The Plasticity of Dendritic Cell Responses to Pathogens and Their Components

Dendritic cells are involved in the initiation of both innate and adaptive immunity. To systematically explore how dendritic cells modulate the immune system in response to different pathogens, we used oligonucleotide microarrays to measure gene expression profiles of dendritic cells in response to...

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Vydáno v:	Science (American Association for the Advancement of Science) Ročník 294; číslo 5543; s. 870 - 875
Hlavní autoři:	Huang, Qian, Liu, Dongyu, Majewski, Paul, Schulte, Leah C., Korn, Joshua M., Young, Richard A., Lander, Eric S., Hacohen, Nir
Médium:	Journal Article
Jazyk:	angličtina
Vydáno:	Washington, DC American Society for the Advancement of Science 26.10.2001 American Association for the Advancement of Science The American Association for the Advancement of Science
Témata:	Antigen presentation Antigen Presentation - genetics Antigen presenting cells Bacteriology Biological and medical sciences Candida albicans Candida albicans - immunology Cells Cells, Cultured Cytokines Dendritic cells Dendritic Cells - immunology Dendritic Cells - metabolism DNA microarrays Escherichia coli Escherichia coli - immunology Feedback (Response) Fundamental and applied biological sciences. Psychology Gene expression Gene Expression Profiling Gene Expression Regulation Genes Genetic aspects Genetics Humans Immune system Immunity, Innate Immunologic Factors - genetics Immunologic research Immunological research Inflammation - immunology Influenza A virus - immunology Influenza virus Leukocytes - immunology Lipopolysaccharides - immunology Logical Thinking Lymph nodes Mannans - immunology Microbiology Migration Oligonucleotide Array Sequence Analysis Pathogenic microorganisms Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains Pathogens Pattern Recognition Phagocytosis RNA, Double-Stranded - immunology T lymphocytes Up regulation United States Candida albicans Dendritic cell Yeast Immune response Escherichia coli Orthomyxoviridae Host agent relation Gene expression Influenzavirus Host virus relation Fungi Virus Plasticity Bacteria Fungi Imperfecti Enterobacteriaceae Thallophyta
ISSN:	0036-8075, 1095-9203
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Popis
Shrnutí:	Dendritic cells are involved in the initiation of both innate and adaptive immunity. To systematically explore how dendritic cells modulate the immune system in response to different pathogens, we used oligonucleotide microarrays to measure gene expression profiles of dendritic cells in response to Escherichia coli, Candida albicans, and influenza virus as well as to their molecular components. Both a shared core response and pathogen-specific programs of gene expression were observed upon exposure to each of these pathogens. These results reveal that dendritic cells sense diverse pathogens and elicit tailored pathogen-specific immune responses.
Bibliografie:	SourceType-Scholarly Journals-1 ObjectType-Feature-1 content type line 14 ObjectType-Article-2 content type line 23
ISSN:	0036-8075 1095-9203
DOI:	10.1126/science.294.5543.870