IGFBP-1 and IGFBP-2 are associated with a decreased pulse-wave velocity in young, healthy adults
Background and aims In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular health of the subjects. The aim was to identify proteins with a relationship to the early atherosclerotic process in healthy individuals. Methods...
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| Vydáno v: | BMC cardiovascular disorders Ročník 21; číslo 1; s. 131 - 8 |
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| Hlavní autoři: | , , , |
| Médium: | Journal Article |
| Jazyk: | angličtina |
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London
BioMed Central
11.03.2021
BioMed Central Ltd Springer Nature B.V BMC |
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| ISSN: | 1471-2261, 1471-2261 |
| On-line přístup: | Získat plný text |
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| Abstract | Background and aims
In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular health of the subjects. The aim was to identify proteins with a relationship to the early atherosclerotic process in healthy individuals.
Methods
We employed the proximity extension assay from OLINK proteomics to analyze 92 cardiovascular disease (CVD) related proteins on 833 subjects (men and women, ages 18–26). The women were further divided into an estrogen-using group and non-users. Protein expression was analyzed using principal component analysis (PCA). The following vascular examinations were performed: Pulse-wave velocity (PWV), augmentation index (AIX), carotid-intima media thickness (cIMT).
Results
Three principal components were obtained using PCA to analyze the protein expression. None of the obtained principal components correlated significantly with AIX or cIMT. One of the components, explaining 6% of the total variance of the data, was significantly correlated with PWV. Upon examination of the proteins with the highest factor loadings on this component independently in a multivariable model, adjusting for established CVD risk biomarkers, insulin-like growth factor-binding protein 1 (IGFBP-1) and insulin-like growth factor-binding protein 2 (IGFBP-2) were found to independently, negatively correlate with PWV. Among the established risk factors included in the multivariable model, age was significantly and adversely correlated with all vascular measurements.
Conclusions
In this population of healthy, young adults, groups of CVD related proteins correlate with PWV, but not AIX or cIMT. This group of proteins, of which IGFBP-1 and IGFBP-2 were independently, negatively correlated in a multivariable model with PWV, could have benificial effects on vascular stiffness. The robust association between age and PWV, AIX and cIMT provide insight into the impact of aging on the vasculature, which is detectable even in a population of young, healthy, non-smoking individuals of ages spanning only 8 years. |
|---|---|
| AbstractList | Background and aims In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular health of the subjects. The aim was to identify proteins with a relationship to the early atherosclerotic process in healthy individuals. Methods We employed the proximity extension assay from OLINK proteomics to analyze 92 cardiovascular disease (CVD) related proteins on 833 subjects (men and women, ages 18-26). The women were further divided into an estrogen-using group and non-users. Protein expression was analyzed using principal component analysis (PCA). The following vascular examinations were performed: Pulse-wave velocity (PWV), augmentation index (AIX), carotid-intima media thickness (cIMT). Results Three principal components were obtained using PCA to analyze the protein expression. None of the obtained principal components correlated significantly with AIX or cIMT. One of the components, explaining 6% of the total variance of the data, was significantly correlated with PWV. Upon examination of the proteins with the highest factor loadings on this component independently in a multivariable model, adjusting for established CVD risk biomarkers, insulin-like growth factor-binding protein 1 (IGFBP-1) and insulin-like growth factor-binding protein 2 (IGFBP-2) were found to independently, negatively correlate with PWV. Among the established risk factors included in the multivariable model, age was