Recombinant activated protein C attenuates coagulopathy and inflammation when administered early in murine pneumococcal pneumonia

Recombinant human activated protein C (APC), which has both anticoagulant and anti-inflammatory properties, improves survival of patients with severe sepsis. This beneficial effect is especially apparent in patients with pneumococcal pneumonia. Earlier treatment with APC in sepsis has been associate...

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Bibliographic Details
Published in:	Thrombosis and haemostasis Vol. 106; no. 6; p. 1189
Main Authors:	Schouten, Marcel, van 't Veer, Cornelis, Roelofs, Joris J T H, Gerlitz, Bruce, Grinnell, Brian W, Levi, Marcel, van der Poll, Tom
Format:	Journal Article
Language:	English
Published:	Germany 01.12.2011
Subjects:	Animals Anti-Inflammatory Agents - administration & dosage Antithrombin III - metabolism Biomarkers - metabolism Blood Coagulation - drug effects Cytokines - metabolism Disease Models, Animal Down-Regulation Fibrin Fibrinogen Degradation Products - metabolism Humans Lung - drug effects Lung - metabolism Lung - pathology Male Mice Mice, Inbred C57BL Peptide Hydrolases - metabolism Pneumonia, Pneumococcal - blood Pneumonia, Pneumococcal - immunology Protein C - administration & dosage Recombinant Proteins - administration & dosage Streptococcus pneumoniae - growth & development Streptococcus pneumoniae - immunology Streptococcus pneumoniae - pathogenicity
ISSN:	0340-6245, 2567-689X, 2567-689X
Online Access:	Get more information
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