Rare coding variants in PLCG2, ABI3, and TREM2 implicate microglial-mediated innate immunity in Alzheimer's disease

Sven van der Lee, Julie Williams, Gerard Schellenberg and colleagues identify rare coding variants in PLCG2 , ABI3 and TREM2 associated with Alzheimer's disease. These genes are highly expressed in microglia and provide additional evidence that the microglia-mediated immune response contributes...

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Bibliographic Details
Published in:	Nature genetics Vol. 49; no. 9; pp. 1373 - 1384
Main Authors:	Badarinarayan, Nandini, Bis, Joshua C, Heilmann-Heimbach, Stefanie, Sleegers, Kristel, Vronskaya, Maria, White, Charles C, Hamilton-Nelson, Kara L, Choi, Seung-Hoan, Forstner, Andreas J, Bacq, Delphine, Brody, Jennifer A, Wolters, Frank J, Fornage, Myriam, Majounie, Elisa, Wallon, David, Lupton, Michelle K, Jian, Xueqiu, Mukherjee, Shubhabrata, Solfrizzi, Vincenzo, Allen, Mariet, Cupples, L Adrienne, Giegling, Ina, Giedraitis, Vilmantas, Wang, Xue, Mecocci, Patrizia, Eiriksdottir, Gudny, Chen, Yuning, Frosch, Matthew P, Huebinger, Ryan M, Morris, John, Sotolongo-Grau, Oscar, Katz, Mindy J, Braddel, Amy, Chapman, Jade, Hill, Matt, Vellas, Bruno, Soininen, Hilkka, Hughes, Joseph T, Mayhaus, Manuel, Maletta, Raffaele Giovanni, Carrell, David, Pilotto, Alberto, Fox, Nick C, Arnold, Steven E, Becker, James T, Burke, James R, Carlsson, Cynthia M, Clark, David G, Cribbs, David H, Duara, Ranjan, Evans, Denis A, Fallon, Kenneth B, Farlow, Martin R, Foroud, Tatiana M, Galasko, Douglas R, Jin, Lee-Way, Lah, James J, Levey, Allan I, Lieberman, Andrew P, McKee, Ann C, Morris, John C, Paulson, Henry L, Peskind, Elaine, Quinn, Joseph F, Raskind, Murray, Spina, Salvatore, Swerdlow, Russell H, Van Eldik, Linda J, Vinters, Harry V, Vonsattel, Jean Paul, De Deyn, Peter P, Concari, Letizia, Brice, Alexis, Dubois, Bruno, Tschanz, JoAnn, Fitzpatrick, Annette L, Kukull, Walter A, Bullido, María J, Coto, Eliecer, Reiman, Eric M, Gallo, Maura, Scarpini, Elio, Tsuang, Debby W, Bonuccelli, Ubaldo, Rubinsztein, David C, Bras, Jose, Guerreiro, Rita, Lovestone, Simon, Owen, Michael J, Cruchaga, Carlos, Powell, John, De Jager, Philip L, Rujescu, Dan, Ortega-Cubero, Sara, Ikram, M Arfan, Mayeux, Richard, Deleuze, Jean-François, Amin, Najaf, Amouyel, Philippe, van Duijn, Cornelia M
Format:	Journal Article
Language:	English
Published:	New York Nature Publishing Group US 01.09.2017 Nature Publishing Group
Subjects:	45/43 631/208/205/2138 692/699/375/365/1283 Adaptor Proteins, Signal Transducing - genetics Agriculture Alzheimer Disease - genetics Alzheimer's disease Amino Acid Sequence Animal Genetics and Genomics Bioinformatics Biomedicine Cancer Research Case-Control Studies Consortia Development and progression Disease control DNA methylation DNA microarrays Exome - genetics Gene Expression Profiling Gene Frequency Gene Function Genes Genetic aspects Genetic Predisposition to Disease - genetics Genetic variation Genomes Genomics Genotype Genotypes Genotyping Human Genetics Humans Immune response Immune system Immunity Immunity (Disease) Immunity, Innate - genetics Innate immunity letter Life Sciences Linkage Disequilibrium Membrane Glycoproteins - genetics Microglia Microglia - metabolism Neurodegenerative diseases Neurons and Cognition Odds Ratio Phospholipase C gamma - genetics Physiological aspects Polymorphism, Single Nucleotide Protein interaction Protein Interaction Maps - genetics Proteins Receptors, Immunologic - genetics Sequence Homology, Amino Acid Studies United States United Kingdom Netherlands
ISSN:	1061-4036, 1546-1718, 1546-1718
Online Access:	Get full text
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