significantly and adversely correlated with all vascular measurements. Conclusions In this population of healthy, young adults, groups of CVD related proteins correlate with PWV, but not AIX or cIMT. This group of proteins, of which IGFBP-1 and IGFBP-2 were independently, negatively correlated in a multivariable model with PWV, could have benificial effects on vascular stiffness. The robust association between age and PWV, AIX and cIMT provide insight into the impact of aging on the vasculature, which is detectable even in a population of young, healthy, non-smoking individuals of ages spanning only 8 years. Keywords: Proteomics, Principal component analysis, cIMT, Vascular stiffness BACKGROUND AND AIMS: In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular health of the subjects. The aim was to identify proteins with a relationship to the early atherosclerotic process in healthy individuals. METHODS: We employed the proximity extension assay from OLINK proteomics to analyze 92 cardiovascular disease (CVD) related proteins on 833 subjects (men and women, ages 18-26). The women were further divided into an estrogen-using group and non-users. Protein expression was analyzed using principal component analysis (PCA). The following vascular examinations were performed: Pulse-wave velocity (PWV), augmentation index (AIX), carotid-intima media thickness (cIMT). RESULTS: Three principal components were obtained using PCA to analyze the protein expression. None of the obtained principal components correlated significantly with AIX or cIMT. One of the components, explaining 6% of the total variance of the data, was significantly correlated with PWV. Upon examination of the proteins with the highest factor loadings on this component independently in a multivariable model, adjusting for established CVD risk biomarkers, insulin-like growth factor-binding protein 1 (IGFBP-1) and insulin-like growth factor-binding protein 2 (IGFBP-2) were found to independently, negatively correlate with PWV. Among the established risk factors included in the multivariable model, age was significantly and adversely correlated with all vascular measurements. CONCLUSIONS: In this population of healthy, young adults, groups of CVD related proteins correlate with PWV, but not AIX or cIMT. This group of proteins, of which IGFBP-1 and IGFBP-2 were independently, negatively correlated in a multivariable model with PWV, could have benificial effects on vascular stiffness. The robust association between age and PWV, AIX and cIMT provide insight into the impact of aging on the vasculature, which is detectable even in a population of young, healthy, non-smoking individuals of ages spanning only 8 years. Abstract Background and aims In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular health of the subjects. The aim was to identify proteins with a relationship to the early atherosclerotic process in healthy individuals. Methods We employed the proximity extension assay from OLINK proteomics to analyze 92 cardiovascular disease (CVD) related proteins on 833 subjects (men and women, ages 18–26). The women were further divided into an estrogen-using group and non-users. Protein expression was analyzed using principal component analysis (PCA). The following vascular examinations were performed: Pulse-wave velocity (PWV), augmentation index (AIX), carotid-intima media thickness (cIMT). Results Three principal components were obtained using PCA to analyze the protein expression. None of the obtained principal components correlated significantly with AIX or cIMT. One of the components, explaining 6% of the total variance of the data, was significantly correlated with PWV. Upon examination of the proteins with the highest factor loadings on this component independently in a multivariable model, adjusting for established CVD risk biomarkers, insulin-like growth factor-binding protein 1 (IGFBP-1) and insulin-like growth factor-binding protein 2 (IGFBP-2) were found to independently, negatively correlate with PWV. Among the established risk factors included in the multivariable model, age was significantly and adversely correlated with all vascular measurements. Conclusions In this population of healthy, young adults, groups of CVD related proteins correlate with PWV, but not AIX or cIMT. This group of proteins, of which IGFBP-1 