Genomewide association study for susceptibility genes contributing to familial Parkinson disease

Five genes have been identified that contribute to Mendelian forms of Parkinson disease (PD); however, mutations have been found in fewer than 5% of patients, suggesting that additional genes contribute to disease risk. Unlike previous studies that focused primarily on sporadic PD, we have performed...

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Bibliographic Details
Published in:	Human genetics Vol. 124; no. 6; pp. 593 - 605
Main Authors:	Pankratz, Nathan, Wilk, Jemma B, Latourelle, Jeanne C, DeStefano, Anita L, Halter, Cheryl, Pugh, Elizabeth W, Doheny, Kimberly F, Gusella, James F, Nichols, William C, Foroud, Tatiana, Myers, Richard H
Format:	Journal Article
Language:	English
Published:	Berlin/Heidelberg Berlin/Heidelberg : Springer-Verlag 01.01.2009 Springer-Verlag Springer
Subjects:	Adult Aged alpha-Synuclein - genetics Analysis Biological and medical sciences Biomedical and Life Sciences Biomedicine Case-Control Studies chromosomes Classical genetics, quantitative genetics, hybrids Degenerative and inherited degenerative diseases of the nervous system. Leukodystrophies. Prion diseases Diacylglycerol Kinase - genetics Disease susceptibility Female Fundamental and applied biological sciences. Psychology gender Gene Function Genes Genes, Recessive Genetic aspects Genetic Predisposition to Disease Genetics of eukaryotes. Biological and molecular evolution Genomes genotyping Human Human Genetics Humans Intracellular Signaling Peptides and Proteins - genetics Logistic Models logit analysis Male Medical research Medical sciences Medicine, Experimental meta-analysis Metabolic Diseases Middle Aged Models, Genetic Molecular Medicine Nervous system (semeiology, syndromes) Nervous system as a whole Neurology Original Investigations Parkinson disease Parkinson Disease - genetics Parkinson's disease Polymorphism, Single Nucleotide Protein Serine-Threonine Kinases - genetics risk tau Proteins - genetics Parkinson Disease Genomewide Association Study Parkinson Disease Patient MAPT Region Recessive Model Nervous system diseases Familial disease Sensitivity Association Central nervous system disease Parkinson disease Genetics Degenerative disease Cerebral disorder Extrapyramidal syndrome
ISSN:	0340-6717, 1432-1203, 1432-1203
Online Access:	Get full text
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