mm3. Within each WBC group, age-adjusted mortality rates declined in successive cohorts from the 1960s to the 1990s. Participants who died had higher WBC than those who survived, and the difference was statistically significant within 5 years before death.Our study provides evidence for a secular downward trend in WBC count over the period from 1958 to 2002. Higher WBC counts are associated with higher mortality in successive cohorts. We found no evidence that the decline of age-specific mortality rates that occurred from 1960 to 2000 was attributable to a secular downward trend in WBC.CONCLUSIONSOur study provides evidence for a secular downward trend in WBC count over the period from 1958 to 2002. Higher WBC counts are associated with higher mortality in successive cohorts. We found no evidence that the decline of age-specific mortality rates that occurred from 1960 to 2000 was attributable to a secular downward trend in WBC. We investigated the secular trend in white blood cell (WBC) count and the relationship between WBC count and mortality between 1958 and 2002. The WBC count is a clinical marker of inflammation and a strong predictor of mortality. Limited data exist on the WBC count secular trend and the relationship between WBC and mortality. One thousand eighty-three women and 1,720 men were evaluated longitudinally in the Baltimore Longitudinal Study of Aging. Blood samples and medical information were collected at the study entry and every 2 years during follow-up visits. The WBC count and all-cause, cardiovascular, and cancer mortality were assessed. A downward trend in WBC count was observed from 1958 to 2002. The secular downward trend was independent of age, gender, race, smoking, body mass index, and physical activity. The WBC count was nonlinearly associated with all-cause mortality and almost linearly associated with cardiovascular mortality. Participants with baseline WBC <3,500 cells/mm3 and WBC >6,000 cells/mm3 had higher mortality than those with 3,500 to 6,000 WBC/mm3. Within each WBC group, age-adjusted mortality rates declined in successive cohorts from the 1960s to the 1990s. Participants who died had higher WBC than those who survived, and the difference was statistically significant within 5 years before death. Our study provides evidence for a secular downward trend in WBC count over the period from 1958 to 2002. Higher WBC counts are associated with higher mortality in successive cohorts. We found no evidence that the decline of age-specific mortality rates that occurred from 1960 to 2000 was attributable to a secular downward trend in WBC.
Author	Cherubini, Antonio Maggio, Marcello Metter, E Jeffrey Sen, Ranjan Windham, Gwen B Ruggiero, Carmelinda Najjar, Samer S Senin, Umberto Ble, Alessandro Ferrucci, Luigi
Author_xml	– sequence: 1 givenname: Carmelinda surname: Ruggiero fullname: Ruggiero, Carmelinda email: ruggieroc07@hotmail.it organization: Longitudinal Studies Section, Clinical Research Branch, National Institute on Aging, National Institutes of Health, Baltimore, Maryland 21225, USA. ruggieroc07@hotmail.it – sequence: 2 givenname: E Jeffrey surname: Metter fullname: Metter, E Jeffrey – sequence: 3 givenname: Antonio surname: Cherubini fullname: Cherubini, Antonio – sequence: 4 givenname: Marcello surname: Maggio fullname: Maggio, Marcello – sequence: 5 givenname: Ranjan surname: Sen fullname: Sen, Ranjan – sequence: 6 givenname: Samer S surname: Najjar fullname: Najjar, Samer S – sequence: 7 givenname: Gwen B surname: Windham fullname: Windham, Gwen B – sequence: 8 givenname: Alessandro surname: Ble fullname: Ble, Alessandro – sequence: 9 givenname: Umberto surname: Senin fullname: Senin, Umberto – sequence: 10 givenname: Luigi surname: Ferrucci fullname: Ferrucci, Luigi
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SubjectTerms	Baltimore - epidemiology Body Mass Index Cardiovascular Diseases - blood Cardiovascular Diseases - mortality Cause of Death Female Humans Leukocyte Count Longitudinal Studies Male Mortality Proportional Hazards Models Survival Analysis
Title	White blood cell count and mortality in the Baltimore Longitudinal Study of Aging
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