and IGFBP-2 were independently, negatively correlated in a multivariable model with PWV, could have benificial effects on vascular stiffness. The robust association between age and PWV, AIX and cIMT provide insight into the impact of aging on the vasculature, which is detectable even in a population of young, healthy, non-smoking individuals of ages spanning only 8 years. In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular health of the subjects. The aim was to identify proteins with a relationship to the early atherosclerotic process in healthy individuals. We employed the proximity extension assay from OLINK proteomics to analyze 92 cardiovascular disease (CVD) related proteins on 833 subjects (men and women, ages 18-26). The women were further divided into an estrogen-using group and non-users. Protein expression was analyzed using principal component analysis (PCA). The following vascular examinations were performed: Pulse-wave velocity (PWV), augmentation index (AIX), carotid-intima media thickness (cIMT). Three principal components were obtained using PCA to analyze the protein expression. None of the obtained principal components correlated significantly with AIX or cIMT. One of the components, explaining 6% of the total variance of the data, was significantly correlated with PWV. Upon examination of the proteins with the highest factor loadings on this component independently in a multivariable model, adjusting for established CVD risk biomarkers, insulin-like growth factor-binding protein 1 (IGFBP-1) and insulin-like growth factor-binding protein 2 (IGFBP-2) were found to independently, negatively correlate with PWV. Among the established risk factors included in the multivariable model, age was significantly and adversely correlated with all vascular measurements. In this population of healthy, young adults, groups of CVD related proteins correlate with PWV, but not AIX or cIMT. This group of proteins, of which IGFBP-1 and IGFBP-2 were independently, negatively correlated in a multivariable model with PWV, could have benificial effects on vascular stiffness. The robust association between age and PWV, AIX and cIMT provide insight into the impact of aging on the vasculature, which is detectable even in a population of young, healthy, non-smoking individuals of ages spanning only 8 years. Background and aims In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular health of the subjects. The aim was to identify proteins with a relationship to the early atherosclerotic process in healthy individuals. Methods We employed the proximity extension assay from OLINK proteomics to analyze 92 cardiovascular disease (CVD) related proteins on 833 subjects (men and women, ages 18–26). The women were further divided into an estrogen-using group and non-users. Protein expression was analyzed using principal component analysis (PCA). The following vascular examinations were performed: Pulse-wave velocity (PWV), augmentation index (AIX), carotid-intima media thickness (cIMT). Results Three principal components were obtained using PCA to analyze the protein expression. None of the obtained principal components correlated significantly with AIX or cIMT. One of the components, explaining 6% of the total variance of the data, was significantly correlated with PWV. Upon examination of the proteins with the highest factor loadings on this component independently in a multivariable model, adjusting for established CVD risk biomarkers, insulin-like growth factor-binding protein 1 (IGFBP-1) and insulin-like growth factor-binding protein 2 (IGFBP-2) were found to independently, negatively correlate with PWV. Among the established risk factors included in the multivariable model, age was significantly and adversely correlated with all vascular measurements. Conclusions In this population of healthy, young adults, groups of CVD related proteins correlate with PWV, but not AIX or cIMT. This group of proteins, of which IGFBP-1 and IGFBP-2 were independently, negatively correlated in a multivariable model with PWV, could have benificial effects on vascular stiffness. The robust association between age and PWV, AIX and cIMT provide insight into the impact of aging on the vasculature, which is detectable even in a population of young, healthy, non-smoking individuals of ages spanning only 8 