A Thermostable Salmonella Phage Endolysin, Lys68, with Broad Bactericidal Properties against Gram-Negative Pathogens in Presence of Weak Acids

Resistance rates are increasing among several problematic Gram-negative pathogens, a fact that has encouraged the development of new antimicrobial agents. This paper characterizes a Salmonella phage endolysin (Lys68) and demonstrates its potential antimicrobial effectiveness when combined with organ...

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Bibliographic Details
Published in:	PloS one Vol. 9; no. 10; p. e108376
Main Authors:	Oliveira, Hugo, Thiagarajan, Viruthachalam, Walmagh, Maarten, Sillankorva, Sanna, Lavigne, Rob, Neves-Petersen, Maria Teresa, Kluskens, Leon D., Azeredo, Joana
Format:	Journal Article
Language:	English
Published:	United States Public Library of Science 07.10.2014 Public Library of Science (PLoS)
Subjects:	Acid resistance Acidity Analysis Anti-Bacterial Agents - chemistry Anti-Bacterial Agents - pharmacology Antimicrobial agents Bacteria Bioengineering Biofilms Biology and Life Sciences Cell Membrane Permeability Circular dichroism Citric acid Citric Acid - pharmacology Conformation Deoxyribonucleic acid Destabilization Dichroism DNA E coli Edetic acid Endopeptidases - chemistry Endopeptidases - genetics Endopeptidases - pharmacology Engineering Enzyme Stability Enzymes Escherichia coli Ethylenediaminetetraacetic acids Food industry Gram-negative bacteria Gram-Negative Bacteria - drug effects Hydrogen-Ion Concentration Hydrolysis Laboratories Malates - pharmacology Malic acid Organic acids Pathogenic microorganisms Pathogens pH effects Phages Protein denaturation Proteins Pseudomonas Salmonella Salmonella Phages - genetics Salmonella Phages - metabolism Thermal denaturation Thermal stability Thermodynamics United Kingdom > UK Belgium United States > US Portugal
ISSN:	1932-6203, 1932-6203
Online Access:	Get full text
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