Clonal evolution and resistance to EGFR blockade in the blood of colorectal cancer patients

By monitoring ctDNA, the authors reveal the dynamic adaption of clonal populations in colorectal cancer patients treated with anti-EGFR therapy, suggesting that therapeutic re-challenge may have some benefit. Colorectal cancers (CRCs) evolve by a reiterative process of genetic diversification and cl...

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Bibliographic Details
Published in:	Nature medicine Vol. 21; no. 7; pp. 795 - 801
Main Authors:	Siravegna, Giulia, Mussolin, Benedetta, Buscarino, Michela, Corti, Giorgio, Cassingena, Andrea, Crisafulli, Giovanni, Ponzetti, Agostino, Cremolini, Chiara, Amatu, Alessio, Lauricella, Calogero, Lamba, Simona, Hobor, Sebastijan, Avallone, Antonio, Valtorta, Emanuele, Rospo, Giuseppe, Medico, Enzo, Motta, Valentina, Antoniotti, Carlotta, Tatangelo, Fabiana, Bellosillo, Beatriz, Veronese, Silvio, Budillon, Alfredo, Montagut, Clara, Racca, Patrizia, Marsoni, Silvia, Falcone, Alfredo, Corcoran, Ryan B, Di Nicolantonio, Federica, Loupakis, Fotios, Siena, Salvatore, Sartore-Bianchi, Andrea, Bardelli, Alberto
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.07.2015 Nature Publishing Group
Subjects:	45/22 45/23 45/62 45/77 631/67/2329 Alleles Antibodies - pharmacology Antibodies - therapeutic use Antibodies, Neoplasm - blood Antineoplastic Agents - pharmacology Antineoplastic Agents - therapeutic use Biomedicine Blood Cancer Research Care and treatment Clonal Evolution Clone Cells Colorectal cancer Colorectal carcinoma Colorectal Neoplasms - blood Colorectal Neoplasms - drug therapy Colorectal Neoplasms - genetics Colorectal Neoplasms - pathology Development and progression DNA, Neoplasm - blood Drug Resistance, Neoplasm - genetics Genetic aspects Heterogeneity Humans Infectious Diseases letter Metabolic Diseases Molecular Medicine Mutation - genetics Neurosciences Proto-Oncogene Proteins - genetics Proto-Oncogene Proteins p21(ras) ras Proteins - genetics Receptor, Epidermal Growth Factor - antagonists & inhibitors Receptor, Epidermal Growth Factor - genetics Receptor, Epidermal Growth Factor - immunology Italy United Kingdom
ISSN:	1078-8956, 1546-170X
Online Access:	Get full text
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