years. In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular health of the subjects. The aim was to identify proteins with a relationship to the early atherosclerotic process in healthy individuals.BACKGROUND AND AIMSIn healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular health of the subjects. The aim was to identify proteins with a relationship to the early atherosclerotic process in healthy individuals.We employed the proximity extension assay from OLINK proteomics to analyze 92 cardiovascular disease (CVD) related proteins on 833 subjects (men and women, ages 18-26). The women were further divided into an estrogen-using group and non-users. Protein expression was analyzed using principal component analysis (PCA). The following vascular examinations were performed: Pulse-wave velocity (PWV), augmentation index (AIX), carotid-intima media thickness (cIMT).METHODSWe employed the proximity extension assay from OLINK proteomics to analyze 92 cardiovascular disease (CVD) related proteins on 833 subjects (men and women, ages 18-26). The women were further divided into an estrogen-using group and non-users. Protein expression was analyzed using principal component analysis (PCA). The following vascular examinations were performed: Pulse-wave velocity (PWV), augmentation index (AIX), carotid-intima media thickness (cIMT).Three principal components were obtained using PCA to analyze the protein expression. None of the obtained principal components correlated significantly with AIX or cIMT. One of the components, explaining 6% of the total variance of the data, was significantly correlated with PWV. Upon examination of the proteins with the highest factor loadings on this component independently in a multivariable model, adjusting for established CVD risk biomarkers, insulin-like growth factor-binding protein 1 (IGFBP-1) and insulin-like growth factor-binding protein 2 (IGFBP-2) were found to independently, negatively correlate with PWV. Among the established risk factors included in the multivariable model, age was significantly and adversely correlated with all vascular measurements.RESULTSThree principal components were obtained using PCA to analyze the protein expression. None of the obtained principal components correlated significantly with AIX or cIMT. One of the components, explaining 6% of the total variance of the data, was significantly correlated with PWV. Upon examination of the proteins with the highest factor loadings on this component independently in a multivariable model, adjusting for established CVD risk biomarkers, insulin-like growth factor-binding protein 1 (IGFBP-1) and insulin-like growth factor-binding protein 2 (IGFBP-2) were found to independently, negatively correlate with PWV. Among the established risk factors included in the multivariable model, age was significantly and adversely correlated with all vascular measurements.In this population of healthy, young adults, groups of CVD related proteins correlate with PWV, but not AIX or cIMT. This group of proteins, of which IGFBP-1 and IGFBP-2 were independently, negatively correlated in a multivariable model with PWV, could have benificial effects on vascular stiffness. The robust association between age and PWV, AIX and cIMT provide insight into the impact of aging on the vasculature, which is detectable even in a population of young, healthy, non-smoking individuals of ages spanning only 8 years.CONCLUSIONSIn this population of healthy, young adults, groups of CVD related proteins correlate with PWV, but not AIX or cIMT. This group of proteins, of which IGFBP-1 and IGFBP-2 were independently, negatively correlated in a multivariable model with PWV, could have benificial effects on vascular stiffness. The robust association between age and PWV, AIX and cIMT provide insight into the impact of aging on the vasculature, which is detectable even in a population of young, healthy, non-smoking individuals of ages spanning only 8 years. Background and aims: In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular health of the subjects. The aim was to identify proteins with a relationship to the early atherosclerotic process in healthy individuals. Methods: We employed the proximity extension assay from OLINK proteomics to analyze 92 cardiovascular disease (CVD) related proteins on 833 subjects (men and