Impaired hepatic amyloid-beta degradation in Alzheimer’s disease

Extensive research strongly suggests that amyloid beta (Aβ) aggregates in the brain have a central role in Alzheimer's disease (AD) pathogenesis. Pathological Aβ deposition is likely due to an altered balance between overproduction and elimination. Rodent studies have suggested that the liver h...

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Veröffentlicht in:	PloS one Jg. 13; H. 9; S. e0203659
Hauptverfasser:	Maarouf, Chera L., Walker, Jessica E., Sue, Lucia I., Dugger, Brittany N., Beach, Thomas G., Serrano, Geidy E.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	United States Public Library of Science 07.09.2018 Public Library of Science (PLoS)
Schlagworte:	Aged, 80 and over Aging Alzheimer Disease - metabolism Alzheimer's disease Amyloid beta-Peptides - chemistry Amyloid beta-Peptides - metabolism Amyloid beta-protein Apolipoprotein E Biology and Life Sciences Blood & organ donations Blood levels Brain Brain research Cathepsin D Degradation Dementia Development and progression Down syndrome Enzymes Female Fluorescein Gene expression Genetic aspects Genotypes Humans Insulin Insulysin Liver Liver - metabolism Male Medical research Medicine and Health Sciences Neprilysin Neuropathology Pathogenesis Pathology Peptides Physiological aspects Protein Aggregates Proteins Proteolysis Research and Analysis Methods Studies Sucrose Working groups United States United States > US Arizona
ISSN:	1932-6203, 1932-6203
Online-Zugang:	Volltext
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