Urinary metabolic phenotyping for Alzheimer’s disease

Finding early disease markers using non-invasive and widely available methods is essential to develop a successful therapy for Alzheimer’s Disease. Few studies to date have examined urine, the most readily available biofluid. Here we report the largest study to date using comprehensive metabolic phe...

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Veröffentlicht in:	Scientific reports Jg. 10; H. 1; S. 21745 - 17
Hauptverfasser:	Kurbatova, Natalja, Garg, Manik, Whiley, Luke, Chekmeneva, Elena, Jiménez, Beatriz, Gómez-Romero, María, Pearce, Jake, Kimhofer, Torben, D’Hondt, Ellie, Soininen, Hilkka, Kłoszewska, Iwona, Mecocci, Patrizia, Tsolaki, Magda, Vellas, Bruno, Aarsland, Dag, Nevado-Holgado, Alejo, Liu, Benjamine, Snowden, Stuart, Proitsi, Petroula, Ashton, Nicholas J., Hye, Abdul, Legido-Quigley, Cristina, Lewis, Matthew R., Nicholson, Jeremy K., Holmes, Elaine, Brazma, Alvis, Lovestone, Simon
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 10.12.2020 Nature Publishing Group Nature Portfolio
Schlagworte:	631/61/212 631/61/320 692/53 692/699/375/132 692/699/375/132/1283 Aged Aged, 80 and over Alzheimer Disease - genetics Alzheimer Disease - metabolism Alzheimer Disease - urine Alzheimer's disease amyloid-beta association bile-acids biomarkers Biomarkers - urine Cholesterol Cognitive ability Cognitive Dysfunction - genetics Cognitive Dysfunction - metabolism Cognitive Dysfunction - urine cognitive impairment discovery Female Gene mapping Genetic diversity Genetic variance gut microbiota Humanities and Social Sciences Humans Life Sciences Magnetic resonance spectroscopy Male Metabolism Metabolites Metabolomics Metabolomics - methods mouse models multidisciplinary Neurodegenerative diseases Neurosciences Neurovetenskaper NMR Nuclear magnetic resonance Phenotype Phenotyping pregnenolone sulfate primary biliary-cirrhosis Quantitative Trait Loci Santé publique et épidémiologie Science Science & Technology - Other Topics Science (multidisciplinary) Biomarkers Metabolomics Alzheimer's disease Genomics Dementia
ISSN:	2045-2322, 2045-2322
Online-Zugang:	Volltext
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