women, ages 18–26). The women were further divided into an estrogen-using group and non-users. Protein expression was analyzed using principal component analysis (PCA). The following vascular examinations were performed: Pulse-wave velocity (PWV), augmentation index (AIX), carotid-intima media thickness (cIMT). Results: Three principal components were obtained using PCA to analyze the protein expression. None of the obtained principal components correlated significantly with AIX or cIMT. One of the components, explaining 6% of the total variance of the data, was significantly correlated with PWV. Upon examination of the proteins with the highest factor loadings on this component independently in a multivariable model, adjusting for established CVD risk biomarkers, insulin-like growth factor-binding protein 1 (IGFBP-1) and insulin-like growth factor-binding protein 2 (IGFBP-2) were found to independently, negatively correlate with PWV. Among the established risk factors included in the multivariable model, age was significantly and adversely correlated with all vascular measurements. Conclusions: In this population of healthy, young adults, groups of CVD related proteins correlate with PWV, but not AIX or cIMT. This group of proteins, of which IGFBP-1 and IGFBP-2 were independently, negatively correlated in a multivariable model with PWV, could have benificial effects on vascular stiffness. The robust association between age and PWV, AIX and cIMT provide insight into the impact of aging on the vasculature, which is detectable even in a population of young, healthy, non-smoking individuals of ages spanning only 8 years. In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular health of the subjects. The aim was to identify proteins with a relationship to the early atherosclerotic process in healthy individuals. We employed the proximity extension assay from OLINK proteomics to analyze 92 cardiovascular disease (CVD) related proteins on 833 subjects (men and women, ages 18-26). The women were further divided into an estrogen-using group and non-users. Protein expression was analyzed using principal component analysis (PCA). The following vascular examinations were performed: Pulse-wave velocity (PWV), augmentation index (AIX), carotid-intima media thickness (cIMT). Three principal components were obtained using PCA to analyze the protein expression. None of the obtained principal components correlated significantly with AIX or cIMT. One of the components, explaining 6% of the total variance of the data, was significantly correlated with PWV. Upon examination of the proteins with the highest factor loadings on this component independently in a multivariable model, adjusting for established CVD risk biomarkers, insulin-like growth factor-binding protein 1 (IGFBP-1) and insulin-like growth factor-binding protein 2 (IGFBP-2) were found to independently, negatively correlate with PWV. Among the established risk factors included in the multivariable model, age was significantly and adversely correlated with all vascular measurements. In this population of healthy, young adults, groups of CVD related proteins correlate with PWV, but not AIX or cIMT. This group of proteins, of which IGFBP-1 and IGFBP-2 were independently, negatively correlated in a multivariable model with PWV, could have benificial effects on vascular stiffness. The robust association between age and PWV, AIX and cIMT provide insight into the impact of aging on the vasculature, which is detectable even in a population of young, healthy, non-smoking individuals of ages spanning only 8 years. Background and aims In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular health of the subjects. The aim was to identify proteins with a relationship to the early atherosclerotic process in healthy individuals. Methods We employed the proximity extension assay from OLINK proteomics to analyze 92 cardiovascular disease (CVD) related proteins on 833 subjects (men and women, ages 18–26). The women were further divided into an estrogen-using group and non-users. Protein expression was analyzed using principal component analysis (PCA). The following vascular examinations were performed: Pulse-wave velocity (PWV), augmentation index (AIX), carotid-intima media thickness (cIMT). Results Three principal components were obtained using PCA to