Trapping the dynamic acyl carrier protein in fatty acid biosynthesis

A highly specific chemical crosslinking method is used to trap a complex between an acyl carrier protein and a fatty acid dehydratase during fatty acid biosynthesis; subsequent X-ray crystallography, NMR spectroscopy and molecular dynamics simulations techniques enable the detailed study of this com...

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Veröffentlicht in:	Nature (London) Jg. 505; H. 7483; S. 427 - 431
Hauptverfasser:	Nguyen, Chi, Haushalter, Robert W., Lee, D. John, Markwick, Phineus R. L., Bruegger, Joel, Caldara-Festin, Grace, Finzel, Kara, Jackson, David R., Ishikawa, Fumihiro, O’Dowd, Bing, McCammon, J. Andrew, Opella, Stanley J., Tsai, Shiou-Chuan, Burkart, Michael D.
Format:	Journal Article
Sprache:	Englisch
Veröffentlicht:	London Nature Publishing Group UK 16.01.2014 Nature Publishing Group
Schlagworte:	631/535/1266 631/92/287/1183 631/92/60 Acyl Carrier Protein - chemistry Acyl Carrier Protein - metabolism Binding Sites Biosynthesis Catalytic Domain Cross-Linking Reagents - chemistry Crosslinked polymers Crystal structure Crystallography, X-Ray Dehydration E coli Enzymes Escherichia coli - chemistry Fatty Acid Synthase, Type II - chemistry Fatty Acid Synthase, Type II - metabolism Fatty acids Fatty Acids - biosynthesis Histidine - metabolism Humanities and Social Sciences Hydro-Lyases - chemistry Hydro-Lyases - metabolism Infectious diseases letter Magnetic Resonance Spectroscopy Metabolites Models, Molecular Molecular Dynamics Simulation multidisciplinary NMR Nuclear magnetic resonance Physiological aspects Protein Binding Protein Interaction Maps Proteins Science Synthesis United States
ISSN:	0028-0836, 1476-4687, 1476-4687
Online-Zugang:	Volltext
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