Induction of functional dopamine neurons from human astrocytes in vitro and mouse astrocytes in a Parkinson's disease model

In vivo reprogramming of astrocytes to dopamine neurons improves motor behavior in a mouse model of Parkinson's disease. Cell replacement therapies for neurodegenerative disease have focused on transplantation of the cell types affected by the pathological process. Here we describe an alternati...

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Veröffentlicht in:	Nature biotechnology Jg. 35; H. 5; S. 444 - 452
Hauptverfasser:	Rivetti di Val Cervo, Pia, Romanov, Roman A, Spigolon, Giada, Masini, Débora, Martín-Montañez, Elisa, Toledo, Enrique M, La Manno, Gioele, Feyder, Michael, Pifl, Christian, Ng, Yi-Han, Sánchez, Sara Padrell, Linnarsson, Sten, Wernig, Marius, Harkany, Tibor, Fisone, Gilberto, Arenas, Ernest
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	New York Springer New York 01.05.2017 Nature Publishing Group
Schlagworte:	13/106 13/51 14/1 14/19 14/34 14/63 38/39 38/77 38/91 631/378/1687 631/61/490 64/60 Agriculture Animals ASCL1 protein Astrocytes Astrocytes - cytology Astrocytes - transplantation Beta2 protein Bioinformatics Biomedical and Life Sciences Biomedical Engineering/Biotechnology Biomedicine Biotechnology Cell Differentiation - genetics Cells Cells, Cultured Cellular Reprogramming Techniques - methods Chromatin remodeling Direct conversion Dopamine Dopaminergic Neurons - cytology Efficiency Excitability Fibroblasts Health aspects Humans Infections Life Sciences Mesencephalon Mice miRNA Morphology Movement disorders Movement Disorders - etiology Movement Disorders - pathology Movement Disorders - prevention & control Neostriatum Neural circuitry Neurodegeneration Neurodegenerative diseases Neurogenesis Neurons Neurosciences Parkinson disease Parkinson Disease - complications Parkinson Disease - pathology Parkinson Disease - therapy Parkinson's disease Physiological aspects Sample variance Transcription factors Treatment Outcome Wnt protein Sweden
ISSN:	1087-0156, 1546-1696, 1546-1696
Online-Zugang:	Volltext
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