analyze the protein expression. None of the obtained principal components correlated significantly with AIX or cIMT. One of the components, explaining 6% of the total variance of the data, was significantly correlated with PWV. Upon examination of the proteins with the highest factor loadings on this component independently in a multivariable model, adjusting for established CVD risk biomarkers, insulin-like growth factor-binding protein 1 (IGFBP-1) and insulin-like growth factor-binding protein 2 (IGFBP-2) were found to independently, negatively correlate with PWV. Among the established risk factors included in the multivariable model, age was significantly and adversely correlated with all vascular measurements. Conclusions In this population of healthy, young adults, groups of CVD related proteins correlate with PWV, but not AIX or cIMT. This group of proteins, of which IGFBP-1 and IGFBP-2 were independently, negatively correlated in a multivariable model with PWV, could have benificial effects on vascular stiffness. The robust association between age and PWV, AIX and cIMT provide insight into the impact of aging on the vasculature, which is detectable even in a population of young, healthy, non-smoking individuals of ages spanning only 8 years. |
| ArticleNumber | 131 |
| Audience | Academic |
| Author | Breimer, Lars H. Pettersson-Pablo, Paul Nilsson, Torbjörn K. Hurtig-Wennlöf, Anita |
| Author_xml | – sequence: 1 givenname: Paul surname: Pettersson-Pablo fullname: Pettersson-Pablo, Paul email: paul.pettersson-pablo@regionorebrolan.se organization: Department of Laboratory Medicine, Clinical Chemistry, Faculty of Medicine and Health, Örebro University Hospital, School of Medicine, Faculty of Medicine and Health, Örebro University, Department of Medical Biosciences/Clinical Chemistry, Umeå University – sequence: 2 givenname: Torbjörn K. surname: Nilsson fullname: Nilsson, Torbjörn K. organization: Department of Medical Biosciences/Clinical Chemistry, Umeå University – sequence: 3 givenname: Lars H. surname: Breimer fullname: Breimer, Lars H. organization: Department of Laboratory Medicine, Clinical Chemistry, Faculty of Medicine and Health, Örebro University Hospital, School of Medicine, Faculty of Medicine and Health, Örebro University – sequence: 4 givenname: Anita surname: Hurtig-Wennlöf fullname: Hurtig-Wennlöf, Anita organization: School of Health, Faculty of Medicine and Health, Örebro University, The Biomedical platform, Department of Natural Science and Biomedicine, School of Health and Welfare, Jönköping University |
| BackLink | https://www.ncbi.nlm.nih.gov/pubmed/33706704$$D View this record in MEDLINE/PubMed https://urn.kb.se/resolve?urn=urn:nbn:se:hj:diva-52064$$DView record from Swedish Publication Index (Högskolan i Jönköping) https://urn.kb.se/resolve?urn=urn:nbn:se:oru:diva-90459$$DView record from Swedish Publication Index (Örebro universitet) https://urn.kb.se/resolve?urn=urn:nbn:se:umu:diva-181792$$DView record from Swedish Publication Index (Umeå universitet) |
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| CitedBy_id | crossref_primary_10_1016_j_numecd_2023_05_030 crossref_primary_10_1017_S1047951124000076 crossref_primary_10_1186_s12872_024_03765_7 crossref_primary_10_1016_j_atherosclerosis_2024_118613 crossref_primary_10_1016_j_mvr_2022_104423 |
| Cites_doi | 10.1007/BF00280883 10.1136/hrt.2006.090092 10.1093/eurheartj/ehx144 10.1002/clc.22934 10.1210/jc.2009-1508 10.1016/j.annepidem.2005.09.005 10.2337/db12-1753 10.1016/j.jacc.2009.10.061 10.1177/2047487317720796 10.1007/s12079-015-0261-2 10.1093/eurheartj/ehu049 10.1161/RES.0b013e31824da8ad 10.1007/s11892-017-0955-3 10.1159/000330699 10.1152/ajpheart.00655.2013 10.4070/kcj.2015.45.1.44 10.1007/s11845-018-1835-9 10.1097/MOL.0000000000000237 10.1097/HJH.0b013e328346a5af 10.2147/VHRM.S125966 10.1161/01.CIR.0000131515.03336.f8 10.1210/er.2001-0033 10.1038/oby.2012.90 10.1186/s12872-019-1167-3 10.1161/JAHA.118.011852 10.1016/j.atherosclerosis.2014.09.022 10.1002/jcp.21123 10.1016/j.ijcard.2017.03.101 10.1038/s41371-020-00453-9 10.1210/er.2007-0036 10.1007/s00125-017-4442-9 10.1016/j.ghir.2011.04.003 10.1016/j.carpath.2012.02.003 10.1507/endocrj.EJ11-0358 10.3109/14017431.2014.891760 10.1093/eurheartj/ehs380 10.1097/HJH.0000000000000012 10.1038/nrm1203 10.1155/2018/4670521 10.1177/2047487317720287 10.1161/01.CIR.100.7.717 10.1093/nar/gkr424 |
