The Plasticity of Dendritic Cell Responses to Pathogens and Their Components

Dendritic cells are involved in the initiation of both innate and adaptive immunity. To systematically explore how dendritic cells modulate the immune system in response to different pathogens, we used oligonucleotide microarrays to measure gene expression profiles of dendritic cells in response to...

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Bibliographic Details
Published in:Science (American Association for the Advancement of Science) Vol. 294; no. 5543; pp. 870 - 875
Main Authors: Huang, Qian, Liu, Dongyu, Majewski, Paul, Schulte, Leah C., Korn, Joshua M., Young, Richard A., Lander, Eric S., Hacohen, Nir
Format: Journal Article
Language:English
Published: Washington, DC American Society for the Advancement of Science 26.10.2001
American Association for the Advancement of Science
The American Association for the Advancement of Science
Subjects:
Antigen presentation
Antigen Presentation - genetics
Antigen presenting cells
Bacteriology
Biological and medical sciences
Candida albicans
Candida albicans - immunology
Cells
Cells, Cultured
Cytokines
Dendritic cells
Dendritic Cells - immunology
Dendritic Cells - metabolism
DNA microarrays
Escherichia coli
Escherichia coli - immunology
Feedback (Response)
Fundamental and applied biological sciences. Psychology
Gene expression
Gene Expression Profiling
Gene Expression Regulation
Genes
Genetic aspects
Genetics
Humans
Immune system
Immunity, Innate
Immunologic Factors - genetics
Immunologic research
Immunological research
Inflammation - immunology
Influenza A virus - immunology
Influenza virus
Leukocytes - immunology
Lipopolysaccharides - immunology
Logical Thinking
Lymph nodes
Mannans - immunology
Microbiology
Migration
Oligonucleotide Array Sequence Analysis
Pathogenic microorganisms
Pathogenicity, virulence, toxins, bacteriocins, pyrogens, host-bacteria relations, miscellaneous strains
Pathogens
Pattern Recognition
Phagocytosis
RNA, Double-Stranded - immunology
T lymphocytes
Up regulation
United States
Candida albicans
Dendritic cell
Yeast
Immune response
Escherichia coli
Orthomyxoviridae
Host agent relation
Gene expression
Influenzavirus
Host virus relation
Fungi
Virus
Plasticity
Bacteria
Fungi Imperfecti
Enterobacteriaceae
Thallophyta
ISSN:0036-8075, 1095-9203
Online Access:Get full text
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Summary:Dendritic cells are involved in the initiation of both innate and adaptive immunity. To systematically explore how dendritic cells modulate the immune system in response to different pathogens, we used oligonucleotide microarrays to measure gene expression profiles of dendritic cells in response to Escherichia coli, Candida albicans, and influenza virus as well as to their molecular components. Both a shared core response and pathogen-specific programs of gene expression were observed upon exposure to each of these pathogens. These results reveal that dendritic cells sense diverse pathogens and elicit tailored pathogen-specific immune responses.
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ISSN:0036-8075
1095-9203
DOI:10.1126/science.294.5543.870