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| Keywords | cIMT Vascular stiffness Proteomics Principal component analysis |
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| License | Open AccessThis article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons licence, and indicate if changes were made. The images or other third party material in this article are included in the article's Creative Commons licence, unless indicated otherwise in a credit line to the material. If material is not included in the article's Creative Commons licence and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this licence, visit http://creativecommons.org/licenses/by/4.0/. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated in a credit line to the data. |
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| References | A Gohar (1914_CR32) 2017; 241 LK Er (1914_CR34) 2018; 2018 1914_CR42 DJ Degraff (1914_CR23) 2007; 213 R Perrault (1914_CR37) 2019; 19 U Fernberg (1914_CR13) 2017; 24 H Johnen (1914_CR33) 2012; 21 M Cushman (1914_CR11) 1999; 100 SW Yau (1914_CR21) 2015; 9 DR Matthews (1914_CR17) 1985; 28 M Lundberg (1914_CR18) 2011; 39 K Brandt (1914_CR22) 2011; 21 D Taupin (1914_CR30) 2003; 4 ST Vernon (1914_CR5) 2017; 24 G Urbonaviciene (1914_CR28) 2014; 48 Z Li (1914_CR27) 2012; 20 A Giustina (1914_CR19) 2008; 29 SP Dongerkery (1914_CR15) 2017; 17 A Yu (1914_CR41) 2014; 32 JM Ko (1914_CR26) 2012; 59 BC Astor (1914_CR31) 2011; 34 M Fernstrom (1914_CR12) 2017; 13 R Verbeek (1914_CR14) 2015; 26 MJ Van Trijp (1914_CR35) 2006; 16 KN Bachmann (1914_CR7) 2018; 61 S Hassfeld (1914_CR29) 2007; 93 JP Ioannidis (1914_CR8) 2012; 110 1914_CR10 ICL van den Munckhof (1914_CR38) 2018; 41 1914_CR39 1914_CR16 S Carter (1914_CR24) 2014; 237 1914_CR2 K King (1914_CR4) 2019; 188 SW de Kort (1914_CR25) 2010; 95 C Vlachopoulos (1914_CR3) 2010; 55 S Gall (1914_CR1) 2014; 35 M Juonala (1914_CR6) 2019; 8 SM Gordon (1914_CR9) 2013; 62 CL Dinardo (1914_CR36) 2014; 306 SK Cho (1914_CR40) 2015; 45 SM Firth (1914_CR20) 2002; 23 |
| References_xml | – volume: 28 start-page: 412 issue: 7 year: 1985 ident: 1914_CR17 publication-title: Diabetologia doi: 10.1007/BF00280883 – volume: 93 start-page: 359 issue: 3 year: 2007 ident: 1914_CR29 publication-title: Heart doi: 10.1136/hrt.2006.090092 – ident: 1914_CR16 doi: 10.1093/eurheartj/ehx144 – volume: 41 start-page: 698 issue: 5 year: 2018 ident: 1914_CR38 publication-title: Clin Cardiol doi: 10.1002/clc.22934 – volume: 95 start-page: 864 issue: 2 year: 2010 ident: 1914_CR25 publication-title: J Clin Endocrinol Metab doi: 10.1210/jc.2009-1508 – volume: 16 start-page: 71 issue: 2 year: 2006 ident: 1914_CR35 publication-title: Ann Epidemiol doi: 10.1016/j.annepidem.2005.09.005 – volume: 62 start-page: 2958 issue: 8 year: 2013 ident: 1914_CR9 publication-title: Diabetes doi: 10.2337/db12-1753 – volume: 55 start-page: 1318 issue: 13 year: 2010 ident: 1914_CR3 publication-title: J Am Coll Cardiol doi: 10.1016/j.jacc.2009.10.061 – volume: 24 start-page: 1809 issue: 17 year: 2017 ident: 1914_CR13 publication-title: Eur J Prev Cardiol doi: 10.1177/2047487317720796 – volume: 9 start-page: 125 issue: 2 year: 2015 ident: 1914_CR21 publication-title: J Cell Commun Signal doi: 10.1007/s12079-015-0261-2 – volume: 35 start-page: 2484 issue: 36 year: 2014 ident: 1914_CR1 publication-title: Eur Heart J doi: 10.1093/eurheartj/ehu049 – volume: 110 start-page: 658 issue: 5 year: 2012 ident: 1914_CR8 publication-title: Circ Res doi: 10.1161/RES.0b013e31824da8ad – volume: 17 start-page: 120 issue: 12 year: 2017 ident: 1914_CR15 publication-title: Curr Diab Rep doi: 10.1007/s11892-017-0955-3 – volume: 34 start-page: 291 issue: 4 year: 2011 ident: 1914_CR31 publication-title: Am J Nephrol doi: 10.1159/000330699 – volume: 306 start-page: H505 issue: 4 year: 2014 ident: 1914_CR36 publication-title: Am J Physiol Heart Circ Physiol doi: 10.1152/ajpheart.00655.2013 – volume: 45 start-page: 44 issue: 1 year: 2015 ident: 1914_CR40 publication-title: Korean Circ J doi: 10.4070/kcj.2015.45.1.44 – volume: 188 start-page: 179 issue: 1 year: 2019 ident: 1914_CR4 publication-title: Ir J Med Sci doi: 10.1007/s11845-018-1835-9 – volume: 26 start-page: 502 issue: 6 year: 2015 ident: 1914_CR14 publication-title: Curr Opin Lipidol doi: 10.1097/MOL.0000000000000237 – ident: 1914_CR42 doi: 10.1097/HJH.0b013e328346a5af – volume: 13 start-page: 91 year: 2017 ident: 1914_CR12 publication-title: Vasc Health Risk Manag doi: 10.2147/VHRM.S125966 – ident: 1914_CR2 doi: 10.1161/01.CIR.0000131515.03336.f8 – volume: 23 start-page: 824 issue: 6 year: 2002 ident: 1914_CR20 publication-title: Endocr Rev doi: 10.1210/er.2001-0033 – volume: 20 start-page: 1469 issue: 7 year: 2012 ident: 1914_CR27 publication-title: Obesity (Silver Spring) doi: 10.1038/oby.2012.90 – volume: 19 start-page: 190 issue: 1 year: 2019 ident: 1914_CR37 publication-title: BMC Cardiovasc Disord doi: 10.1186/s12872-019-1167-3 – volume: 8 start-page: e011852 issue: 14 year: 2019 ident: 1914_CR6 publication-title: J Am Heart Assoc doi: 10.1161/JAHA.118.011852 – volume: 237 start-page: 645 issue: 2 year: 2014 ident: 1914_CR24 publication-title: Atherosclerosis doi: 10.1016/j.atherosclerosis.2014.09.022 – volume: 213 start-page: 261 issue: 1 year: 2007 ident: 1914_CR23 publication-title: J Cell Physiol doi: 10.1002/jcp.21123 – volume: 241 start-page: 430 year: 2017 ident: 1914_CR32 publication-title: Int J Cardiol doi: 10.1016/j.ijcard.2017.03.101 – ident: 1914_CR10 doi: 10.1038/s41371-020-00453-9 – volume: 29 start-page: 535 issue: 5 year: 2008 ident: 1914_CR19 publication-title: Endocr Rev doi: 10.1210/er.2007-0036 – volume: 61 start-page: 987 issue: 5 year: 2018 ident: 1914_CR7 publication-title: Diabetologia doi: 10.1007/s00125-017-4442-9 – volume: 21 start-page: 167 issue: 3 year: 2011 ident: 1914_CR22 publication-title: Growth Horm IGF Res doi: 10.1016/j.ghir.2011.04.003 – volume: 21 start-page: 499 issue: 6 year: 2012 ident: 1914_CR33 publication-title: Cardiovasc Pathol doi: 10.1016/j.carpath.2012.02.003 – volume: 59 start-page: 335 issue: 4 year: 2012 ident: 1914_CR26 publication-title: Endocr J doi: 10.1507/endocrj.EJ11-0358 – volume: 48 start-page: 99 issue: 2 year: 2014 ident: 1914_CR28 publication-title: Scand Cardiovasc J doi: 10.3109/14017431.2014.891760 – ident: 1914_CR39 doi: 10.1093/eurheartj/ehs380 – volume: 32 start-page: 100 issue: 1 year: 2014 ident: 1914_CR41 publication-title: J Hypertens doi: 10.1097/HJH.0000000000000012 – volume: 4 start-page: 721 issue: 9 year: 2003 ident: 1914_CR30 publication-title: Nat Rev Mol Cell Biol doi: 10.1038/nrm1203 – volume: 2018 start-page: 4670521 year: 2018 ident: 1914_CR34 publication-title: Mediators Inflamm doi: 10.1155/2018/4670521 – volume: 24 start-page: 1824 issue: 17 year: 2017 ident: 1914_CR5 publication-title: Eur J Prev Cardiol doi: 10.1177/2047487317720287 – volume: 100 start-page: 717 issue: 7 year: 1999 ident: 1914_CR11 publication-title: Circulation doi: 10.1161/01.CIR.100.7.717 – volume: 39 start-page: e102 issue: 15 year: 2011 ident: 1914_CR18 publication-title: Nucleic Acids Res doi: 10.1093/nar/gkr424 |
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In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular... In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular health of the subjects.... Background and aims In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular... In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular health of the subjects.... Background and aims: In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular... BACKGROUND AND AIMS: In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the vascular... Abstract Background and aims In healthy, young adults we analyzed a panel of cardiovascular disease related proteins in plasma and compared them with the... |
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| SubjectTerms | Age Aging Angiology Apolipoproteins Arteriosclerosis Atherosclerosis Biomarkers Birth control Blood pressure Blood Transfusion Medicine Body fat Cardiac Surgery Cardiology Cardiovascular diseases Carrier proteins cIMT Diabetes Estrogens Family medical history Glucose Health aspects Insulin Insulin resistance Insulin-like growth factor-binding protein 1 Insulin-like growth factor-binding protein 2 Internal Medicine Medicine Medicine & Public Health Physiological aspects Plasma Population Principal component analysis Principal components analysis Protein expression Proteins Proteomics Regression analysis Research Article Risk assessment Risk factors Vascular stiffness Velocity Women Young adults |
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